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Article ; Online: Type 2 Diabetes Mellitus in Children.

Xu, Hanna / Verre, Michael C

2018 Volume 98, Issue 9, Page(s) 590–594

Abstract: The prevalence of type 2 diabetes mellitus in children and adolescents has increased worldwide over the past three decades. This increase has coincided with the obesity epidemic, and minority groups are disproportionately affected. The American Diabetes ... ...

Abstract	The prevalence of type 2 diabetes mellitus in children and adolescents has increased worldwide over the past three decades. This increase has coincided with the obesity epidemic, and minority groups are disproportionately affected. The American Diabetes Association recommends screening for type 2 diabetes beginning at 10 years of age or the onset of puberty in children who are overweight or obese and have two additional risk factors. Diagnostic criteria include a fasting blood glucose level of 126 mg per dL or greater, a two-hour plasma glucose level of 200 mg per dL or greater during an oral glucose tolerance test, an A1C level of 6.5% or more, or a random plasma glucose level of 200 mg per dL or greater plus symptoms of polyuria, polydipsia, or unintentional weight loss. Management should be focused on a multidisciplinary, family-centered approach. Nutrition and exercise counseling should be started at the time of diagnosis and as a part of ongoing management. Metformin is the first-line therapy in conjunction with lifestyle changes. Insulin therapy should be initiated if there are signs of ketosis or ketoacidosis, or if the patient has significant hyperglycemia (A1C greater than 9% or a random plasma glucose level of 250 mg per dL or greater).
MeSH term(s)	Adolescent ; Child ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/therapy ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Life Style ; Male ; Mass Screening ; Metformin/therapeutic use ; Obesity/epidemiology ; Obesity/prevention & control ; Prevalence ; Risk Factors ; United States/epidemiology
Chemical Substances	Hypoglycemic Agents ; Insulin ; Metformin (9100L32L2N)
Language	English
Publishing date	2018-10-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	412694-4
ISSN	1532-0650 ; 0002-838X ; 0572-3612
ISSN (online)	1532-0650
ISSN	0002-838X ; 0572-3612
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Article ; Online: The Use of Shape-Memory Alloy Staples (Nitinol) in the Treatment of Pubic Symphyseal Disruptions: Clinical Results and Radiographic Outcomes.

Passias, Braden J / Verre, John J / McGrath, Kyle / DeGenova, Daniel T / Taylor, Benjamin C

Journal of long-term effects of medical implants

2022 Volume 33, Issue 1, Page(s) 67–74

Abstract: Nitinol is a shape-memory alloy that has many diverse applications in the field of orthopedics. There have been no previous investigations reporting clinical or radiographic outcomes of the use of nitinol staples in the definitive stabilization of the ... ...

Abstract	Nitinol is a shape-memory alloy that has many diverse applications in the field of orthopedics. There have been no previous investigations reporting clinical or radiographic outcomes of the use of nitinol staples in the definitive stabilization of the pubic symphysis. A retrospective chart review was completed on 42 patients who underwent operative stabilization of pubic symphyseal disruption at an urban level-1 trauma center. Patients treated with pelvic staples alone, or in conjunction with traditional plates and screws, were compared with those treated without the use of a shape memory alloys. Thirty-four patients were included for final analysis (8 staples and 26 controls) in this investigation. Three of eight patients in the pelvic staple group had implant failures, with two having a loss of reduction (25%); this was not significantly different from the seven hardware failures (P = 0.61) seen in the control group without any loss of reduction (P = 0.17). Failures in the nitinol staple group occurred earlier at 17.3 days compared with the control group at 101.7 days (P = 0.003). There were no significant differences between groups with regards to any of the other pre- or postoperative variables investigated. The use of nitinol staples vs. traditional plate and screw constructs for stabilizing the pubic symphysis did not result in more clinical failures. The hardware failures identified in the nitinol staple group occurred significantly earlier in the postoperative period, and were associated with a loss of reduction of the pubic symphysis.
MeSH term(s)	Humans ; Pubic Symphysis/diagnostic imaging ; Pubic Symphysis/surgery ; Pubic Symphysis/injuries ; Shape Memory Alloys ; Fracture Fixation, Internal/methods ; Retrospective Studies ; Bone Plates
Chemical Substances	Shape Memory Alloys ; nitinol (2EWL73IJ7F)
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073166-0
ISSN	1940-4379 ; 1050-6934
ISSN (online)	1940-4379
ISSN	1050-6934
DOI	10.1615/JLongTermEffMedImplants.2022043658
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Article ; Online: Management of Children With Uncomplicated Cellulitis in Emergency and Hospital Settings.

St Cyr, Grace / Jaffe, Jana / McMahon, Maxwell / Florin, Todd A / Verre, Michael C / Chua, Wee-Jhong

Pediatric emergency care

2023 Volume 39, Issue 12, Page(s) 913–917

Abstract: Objective: The aim of the study is to establish consensus recommendations on features used to determine the route of antibiotic administration and disposition for children with uncomplicated cellulitis.: Methods: Modified Delphi methodology was ... ...

Abstract	Objective: The aim of the study is to establish consensus recommendations on features used to determine the route of antibiotic administration and disposition for children with uncomplicated cellulitis. Methods: Modified Delphi methodology was performed with 2 rounds of confidential surveys of Emergency medicine and hospital medicine (HM) providers at Lurie Children's Hospital to assess cellulitis management in children (ages 6 months-18 years) without signs of sepsis or abscess formation. Using a 9-point Likert scale, emergency medicine providers ranked features by perceived level of importance when deciding initial antibiotic route and HM providers ranked features on importance when transitioning to oral antibiotics. Responses were grouped as not important (1-3), neutral (4-6), and important (7-9) and re-evaluated in the second round to reach consensus, defined as ≥70% agreement. Results: Emergency medicine providers (n = 17) reached consensus on 15 of 16 features (93.8%), 10 deemed important. Participants reached greatest consensus (100%) on fevers/chills, lymphangitis, and functional impairment as considerations for initiating intravenous antibiotics. HM providers (n = 15) reached consensus on 9 of 11 factors (81.8%), with 7 considered important when deciding on readiness for oral antibiotics. Providers indicated that stability, rather than reduction, of erythematous margins is sufficient to consider transition and de-escalation of therapy at less than 24 hours if all other clinical improvement criteria are met. Conclusions: This study achieved consensus on important features for treatment and disposition of children with uncomplicated cellulitis in both emergency and inpatient contexts. These features have the potential to aid in decision making and improve standardization of clinical practice.
MeSH term(s)	Child ; Humans ; Cellulitis/diagnosis ; Cellulitis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Administration, Intravenous ; Emergency Medicine ; Delphi Technique
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000003072
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Article ; Online: Hospital Discharge Instructions: Characteristics, Accessibility, and National Guideline Adherence.

Rodriguez, Victoria A / Boggs, Elizabeth F / Verre, Michael C / Siebenaler, Mary Katherine / Wicks, Jennifer S / Castiglioni, Cynthia / Palac, Hannah / Garfield, Craig F

Hospital pediatrics

2022 Volume 12, Issue 11, Page(s) 959–970

Abstract: Objectives: The content of pediatric hospital discharge instructions is highly variable. This study aimed to describe the characteristics, accessibility per patient literacy level and language, and national guideline adherence of pediatric hospital ... ...

Abstract	Objectives: The content of pediatric hospital discharge instructions is highly variable. This study aimed to describe the characteristics, accessibility per patient literacy level and language, and national guideline adherence of pediatric hospital discharge instructions. Methods: This retrospective study assessed discharge instructions at a tertiary children's hospital. Patient and instruction characteristics, including patient health literacy level, grade level of instructions, patient language preference, and language of instructions were collected via chart review and electronic medical record query. Standard admission processes assessed health literacy via Brief Health Literacy Screening. The association between demographic and clinical characteristics and adherence to Solutions for Patient Safety guidelines was analyzed by using unadjusted and adjusted analysis methods. Results: Of 240 discharge instructions, 25% were missing at least 1 recommended content area: signs of worsening, where to seek help, or medication reconciliation. A patient health literacy deficit was identified in 15%; the mean grade level of instructions was 10.1. Limited English proficiency was reported among 17% one quarter of whom received language concordant instructions. Use of discharge instruction templates and discharge services were associated with improved guideline adherence (P <.001). Almost one-half of the study population had a complex medical history, which was associated with decreased guideline adherence (P = .04). Conclusions: One-quarter of discharge instructions for this predominantly medically complex population failed to meet national standards. Accessibility was often limited by the reading grade level or discordant language of instructions. Templates may be a valuable tool for improving discharge instruction content, accessibility, and adherence to national guidelines.
MeSH term(s)	Child ; Humans ; Patient Discharge ; Retrospective Studies ; Guideline Adherence ; Health Literacy ; Hospitals, Pediatric
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2021-006493
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Article ; Online: Optical characterisation of plasmonic nanostructures on planar substrates using second-harmonic generation.

Persechini, Lina / Verre, Ruggero / Smith, Christopher M / Fleischer, Karsten / Shvets, Igor V / Ranjan, Mukesh / Facsko, Stefan / McGilp, John F

Optics express

2015 Volume 23, Issue 20, Page(s) 26486–26498

Abstract: Off-normal, polarization dependent second-harmonic generation (SHG) measurements were performed ex situ on plasmonic nanostructures grown by self-assembly on nanopatterned templates. These exploratory studies of Ag nanoparticle (NP) arrays show that the ... ...

Abstract	Off-normal, polarization dependent second-harmonic generation (SHG) measurements were performed ex situ on plasmonic nanostructures grown by self-assembly on nanopatterned templates. These exploratory studies of Ag nanoparticle (NP) arrays show that the sensitivity of SHG to the local fields, which are modified by the NP size, shape and distribution, makes it a promising fixed wavelength characterization technique that avoids the complexity of spectroscopic SHG. The off-normal geometry provides access to the out-of-plane SH response, which is typically an order-of-magnitude larger than the in-surface-plane response measured using normal incidence, for example in SHG microscopy. By choosing the plane of incidence orthogonal to the NP array direction, it was shown that the p-polarized SH response, as a function of input polarization, is very sensitive to NP morphology, with a change of 20% in the aspect ratio of the NPs producing a variation of a factor of 30 in the easily measureable ratio of the p-polarized SH field strength for s- and p-polarized input. The results show that such a fixed geometry could be used for the in situ characterization of anisotropic nanostructure morphology during growth by self-assembly, which could be particularly useful in situations where rotating the sample may be neither desirable nor easily accomplished.
Language	English
Publishing date	2015-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.23.026486
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Article ; Online: An analytic approach to modeling the optical response of anisotropic nanoparticle arrays at surfaces and interfaces.

Persechini, L / Verre, R / McAlinden, N / Wang, J J / Ranjan, M / Facsko, S / Shvets, I V / McGilp, J F

Journal of physics. Condensed matter : an Institute of Physics journal

2014 Volume 26, Issue 14, Page(s) 145302

Abstract: Anisotropic nanoparticle (NP) arrays with useful optical properties, such as localized plasmon resonances (LPRs), can be grown by self-assembly on substrates. However, these systems often have significant dispersion in NP dimensions and distribution, ... ...

Abstract	Anisotropic nanoparticle (NP) arrays with useful optical properties, such as localized plasmon resonances (LPRs), can be grown by self-assembly on substrates. However, these systems often have significant dispersion in NP dimensions and distribution, which makes a numerical approach to modeling the LPRs very difficult. An improved analytic approach to this problem is discussed in detail and applied successfully to NP arrays from three systems that differ in NP metal, shape and distribution, and in substrate and capping layer. The materials and anisotropic NP structures that will produce LPRs in desired spectral regions can be determined using this approach.
MeSH term(s)	Anisotropy ; Biosensing Techniques ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Models, Molecular ; Nanotechnology ; Optical Fibers ; Surface Plasmon Resonance/methods ; Surface Properties
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2014-04-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/0953-8984/26/14/145302
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Article: Histamine poisoning from ingestion of fish or scombroid syndrome.

Tortorella, Vincenzo / Masciari, Peppino / Pezzi, Mario / Mola, Assunta / Tiburzi, Simona Paola / Zinzi, Maria Concetta / Scozzafava, Annamaria / Verre, Mario

Case reports in emergency medicine

2014 Volume 2014, Page(s) 482531

Abstract: The scombroid poisoning is due to the ingestion of poorly preserved fish (especially tuna, sardines, and mackerel) out of the cold chain. Under the influence of the proliferation of gram negative bacteria that occurs for heating, the histidine content in ...

Abstract	The scombroid poisoning is due to the ingestion of poorly preserved fish (especially tuna, sardines, and mackerel) out of the cold chain. Under the influence of the proliferation of gram negative bacteria that occurs for heating, the histidine content in the muscle of the fish is converted into histamine, by the action of the enzyme histidine decarboxylase. If the histamine is ingested in large quantities, it causes an anaphylactoid reaction with a variety of symptoms from moderate to severe to life-threating. We will describe two cases that came under our observation after consuming a meal of bluefin tuna. The diagnosis of scombroid syndrome was made on the basis of the anamnestic data and the clinical one. The rapid resolution of the signs and symptoms after treatment with histamines H1-H2 receptor blockers confirmed the suspected diagnosis.
Language	English
Publishing date	2014-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2684646-9
ISSN	2090-6498 ; 2090-648X
ISSN (online)	2090-6498
ISSN	2090-648X
DOI	10.1155/2014/482531
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Article ; Online: Socialization patterns and their associations with unprotected anal intercourse, HIV, and syphilis among high-risk men who have sex with men and transgender women in Peru.

Verre, Michael C / Peinado, Jesus / Segura, Eddy R / Clark, Jesse / Gonzales, Pedro / Benites, Carlos / Cabello, Robinson / Sanchez, Jorge / Lama, Javier R

AIDS and behavior

2014 Volume 18, Issue 10, Page(s) 2030–2039

Abstract: The association of socialization patterns with unprotected anal intercourse (UAI) and HIV/STI prevalence remains underexplored in men who have sex with men (MSM) and transgender women (TW) in developing country settings. We evaluated the correlation of ... ...

Abstract	The association of socialization patterns with unprotected anal intercourse (UAI) and HIV/STI prevalence remains underexplored in men who have sex with men (MSM) and transgender women (TW) in developing country settings. We evaluated the correlation of UAI, HIV, and syphilis with MSM/TW venue attendance and social network size among high-risk MSM and TW in Peru according to self-reported sexual identity. Frequency of venue attendance and MSM/TW social network size were lowest among heterosexual MSM and highest among TW respondents. Attendance (frequent or occasional) at MSM/TW venues was associated with increased odds of insertive UAI among heterosexual participants. Frequent venue attendance was associated with increased odds of receptive UAI among gay/homosexual, bisexual, and TW participants. Further investigation of the differing socialization patterns and associations with HIV/STI transmission within subgroups of Peruvian MSM and TW will enable more effective prevention interventions for these populations.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Female ; HIV Seropositivity/psychology ; HIV Seropositivity/transmission ; Health Knowledge, Attitudes, Practice ; Homosexuality, Male/psychology ; Homosexuality, Male/statistics & numerical data ; Humans ; Male ; Peru/epidemiology ; Prevalence ; Sentinel Surveillance ; Sexual Behavior/psychology ; Sexual Behavior/statistics & numerical data ; Sexual Partners/psychology ; Socialization ; Syphilis/epidemiology ; Syphilis/prevention & control ; Syphilis/psychology ; Transgender Persons/psychology ; Transgender Persons/statistics & numerical data ; Unsafe Sex/statistics & numerical data ; Urban Population
Language	English
Publishing date	2014-05-02
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-014-0787-y
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Zs.A 6451: Show issues

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Article ; Online: Manipulating and probing the growth of plasmonic nanoparticle arrays using light.

Ualibek, Oral / Verre, Ruggero / Bulfin, Brendan / Usov, Victor / Fleischer, Karsten / McGilp, John F / Shvets, Igor V

Nanoscale

2013 Volume 5, Issue 11, Page(s) 4923–4930

Abstract: Highly ordered self-assembled silver nanoparticle (NP) arrays have been produced by glancing angle deposition on faceted c-plane Al2O3 templates. The NP shape can be tuned by changing the substrate temperature during deposition. Reflectance anisotropy ... ...

Abstract	Highly ordered self-assembled silver nanoparticle (NP) arrays have been produced by glancing angle deposition on faceted c-plane Al2O3 templates. The NP shape can be tuned by changing the substrate temperature during deposition. Reflectance anisotropy spectroscopy has been used to monitor the plasmonic evolution of the sample during the growth. The structures showed a strong dichroic response related to NP anisotropy and dipolar coupling. Furthermore, multipolar resonances due to sharp edge effects between NP and substrate were observed. Analytical and numerical methods have been used to explain the results and extract semi-quantitative information on the morphology of the NPs. The results provide insights on the growth mechanisms by the glancing angle deposition. Finally, it has been shown that the NP morphology can be manipulated by a simple illumination of the surface with an intense light source, inducing changes in the optical response. This opens up new possibilities for engineering plasmonic structure over large active areas.
Language	English
Publishing date	2013-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c3nr00087g
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Article ; Online: Controlled in situ growth of tunable plasmonic self-assembled nanoparticle arrays.

Verre, R / Fleischer, K / McGilp, J F / Fox, D / Behan, G / Zhang, H / Shvets, I V

Nanotechnology

2012 Volume 23, Issue 3, Page(s) 35606

Abstract: Self-assembled silver nanoparticle (NP) arrays were produced by deposition at glancing angles on transparent stepped Al2O3 templates. The evolution of the plasmonic resonances has been monitored using reflection anisotropy spectroscopy (RAS) during ... ...

Abstract	Self-assembled silver nanoparticle (NP) arrays were produced by deposition at glancing angles on transparent stepped Al2O3 templates. The evolution of the plasmonic resonances has been monitored using reflection anisotropy spectroscopy (RAS) during growth. It is demonstrated that the morphology of the array can be tailored by changing the template structure, resulting in a large tunability of the optical resonances. In order to extract detailed information on the origin of the measured dichroic response of the system, a model based on dipolar interactions has been developed and the effect of tarnishing and morphological dispersion addressed.
Language	English
Publishing date	2012-01-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/0957-4484/23/3/035606
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