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Article ; Online: The Association between Neighborhood Disorder and Health: Exploring the Moderating Role of Genotype and Marriage.

Lei, Man-Kit / Simons, Ronald L

International journal of environmental research and public health

2021 Volume 18, Issue 3

Abstract: The present study extends prior research on the link between neighborhood disorder and health by testing an integrated model that combines various social and biological factors. Hypotheses were tested using a sample of 325 African American women from the ...

Abstract	The present study extends prior research on the link between neighborhood disorder and health by testing an integrated model that combines various social and biological factors. Hypotheses were tested using a sample of 325 African American women from the Family and Community Health Study (FACHS). As expected, inflammatory burden was the biophysiological mechanism that mediated much of the association between neighborhood physical disorder and perceived physical health. This finding provided additional support for the view that global self-ratings of health are powerful predictors of morbidity because, in large measure, they are indicators of chronic, systemic inflammation. Further, both genetic variation and marital status served to moderate the association between neighborhood disorder and health. Finally, being married largely eliminated the probability that neighborhood disorder would combine with genetic vulnerability to increase inflammatory burden and perceived illness. Overall, the findings demonstrate the value of constructing integrated models that specify various biophysiological mechanisms that link social conditions to physical health.
MeSH term(s)	African Americans/genetics ; Female ; Genotype ; Humans ; Marriage ; Residence Characteristics ; Social Conditions
Language	English
Publishing date	2021-01-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18030898
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Article ; Online: Neighborhood disadvantage is associated with biological aging: Intervention-induced enhancement of couple functioning confers resilience.

Lei, Man-Kit / Beach, Steven R H

Family process

2022 Volume 62, Issue 2, Page(s) 818–834

Abstract: The accelerated pace of biological aging predicts mortality and morbidity later in life. The current study examines whether a change in supportive couple functioning buffers accelerated aging associated with stressful community environments among Black ... ...

Abstract	The accelerated pace of biological aging predicts mortality and morbidity later in life. The current study examines whether a change in supportive couple functioning buffers accelerated aging associated with stressful community environments among Black Americans who live in rural, Southern, disadvantaged neighborhoods. We examined 348 Black American middle-aged adults assigned randomly to receive the Protecting Strong African American Families (ProSAAF) intervention or a control condition. The program was designed to enhance supportive couple functioning among Black Americans. We used DunedinPoAm to quantify the methylation pace of aging and employed the Area Deprivation Index at the census block group level to measure neighborhood disadvantage. Neighborhood disadvantage was associated with the accelerated pace of aging. Further, participation in ProSAAF enhanced supportive couple functioning, and improvement in couple functioning protected participants from the harmful effects of neighborhood disadvantage on the accelerated pace of aging. These findings supported mediated moderation and suggested that family-based prevention programs that enhance couple support may decrease the erosive effects of neighborhood disadvantage and improve prospects for healthy aging among rural, Southern, Black Americans living in difficult circumstances. This may provide a supplemental strategy for decreasing health disparities due to neighborhood disadvantage by enhancing family systems.
MeSH term(s)	Adult ; Middle Aged ; Humans ; Aging ; Black or African American ; Residence Characteristics ; Rural Population ; Neighborhood Characteristics
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	212740-4
ISSN	1545-5300 ; 0014-7370
ISSN (online)	1545-5300
ISSN	0014-7370
DOI	10.1111/famp.12808
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Article ; Online: Social and psychological consequences of the COVID-19 outbreak: The experiences of Taiwan and Hong Kong.

Lei, Man-Kit / Klopack, Eric T

Psychological trauma : theory, research, practice and policy

2020 Volume 12, Issue S1, Page(s) S35–S37

Abstract: This article discusses the value of studying past social and psychological responses to pandemics and natural disasters in understanding reactions to coronavirus disease of 2019 (COVID-19). By examining severe acute respiratory syndrome (SARS) ... ...

Abstract	This article discusses the value of studying past social and psychological responses to pandemics and natural disasters in understanding reactions to coronavirus disease of 2019 (COVID-19). By examining severe acute respiratory syndrome (SARS) experiences in both Taiwan and Hong Kong, we indicate that psychological trauma might be a pathway whereby the COVID-19 outbreak affects long-term health and well-being and that psychological and collective trauma caused by the COVID-19 may relate to future preparedness and risk awareness. We conclude with a consideration of social-psychological processes for future research. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
MeSH term(s)	COVID-19 ; Coronavirus Infections/psychology ; Hong Kong ; Humans ; Pandemics ; Pneumonia, Viral/psychology ; Psychological Trauma/psychology ; Risk ; Severe Acute Respiratory Syndrome/psychology ; Taiwan
Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0000633
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Association between Neighborhood Disorder and Health

Man-Kit Lei / Ronald L. Simons

International Journal of Environmental Research and Public Health, Vol 18, Iss 898, p

Exploring the Moderating Role of Genotype and Marriage

2021 Volume 898

Abstract	The present study extends prior research on the link between neighborhood disorder and health by testing an integrated model that combines various social and biological factors. Hypotheses were tested using a sample of 325 African American women from the Family and Community Health Study (FACHS). As expected, inflammatory burden was the biophysiological mechanism that mediated much of the association between neighborhood physical disorder and perceived physical health. This finding provided additional support for the view that global self-ratings of health are powerful predictors of morbidity because, in large measure, they are indicators of chronic, systemic inflammation. Further, both genetic variation and marital status served to moderate the association between neighborhood disorder and health. Finally, being married largely eliminated the probability that neighborhood disorder would combine with genetic vulnerability to increase inflammatory burden and perceived illness. Overall, the findings demonstrate the value of constructing integrated models that specify various biophysiological mechanisms that link social conditions to physical health.
Keywords	neighborhood disorder ; inflammatory burden ; physical health ; genotype ; marital status ; African Americans ; Medicine ; R
Subject code	360
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans.

Simons, Ronald L / Ong, Mei Ling / Lei, Man-Kit / Beach, Steven R H / Zhang, Yue / Philibert, Robert / Mielke, Michelle M

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024

Abstract: Introduction: Recent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans.: Methods: The present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to ... ...

Abstract	Introduction: Recent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans. Methods: The present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to which exposure to racial discrimination predicts subsequent changes in serum Alzheimer's Disease Research Center (ADRC) biomarkers: serum phosphorylated tau181(p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). We hypothesized that racial discrimination assessed during middle age would predict increases in these serum biomarkers as the participants aged into their 60s. Results: Our findings indicate that exposure to various forms of racial discrimination during a person's 40s and early 50s predicts an 11-year increase in both serum p-tau181 and NfL. Racial discrimination was not associated with subsequent levels of GFAP. Discussion: These findings suggest that racial discrimination in midlife may contribute to increased AD pathology and neurodegeneration later in life. Highlights: A 17-year longitudinal study of Black Americans. Assessments of change in serum p-tau181, neurofilament light, and glial fibrillary acidic protein. Exposure to racial discrimination during middle age predicted increases in p-tau181 and neurofilament light. Education was positively related to both p-tau181 and exposure to racial discrimination.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13751
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Article ; Online: Intervention effects on self-control decrease speed of biological aging mediated by changes in substance use: A longitudinal study of African American youth.

Lei, Man-Kit / Brody, Gene H / Beach, Steven R H

Family process

2021 Volume 61, Issue 2, Page(s) 659–673

Abstract: Biological aging is a common root for multiple diseases causing morbidity and mortality, and trajectories of aging may start early in life. This study was designed to examine whether a universal family-based substance use preventive intervention to ... ...

Abstract	Biological aging is a common root for multiple diseases causing morbidity and mortality, and trajectories of aging may start early in life. This study was designed to examine whether a universal family-based substance use preventive intervention to enhance self-control and reduce substance use would also result in reductions in biological aging among Black youth from the rural South. The Adults in the Making (AIM) program is a randomized controlled trial with six 2-h sessions for Black youth. The 216 youths agreeing to provide blood at age 22 included 114 who had received the AIM intervention and 102 who assigned to the control group. We examined accelerated DNA methylation (DNAm)-based aging using a recently developed measure, "GrimAge," that has been shown to predict the risk of early mortality and that is known to be more strongly affected by substance use than other DNAm-based aging indices. Relative to those randomly assigned to the control group, those receiving the intervention demonstrated significantly enhanced self-control, slower increases in substance use, and reduced Grim aging at age 22. Using a bootstrapping method with 1000 replications, we found a significant indirect effect of AIM on reduced Grim aging through its effect on self-control and substance use. Sensitivity analyses examined effects using other indices of DNAm-based aging. These findings suggest that a family-based program designed to enhance rural Black youth's self-control can have beneficial effects on self-control, enhancing young adult health and health behavior, and ultimately decreased mortality risk.
MeSH term(s)	Adolescent ; Adult ; African Americans ; Aging ; Humans ; Longitudinal Studies ; Self-Control ; Substance-Related Disorders/prevention & control ; Young Adult
Language	English
Publishing date	2021-08-14
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	212740-4
ISSN	1545-5300 ; 0014-7370
ISSN (online)	1545-5300
ISSN	0014-7370
DOI	10.1111/famp.12715
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Article: The Impact of Harsh Parenting on the Development of Obesity in Adulthood: An Examination of Epigenetic/Gene Expression Mediators Among African American Youth.

Lei, Man-Kit / Beach, Steven R H / Simons, Ronald L / Ye, Kaixiong

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 755458

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.755458
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Article ; Online: Social and psychological consequences of the COVID-19 outbreak

Lei, Man-Kit / Klopack, Eric T.

Psychological Trauma: Theory, Research, Practice, and Policy

The experiences of Taiwan and Hong Kong.

2020 Volume 12, Issue S1, Page(s) S35–S37

Keywords	Clinical Psychology ; Social Psychology ; covid19
Language	English
Publisher	American Psychological Association (APA)
Publishing country	us
Document type	Article ; Online
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0000633
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Losing Years Doing Time: Incarceration Exposure and Accelerated Biological Aging among African American Adults.

Berg, Mark T / Rogers, Ethan M / Lei, Man-Kit / Simons, Ronald L

Journal of health and social behavior

2021 Volume 62, Issue 4, Page(s) 460–476

Abstract: Research suggests that incarceration exposure increases the prevalence of morbidity and premature mortality. This work is only beginning to examine whether the stressors of the incarceration experience become biologically embedded in ways that affect ... ...

Abstract	Research suggests that incarceration exposure increases the prevalence of morbidity and premature mortality. This work is only beginning to examine whether the stressors of the incarceration experience become biologically embedded in ways that affect physiological deterioration. Using data from a longitudinal sample of 410 African American adults in the Family and Community Health Study and an epigenetic index of aging, this study tests the extent to which incarceration accelerates epigenetic aging and whether experiences with violence moderate this association. Results from models that adjust for selection effects suggest that incarceration exposure predicted accelerated aging, leaving formerly incarcerated African American individuals biologically older than their calendar age. Direct experiences with violence also exacerbated the effects of incarceration. These findings suggest that incarceration possibly triggers a stress response that affects a biological signature of physiological deterioration.
MeSH term(s)	Adult ; African Americans ; Aging ; Humans ; Prevalence ; Prisoners
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	218206-3
ISSN	2150-6000 ; 0022-1465
ISSN (online)	2150-6000
ISSN	0022-1465
DOI	10.1177/00221465211052568
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Article ; Online: Can We Uncouple Neighborhood Disadvantage and Delinquent Behaviors? An Experimental Test of Family Resilience Guided by the Social Disorganization Theory of Delinquent Behaviors.

Lei, Man-Kit / Beach, Steven R H

Family process

2020 Volume 59, Issue 4, Page(s) 1801–1817

Abstract: Although the influence of neighborhood disadvantage on youth development of delinquent behavior is well established, findings from this research have yet to inform the development of family-centered prevention programming to protect youth from these ... ...

Abstract	Although the influence of neighborhood disadvantage on youth development of delinquent behavior is well established, findings from this research have yet to inform the development of family-centered prevention programming to protect youth from these erosive effects. The current paper examines the role of family integration in buffering the impact of social disadvantage in a sample of N = 298 families randomly assigned either to a control condition or to a family-based prevention program previously shown to enhance marriage and parenting. We first confirmed that neighborhood concentrated disadvantage predicted change in delinquent behaviors across the course of the study. Additionally, replicating prior work, parents participating in the Protecting Strong African American Families (ProSAAF) program, relative to those randomly assigned to the control group, significantly improved their use of effective communication strategies with each other and reduced ineffective conflict in front of youth. This resulted in a significant indirect effect of ProSAAF on change in youth delinquent behaviors. Furthermore, using mediated moderation analysis, the study tested the buffering effect of greater family integration, showing that experimentally produced change in interparental communication skills and the resulting reduction in youth exposure to parental conflict buffered the effect of neighborhood disadvantage on change in youth delinquent behaviors, supporting a mediated moderation model in which family environments buffer neighborhood effects.
MeSH term(s)	Adolescent ; Adult ; African Americans/psychology ; Anomie ; Child ; Communication ; Family Conflict/psychology ; Family Therapy/methods ; Female ; Humans ; Juvenile Delinquency/prevention & control ; Juvenile Delinquency/psychology ; Male ; Mediation Analysis ; Parenting/psychology ; Program Evaluation ; Psychological Theory ; Residence Characteristics ; Resilience, Psychological ; Social Environment ; Vulnerable Populations/psychology
Language	English
Publishing date	2020-02-19
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	212740-4
ISSN	1545-5300 ; 0014-7370
ISSN (online)	1545-5300
ISSN	0014-7370
DOI	10.1111/famp.12527
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