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  1. Book ; Online: Stable oxygen and carbon isotope data for planktic and benthic foraminifera from southern Atlantic of DSDP Hole 74-525A and ODP Hole 113-690C, supplementary data to: Friedrich, Oliver; Herrle, Jens O; Wilson, Paul A; Cooper, Matthew J; Erbacher, Jochen; Hemleben, Christoph (2009): Early Maastrichtian carbon cycle perturbation and cooling event: Implications from the South Atlantic Ocean. Paleoceanography, 24, PA2211

    Friedrich, Oliver / Cooper, Matthew J / Erbacher, Jochen / Hemleben, Christoph / Herrle, Jens O / Wilson, Paul A

    2009  

    Abstract: Published stable isotope records in marine carbonate are characterized by a positive d18O excursion associated with a negative d13C shift during the early Maastrichtian. However, the cause and even the precise timing of these excursions remain uncertain. ...

    Abstract Published stable isotope records in marine carbonate are characterized by a positive d18O excursion associated with a negative d13C shift during the early Maastrichtian. However, the cause and even the precise timing of these excursions remain uncertain. We have generated high-resolution foraminiferal stable isotope and gray-scale records for the latest Campanian to early Maastrichtian (73-68 Ma) at two Ocean Drilling Program sites, 525 (Walvis Ridge) and 690 (Weddell Sea). We demonstrate that the negative d13C excursion is decoupled from the d18O increase with a lag of about 600 ka. Our d13C records (both planktic and benthic) show an amplitude for the negative excursion of 0.7 per mill that falls between about 72.1 and 70.7 Ma. Our planktic d18O records indicate an overall increase of 1.2 per mill from 73 to 68 Ma at Site 690, whereas at Site 525 they record a slightly smaller increase (1 per mill) that peaks around 70.1 Ma with decreasing values thereafter. Our benthic d18O data indicate an increase of 1.5 per mill at Site 525 and 0.7 per mill at Site 690 between about 71.4 and 69.9 Ma. Benthic d18O values show different baseline values at the two sites before and after the excursion, but the larger increase at Site 525 means that the values attained at the peak of the excursion are similar at the two sites. We interpret this observation in terms of water mass changes. The excursion is interpreted to reflect a cooling of bottom waters in response to the strengthening contribution of intermediate- to deep-water production in the high southern latitudes rather than increased ice volume. The associated carbon cycle perturbations that we observe are interpreted to reflect a weakening of surface water stratification and increased productivity, as supported by our gray value data.
    Language English
    Dates of publication 2009-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1029/2008PA001654
    DOI 10.1594/PANGAEA.753191
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Book ; Online: (Table 1) 87Sr/86Sr ratios and ages of DSDP Site 144A samples, supplementary data to: Wilson, Paul A; Norris, Richard D; Cooper, Matthew J (2002): Warming the fuel for the fire: Evidence for the thermal dissociation of methane hydrate during the Paleocene-Eocene thermal maximum. Geology, 30(7), 1067-1070

    Wilson, Paul A / Cooper, Matthew J / Norris, Richard D

    2002  

    Abstract: Glassy Turonian foraminifera preserved in clay-rich sediments from the western tropical Atlantic yield the warmest equivalent d18O sea-surface temperatures (SSTs) yet reported for the entire Cretaceous-Cenozoic. We estimate Turonian SSTs that were at ... ...

    Abstract Glassy Turonian foraminifera preserved in clay-rich sediments from the western tropical Atlantic yield the warmest equivalent d18O sea-surface temperatures (SSTs) yet reported for the entire Cretaceous-Cenozoic. We estimate Turonian SSTs that were at least as warm as (conservative mean ~30 ?C) to significantly warmer (warm mean ~33 ?C) than those in the region today. However, if independent evidence for high middle Cretaceous pCO2 is reliable and resulted in greater isotopic fractionation between seawater and calcite because of lower sea-surface pH, our conservative and warm SST estimates would be even higher (32 and 36?C, respectively). Our new tropical SSTs help reconcile geologic data with the predictions of general circulation models that incorporate high Cretaceous pCO2 and lend support to the hypothesis of a Cretaceous greenhouse. Our data also strengthen the case for a Turonian age for the Cretaceous thermal maximum and highlight a 20-40 m.y. mismatch between peak Cretaceous-Cenozoic global warmth and peak inferred tectonic CO2 production. We infer that this mismatch is either an artifact of a hidden Turonian pulse in global ocean-crust cycling or real evidence of the influence of some other factor on atmospheric CO2 and/or SSTs. A hidden pulse in crust cycling would explain the timing of peak Cretaceous-Cenozoic sea level (also Turonian), but other factors are needed to explain high-frequency (~10-100 k.y.) instability in middle Cretaceous SSTs reported elsewhere.
    Language English
    Dates of publication 2002-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1130/0091-7613(2002)030<0607:TTCGHU>2.0.CO;2
    DOI 10.1594/PANGAEA.713542
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book: Paul's fundamental immunology

    Flajnik, Martin F. / Singh, Nevil J. / Holland, Steven M. / Paul, William E.

    2023  

    Title variant Fundamental immunology
    Author's details Martin F. Flajnik, Nevil J. Singh, Steven M. Holland
    Keywords Immune System Phenomena
    Language English
    Size xix, 1669 Seiten, Illustrationen
    Edition Eighth edition
    Publisher Wolters Kluwer
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    HBZ-ID HT021692030
    ISBN 978-1-975142-51-3 ; 1-975142-51-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2023 A 212 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Article: Improving Photosynthetic Metabolism for Crop Yields: What Is Going to Work?

    Paul, Matthew J

    Frontiers in plant science

    2021  Volume 12, Page(s) 743862

    Language English
    Publishing date 2021-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.743862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pelizaeus-Merzbacher disease: on the cusp of myelin medicine.

    Elitt, Matthew S / Tesar, Paul J

    Trends in molecular medicine

    2024  

    Abstract: Pelizaeus-Merzbacher disease (PMD) is caused by mutations in the proteolipid protein 1 (PLP1) gene encoding proteolipid protein (PLP). As a major component of myelin, mutated PLP causes progressive neurodegeneration and eventually death due to severe ... ...

    Abstract Pelizaeus-Merzbacher disease (PMD) is caused by mutations in the proteolipid protein 1 (PLP1) gene encoding proteolipid protein (PLP). As a major component of myelin, mutated PLP causes progressive neurodegeneration and eventually death due to severe white matter deficits. Medical care has long been limited to symptomatic treatments, but first-in-class PMD therapies with novel mechanisms now stand poised to enter clinical trials. Here, we review PMD disease mechanisms and outline rationale for therapeutic interventions, including PLP1 suppression, cell transplantation, iron chelation, and intracellular stress modulation. We discuss available preclinical data and their implications on clinical development. With several novel treatments on the horizon, PMD is on the precipice of a new era in the diagnosis and treatment of patients suffering from this debilitating disease.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4345: Show issues Location:
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  6. Article ; Online: What are the regulatory targets for intervention in assimilate partitioning to improve crop yield and resilience?

    Paul, Matthew J

    Journal of plant physiology

    2021  Volume 266, Page(s) 153537

    Abstract: Sucrose utilisation for the synthesis of cellular components involved in growth and development and the accumulation of biomass determines diversity in the plant kingdom; sucrose utilisation and partitioning also underpin crop yields. As a complex ... ...

    Abstract Sucrose utilisation for the synthesis of cellular components involved in growth and development and the accumulation of biomass determines diversity in the plant kingdom; sucrose utilisation and partitioning also underpin crop yields. As a complex process the use of sucrose for the partitioning of plant products for yield is decided by the interaction of several regulatory hubs and the integration of metabolism and development. Understanding the regulation of assimilate partitioning has been a grand challenge in plant and crop science. There are emerging examples of genes and processes that appear important for assimilate partitioning that underpin yield in crops and which are amenable to intervention. Enzymes of carbon metabolism were some of the first targets in attempts to modify assimilate partitioning at the beginning (source) and end (sink) of the whole plant assimilate partitioning process. Metabolic enzymes are subject to regulatory and homeostatic mechanisms, a key factor to consider in modifying assimilate partitioning. Trehalose 6-phosphate, as a sucrose signal, may represent a special case in its ability to regulate and coordinate source and sink processes. This review summarises recent progress in understanding the underlying regulators of assimilate partitioning and the current and potentially most promising routes to crop yield enhancement with a main focus on cereals. A framework for how source-sink may regulate whole plant assimilate partitioning involving a few key elements and the central importance of reproductive development is presented.
    MeSH term(s) Carbon/metabolism ; Crops, Agricultural/growth & development ; Edible Grain/growth & development ; Plant Breeding ; Sucrose
    Chemical Substances Sucrose (57-50-1) ; Carbon (7440-44-0)
    Language English
    Publishing date 2021-09-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2021.153537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  7. Article ; Online: Sucrose homeostasis: Mechanisms and opportunity in crop yield improvement.

    Miret, Javier A / Griffiths, Cara A / Paul, Matthew J

    Journal of plant physiology

    2024  Volume 294, Page(s) 154188

    Abstract: Sugar homeostasis is a critical feature of biological systems. In humans, raised and dysregulated blood sugar is a serious health issue. In plants, directed changes in sucrose homeostasis and allocation represent opportunities in crop improvement. Plant ... ...

    Abstract Sugar homeostasis is a critical feature of biological systems. In humans, raised and dysregulated blood sugar is a serious health issue. In plants, directed changes in sucrose homeostasis and allocation represent opportunities in crop improvement. Plant tissue sucrose varies more than blood glucose and is found at higher concentrations (cytosol and phloem ca. 100 mM v 3.9-6.9 mM for blood glucose). Tissue sucrose varies with developmental stage and environment, but cytosol and phloem exhibit tight sucrose control. Sucrose homeostasis is a consequence of the integration of photosynthesis, synthesis of storage end-products such as starch, transport of sucrose to sinks and sink metabolism. Trehalose 6-phosphate (T6P)-SnRK1 and TOR play central, still emerging roles in regulating and coordinating these processes. Overall, tissue sucrose levels are more strongly related to growth than to photosynthesis. As a key sucrose signal, T6P regulates sucrose levels, transport and metabolic pathways to coordinate source and sink at a whole plant level. Emerging evidence shows that T6P interacts with meristems. With careful targeting, T6P manipulation through exploiting natural variation, chemical intervention and genetic modification is delivering benefits for crop yields. Regulation of cereal grain set, filling and retention may be the most strategically important aspect of sucrose allocation and homeostasis for food security.
    MeSH term(s) Humans ; Sucrose/metabolism ; Blood Glucose ; Sugar Phosphates/metabolism ; Plants/metabolism ; Photosynthesis ; Trehalose ; Homeostasis
    Chemical Substances Sucrose (57-50-1) ; Blood Glucose ; Sugar Phosphates ; Trehalose (B8WCK70T7I)
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2024.154188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: No increase in corticospinal excitability during motor simulation provides a platform to explore the neurophysiology of aphantasia.

    Esselaar, Maaike / Holmes, Paul S / Scott, Matthew W / Wright, David J

    Brain communications

    2024  Volume 6, Issue 2, Page(s) fcae084

    Abstract: This scientific commentary refers to 'Explicit and implicit motor simulations are impaired in individuals with aphantasia', by ... ...

    Abstract This scientific commentary refers to 'Explicit and implicit motor simulations are impaired in individuals with aphantasia', by Dupont
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcae084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components.

    Vandermeulen, Matthew D / Cullen, Paul J

    mSphere

    2023  Volume 8, Issue 5, Page(s) e0028423

    Abstract: Signaling modules, such as mitogen-activated protein kinase (MAPK) pathways, are evolutionarily conserved drivers of cell differentiation and stress responses. In many fungal species including pathogens, MAPK pathways control filamentous growth, where ... ...

    Abstract Signaling modules, such as mitogen-activated protein kinase (MAPK) pathways, are evolutionarily conserved drivers of cell differentiation and stress responses. In many fungal species including pathogens, MAPK pathways control filamentous growth, where cells differentiate into an elongated cell type. The convenient model budding yeast
    MeSH term(s) Animals ; Saccharomyces cerevisiae/metabolism ; Galactose ; Signal Transduction ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Ethanol/pharmacology ; Carbon/metabolism
    Chemical Substances Galactose (X2RN3Q8DNE) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Ethanol (3K9958V90M) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00284-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Outcomes of Mohs micrographic surgery for periocular squamous cell carcinoma.

    Hartley, Matthew J / Meredith, Paul R / Oliphant, Thomas

    European journal of ophthalmology

    2024  , Page(s) 11206721231225497

    Abstract: Introduction: Periocular cutaneous squamous cell carcinoma (cSCC) accounts for 5-10% of all eyelid malignancies. Periocular cSCC carries a low mortality rate but can be destructive to local tissues. Due to the unique function and anatomy of the eyelids, ...

    Abstract Introduction: Periocular cutaneous squamous cell carcinoma (cSCC) accounts for 5-10% of all eyelid malignancies. Periocular cSCC carries a low mortality rate but can be destructive to local tissues. Due to the unique function and anatomy of the eyelids, Mohs micrographic surgery (MMS) is gold standard for treating cSCC to preserve healthy tissue and reduce rates of local recurrence. In this study, we describe the success and outcomes of MMS and subsequent oculoplastic reconstruction for periocular cSCC in the North East of England.
    Methods: Retrospective analysis of 34 patients who underwent MMS for periocular cSCC in the North of England between 2013 and 2020. Primary outcome measure of success is defined as no recurrence of cSCC after minimum 24 months' time elapsed post-MMS. Secondary outcome measures included analysis of disease characteristics, describing the surgical techniques utilised for oculoplastic reconstruction following MMS and surgical complications should they occur.
    Results: Two patients (5.9%) had local recurrence of periocular cSCC. Median time elapsed since MMS was 60 months. A variety of oculoplastic surgical techniques were utilised in the repair of the Mohs defect. One patient (2.9%) developed a significant post-operative reconstruction complication.
    Conclusion: Periocular cSCC recurrence following MMS in the North of England is 5.9%, which is comparable to the literature. Significant post-operative complications following oculoplastic reconstruction of periocular MMS are very low, occurring in 2.9% of cases in this study.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721231225497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3342: Show issues Location:
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