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Article: Feasible non-surgical options for management of knee osteoarthritis during the COVID-19 pandemic and beyond.

Khoo, J R / Chan, P K / Wen, C / Lau, L C M / Leung, T K C / Luk, M H / Chan, V W K / Cheung, A / Cheung, M H / Fu, H / Chiu, K Y

Hong Kong medical journal = Xianggang yi xue za zhi

2024 Volume 30, Issue 1, Page(s) 56–61

MeSH term(s)	Humans ; Osteoarthritis, Knee/surgery ; Pandemics ; COVID-19 ; Exercise Therapy
Language	English
Publishing date	2024-02-19
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj2210209
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Article ; Online: Perioperative and anaesthetic considerations in rural patients on GLP-1 receptor agonists: An update.

Chan, Luke K M

The Australian journal of rural health

2024 Volume 32, Issue 2, Page(s) 406–407

MeSH term(s)	Humans ; Glucagon-Like Peptide-1 Receptor/agonists ; Perioperative Care/methods ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/therapeutic use ; Rural Population ; Anesthesia/methods ; Female ; Male ; Glucagon-Like Peptide-1 Receptor Agonists
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor Agonists
Language	English
Publishing date	2024-02-29
Publishing country	Australia
Document type	Journal Article ; Letter
ZDB-ID	2069573-1
ISSN	1440-1584 ; 1038-5282
ISSN (online)	1440-1584
ISSN	1038-5282
DOI	10.1111/ajr.13096
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Article ; Online: Parkinson's disease and delirium: unveiling the new insights and their impact.

Chan, Daniel K Y / Chan, Luke K M

Age and ageing

2024 Volume 53, Issue 4

MeSH term(s)	Humans ; Aged ; Prospective Studies ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/epidemiology ; Longitudinal Studies ; Delirium/diagnosis ; Delirium/epidemiology ; Delirium/etiology
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afae065
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 448: Show issues

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Article ; Online: Pain Relief After Total Knee Arthroplasty with Intravenous and Periarticular Corticosteroid: A Randomized Controlled Trial.

Chan, P K / Chan, T C W / Mak, C Y H / Chan, T H M / Chan, S H W / Wong, S S C / Fu, H / Cheung, A / Chan, V W K / Cheung, M H / Cheung, C W / Chiu, K Y

The Journal of bone and joint surgery. American volume

2023 Volume 105, Issue 12, Page(s) 924–932

Abstract: Background: Total knee arthroplasty (TKA) is a cost-effective procedure, but it is also associated with substantial postoperative pain. The present study aimed to compare pain relief and functional recovery after TKA among groups that received ... ...

Abstract	Background: Total knee arthroplasty (TKA) is a cost-effective procedure, but it is also associated with substantial postoperative pain. The present study aimed to compare pain relief and functional recovery after TKA among groups that received intravenous corticosteroids, periarticular corticosteroids, or a combination of both. Methods: This randomized, double-blinded clinical trial in a local institution in Hong Kong recruited 178 patients who underwent primary unilateral TKA. Six of these patients were excluded because of changes in surgical technique; 4, because of their hepatitis B status; 2, because of a history of peptic ulcer; and 2, because they declined to participate in the study. Patients were randomized 1:1:1:1 to receive placebo (P), intravenous corticosteroids (IVS), periarticular corticosteroids (PAS), or a combination of intravenous and periarticular corticosteroids (IVSPAS). Results: The pain scores at rest were significantly lower in the IVSPAS group than in the P group over the first 48 hours (p = 0.034) and 72 hours (p = 0.043) postoperatively. The pain scores during movement were also significantly lower in the IVS and IVSPAS groups than in the P group over the first 24, 48, and 72 hours (p ≤ 0.023 for all). The flexion range of the operatively treated knee was significantly better in the IVSPAS group than in the P group on postoperative day 3 (p = 0.027). Quadriceps power was also greater in the IVSPAS group than in the P group on postoperative days 2 (p = 0.005) and 3 (p = 0.007). Patients in the IVSPAS group were able to walk significantly further than patients in the P group in the first 3 postoperative days (p ≤ 0.003). Patients in the IVSPAS group also had a higher score on the Elderly Mobility Scale than those in the P group (p = 0.036). Conclusions: IVS and IVSPAS yielded similar pain relief, but IVSPAS yielded a larger number of rehabilitation parameters that were significantly better than those in the P group. This study provides new insights into pain management and postoperative rehabilitation following TKA. Level of evidence: Therapeutic Level I . See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Humans ; Aged ; Pain Management/methods ; Arthroplasty, Replacement, Knee/adverse effects ; Treatment Outcome ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Adrenal Cortex Hormones ; Anesthetics, Local ; Double-Blind Method
Chemical Substances	Adrenal Cortex Hormones ; Anesthetics, Local
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.22.01218
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Zs.MO 464: Show issues

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Article: Ten-year territory-wide trends in the utilisation and clinical outcomes of extracorporeal membrane oxygenation in Hong Kong.

Ng, P Y / Chan, V W S / Ip, A / Ling, L / Chan, K M / Leung, A K H / Chan, K K C / So, D / Shum, H P / Ngai, C W / Chan, W M / Sin, W C

Hong Kong medical journal = Xianggang yi xue za zhi

2023 Volume 29, Issue 6, Page(s) 514–523

Abstract: Introduction: The utilisation of extracorporeal membrane oxygenation (ECMO) has been rapidly increasing in Hong Kong. This study examined 10-year trends in the utilisation and clinical outcomes of ECMO in Hong Kong.: Methods: We retrospectively ... ...

Abstract	Introduction: The utilisation of extracorporeal membrane oxygenation (ECMO) has been rapidly increasing in Hong Kong. This study examined 10-year trends in the utilisation and clinical outcomes of ECMO in Hong Kong. Methods: We retrospectively reviewed the records of all adult patients receiving ECMO who were admitted to the intensive care units (ICUs) of public hospitals in Hong Kong between 2010 and 2019. Temporal trends across years were assessed using the Mann-Kendall test. Observed hospital mortality was compared with the Acute Physiology and Chronic Health Evaluation (APACHE) IV-predicted mortality. Results: The annual number of patients receiving ECMO increased from 18 to 171 over 10 years. In total, 911 patients received ECMO during the study period: 297 (32.6%) received veno-arterial ECMO, 450 (49.4%) received veno-venous ECMO, and 164 (18.0%) received extracorporeal cardiopulmonary resuscitation. The annual number of patients aged ≥65 years increased from 0 to 47 (27.5%) [P for trend=0.001]. The median (interquartile range) Charlson Comorbidity Index increased from 1 (0-1) to 2 (1-3) [P for trend<0.001] while the median (interquartile range) APACHE IV score increased from 90 (57-112) to 105 (77-137) [P for trend=0.003]. The overall standardised mortality ratio comparing hospital mortality with APACHE IV-predicted mortality was 1.11 (95% confidence interval=1.01-1.22). Hospital and ICU length of stay both significantly decreased (P for trend=0.011 and <0.001, respectively). Conclusion: As ECMO utilisation increased in Hong Kong, patients put on ECMO were older, more critically ill, and had more co-morbidities. It is important to combine service expansion with adequate resource allocation and training to maintain quality of care.
MeSH term(s)	Adult ; Humans ; Hong Kong ; Retrospective Studies ; Extracorporeal Membrane Oxygenation ; APACHE ; Cardiopulmonary Resuscitation
Language	English
Publishing date	2023-11-16
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj2210025
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Zs.A 4347: Show issues

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Article: Tetraalkylammonium salts (TAS) in solar energy applications - A review on

Mustafa, N M / Jumaah, F N / Ludin, N A / Akhtaruzzaman, M / Hassan, N H / Ahmad, A / Chan, K M / Su'ait, M S

Heliyon

2024 Volume 10, Issue 7, Page(s) e27381

Abstract: Tetraalkylammonium salt (TAS) is an organic salt widely employed as a precursor, additive or electrolyte in solar cell applications, such as perovskite or dye-sensitized solar cells. Notably, Perovskite solar cells (PSCs) have garnered acclaim for their ... ...

Abstract	Tetraalkylammonium salt (TAS) is an organic salt widely employed as a precursor, additive or electrolyte in solar cell applications, such as perovskite or dye-sensitized solar cells. Notably, Perovskite solar cells (PSCs) have garnered acclaim for their exceptional efficiency. However, PSCs have been associated with environmental and health concerns due to the presence of lead (Pb) content, the use of hazardous solvents, and the incorporation of TAS in their fabrication processes, which significantly contributes to environmental and human health toxicity. As a response, there is a growing trend towards transitioning to safer and biobased materials in PSC fabrication to address these concerns. However, the potential health hazards associated with TAS necessitate a thorough evaluation, considering the widespread use of this substance. Nevertheless, the overexploitation of TAS could potentially increase the disposal of TAS in the ecosystem, thus, posing a major health risk and severe pollution. Therefore, this review article presents a comprehensive discussion on the
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27381
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Article ; Online: Meaning in Life and Depression in Low-Income Families in Hong Kong during the COVID-19 Pandemic.

Chen, E M / Chan, B K K / Lee, A T C

East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan

2023 Volume 33, Issue 1, Page(s) 15–20

Abstract: Objective: To determine whether meaning in life (MIL) was associated with a lower risk of depression in people from low-income families during the COVID-19 pandemic.: Methods: Individuals from low-income families were recruited at a community centre ... ...

Abstract	Objective: To determine whether meaning in life (MIL) was associated with a lower risk of depression in people from low-income families during the COVID-19 pandemic. Methods: Individuals from low-income families were recruited at a community centre during the fourth wave of the COVID-19 pandemic in Hong Kong. Levels of MIL were assessed using the Meaning in Life Questionnaire (MLQ). Severity of depressive symptoms was assessed using the Patient Health Questionnaire-9 (PHQ-9). Scores of ≥24 on the Presence of Meaning subscale (MLQ-P) and Search for Meaning subscale (MLQ-S) were considered high. A score of ≥10 on the PHQ-9 was indicative of clinical depression. Correlations between MLQ and PHQ-9 scores were examined, along with associations between presence of/search for meaning and risk of clinical depression. Results: Among 102 participants, 64 (62.7%) had clinical depression; 14 (13.7%) had both high presence of meaning and high search for meaning. The MLQ score was correlated with the PHQ-9 score ( Conclusion: Among people with lower socioeconomic status, MIL may be important for protecting against depression during the COVID-19 pandemic.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Hong Kong/epidemiology ; Depression/epidemiology ; Depression/diagnosis ; Pandemics ; Surveys and Questionnaires
Language	English
Publishing date	2023-03-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2568836-4
ISSN	2224-7041 ; 2224-7041
ISSN (online)	2224-7041
ISSN	2224-7041
DOI	10.12809/eaap2244
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Article ; Online: Perioperative Management of Giant Coronary Artery Aneurysm.

Scarpa, Julia / Zhu, Andrew / Morikawa, Nicole K / Chan, June M

Journal of cardiothoracic and vascular anesthesia

2023 Volume 37, Issue 10, Page(s) 2040–2045

MeSH term(s)	Humans ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/surgery ; Coronary Artery Bypass ; Coronary Angiography
Language	English
Publishing date	2023-05-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2023.05.030
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 31: Show issues

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Article: Exploring measurement tools to optimise hospital physician distribution.

Suan, N A M / Soelar, S A / Rani, R A / Anuar, N A / Aziz, K A A / Chan, H K / Cheah, W K / Sani, S S M / Said, R M / Hassan, M R A

The Medical journal of Malaysia

2024 Volume 79, Issue 2, Page(s) 222–233

Abstract: Introduction: Equitable healthcare delivery is essential and requires resources to be distributed, which include assets and healthcare workers. To date, there is no gold standard for measuring the correct number of physicians to meet healthcare needs. ... ...

Abstract	Introduction: Equitable healthcare delivery is essential and requires resources to be distributed, which include assets and healthcare workers. To date, there is no gold standard for measuring the correct number of physicians to meet healthcare needs. This rapid review aims to explore measurement tools employed to optimise the distribution of hospital physicians, with a focus on ensuring fair resource allocation for equitable healthcare delivery. Materials and methods: A literature search was performed across PubMed, EMBASE, Emerald Insight and grey literature sources. The key terms used in the search include 'distribution', 'method', and 'physician', focusing on research articles published in English from 2002 to 2022 that described methods or tools to measure hospital-based physicians' distribution. Relevant articles were selected through a two-level screening process and critically appraised. The primary outcome is the measurement tools used to assess the distribution of hospital-based physicians. Study characteristics, tool advantages and limitations were also extracted. The extracted data were synthesised narratively. Results: Out of 7,199 identified articles, 13 met the inclusion criteria. Among the selected articles, 12 were from Asia and one from Africa. The review identified eight measurement tools: Gini coefficients and Lorenz curve, Robin Hood index, Theil index, concentration index, Workload Indicator of Staffing Need method, spatial autocorrelation analysis, mixed integer linear programming model and cohortcomponent model. These tools rely on fundamental data concerning population and physician numbers to generate outputs. Additionally, five studies employed a combination of these tools to gain a comprehensive understanding of physician distribution dynamics. Conclusion: Measurement tools can be used to assess physician distribution according to population needs. Nevertheless, each tool has its own merits and limitations, underscoring the importance of employing a combination of tools. The choice of measuring tool should be tailored to the specific context and research objectives.
MeSH term(s)	Humans ; Delivery of Health Care ; Hospitals ; Physicians ; Health Personnel
Language	English
Publishing date	2024-03-30
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Zs.A 1206: Show issues

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Article: Prediction of hospital mortality among critically ill patients in a single centre in Asia: comparison of artificial neural networks and logistic regression-based model.

Lau, S / Shum, H P / Chan, C C Y / Man, M Y / Tang, K B / Chan, K K C / Leung, A K H / Yan, W W

Hong Kong medical journal = Xianggang yi xue za zhi

2024 Volume 30, Issue 2, Page(s) 130–138

Abstract: Introduction: This study compared the performance of the artificial neural network (ANN) model with the Acute Physiologic and Chronic Health Evaluation (APACHE) II and IV models for predicting hospital mortality among critically ill patients in Hong ... ...

Abstract	Introduction: This study compared the performance of the artificial neural network (ANN) model with the Acute Physiologic and Chronic Health Evaluation (APACHE) II and IV models for predicting hospital mortality among critically ill patients in Hong Kong. Methods: This retrospective analysis included all patients admitted to the intensive care unit of Pamela Youde Nethersole Eastern Hospital from January 2010 to December 2019. The ANN model was constructed using parameters identical to the APACHE IV model. Discrimination performance was assessed using area under the receiver operating characteristic curve (AUROC); calibration performance was evaluated using the Brier score and Hosmer-Lemeshow statistic. Results: In total, 14 503 patients were included, with 10% in the validation set and 90% in the ANN model development set. The ANN model (AUROC=0.88, 95% confidence interval [CI]=0.86-0.90, Brier score=0.10; P in Hosmer-Lemeshow test=0.37) outperformed the APACHE II model (AUROC=0.85, 95% CI=0.80-0.85, Brier score=0.14; P<0.001 for both comparisons of AUROCs and Brier scores) but showed performance similar to the APACHE IV model (AUROC=0.87, 95% CI=0.85-0.89, Brier score=0.11; P=0.34 for comparison of AUROCs, and P=0.05 for comparison of Brier scores). The ANN model demonstrated better calibration than the APACHE II and APACHE IV models. Conclusion: Our ANN model outperformed the APACHE II model but was similar to the APACHE IV model in terms of predicting hospital mortality in Hong Kong. Artificial neural networks are valuable tools that can enhance real-time prognostic prediction.
MeSH term(s)	Humans ; Neural Networks, Computer ; Critical Illness/mortality ; Male ; APACHE ; Female ; Retrospective Studies ; Hospital Mortality ; Hong Kong/epidemiology ; Middle Aged ; Aged ; Logistic Models ; ROC Curve ; Intensive Care Units/statistics & numerical data ; Area Under Curve
Language	English
Publishing date	2024-03-28
Publishing country	China
Document type	Journal Article ; Comparative Study
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj2210235
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