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  1. Article ; Online: Response to Bernardy et al. comment on "pregnancy in axial spondyloarthropathy: A systematic review and meta-analysis.

    Maguire, Sinead

    Seminars in arthritis and rheumatism

    2021  Volume 51, Issue 5, Page(s) e2–e4

    MeSH term(s) Female ; Humans ; Pregnancy ; Spondylarthritis ; Spondylarthropathies/drug therapy
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2021.05.003
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  2. Article ; Online: Pregnancy & neonatal outcomes in spondyloarthritis.

    Maguire, Sinead / Molto, Anna

    Best practice & research. Clinical rheumatology

    2023  Volume 37, Issue 3, Page(s) 101868

    Abstract: Limited research has been conducted on the impact of spondylitis (SpA) on fertility, but some studies suggest a higher risk of subfertility in women with SpA compared to the general population. Factors associated with impaired fertility in SpA include ... ...

    Abstract Limited research has been conducted on the impact of spondylitis (SpA) on fertility, but some studies suggest a higher risk of subfertility in women with SpA compared to the general population. Factors associated with impaired fertility in SpA include pain, fatigue, stiffness, functional disorders, depression, anxiety, negative body image, and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) preconceptionally, while TNF alpha inhibitors may play a role in improving fertility in certain cases. There has been a recent increase in clinical research focused on pregnancy outcomes in SpA. However, clear trends in terms of risk of pregnancy and fetal complications have been slow to emerge and many questions remain for women with SpA planning a pregnancy. This article discusses the current evidence for risk of specific pregnancy and fetal complications in women with axial and psoriatic SpA.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Humans ; Female ; Pregnancy Outcome ; Spondylarthritis/complications ; Spondylarthritis/drug therapy ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Spondylitis, Ankylosing/drug therapy
    Chemical Substances Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-08-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2023.101868
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  3. Article ; Online: The negative impact of depression in women with Axial Spondyloarthropathy.

    Maguire, Sinead / Gallagher, Phil / O'Shea, Finbar

    Joint bone spine

    2021  Volume 89, Issue 1, Page(s) 105261

    MeSH term(s) Depression/epidemiology ; Depression/etiology ; Female ; Humans ; Spondylarthritis ; Spondylarthropathies/complications
    Language English
    Publishing date 2021-09-02
    Publishing country France
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2021.105261
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  4. Article: The negative impact of undiagnosed depression in axial spondyloarthropathy.

    Maguire, Sinead / Gallagher, Phil / O'Shea, Finbar

    Clinical and experimental rheumatology

    2021  Volume 40, Issue 3, Page(s) 669–670

    MeSH term(s) Depression/diagnosis ; Depression/etiology ; Humans ; Spondylarthritis ; Spondylarthropathies/diagnosis
    Language English
    Publishing date 2021-10-21
    Publishing country Italy
    Document type Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/d6518k
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  5. Article: Undiagnostizierte Depressionen bei axialer SpA

    Maguire, Sinead / Gallagher, Phil / O'Shea, Finbar

    Morbus-Bechterew-Journal

    2022  Volume 43, Issue 170, Page(s) 16

    Language German
    Document type Article
    ZDB-ID 2119820-2
    ISSN 1861-2105
    Database Current Contents Medicine

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  6. Article: Employment and Functional Ability in Men and Women With Axial Spondyloarthritis as Described in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

    Maguire, Sinead / Fitzgerald, Gillian / O'Shea, Finbar

    The Journal of rheumatology

    2021  Volume 48, Issue 12, Page(s) 1890

    MeSH term(s) Arthritis, Psoriatic ; Axial Spondyloarthritis ; Employment ; Female ; Humans ; Male ; Registries ; Spondylarthritis
    Language English
    Publishing date 2021-09-01
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.210469
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  7. Article ; Online: Effectiveness of Ultrasound-guided versus Landmark-based Glucocorticoid Injection in the Treatment of First Carpometacarpal Joint Osteoarthritis.

    Al-Nokhatha, Shamma Ahmad / Maguire, Sinead / Corcoran, Luke / Mac Eoin, Neil / Conway, Richard / Johnson, Ciaran

    POCUS journal

    2023  Volume 8, Issue 2, Page(s) 230–236

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-27
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-8543
    ISSN (online) 2369-8543
    DOI 10.24908/pocus.v8i2.16594
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  8. Article ; Online: Social isolation due to the COVID-19 pandemic has led to worse outcomes in females with inflammatory arthritis.

    Maguire, Sinead / O'Shea, Finbar

    Irish journal of medical science

    2020  Volume 190, Issue 1, Page(s) 33–38

    Abstract: Background: Prolonged social isolation as a result of the COVID-19 global pandemic has been a source of considerable psychological distress for many people. This can manifest in many ways and if left undetected can impact negatively on general health. ... ...

    Abstract Background: Prolonged social isolation as a result of the COVID-19 global pandemic has been a source of considerable psychological distress for many people. This can manifest in many ways and if left undetected can impact negatively on general health. It is essential to understand the impact of these conditions on inflammatory arthritis (IA) patients, especially axial spondyloarthropathy (axSpA).
    Aim: To capture the level of psychological distress for patients with IA following prolonged social isolation.
    Methods: A survey was sent out to patients with a confirmed diagnosis of IA. This captured changes in sleep, mood, disease activity, employment and general health since the beginning of the social isolation period. A PHQ-4 (Patient Health Questionnaire) was included to determine level of psychological distress.
    Results: Females with IA reported significantly higher rates of decline in general health (40% vs 16%, p = 0.01), mood disturbance (43.4% vs 26%, p = 0.03) and increased disease activity (50% vs 16%, p = 0.01) compared to males. Evaluating the mean PHQ-4 scores, no significant difference was noted between genders (4.80 vs 3.44, p = 0.10). However, females demonstrated a non-significant trend toward increased rates of moderate to severe psychological distress (40% vs 30%, p = 0.13). Subanalysis of patients with axSpA found high rates of moderate to severe distress in both genders.
    Conclusions: Females with IA reported significantly higher rates of decline in general health, mood disturbance and increased disease activity during the period of social isolation. This was reflected in a trend towards greater levels of psychological distress.
    MeSH term(s) Affect ; Arthritis/physiopathology ; Arthritis/psychology ; COVID-19 ; Employment ; Female ; Health Status ; Humans ; Ireland ; Male ; Middle Aged ; Pandemics ; Patient Health Questionnaire ; Physical Distancing ; Psychological Distress ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Sex Factors ; Sleep ; Social Isolation/psychology ; Spondylarthropathies/physiopathology ; Spondylarthropathies/psychology ; Surveys and Questionnaires ; Teleworking ; Unemployment
    Keywords covid19
    Language English
    Publishing date 2020-07-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-020-02307-2
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  9. Article: Central Obesity in Axial Spondyloarthritis: The Missing Link to Understanding Worse Outcomes in Women?

    Maguire, Sinead / Wilson, Fiona / Gallagher, Phil / O'Shea, Finbar

    The Journal of rheumatology

    2022  Volume 49, Issue 6, Page(s) 577–584

    Abstract: Objective: To determine (1) the prevalence of central obesity in axial spondyloarthritis (axSpA) and its effect on disease-related outcomes and (2) how this differs between sexes.: Methods: Data were extracted from the Ankylosing Spondylitis Registry ...

    Abstract Objective: To determine (1) the prevalence of central obesity in axial spondyloarthritis (axSpA) and its effect on disease-related outcomes and (2) how this differs between sexes.
    Methods: Data were extracted from the Ankylosing Spondylitis Registry of Ireland. Patients with physical measurements for the calculation of anthropometric measures were included. BMI and waist-to-hip ratio (WHR) were used to compare classifications of obesity. Comparison analyses based on sex and central obesity were carried out. Multivariate analysis examined the effects of these factors on the following patient-reported outcomes: the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, and the Health Assessment Questionnaire (HAQ).
    Results: In total, 753 patients were included in the analysis. Of these patients, 29.6% (n = 223) were classified as obese based on their BMI, and 41.3% (n = 311) were classified as centrally obese according to the WHR. The prevalence of central obesity was significantly higher among women with axSpA compared to men (71.6% vs 29.9%,
    Conclusion: There was a high prevalence of central obesity as assessed by the WHR in axSpA, most notably among women with axSpA. This modifiable comorbidity was significantly associated with worse quality of life, greater impairment of functional ability, and a trend toward worse disease activity. Regular use of the WHR to screen for central obesity as part of an axSpA assessment would provide an opportunity for prompt identification and intervention for at-risk patients.
    MeSH term(s) Axial Spondyloarthritis ; Cross-Sectional Studies ; Female ; Humans ; Male ; Obesity/complications ; Obesity/epidemiology ; Obesity, Abdominal/complications ; Obesity, Abdominal/epidemiology ; Quality of Life ; Severity of Illness Index ; Spondylarthritis/complications ; Spondylarthritis/epidemiology ; Spondylitis, Ankylosing/complications
    Language English
    Publishing date 2022-03-01
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.211062
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  10. Article ; Online: Advances in treatment of axial spondyloarthritis are associated with improved patient outcomes: data from the Ankylosing Spondylitis Registry of Ireland (ASRI).

    Maguire, Sinead / Fitzgerald, Gillian / Gallagher, Phil / O'Shea, Finbar

    Rheumatology international

    2022  Volume 42, Issue 5, Page(s) 831–838

    Abstract: The Ankylosing Spondylitis Registry of Ireland (ASRI) captures both radiographic and non-radiographic axial spondyloarthritis (axSpA) in a large, well characterised cohort. This is a valuable resource for studies in therapeutics and burden of disease, ... ...

    Abstract The Ankylosing Spondylitis Registry of Ireland (ASRI) captures both radiographic and non-radiographic axial spondyloarthritis (axSpA) in a large, well characterised cohort. This is a valuable resource for studies in therapeutics and burden of disease, following a period of rapid change in the field of axSpA. This study aims to perform a focused analysis on patient outcomes and pattern of medication usage in axSpA. This is a cross-sectional study of registry data on 885 patients with confirmed axSpA as per the ASAS criteria for axSpA, as diagnosed by a Rheumatologist. Analysis was performed using IBM SPSS version 26. Patients were analysed on the basis of treatment categorised as: no medication, NSAIDs, biologics or combination therapy. Statistical significance was indicated by p value of < 0.05. Currently 885 patients are enrolled in the ASRI, made up of 72.5% (642) males and 26.9% (238) females. The majority of the cohort was categorized as radiographic axSpA 78.3% (693), with 21.7% (192) meeting criteria for non-radiographic disease. Overall 40.6% (359) reported at least one comorbidity. Older age was associated with no medications compared to those on biologic therapy (50.3 vs 45, p = 0.01). Lower levels of disease activity and higher quality of life were noted in those on biologics as compared to NSAIDs alone. This analysis provides detailed epidemiological data on axSpA from a large national registry. These results detail significant differences in prescribing patterns and impact on patient outcomes in axSpA. Ongoing development of registries provides a valuable insight into the real-world effects of axSpA.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Axial Spondyloarthritis ; Biological Products/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Ireland/epidemiology ; Male ; Quality of Life ; Registries ; Spondylarthritis/diagnostic imaging ; Spondylarthritis/drug therapy ; Spondylarthritis/epidemiology ; Spondylitis, Ankylosing/diagnostic imaging ; Spondylitis, Ankylosing/drug therapy ; Spondylitis, Ankylosing/epidemiology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Biological Products
    Language English
    Publishing date 2022-01-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-021-05067-z
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