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Article ; Online: GPR84 regulates pulmonary inflammation by modulating neutrophil functions.

Wang, Si-Wei / Zhang, Qing / Lu, Dan / Fang, You-Chen / Yan, Xiao-Ci / Chen, Jing / Xia, Zhi-Kan / Yuan, Qian-Ting / Chen, Lin-Hai / Zhang, Yang-Ming / Nan, Fa-Jun / Xie, Xin

Acta pharmacologica Sinica

2023 Volume 44, Issue 8, Page(s) 1665–1675

Abstract: Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by uncontrolled inflammation, and multiple types ... ...

Abstract	Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by uncontrolled inflammation, and multiple types of immune cells, especially neutrophils, are critically involved in the development of ALI. The treatment for ALI/ARDS is very limited, a better understanding of the pathogenesis and new therapies are urgently needed. Here we discover that GPR84, a medium chain fatty acid receptor, plays critical roles in ALI development by regulating neutrophil functions. GPR84 is highly upregulated in the cells isolated from the bronchoalveolar lavage fluid of LPS-induced ALI mice. GPR84 deficiency or blockage significantly ameliorated ALI mice lung inflammation by reducing neutrophils infiltration and oxidative stress. Further studies reveal that activation of GPR84 strongly induced reactive oxygen species production from neutrophils by stimulating Lyn, AKT and ERK1/2 activation and the assembly of the NADPH oxidase. These results reveal an important role of GPR84 in neutrophil functions and lung inflammation and strongly suggest that GPR84 is a potential drug target for ALI.
MeSH term(s)	Animals ; Mice ; Neutrophils/pathology ; Pneumonia/pathology ; Inflammation/drug therapy ; Acute Lung Injury/drug therapy ; Respiratory Distress Syndrome/pathology ; Lipopolysaccharides/adverse effects
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1360774-1
ISSN	1745-7254 ; 0253-9756 ; 1671-4083
ISSN (online)	1745-7254
ISSN	0253-9756 ; 1671-4083
DOI	10.1038/s41401-023-01080-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Construction of Multifunctional Covalent Organic Frameworks for Photocatalysis.

Chen, Zhi / Wang, Jian-Cheng / Du, Jia-Qi / Kan, Xuan / Sun, Ting / Kan, Jing-Lan / Dong, Yu-Bin

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 10, Page(s) e202303497

Abstract: Covalent organic frameworks (COFs) have recently drawn intense attention due to their potential applications in photocatalysis. Herein, we report a multifunctional COF which consists of triphenylamine (TPA) and 2,2'-bipyridine (2, 2'-bipy) entities. The ... ...

Abstract	Covalent organic frameworks (COFs) have recently drawn intense attention due to their potential applications in photocatalysis. Herein, we report a multifunctional COF which consists of triphenylamine (TPA) and 2,2'-bipyridine (2, 2'-bipy) entities. The obtained TAPA-BPy-COF is a heterogeneous photocatalyst and can efficiently catalyze the oxidative coupling of thiols to disulfides. In addition, TAPA-BPy-COF can be further metalated by Pd(II) via 2,2'-bipy-metal coordination. The generated Pd@TAPA-BPy-COF can highly promote photocatalytic synthesis of 3-cyanopyridines via cascade addition/cyclization of arylboronic acids with γ-ketodinitriles in heterogeneous way. This work has demonstrated the way for the rational design and preparation of more efficient photoactive COFs for photocatalysis.
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303497
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Article ; Online: MOFs-Modified Electrochemical Sensors and the Application in the Detection of Opioids.

Zhao, Jiaqi / Kan, Ying / Chen, Zhi / Li, Hongmei / Zhang, Weifei

Biosensors

2023 Volume 13, Issue 2

Abstract: Opioids are widely used in clinical practice, but drug overdoses can lead to many adverse reactions, and even endanger life. Therefore, it is essential to implement real-time measurement of drug concentrations to adjust the dosage given during treatment, ...

Abstract	Opioids are widely used in clinical practice, but drug overdoses can lead to many adverse reactions, and even endanger life. Therefore, it is essential to implement real-time measurement of drug concentrations to adjust the dosage given during treatment, keeping drug levels within therapeutic levels. Metal-Organic frameworks (MOFs) and their composite materials modified bare electrode electrochemical sensors have the advantages of fast production, low cost, high sensitivity, and low detection limit in the detection of opioids. In this review, MOFs and MOFs composites, electrochemical sensors modified with MOFs for the detection of opioids, as well as the application of microfluidic chips in combination with electrochemical methods are all reviewed, and the potential for the development of microfluidic chips electrochemical methods with MOFs surface modifications for the detection of opioids is also prospected. We hope that this review will provide contributions to the study of electrochemical sensors modified with MOFs for the detection of opioids.
MeSH term(s)	Metal-Organic Frameworks ; Analgesics, Opioid
Chemical Substances	Metal-Organic Frameworks ; Analgesics, Opioid
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13020284
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Article ; Online: Phenanthroline-Decorated Covalent Organic Framework for Catalytic Synthesis of 2-Aminobenzothiazoles in Water.

Wang, Jian-Cheng / Yu, Zhi-Gao / Yang, Wen-Ting / Du, Jia-Qi / Chen, Zhi / Kan, Jing-Lan / Dong, Ying / Dong, Yu-Bin

ChemPlusChem

2023 Volume 89, Issue 4, Page(s) e202300494

Abstract: 2-Aminobenzothiazoles are widely used in the fields of pharmaceuticals and pesticides. Herein, we report a metal-free protocol for the preparation of 2-aminobenzothiazoles by a covalent organic framework (COF) catalyzed tandem reaction. In the presence ... ...

Abstract	2-Aminobenzothiazoles are widely used in the fields of pharmaceuticals and pesticides. Herein, we report a metal-free protocol for the preparation of 2-aminobenzothiazoles by a covalent organic framework (COF) catalyzed tandem reaction. In the presence of catalytic amount of phenanthroline-decorated COF (Phen-COF), a variety of 2-aminobenzothiazoles are obtained in excellent yields by the cross-coupling of 2-iodoanilines with isothiocyanates at room temperature in water. In addition, the COF-catalyst is very stable and can be reused at least seven times without loss of its catalytic activity.
Language	English
Publishing date	2023-11-22
Publishing country	Germany
Document type	Journal Article
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202300494
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Article ; Online: Multi-heteroatom-doping promotes molecular oxygen activation on polymeric carbon nitride for simultaneous generation of H

Chen, Derui / Yao, Bingling / Zhi, Xinyu / Tian, Chang / Chen, Minghao / Cao, Siyi / Feng, Xinyu / Che, Huinan / Zhang, Kan / Ao, Yanhui

Nanoscale

2023 Volume 15, Issue 27, Page(s) 11482–11490

Abstract: Simultaneously realizing the efficient generation of ... ...

Abstract	Simultaneously realizing the efficient generation of H
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr01299a
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Article ; Online: Estimated Pulse Wave Velocity Predicts All-Cause and Cardiovascular-Cause Mortality in Individuals With Hypertension　- Findings From a National Health and Nutrition Examination Study 1999-2018.

Shi, Yi / Wu, Li-Da / Feng, Xiao-Hua / Kan, Jun-Yan / Kong, Chao-Hua / Ling, Zhi-Yu / Zhang, Jun-Xia / Chen, Shao-Liang

Circulation journal : official journal of the Japanese Circulation Society

2024 Volume 88, Issue 3, Page(s) 417–424

Abstract: Background: This study aimed to investigate the association between estimated pulse wave velocity (ePWV) and mortality outcomes among individuals with hypertension.Methods and Results: Based on the National Health and Nutrition Examination Survey ( ... ...

Abstract	Background: This study aimed to investigate the association between estimated pulse wave velocity (ePWV) and mortality outcomes among individuals with hypertension.Methods and Results: Based on the National Health and Nutrition Examination Survey (NHANES) 1999-2018, a total of 14,396 eligible participants with hypertension were enrolled. The ePWV was calculated using the equation based on blood pressure and age. The mortality outcomes of included participants were directly acquired from the National Death Index database. The multivariable Cox regression analysis was used to examine the relationship between ePWV and mortality outcomes. Moreover, the restricted cubic spline (RCS) was also used to explore this relationship. Receiver operating characteristics curves (ROC) were adopted to evaluate the prognostic ability of ePWV for predicting mortality outcomes of patients with hypertension. The median follow-up duration was 10.8 years; individuals with higher an ePWV had higher risks of mortality from both all causes (HR: 2.79, 95% CI: 2.43-3.20) and cardiovascular diseases (HR: 3.41, 95% CI: 2.50-4.64). After adjusting for confounding factors, each 1 m/s increase in ePWV was associated with a 43% increase in all-cause mortality risk (HR: 1.43, 95% CI: 1.37-1.48) and a 54% increase in cardiovascular mortality risk (HR: 1.54, 95% CI: 1.43-1.66). Conclusions: This study indicates that ePWV is a novel prognostic indicator for predicting the risks of mortality among patients with hypertension.
MeSH term(s)	Humans ; Nutrition Surveys ; Pulse Wave Analysis ; Cardiovascular System ; Hypertension ; Cardiovascular Diseases
Language	English
Publishing date	2024-01-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-23-0674
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Article ; Online: A hybrid particle swarm optimization algorithm for solving engineering problem.

Qiao, Jinwei / Wang, Guangyuan / Yang, Zhi / Luo, Xiaochuan / Chen, Jun / Li, Kan / Liu, Pengbo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8357

Abstract: To overcome the disadvantages of premature convergence and easy trapping into local optimum solutions, this paper proposes an improved particle swarm optimization algorithm (named NDWPSO algorithm) based on multiple hybrid strategies. Firstly, the elite ... ...

Abstract	To overcome the disadvantages of premature convergence and easy trapping into local optimum solutions, this paper proposes an improved particle swarm optimization algorithm (named NDWPSO algorithm) based on multiple hybrid strategies. Firstly, the elite opposition-based learning method is utilized to initialize the particle position matrix. Secondly, the dynamic inertial weight parameters are given to improve the global search speed in the early iterative phase. Thirdly, a new local optimal jump-out strategy is proposed to overcome the "premature" problem. Finally, the algorithm applies the spiral shrinkage search strategy from the whale optimization algorithm (WOA) and the Differential Evolution (DE) mutation strategy in the later iteration to accelerate the convergence speed. The NDWPSO is further compared with other 8 well-known nature-inspired algorithms (3 PSO variants and 5 other intelligent algorithms) on 23 benchmark test functions and three practical engineering problems. Simulation results prove that the NDWPSO algorithm obtains better results for all 49 sets of data than the other 3 PSO variants. Compared with 5 other intelligent algorithms, the NDWPSO obtains 69.2%, 84.6%, and 84.6% of the best results for the benchmark function (
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59034-2
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Article ; Online: Synthesis of Metal-Free Chiral Covalent Organic Framework for Visible-Light-Mediated Enantioselective Photooxidation in Water.

Kan, Xuan / Wang, Jian-Cheng / Chen, Zhi / Du, Jia-Qi / Kan, Jing-Lan / Li, Wen-Yan / Dong, Yu-Bin

Journal of the American Chemical Society

2022 Volume 144, Issue 15, Page(s) 6681–6686

Abstract: Although chiral covalent organic frameworks (CCOFs) presence grows in thermal asymmetric catalysis, their application in equally important asymmetric photocatalysis has yet to begin. Herein, we first report a propargylamine-linked and quaternary ammonium ...

Abstract	Although chiral covalent organic frameworks (CCOFs) presence grows in thermal asymmetric catalysis, their application in equally important asymmetric photocatalysis has yet to begin. Herein, we first report a propargylamine-linked and quaternary ammonium bromide decorated porphyrin-CCOF which can highly promote visible-light-driven enantioselective photooxidation of sulfides to sulfoxides in water and in air. This methodology has also been applied to the synthesis of (
MeSH term(s)	Catalysis ; Metal-Organic Frameworks ; Metals ; Stereoisomerism ; Sulfoxides ; Water
Chemical Substances	Metal-Organic Frameworks ; Metals ; Sulfoxides ; Water (059QF0KO0R)
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c01186
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Article: A fusion model integrating magnetic resonance imaging radiomics and deep learning features for predicting alpha-thalassemia X-linked intellectual disability mutation status in isocitrate dehydrogenase-mutant high-grade astrocytoma: a multicenter study.

Liu, Zhi / Xu, Xinyi / Zhang, Wang / Zhang, Liqiang / Wen, Ming / Gao, Jueni / Yang, Jun / Kan, Yubo / Yang, Xing / Wen, Zhipeng / Chen, Shanxiong / Cao, Xu

Quantitative imaging in medicine and surgery

2024 Volume 14, Issue 1, Page(s) 251–263

Abstract: Background: The mutational status of alpha-thalassemia X-linked intellectual disability (: Methods: A total of 234 patients with : Results: The overall hybrid model constructed with radiomics and DL features from the overall lesion was identified ... ...

Abstract	Background: The mutational status of alpha-thalassemia X-linked intellectual disability ( Methods: A total of 234 patients with Results: The overall hybrid model constructed with radiomics and DL features from the overall lesion was identified as the optimal imaging model. The fusion model showed the best prediction performance with an area under curve of 0.969 in the training set, 0.956 in the validation set, and 0.949 in the test set as compared to the optimal imaging model (0.966, 0.916, and 0.936, respectively) and clinical model (0.677, 0.641, 0.772, respectively). Conclusions: The clinical trait-imaging fusion model based on preoperative MRI could effectively predict the
Language	English
Publishing date	2024-01-02
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-807
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Article ; Online: Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord.

Chen, Xue-Tai / Chen, Li-Ping / Fan, Li-Jun / Kan, Hou-Ming / Wang, Zi-Zhu / Qian, Bin / Pan, Zhi-Qiang / Shen, Wen

The journal of pain

2023 Volume 24, Issue 5, Page(s) 901–917

Abstract: Administration of cisplatin and other chemotherapy drugs is crucial for treating tumors. However, cisplatin-induced pain hypersensitivity is still a critical clinical issue, and the underlying molecular mechanisms have remained unresolved to date. In ... ...

Abstract	Administration of cisplatin and other chemotherapy drugs is crucial for treating tumors. However, cisplatin-induced pain hypersensitivity is still a critical clinical issue, and the underlying molecular mechanisms have remained unresolved to date. In this study, we found that repeated cisplatin treatments remarkedly upregulated the P2Y12 expression in the spinal cord. Expression of P2Y12 was predominant in the microglia. Pharmacological inhibition of P2Y12 expression markedly attenuated the cisplatin-induced pain hypersensitivity. Meanwhile, blocking the P2Y12 signal also suppressed cisplatin-induced microglia hyperactivity. Furthermore, the microglia Src family kinase/p38 pathway is required for P2Y12-mediated cisplatin-induced pain hypersensitivity via the proinflammatory cytokine IL-18 production in the spinal cord. Blocking the P2Y12/IL-18 signaling pathway reversed cisplatin-induced pain hypersensitivity, as well as activation of N-methyl-D-aspartate receptor and subsequent Ca
MeSH term(s)	Humans ; Microglia/metabolism ; Cisplatin/toxicity ; Interleukin-18/metabolism ; Central Nervous System Sensitization ; Hyperalgesia/metabolism ; Pain/chemically induced ; Pain/drug therapy ; Pain/metabolism ; Spinal Cord/metabolism ; Signal Transduction/physiology ; Antineoplastic Agents/adverse effects
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Interleukin-18 ; Antineoplastic Agents
Language	English
Publishing date	2023-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2018789-0
ISSN	1528-8447 ; 1526-5900
ISSN (online)	1528-8447
ISSN	1526-5900
DOI	10.1016/j.jpain.2023.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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