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Article ; Online: Editorial for "Deep Learning-Based Acceleration of Compressed Sensing Noncontrast-Enhanced Coronary Magnetic Resonance Angiography in Patients With Suspected Coronary Artery Disease".

Allen, Bradley D

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 5, Page(s) 1531–1532

MeSH term(s)	Humans ; Coronary Artery Disease/diagnostic imaging ; Magnetic Resonance Angiography ; Deep Learning ; Coronary Angiography ; Arteries ; Acceleration ; Coronary Vessels
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28654
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Article ; Online: What's Keeping Residents "Out of the Mainstream": Challenges to Participation in the News Media for Older People Living in Residential Care.

Allen, Laura D / Bradley, Dana Burr / Ayalon, Liat

Journal of applied gerontology : the official journal of the Southern Gerontological Society

2022 Volume 42, Issue 6, Page(s) 1313–1323

Abstract: The voices of older people living in residential care are often excluded from news articles about residential care, and this exclusion was especially apparent during the COVID-19 pandemic. The aim of this study is to identify and understand the barriers ... ...

Abstract	The voices of older people living in residential care are often excluded from news articles about residential care, and this exclusion was especially apparent during the COVID-19 pandemic. The aim of this study is to identify and understand the barriers which may be obstructing the news media participation of older residents. Semi-structured interviews were conducted with 7 journalists, 7 administrators, and 12 residents. Interview transcripts were analyzed using a thematic analysis, which resulted in the following themes: (1) residents are physically separated from their communities; (2) journalists do not consider residents to be official sources for news stories; (3) administrators feel they must manage their care home's reputation and control access to residents; and (4) journalists and administrators are not equipped to handle issues of consent and privacy. The role of ableism and ageism in the news reporting process is discussed.
MeSH term(s)	Humans ; Aged ; Pandemics ; COVID-19 ; Mass Media ; Emotions ; Ageism
Language	English
Publishing date	2022-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	155897-3
ISSN	1552-4523 ; 0733-4648
ISSN (online)	1552-4523
ISSN	0733-4648
DOI	10.1177/07334648221143619
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Zs.A 2901: Show issues

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Article ; Online: Coronary Computed Tomography Angiography Results in More Computed Tomography Chest Follow-up for Incidental Findings at 1 Year Relative to Stress-perfusion Cardiac Magnetic Resonance Imaging.

Smith, Ben C / Allen, Bradley D

Journal of thoracic imaging

2022 Volume 37, Issue 5, Page(s) 292–299

Abstract: Rationale and objectives: The aim of this study is to elucidate the prevalence and factors associated with follow-up chest computed tomography (CT) imaging in patients undergoing stress-perfusion cardiac magnetic resonance imaging (sCMR) and coronary CT ...

Abstract	Rationale and objectives: The aim of this study is to elucidate the prevalence and factors associated with follow-up chest computed tomography (CT) imaging in patients undergoing stress-perfusion cardiac magnetic resonance imaging (sCMR) and coronary CT angiography (cCTA). Materials and methods: Cardiac imaging encounters between January 1, 2015 and May 16, 2020 were selected for analysis. Follow-up was tracked within 1-year of initial cardiac imaging, up to May 16, 2021. Patient demographics, comorbidities, and cardiopulmonary outcomes were also analyzed. Results: Between 2015 and 2020, there were 4024 cCTA and 837 sCMR imaging procedures on unique patients with 1.1% and 0.5% of patients having follow-up CT chest studies within 1 year, respectively. When controlling for patient demographic factors, body mass index, insurance status, smoking history, and comorbid diagnostic codes, there was statistically significant increased odds (adjusted odds ratio [95% confidence interval]: 2.864 [1.129-7.265]) of undergoing follow-up within the cCTA cohort. Pulmonary nodules represented the most common incidental finding, with cCTA associated with higher rates of pulmonary nodules detected on imaging (adjusted odds ratio [95% confidence interval]: 5.947 [4.136-8.552]). sCMR was associated with higher rates of MI, percutaneous coronary intervention, and lung malignancy within 1 year, with no difference in all-cause mortality. Conclusions: Patients undergoing either cCTA and sCMR demonstrated a low prevalence of follow-up CT chest imaging; however, follow-up was 2 times greater after cCTA due to greater pulmonary nodule detection. Potential for follow-up should be considered when evaluating the comparative effectiveness of these modalities, including the impact of follow-up imaging on cost and patient outcomes. Strategies to improve lung nodule detection and characterization at the time of sCMR may provide added value in these patients.
MeSH term(s)	Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Artery Disease ; Follow-Up Studies ; Humans ; Incidental Findings ; Magnetic Resonance Imaging ; Perfusion ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0000000000000642
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Zs.A 2187: Show issues

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Article ; Online: Energy and Greenhouse Gas Emission Savings Associated with Implementation of an Abbreviated Cardiac MRI Protocol.

Ibrahim, Fadi / Cadour, Farah / Campbell-Washburn, Adrienne E / Allen, Bradley D / Vosshenrich, Jan / Brown, Maura J / Thavendiranathan, Paaladinesh / Hanneman, Kate

Radiology

2024 Volume 311, Issue 1, Page(s) e240588

Abstract: Supplemental material is available for this article. ...

Abstract	Supplemental material is available for this article.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/economics ; Greenhouse Gases
Chemical Substances	Greenhouse Gases
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.240588
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Article ; Online: Standardized medical terminology for cardiac computed tomography 2023 update- commentary by North American Society of Cardiovascular Imaging (NASCI).

Rai, Archana / Allen, Bradley D / Fuss, Cristina / Dennie, Carole / Hanneman, Kate

The international journal of cardiovascular imaging

2023 Volume 39, Issue 11, Page(s) 2255–2257

MeSH term(s)	Humans ; United States ; Predictive Value of Tests ; Coronary Angiography ; Tomography, X-Ray Computed ; North America ; Societies, Medical
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Editorial
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-023-02922-x
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Zs.A 2104: Show issues

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Article ; Online: SIMPEL: using stable isotopes to elucidate dynamics of context specific metabolism.

Kambhampati, Shrikaar / Hubbard, Allen H / Koley, Somnath / Gomez, Javier D / Marsolais, Frédéric / Evans, Bradley S / Young, Jamey D / Allen, Doug K

Communications biology

2024 Volume 7, Issue 1, Page(s) 172

Abstract: The capacity to leverage high resolution mass spectrometry (HRMS) with transient isotope labeling experiments is an untapped opportunity to derive insights on context-specific metabolism, that is difficult to assess quantitatively. Tools are needed to ... ...

Abstract	The capacity to leverage high resolution mass spectrometry (HRMS) with transient isotope labeling experiments is an untapped opportunity to derive insights on context-specific metabolism, that is difficult to assess quantitatively. Tools are needed to comprehensively mine isotopologue information in an automated, high-throughput way without errors. We describe a tool, Stable Isotope-assisted Metabolomics for Pathway Elucidation (SIMPEL), to simplify analysis and interpretation of isotope-enriched HRMS datasets. The efficacy of SIMPEL is demonstrated through examples of central carbon and lipid metabolism. In the first description, a dual-isotope labeling experiment is paired with SIMPEL and isotopically nonstationary metabolic flux analysis (INST-MFA) to resolve fluxes in central metabolism that would be otherwise challenging to quantify. In the second example, SIMPEL was paired with HRMS-based lipidomics data to describe lipid metabolism based on a single labeling experiment. Available as an R package, SIMPEL extends metabolomics analyses to include isotopologue signatures necessary to quantify metabolic flux.
MeSH term(s)	Carbon Isotopes/chemistry ; Mass Spectrometry/methods ; Metabolomics/methods ; Carbon
Chemical Substances	Carbon Isotopes ; Carbon (7440-44-0)
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05844-z
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Article ; Online: Program for Integration and Rapid Analysis of Mass Isotopomer Distributions (PIRAMID).

Gomez, Javier D / Wall, Martha L / Rahim, Mohsin / Kambhampati, Shrikaar / Evans, Bradley S / Allen, Doug K / Antoniewicz, Maciek R / Young, Jamey D

Bioinformatics (Oxford, England)

2024 Volume 39, Issue 11

Abstract: Summary: The analysis of stable isotope labeling experiments requires accurate, efficient, and reproducible quantification of mass isotopomer distributions (MIDs), which is not a core feature of general-purpose metabolomics software tools that are ... ...

Abstract	Summary: The analysis of stable isotope labeling experiments requires accurate, efficient, and reproducible quantification of mass isotopomer distributions (MIDs), which is not a core feature of general-purpose metabolomics software tools that are optimized to quantify metabolite abundance. Here, we present PIRAMID (Program for Integration and Rapid Analysis of Mass Isotopomer Distributions), a MATLAB-based tool that addresses this need by offering a user-friendly, graphical user interface-driven program to automate the extraction of isotopic information from mass spectrometry (MS) datasets. This tool can simultaneously extract ion chromatograms for various metabolites from multiple data files in common vendor-agnostic file formats, locate chromatographic peaks based on a targeted list of characteristic ions and retention times, and integrate MIDs for each target ion. These MIDs can be corrected for natural isotopic background based on the user-defined molecular formula of each ion. PIRAMID offers support for datasets acquired from low- or high-resolution MS, and single (MS) or tandem (MS/MS) instruments. It also enables the analysis of single or dual labeling experiments using a variety of isotopes (i.e. 2H, 13C, 15N, 18O, 34S). Data availability and implementation: MATLAB p-code files are freely available for non-commercial use and can be downloaded from https://mfa.vueinnovations.com/. Commercial licenses are also available. All the data presented in this publication are available under the "Help_menu" folder of the PIRAMID software.
MeSH term(s)	Tandem Mass Spectrometry ; Oxygen Isotopes ; Software ; Metabolomics/methods
Chemical Substances	Oxygen-18 ; Oxygen Isotopes
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btad661
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Zs.A 2374: Show issues

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Article ; Online: The current and future role of imaging of thoracic aortic disease: a North American society for cardiovascular imaging commentary on the 2022 AHA/ACC guidelines for the diagnosis and management of aortic disease.

Hamid, Aws / Gupta, Monesha / Rajiah, Prabhakar Shantha / Abbara, Suhny / Hanneman, Kate / Allen, Bradley D

The international journal of cardiovascular imaging

2023 Volume 40, Issue 1, Page(s) 5–14

Abstract: The 2022 AHA/ACC Guidelines for the Diagnosis and Management of Aortic Disease introduced important updates for managing thoracic aorta aortic disease (TAD). In particular, the Guidelines underscore multimodality imaging's role in diagnosis, risk ... ...

Abstract	The 2022 AHA/ACC Guidelines for the Diagnosis and Management of Aortic Disease introduced important updates for managing thoracic aorta aortic disease (TAD). In particular, the Guidelines underscore multimodality imaging's role in diagnosis, risk assessment, and monitoring of patients with TAD. This commentary aims to distill key imaging aspects from the Guidelines to provide a concise reference for the cardiovascular imaging community. Primary areas of focus include: (1) The importance of imagers in the multidisciplinary TAD care team, (2) Appropriate imaging techniques along with their strengths and weaknesses, (3) Aortic measurement methods and how aortic size and growth should contribute to TAD risk assessment, (4) Imaging evaluation of acute aortic syndrome. We have also highlighted several areas of ongoing uncertainty and confusion, specifically related to aortic measurement techniques and descriptive terminology. Finally, a perspective on the future of TAD imaging is discussed with a focus on advanced imaging tools and techniques as well as the potential role of artificial intelligence.
MeSH term(s)	Humans ; Artificial Intelligence ; Predictive Value of Tests ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/therapy ; Multimodal Imaging ; North America ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/therapy ; Aorta, Thoracic/diagnostic imaging
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-023-02964-1
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Zs.A 2104: Show issues

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Article ; Online: Multiyear Interval Changes in Aortic Wall Shear Stress in Patients with Bicuspid Aortic Valve Assessed by 4D Flow MRI.

Maroun, Anthony / Scott, Michael B / Catania, Roberta / Berhane, Haben / Jarvis, Kelly / Allen, Bradley D / Barker, Alex J / Markl, Michael

Journal of magnetic resonance imaging : JMRI

2024

Abstract: Background: In patients with bicuspid aortic valve (BAV), 4D flow MRI can quantify regions exposed to abnormal aortic hemodynamics, including high wall shear stress (WSS), a known stimulus for arterial wall dysfunction. However, the long-term multiscan ... ...

Abstract	Background: In patients with bicuspid aortic valve (BAV), 4D flow MRI can quantify regions exposed to abnormal aortic hemodynamics, including high wall shear stress (WSS), a known stimulus for arterial wall dysfunction. However, the long-term multiscan reproducibility of 4D flow MRI-derived hemodynamic parameters is unknown. Purpose: To investigate the long-term stability of 4D flow MRI-derived peak velocity, WSS, and WSS-derived heatmaps in patients with BAV undergoing multiyear surveillance imaging. Study type: Retrospective. Population: 20 BAV patients (mean age 48.4 ± 13.9 years; 14 males) with five 4D flow MRI scans, with intervals of at least 6 months between scans, and 125 controls (mean age: 50.7 ± 15.8 years; 67 males). Field strength/sequence: 1.5 and 3.0T, prospectively ECG and respiratory navigator-gated aortic 4D flow MRI. Assessment: Automated AI-based 4D flow analysis pipelines were used for data preprocessing, aorta 3D segmentation, and quantification of ascending aorta (AAo) peak velocity, peak systolic WSS, and heatmap-derived relative area of elevated WSS compared to WSS ranges in age and sex-matched normative control populations. Growth rate was derived from the maximum AAo diameters measured on the first and fifth MRI scans. Statistical tests: One-way repeated measures analysis of variance. P < 0.05 indicated significance. Results: One hundred 4D flow MRI exams (five per patient) were analyzed. The mean total follow-up duration was 5.5 ± 1.1 years, and the average growth rate was 0.3 ± 0.2 mm/year. Peak velocity, peak systolic WSS, and relative area of elevated WSS did not change significantly over the follow-up period (P = 0.64, P = 0.69, and P = 0.35, respectively). The patterns and areas of elevated WSS demonstrated good reproducibility on semiquantitative assessment. Conclusion: 4D flow MRI-derived peak velocity, WSS, and WSS-derived heatmaps showed good multiyear and multiscan stability in BAV patients with low aortic growth rates. These findings underscore the reliability of these metrics in monitoring BAV patients for potential risk of dilation. Level of evidence: 3 TECHNICAL EFFICACY: Stage 1.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29305
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical Applications of Four-Dimensional Flow MRI.

Maroun, Anthony / Quinn, Sandra / Dushfunian, David / Weiss, Elizabeth K / Allen, Bradley D / Carr, James C / Markl, Michael

Magnetic resonance imaging clinics of North America

2023 Volume 31, Issue 3, Page(s) 451–460

Abstract: Four-dimensional flow MRI is a powerful phase contrast technique used for assessing three-dimensional (3D) blood flow dynamics. By acquiring a time-resolved velocity field, it enables flexible retrospective analysis of blood flow that can include ... ...

Abstract	Four-dimensional flow MRI is a powerful phase contrast technique used for assessing three-dimensional (3D) blood flow dynamics. By acquiring a time-resolved velocity field, it enables flexible retrospective analysis of blood flow that can include qualitative 3D visualization of complex flow patterns, comprehensive assessment of multiple vessels, reliable placement of analysis planes, and calculation of advanced hemodynamic parameters. This technique provides several advantages over routine two-dimensional flow imaging techniques, allowing it to become part of clinical practice at major academic medical centers. In this review, we present the current state-of-the-art cardiovascular, neurovascular, and abdominal applications.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Blood Flow Velocity/physiology ; Hemodynamics/physiology ; Heart ; Imaging, Three-Dimensional/methods
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196851-5
ISSN	1557-9786 ; 1064-9689
ISSN (online)	1557-9786
ISSN	1064-9689
DOI	10.1016/j.mric.2023.04.005
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