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Article: Monitoring Thyrotropin in Veterans With Thyroid Nodules.

Kaul, Sabrina / Gupta, Ankur

Federal practitioner : for the health care professionals of the VA, DoD, and PHS

2023 Volume 40, Issue 11, Page(s) 378–382

Abstract: Background: After the initial thyroid nodule diagnosis, a patient's thyrotropin is often monitored. However, the American Thyroid Association guidelines do not offer recommendations for follow-up thyrotropin testing for patients with thyroid nodules who ...

Abstract	Background: After the initial thyroid nodule diagnosis, a patient's thyrotropin is often monitored. However, the American Thyroid Association guidelines do not offer recommendations for follow-up thyrotropin testing for patients with thyroid nodules who have no history of conditions or known medications that affect thyroid hormone levels. Methods: At the Veterans Affairs Dayton Healthcare System in Ohio, we conducted a retrospective chart review from January 2010 to December 2016 of 100 patients diagnosed with ≥ 1 thyroid nodule on imaging studies who had normal blood thyrotropin at the time of nodule diagnosis. The thyrotropin value was studied at and after diagnosis. A 95% CI was determined for the true population rate of patients with an abnormal thyrotropin at their most recent testing. χ Results: One hundred patients (male [83%], White race [82%]) with normal thyrotropin at nodule diagnosis had thyrotropin monitoring for a mean (SD) of 5.7 (2.5) years. Six of 100 patients (6%; 95% CI, 2.5%-12.7%) developed abnormal thyrotropin levels in a mean (SD) of 6.9 (3.1) years. When comparing the 6 patients with abnormal thyrotropin vs the 94 with normal thyrotropin, there were no significant differences in sex ( Conclusions: This study found no significant change in thyrotropin levels over time in patients with thyroid nodules and no history of medical conditions or medications known to affect thyrotropin levels. Monitoring thyrotropin over time may not be required in these patients. More studies are needed to provide additional data on thyrotropin monitoring for thyroid nodules so that clinicians can make evidence-based decisions.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ISSN	1078-4497
ISSN	1078-4497
DOI	10.12788/fp.0431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Substance use concerns among Punjabi-Indian communities in Australia: Kamini and alcohol.

Hulme, Ganesh / Higgs, Peter / Erbas, Bircan / Gupta, Sabrina

Drug and alcohol review

2022 Volume 42, Issue 3, Page(s) 515–516

MeSH term(s)	Humans ; Substance-Related Disorders/epidemiology ; Ethanol ; Ethnicity ; Australia/epidemiology ; Indians, North American
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-10-10
Publishing country	Australia
Document type	Letter
ZDB-ID	1080442-0
ISSN	1465-3362 ; 0959-5236
ISSN (online)	1465-3362
ISSN	0959-5236
DOI	10.1111/dar.13560
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Article ; Online: Barriers and facilitators of lifestyle management among adult South Asian migrants living with chronic diseases: A mixed-methods systematic review.

Gulyani, Purva / Rawat, Priya / Elmi, Yusra / Gupta, Sabrina / Wan, Ching Shan

Diabetes & metabolic syndrome

2024 Volume 18, Issue 2, Page(s) 102944

Abstract: Background and aim: South Asian migrants have a higher prevalence of chronic diseases than Caucasians. Despite much literature that has explored challenges in chronic disease management amongst the South Asian population in the past decades, their ... ...

Abstract	Background and aim: South Asian migrants have a higher prevalence of chronic diseases than Caucasians. Despite much literature that has explored challenges in chronic disease management amongst the South Asian population in the past decades, their chronic disease management is still suboptimal. Understanding their determinants of disease management behaviour using the Theoretical Domains Framework will inform the development of a culturally sensitive intervention relevant to consumer-end-users. This study aimed to synthesise qualitative and quantitative studies on chronic disease management among adult South Asian immigrants. Methods: A mixed-methods systematic review was conducted using electronic databases. The Mixed Methods Appraisal Tool assessed the quality of the included studies. Quantitative data were transformed into qualitative data and analysed thematically. Subthemes were mapped in the Theoretical Domains Framework presenting barriers and facilitators under each theme. Results: 18293 studies were identified, of which 37 studies were included. The barriers and facilitators identified were categorised into four overarching themes: patient-provider interaction and relationship (e.g., complex language use by health professionals), the impact of migration (e.g., weather conditions had an impact on engagement with physical activity), heritage-based practices (e.g., an obligation to consume energy-dense food in social gatherings), and chronic disease management strategies (e.g., lack understanding of appropriate disease management strategies). Conclusion: This review provides a comprehensive understanding of the complexity of chronic disease management among South Asian migrants and insights into developing multifaceted interventions to address barriers to chronic disease management, guiding the healthcare professionals in helping overcome South Asians perceived barriers to managing chronic disease in the host countries.
MeSH term(s)	Adult ; Humans ; Chronic Disease ; Life Style ; Transients and Migrants ; South Asian People
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2024.102944
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Article: An Automated Segmentation of Leukocytes Using Modified Watershed Algorithm on Peripheral Blood Smear Images.

Abrol, Vipasha / Dhalla, Sabrina / Gupta, Savita / Singh, Sukhwinder / Mittal, Ajay

Wireless personal communications

2023 , Page(s) 1–19

Abstract: Leukemia can be detected by an abnormal rise in the number of immature lymphocytes and by a decrease in the number of other blood cells. To diagnose leukemia, image processing techniques are utilized to examine microscopic peripheral blood smear (PBS) ... ...

Abstract	Leukemia can be detected by an abnormal rise in the number of immature lymphocytes and by a decrease in the number of other blood cells. To diagnose leukemia, image processing techniques are utilized to examine microscopic peripheral blood smear (PBS) images automatically and swiftly. To the best of our knowledge, the initial step in subsequent processing is a robust segmentation technique for identifying leukocytes from their surroundings. The paper presents the segmentation of leukocytes in which three color spaces are considered in this study for image enhancement. The proposed algorithm uses a marker-based watershed algorithm and peak local maxima. The algorithm was used on three different datasets with various color tones, image resolutions, and magnifications. The average precision for all three-color spaces was the same, i.e. 94% but the Structural Similarity Index Metric (SSIM) and recall of HSV were better than other two. The results of this study will aid experts in narrowing down their options for segmenting leukemia. Based on the comparison, it was concluded that when the colour space correction technique is used, the accuracy of the proposed methodology improves.
Language	English
Publishing date	2023-05-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1479327-1
ISSN	1572-834X ; 0929-6212
ISSN (online)	1572-834X
ISSN	0929-6212
DOI	10.1007/s11277-023-10424-1
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Article ; Online: Barriers and Enablers of Diabetes Self-Management Strategies Among Arabic-Speaking Immigrants Living with Type 2 Diabetes in High-Income Western countries- A Systematic Review.

Althubyani, Anwar Noor / Gupta, Sabrina / Tang, Clarice Y / Batra, Mehak / Puvvada, Rahul Krishna / Higgs, Peter / Joisa, Markandeya / Thomas, Jency

Journal of immigrant and minority health

2024

Abstract: The aim of this review is to investigate barriers and enablers of diabetes self-management strategies among migrant Arabic-speaking background [ASB] individuals living with type 2 diabetes in high-income Western countries. Despite living in high-income ... ...

Abstract	The aim of this review is to investigate barriers and enablers of diabetes self-management strategies among migrant Arabic-speaking background [ASB] individuals living with type 2 diabetes in high-income Western countries. Despite living in high-income Western countries, individuals from ASB are perceived to have difficulties adopting self-management strategies and this necessitates gaining an understanding of factors that may impact the uptake of these strategies. Ten studies are included in this review: five quantitative and five qualitative. Quality assessment was conducted using the Joanna Briggs Institute Critical Appraisal and Hawker tools. The findings of the quantitative studies were descriptively analysed, while thematic analysis was performed for the qualitative studies. The results indicate that individuals from ASB are perceived to have low levels of adherence to diabetes self-management. It is also suggested that participants who did not complete high school have poorer glycaemic control compared to those with a high school qualification (30 vs. 16%). Regular exercise was reported to be less likely to be adopted by ASBs homemakers, and those who were unemployed, by 82% and 70%, respectively, compared to those employed (homemakers: OR = 0.187, P = 0.006; 95% CI = 056-0.620), (unemployed OR = 0.30, P = 0.046; 95% CI = 0.093-0.980). Cultural, social, religious beliefs, lack of knowledge and language barriers are some of the factors identified that impact self-management among ASB individuals. It is suggested that diabetes self-management education program (DSME) tailored to ASB immigrants culture may be an effective way to encourage them to uptake self-management strategies.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2220162-2
ISSN	1557-1920 ; 1557-1912
ISSN (online)	1557-1920
ISSN	1557-1912
DOI	10.1007/s10903-023-01576-0
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Article ; Online: Social isolation during Covid-19: Boon or bane to diabetes management.

Gupta, Sabrina / Tang, Clarice / Higgs, Peter

Diabetes & metabolic syndrome

2020 Volume 14, Issue 4, Page(s) 567–568

MeSH term(s)	Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Diabetes Mellitus/therapy ; Diabetes Mellitus/virology ; Disease Management ; Exercise ; Global Health ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sedentary Behavior ; Social Isolation
Keywords	covid19
Language	English
Publishing date	2020-05-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2020.04.046
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Article: Using experiential learning and authentic assessments to support students to become competent health promotion practitioners.

Anderson, Karen / Gupta, Sabrina / Nava Buenfil, Fernanda / Verrinder, Glenda

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

2022 Volume 33 Suppl 1, Page(s) 27–34

Abstract: Title: Using experiential learning and authentic assessments to support students to become competent health promotion practitioners.: Issue addressed: The aim of this article is to describe how experiential learning, authentic assessments, community ... ...

Abstract	Title: Using experiential learning and authentic assessments to support students to become competent health promotion practitioners. Issue addressed: The aim of this article is to describe how experiential learning, authentic assessments, community development and ethical principles were consolidated in the design and delivery of a health promotion planning and evaluation subject (HPE) during 2019 to 2021. Experiential learning and authentic assessments were used to guide the development of health promotion competencies in line with the International Union for Health Promotion and Education (IUHPE) Core Competencies and Professional Standards for Health Promotion. Students were required to complete three sequential authentic assessments. Ethics approval was granted for students to undertake a needs/assets assessment with a local community group following which, students completed a literature review and planned a community development program. Methods: The subject comprises 10 h of weekly engagement over a 12-week semester with weekly topics following a program logic model. Working in teams and individually, students work with a local community group to assess their needs/assets and establish priority areas regarding health and wellbeing. This then informed the development of a health promotion program and evaluation plan. Students undertook three sequential authentic assessment tasks: (i) needs/assets report, (ii) a literature review and (iii) a program folio. Retrospective anonymous student feedback on subject (SFS) data from 2019 to 2021 was used to evaluate HPE. Results and discussion: HPE provides students with the opportunity to understand ethical principles and processes, engage with stakeholders in the community and develop qualitative research skills, to plan and evaluate health promotion programs. SFS scores have improved with an overall score of 3.7 (response rate 49.44%) in 2019 to 4.3 (response rate 39.58%) in 2020 and 4.04 (response rate 28.57%) in 2021. Conclusion: Students acquire a broad range of knowledge and skills in line with IUHPE Core Competency and Professional Standards for Health Promotion preparing them for their future professional practice. SO WHAT?: These teaching and learning experiences show that students can develop health promotion competencies through sound pedagogical approaches, both online and face-to-face and in challenging environments.
MeSH term(s)	Humans ; Problem-Based Learning ; Retrospective Studies ; Students ; Learning ; Health Promotion ; Curriculum
Language	English
Publishing date	2022-09-06
Publishing country	Australia
Document type	Review ; Journal Article
ZDB-ID	2250864-8
ISSN	2201-1617 ; 1036-1073
ISSN (online)	2201-1617
ISSN	1036-1073
DOI	10.1002/hpja.654
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Article ; Online: Assessing the performance of group-based trajectory modeling method to discover different patterns of medication adherence.

Diop, Awa / Gupta, Alind / Mueller, Sabrina / Dron, Louis / Harari, Ofir / Berringer, Heather / Kalatharan, Vinusha / Park, Jay J H / Mésidor, Miceline / Talbot, Denis

Pharmaceutical statistics

2024

Abstract: It is well known that medication adherence is critical to patient outcomes and can decrease patient mortality. The Pharmacy Quality Alliance (PQA) has recognized and identified medication adherence as an important indicator of medication-use quality. ... ...

Abstract	It is well known that medication adherence is critical to patient outcomes and can decrease patient mortality. The Pharmacy Quality Alliance (PQA) has recognized and identified medication adherence as an important indicator of medication-use quality. Hence, there is a need to use the right methods to assess medication adherence. The PQA has endorsed the proportion of days covered (PDC) as the primary method of measuring adherence. Although easy to calculate, the PDC has however several drawbacks as a method of measuring adherence. PDC is a deterministic approach that cannot capture the complexity of a dynamic phenomenon. Group-based trajectory modeling (GBTM) is increasingly proposed as an alternative to capture heterogeneity in medication adherence. The main goal of this paper is to demonstrate, through a simulation study, the ability of GBTM to capture treatment adherence when compared to its deterministic PDC analogue and to the nonparametric longitudinal K-means. A time-varying treatment was generated as a quadratic function of time, baseline, and time-varying covariates. Three trajectory models are considered combining a cat's cradle effect, and a rainbow effect. The performance of GBTM was compared to the PDC and longitudinal K-means using the absolute bias, the variance, the c-statistics, the relative bias, and the relative variance. For all explored scenarios, we find that GBTM performed better in capturing different patterns of medication adherence with lower relative bias and variance even under model misspecification than PDC and longitudinal K-means.
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2083706-9
ISSN	1539-1612 ; 1539-1604
ISSN (online)	1539-1612
ISSN	1539-1604
DOI	10.1002/pst.2365
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Article ; Online: Circulating miR-let7a levels predict future diagnosis of chronic thromboembolic pulmonary hypertension.

Kenneweg, Franziska / Hobohm, Lukas / Bang, Claudia / Gupta, Shashi K / Xiao, Ke / Thum, Sabrina / Ten Cate, Vincent / Rapp, Steffen / Hasenfuß, Gerd / Wild, Philipp / Konstantinides, Stavros / Wachter, Rolf / Lankeit, Mareike / Thum, Thomas

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4514

Abstract: Distinct patterns of circulating microRNAs (miRNAs) were found to be involved in misguided thrombus resolution. Thus, we aimed to investigate dysregulated miRNA signatures during the acute phase of pulmonary embolism (PE) and test their diagnostic and ... ...

Abstract	Distinct patterns of circulating microRNAs (miRNAs) were found to be involved in misguided thrombus resolution. Thus, we aimed to investigate dysregulated miRNA signatures during the acute phase of pulmonary embolism (PE) and test their diagnostic and predictive value for future diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH). Microarray screening and subsequent validation in a large patient cohort (n = 177) identified three dysregulated miRNAs as potential biomarkers: circulating miR-29a and miR-720 were significantly upregulated and miR-let7a was significantly downregulated in plasma of patients with PE. In a second validation study equal expression patterns for miR-29a and miR-let7a regarding an acute event of recurrent venous thromboembolism (VTE) or deaths were found. MiR-let7a concentrations significantly correlated with echocardiographic and laboratory parameters indicating right ventricular (RV) dysfunction. Additionally, circulating miR-let7a levels were associated with diagnosis of CTEPH during follow-up. Regarding CTEPH diagnosis, ROC analysis illustrated an AUC of 0.767 (95% CI 0.54-0.99) for miR-let7a. Using logistic regression analysis, a calculated patient-cohort optimized miR-let7a cut-off value derived from ROC analysis of ≥ 11.92 was associated with a 12.8-fold increased risk for CTEPH. Therefore, miR-let7a might serve as a novel biomarker to identify patients with haemodynamic impairment and as a novel predictor for patients at risk for CTEPH.
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/complications ; Echocardiography/adverse effects ; MicroRNAs/genetics ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/genetics ; Biomarkers ; Venous Thromboembolism/complications ; Chronic Disease
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55223-1
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Article: Social isolation during Covid-19: Boon or bane to diabetes management

Gupta, Sabrina / Tang, Clarice / Higgs, Peter

Diabetes Metab Syndr

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #197616
Database	COVID19

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