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Article ; Online: Socio-economic deprivation and COVID-19 in Germany.

Moissl, Angela P / Lorkowski, Stefan / März, Winfried

2022 Volume 50, Issue 6, Page(s) 668–670

MeSH term(s)	COVID-19/epidemiology ; Germany/epidemiology ; Humans ; Poverty ; Socioeconomic Factors
Language	English
Publishing date	2022-03-23
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1475054-5
ISSN	1651-1905 ; 1403-4948
ISSN (online)	1651-1905
ISSN	1403-4948
DOI	10.1177/14034948221080397
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clusters of prediabetes and type 2 diabetes stratify all-cause mortality in a cohort of participants undergoing invasive coronary diagnostics.

Prystupa, Katsiaryna / Delgado, Graciela E / Moissl, Angela P / Kleber, Marcus E / Birkenfeld, Andreas L / Heni, Martin / Fritsche, Andreas / März, Winfried / Wagner, Robert

Cardiovascular diabetology

2023 Volume 22, Issue 1, Page(s) 211

Abstract: Background: Heterogeneous metabolic clusters have been identified in diabetic and prediabetic states. It is not known whether such pathophysiologic clusters impact survival in at-risk persons being evaluated for coronary heart disease.: Methods: The ... ...

Abstract	Background: Heterogeneous metabolic clusters have been identified in diabetic and prediabetic states. It is not known whether such pathophysiologic clusters impact survival in at-risk persons being evaluated for coronary heart disease. Methods: The LURIC Study recruited patients referred for coronary angiography at a median age of 63 (IQR 56-70) with a follow-up of 16.1 (IQR 9.6, 17.7) years. Clustering of 1269 subjects without diabetes was performed with oGTT-derived glucose and insulin; fasting triglyceride, high-density lipoprotein, BMI, waist and hip circumference. Patients with T2D (n = 794) were clustered using age, BMI, glycemia, homeostasis model assessment, and islet autoantibodies. Associations of clusters with mortality were analysed using Cox regression. Results: Individuals without diabetes were classified into six subphenotypes, with 884 assigned to subjects at low-risk (cluster 1,2,4) and 385 at high-risk (cluster 3,5,6) for diabetes. We found significantly increased mortality in clusters 3 (hazard ratio (HR)1.42), 5 (HR 1.43), and 6 (HR 1.46) after adjusting for age, BMI, HbA1c and sex. In the T2D group, 508 were assigned to mild age-related diabetes (MARD), 183 to severe insulin-resistant diabetes (SIRD), 84 to mild obesity-related diabetes (MOD), 19 to severe insulin-deficient diabetes (SIDD). Compared to the low-risk non-diabetes group, crude mortality was not different in MOD. Increased mortality was found for MARD (HR 2.2), SIRD (HR 2.2), and SIDD (HR 2.5). Conclusions: Metabolic clustering successfully stratifies survival even among persons undergoing invasive coronary diagnostics. Novel clustering approaches based on glucose metabolism can identify persons who require special attention as they are at risk of increased mortality.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Prediabetic State/diagnosis ; Diabetes Mellitus, Type 2/diagnosis ; Insulin ; Autoantibodies ; Coronary Angiography
Chemical Substances	Insulin ; Autoantibodies
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-023-01923-3
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Article ; Online: Gender- and subgroup-specific sensitivity analysis of alcohol consumption and mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

Moissl, Angela P / Delgado, Graciela E / Krämer, Bernhard K / Dawczynski, Christine / Stojakovic, Tatjana / März, Winfried / Kleber, Marcus E / Lorkowski, Stefan

Data in brief

2022 Volume 41, Page(s) 107873

Abstract: This Data in Brief article contains further sensitivity analysis data related to the article "Alcohol consumption and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study" [1]. Alcohol consumption data of participants in LURIC was ... ...

Abstract	This Data in Brief article contains further sensitivity analysis data related to the article "Alcohol consumption and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study" [1]. Alcohol consumption data of participants in LURIC was collected using a questionnaire. This data was used to calculate the amount of alcohol consumption in g ethanol per day by using standard volumes and standard vol-% in different beverages in Germany. The data shown here provide results from the LURIC study stratified by gender. Furthermore, the LURIC study results were reproduced using other classifications, which were stratified in different literature data. In addition, our analysis provides data of alcohol consumption for smokers and non-smokers in the LURIC study cohort separately.
Language	English
Publishing date	2022-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.107873
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Article: High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography.

Krämer, Robert M / Moissl, Angela P / Lorkowski, Stefan / Krämer, Bernhard K / Lehtimäki, Terho / Mishra, Binisha H / Mishra, Pashupati P / Leipe, Jan / März, Winfried / Kleber, Marcus E / Müller-Myhsok, Bertram / Delgado, Graciela E

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1125151

Abstract: Background: Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet.: Aims: The aim of our study was to investigate ... ...

Abstract	Background: Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet. Aims: The aim of our study was to investigate the association of a genetic depression risk score (GDRS) with mortality [all-cause and cardiovascular (CV)] and markers of depression (including intake of antidepressants and a history of depression) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study involving 3,316 patients who had been referred for coronary angiography. Methods and results: The GDRS was calculated in 3,061 LURIC participants according to a previously published method and was found to be associated with all-cause ( Conclusion: A genetic predisposition for depression estimated by a GDRS was independently associated with all-cause and CV mortality in our cohort of patients who had been referred for coronary angiography. No biomarker correlating with the GDRS could be identified.
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1125151
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Article: Gender- and subgroup-specific sensitivity analysis of alcohol consumption and mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Moissl, Angela P. / Delgado, Graciela E. / Krämer, Bernhard K. / Dawczynski, Christine / Stojakovic, Tatjana / März, Winfried / Kleber, Marcus E. / Lorkowski, Stefan

Data in Brief. 2022 Apr., v. 41

2022

Abstract: This Data in Brief article contains further sensitivity analysis data related to the article “Alcohol consumption and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study” [1]. Alcohol consumption data of participants in LURIC was ... ...

Abstract	This Data in Brief article contains further sensitivity analysis data related to the article “Alcohol consumption and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study” [1]. Alcohol consumption data of participants in LURIC was collected using a questionnaire. This data was used to calculate the amount of alcohol consumption in g ethanol per day by using standard volumes and standard vol-% in different beverages in Germany. The data shown here provide results from the LURIC study stratified by gender. Furthermore, the LURIC study results were reproduced using other classifications, which were stratified in different literature data. In addition, our analysis provides data of alcohol consumption for smokers and non-smokers in the LURIC study cohort separately.
Keywords	alcohol drinking ; ethanol ; gender ; mortality ; questionnaires ; risk ; Germany
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.107873
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gender- and subgroup-specific sensitivity analysis of alcohol consumption and mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Angela P. Moissl / Graciela E. Delgado / Bernhard K. Krämer / Christine Dawczynski / Tatjana Stojakovic / Winfried März / Marcus E. Kleber / Stefan Lorkowski

Data in Brief, Vol 41, Iss , Pp 107873- (2022)

2022

Abstract	This Data in Brief article contains further sensitivity analysis data related to the article “Alcohol consumption and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study” [1]. Alcohol consumption data of participants in LURIC was collected using a questionnaire. This data was used to calculate the amount of alcohol consumption in g ethanol per day by using standard volumes and standard vol-% in different beverages in Germany. The data shown here provide results from the LURIC study stratified by gender. Furthermore, the LURIC study results were reproduced using other classifications, which were stratified in different literature data. In addition, our analysis provides data of alcohol consumption for smokers and non-smokers in the LURIC study cohort separately.
Keywords	Gender-specific alcohol consumption ; Sensitivity analysis ; Mortality ; Cardiovascular diseases ; Diabetes mellitus ; Atherosclerosis ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Subject code	310
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

Moissl, Angela P / Lorkowski, Stefan / Meinitzer, Andreas / Pilz, Stefan / Scharnagl, Hubert / Delgado, Graciela E / Kleber, Marcus E / Krämer, Bernhard K / Pieske, Burkert / Grübler, Martin R / Brussee, Helmut / von Lewinski, Dirk / Toplak, Hermann / Fahrleitner-Pammer, Astrid / März, Winfried / Tomaschitz, Andreas

iScience

2023 Volume 26, Issue 4, Page(s) 106459

Abstract: Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and ... ...

Abstract	Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using linear and Cox regression. Adiponectin, hemoglobin, C-peptide, hemoglobin A
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106459
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: Cluster des Prädiabetes und Typ-2-Diabetes stratifizieren die Gesamtmortalität bei kardiovaskulären Hochrisiko-Patienten – Ergebnisse aus der LURIC-Kohorte

Prystupa, Katsiaryna / Delgado, Graciela E. / Moissl, Angela P. / Kleber, Marcus E. / Heni, Martin / Birkenfeld, Andreas L. / Fritsche, Andreas / Wagner, Robert / März, Winfried

Diabetologie und Stoffwechsel

2022 Volume 17, Issue S 01

Event/congress	Diabetes Kongress 2022 - 56. Jahrestagung der DDG, CityCube Berlin, 2022-05-25
Language	German
Publishing date	2022-05-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0042-1746232
Database	Thieme publisher's database

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Zs.A 6479: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 6479/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Alcohol consumption and mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

Moissl, Angela P / Delgado, Graciela E / Krämer, Bernhard K / Dawczynski, Christine / Stojakovic, Tatjana / März, Winfried / Kleber, Marcus E / Lorkowski, Stefan

Atherosclerosis

2021 Volume 335, Page(s) 119–125

Abstract: Background and aims: One of the most important risk factors for morbidity and mortality is the consumption of alcohol. The aim of our study was to examine the effect of alcohol consumption on all-cause mortality and cardiovascular mortality.: Methods!# ...

Abstract	Background and aims: One of the most important risk factors for morbidity and mortality is the consumption of alcohol. The aim of our study was to examine the effect of alcohol consumption on all-cause mortality and cardiovascular mortality. Methods: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study includes 3316 patients hospitalized for coronary angiography at a tertiary care centre in Southwest Germany. Patients were followed-up for a median of 9.9 (range 0.1-11.9 years) years. Total mortality number in the follow-up period was 995, and the number of incident cases, i.e. cardiovascular death, was 622. Information on alcohol consumption assessed by self-report questionnaires was used to calculate intake in grams of ethanol per day. Associations of alcohol consumption with morbidity and mortality were analysed using Cox proportional hazards regression. Results: We found significantly increased mortality for patients in the highest alcohol intake group age- and sex-adjusted (hazard ratio of 1.59 (95%CI, 0.93-2.72)) and a reduced risk for the group of low-volume drinkers (hazard ratio of 0.75 (95%CI, 0.65-0.86)). After adjustment for cardiovascular risk factors, the risk difference between abstainers and low-volume drinkers was not significant anymore. Conclusions: In the LURIC study, the risk of overall mortality and cardiovascular mortality is significantly increased in study participants with very high alcohol consumption and slightly increased in total abstainers as compared to participants with low consumption in unadjusted analysis, replicating the well-known J-curve. Adjusting for cardiovascular risk factors rendered the risk decrease observed for low-volume drinkers insignificant. Therefore, our results do not show a significant health benefit of low-volume alcohol consumption in a cohort of patients at medium-to-high cardiovascular risk.
MeSH term(s)	Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Cardiovascular Diseases/diagnosis ; Ethanol ; Germany/epidemiology ; Humans ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2021-08-12
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2021.08.014
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Article: Diagnostic Performance of Rapid Antigen Testing for SARS-CoV-2: The COVid-19 AntiGen (COVAG) study.

Wertenauer, Christoph / Brenner Michael, Geovana / Dressel, Alexander / Pfeifer, Caroline / Hauser, Ulrike / Wieland, Eberhard / Mayer, Christian / Mutschmann, Caren / Roskos, Martin / Wertenauer, Hans-Jörg / Moissl, Angela P / Lorkowski, Stefan / März, Winfried

Frontiers in medicine

2022 Volume 9, Page(s) 774550

Abstract: Background: Rapid diagnostic testing for SARS-Cov-2 antigens is used to combat the ongoing pandemic. In this study we aimed to compare two RDTs, the SD Biosensor Q SARS-CoV-2 Rapid Antigen Test (Roche) and the Panbio COVID-19 Ag Rapid Test (Abbott), ... ...

Abstract	Background: Rapid diagnostic testing for SARS-Cov-2 antigens is used to combat the ongoing pandemic. In this study we aimed to compare two RDTs, the SD Biosensor Q SARS-CoV-2 Rapid Antigen Test (Roche) and the Panbio COVID-19 Ag Rapid Test (Abbott), against rRT-PCR. Methods: We included 2,215 all-comers at a diagnostic center between February 1 and March 31, 2021. rRT-PCR-positive samples were examined for SARS-CoV-2 variants. Findings: Three hundred and thirty eight participants (15%) were rRT-PCR-positive for SARS-CoV-2. The sensitivities of Roche-RDT and Abbott-RDT were 60.4 and 56.8% ( Interpretation: The sensitivities of the two RDTs for asymptomatic SARS-CoV-2 carriers are unsatisfactory. Their widespread use may not be effective in the ongoing SARS-CoV-2 pandemic. The virus genotype influences the sensitivity of the two RDTs. RDTs should be evaluated for different SARS-CoV-2 variants.
Language	English
Publishing date	2022-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.774550
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