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Article ; Online: Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection.

Van Rhijn, Ildiko / Nguyen, Thi Kim Anh / Michel, Anita / Cooper, Dave / Govaerts, Marc / Cheng, Tan-Yun / van Eden, Willem / Moody, D Branch / Coetzer, Jacobus A W / Rutten, Victor / Koets, Ad P

European journal of immunology

2009 Volume 39, Issue 11, Page(s) 3031–3041

Abstract: ... by MAP than by M. bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell ... Although CD1 proteins are known to present mycobacterial lipid antigens to T cells, there is little ... understanding of the in vivo behavior of T cells restricted by CD1a, CD1b and CD1c, and the relative ...

Abstract	Although CD1 proteins are known to present mycobacterial lipid antigens to T cells, there is little understanding of the in vivo behavior of T cells restricted by CD1a, CD1b and CD1c, and the relative immunogenicity and immunodominance of individual lipids within the total array of lipids that comprise a bacterium. Because bovines express multiple CD1 proteins and are natural hosts of Mycobacterium bovis and Mycobacterium avium paratuberculosis (MAP), we used them as a new animal model of CD1 function. Here, we report the surprisingly divergent responses against lipids produced by these two pathogens during infection. Despite considerable overlap in lipid content, only three out of 69 animals cross-react with M. bovis and MAP total lipid preparations. The unidentified immunodominant compound of M. bovis is a hydrophilic compound, whereas the immunodominant lipid of MAP is presented by CD1b and was identified as glucose monomycolate (GMM). The preferential recognition of GMM antigen by MAP-infected cattle may be explained by the higher expression of GMM by MAP than by M. bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell response affects the approach to development of lipid based immunodiagnostic tests.
MeSH term(s)	Animals ; Antigens, Bacterial/immunology ; Cattle ; Cross Reactions ; Lipids/immunology ; Mycobacterium avium subsp. paratuberculosis/immunology ; Mycobacterium bovis/immunology ; Paratuberculosis/immunology ; T-Lymphocytes/immunology ; Tuberculosis, Bovine/immunology
Chemical Substances	Antigens, Bacterial ; Lipids
Language	English
Publishing date	2009-08-18
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200939619
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Article: Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection

Van Rhijn, Ildiko / Nguyen, Thi Kim Anh / Michel, Anita / Cooper, Dave / Govaerts, Marc / Cheng, Tan-Yun / van Eden, Willem / Moody, D. Branch / Coetzer, Jacobus A.W / Rutten, Victor / Koets, Ad P

European journal of immunology. 2009 Nov., v. 39, no. 11

2009

Abstract	Although CD1 proteins are known to present mycobacterial lipid antigens to T cells, there is little understanding of the in vivo behavior of T cells restricted by CD1a, CD1b and CD1c, and the relative immunogenicity and immunodominance of individual lipids within the total array of lipids that comprise a bacterium. Because bovines express multiple CD1 proteins and are natural hosts of Mycobacterium bovis and Mycobacterium avium paratuberculosis (MAP), we used them as a new animal model of CD1 function. Here, we report the surprisingly divergent responses against lipids produced by these two pathogens during infection. Despite considerable overlap in lipid content, only three out of 69 animals cross-react with M. bovis and MAP total lipid preparations. The unidentified immunodominant compound of M. bovis is a hydrophilic compound, whereas the immunodominant lipid of MAP is presented by CD1b and was identified as glucose monomycolate (GMM). The preferential recognition of GMM antigen by MAP-infected cattle may be explained by the higher expression of GMM by MAP than by M. bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell response affects the approach to development of lipid based immunodiagnostic tests.
Language	English
Dates of publication	2009-11
Size	p. 3031-3041.
Publishing place	Wiley-VCH Verlag
Document type	Article
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200939619
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Article: T.E.A.M. soil judging--an experiment

Cooper, T.H

Journal of agronomic education. Fall 1991. v. 20 (2)

1991

Keywords	soil classification ; soil ; educational methods ; soil science ; agricultural education ; Minnesota
Language	English
Size	p. 123-125.
Document type	Article
ZDB-ID	406210-3
ISSN	0094-2391
ISSN	0094-2391
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Article: Mapping the minimal murine T cell and B cell epitopes within a peptide vaccine candidate from the conserved region of the M protein of group A streptococcus.

Hayman, W A / Brandt, E R / Relf, W A / Cooper, J / Saul, A / Good, M F

International immunology

1997 Volume 9, Issue 11, Page(s) 1723–1733

Abstract: ... However, due to potential cross-reactivity between T cells stimulated by this region of the M protein and host ... The highly conserved C-terminus of the M protein of group A streptococcus (GAS) is a promising ... vaccine candidate. An epitope within the conserved C-terminus of the M protein, peptide 145 (a 20-mer ...

Abstract	The highly conserved C-terminus of the M protein of group A streptococcus (GAS) is a promising vaccine candidate. An epitope within the conserved C-terminus of the M protein, peptide 145 (a 20-mer with the sequence: LRRDLDASREAKKQVEKALE), has been defined which is the target of opsonic antibodies in both humans and mice, and is recognized by the sera of most adults living in areas of high streptococcal exposure. However, due to potential cross-reactivity between T cells stimulated by this region of the M protein and host cardiac myosin, it is critical to define precisely the minimal protective epitopes within p145. Studies have shown that the immunodominant epitope expressed by p145 is conformational, occurring as an alpha-helical coiled-coil. To enable us to map the murine minimal B cell and T cell epitopes within p145, we have used a novel strategy that allowed us to present shorter sequences of p145 in a native-like conformation. The minimal B cell epitope was found to be contained within residues 7-20 of the p145 sequence, and we have shown that mice immunized with this region are able to generate antibodies that bind to and also opsonize the organism GAS. The T cell epitope is located at the N-terminal region of the p145 sequence, residues 3-14. We have managed, therefore, to define a vaccine candidate--a minimal opsonic B cell epitope within the p145 sequence--that does not incorporate a potentially deleterious T cell epitope.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antibodies, Bacterial/biosynthesis ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Antibodies, Monoclonal ; Antibody Specificity ; Antigens, Bacterial/analysis ; Antigens, Bacterial/immunology ; B-Lymphocytes/immunology ; Bacterial Outer Membrane Proteins ; Bacterial Proteins/analysis ; Bacterial Proteins/immunology ; Bacterial Vaccines/analysis ; Bacterial Vaccines/immunology ; Carrier Proteins ; Complement Fixation Tests ; Conserved Sequence ; Epitope Mapping ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Rheumatic Fever/immunology ; Rheumatic Fever/prevention & control ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Bacterial ; Antibodies, Monoclonal ; Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Proteins ; Bacterial Vaccines ; Carrier Proteins ; streptococcal M protein
Language	English
Publishing date	1997-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/9.11.1723
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Article: Human B cell differentiation. IV. Effect of monoclonal anti-immunoglobulin M and D antibodies on B cell proliferation and differentiation induced by T cell factors.

Kuritani, T / Cooper, M D

Journal of immunology (Baltimore, Md. : 1950)

1983 Volume 131, Issue 3, Page(s) 1306–1311

Abstract: Monoclonal anti-mu and anti-delta antibodies and mixed lymphocyte reaction-derived T cell factors ...

Abstract	Monoclonal anti-mu and anti-delta antibodies and mixed lymphocyte reaction-derived T cell factors (MLR-TF) were examined alone and in combination for their effects on proliferation and differentiation of human B cells. MLR-TF induced proliferation and subsequent plasma cell differentiation of blood B cells without additional stimulation. The monoclonal anti-mu and anti-delta antibodies alone did not induce proliferation, but each was capable of augmenting B cell proliferation induced by MLR-TF. In contrast, the anti-mu antibody inhibited the MLR-TF induction of IgM plasma cell differentiation but did not affect the differentiation of IgG and IgA plasma cells. The anti-delta antibody had no effect on MLR-TF-induced plasma cell differentiation. Studies using density gradient separation of B cell subpopulations suggest that MLR-TF induce low-density B cells to proliferate and differentiate into plasma cells but that by themselves MLR-TF have little effect on B cells of relatively high density. The latter subpopulation of small resting B cells responded with proliferation to MLR-TF when combined with either the anti-mu or the anti-delta antibody, but these stimuli were insufficient for induction of terminal plasma cell differentiation.
MeSH term(s)	Animals ; Antibodies, Anti-Idiotypic/physiology ; Antibodies, Monoclonal/physiology ; B-Lymphocytes/classification ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Cell Count ; Cell Differentiation/drug effects ; Humans ; Hydroxyurea/pharmacology ; Immunoglobulin D/immunology ; Immunoglobulin M/immunology ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Mice ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Anti-Idiotypic ; Antibodies, Monoclonal ; Immunoglobulin D ; Immunoglobulin M ; Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	1983-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
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Article ; Online: Third time's a harm? Cardiac risk of SARS-CoV-2 mRNA booster vaccines in younger men.

Cooper, Leslie T / Hasin, Tal / Ryan, Margaret

European heart journal

2024 Volume 45, Issue 15, Page(s) 1336–1338

MeSH term(s)	Male ; Humans ; COVID-19/prevention & control ; SARS-CoV-2/genetics ; Vaccines ; RNA, Messenger
Chemical Substances	Vaccines ; RNA, Messenger
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehae157
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Article ; Online: Measuring the added value of virtual communities of practice for developing the educator role of critical care professionals.

Ghani, Manisa / Cooper-Ioelu, Pauline / Jowsey, Tanisha

BMJ open quality

2024 Volume 13, Issue 1

Abstract: In healthcare settings, workplace learning is often supported by clinicians who strive to combine service provision and educator roles. We evaluated an international 12-month programme that supports widely distributed critical care health professional ... ...

Abstract	In healthcare settings, workplace learning is often supported by clinicians who strive to combine service provision and educator roles. We evaluated an international 12-month programme that supports widely distributed critical care health professional educators (HPEs) through a virtual community of practice (vCoP). Specifically, we evaluate
MeSH term(s)	Humans ; Community Health Services ; Critical Care ; Education, Medical ; Health Facilities ; Health Personnel
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ISSN	2399-6641
ISSN (online)	2399-6641
DOI	10.1136/bmjoq-2023-002556
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Article ; Online: Associations between diabetes status and grip strength trajectory sub-groups in adulthood: findings from over 16 years of follow-up in the MRC National Survey of Health and Development.

Norris, T / Johnson, W / Cooper, R / Pereira, S M Pinto

BMC geriatrics

2023 Volume 23, Issue 1, Page(s) 213

Abstract: Background: Cross-sectional studies suggest a relationship between diabetes status and weaker grip strength (GS) in adulthood and limited evidence from longitudinal studies has focussed on the association with average change in GS. We aimed to ... ...

Abstract	Background: Cross-sectional studies suggest a relationship between diabetes status and weaker grip strength (GS) in adulthood and limited evidence from longitudinal studies has focussed on the association with average change in GS. We aimed to investigate whether diabetes status was related to membership of distinct GS trajectories in mid-to-late adulthood in 2,263 participants in the Medical Research Council National Survey of Health and Development. Methods: Grip strength (kg) was measured at 53, 60-64 and 69 years. Pre-/diabetes was defined at 53 years based on HbA1c > 5.6% and/or doctor-diagnosis of diabetes. Sex-specific latent class trajectory models were developed and multinomial logistic regression was used to investigate the association between pre-/diabetes status and membership into GS trajectory classes. Results: For both males and females, a 3-class solution ('High', 'Intermediate', 'Low') provided the best representation of the GS data and the most plausible solution. There was no evidence that pre-/diabetes status was associated with class membership in either sex: e.g., adjusted odds ratios of being in the 'Low' class (vs. 'High') for males with pre-/diabetes (vs. no-diabetes) was 1.07 (95% CI:0.45,2.55). Conclusion: Using a flexible data-driven approach to identify GS trajectories between 53 and 69 years, we observed three distinct GS trajectories, all declining, in both sexes. There was no association between pre-/diabetes status at 53 years and membership into these GS trajectories. Understanding the diabetes status-GS trajectories association is vital to ascertain the consequences that projected increases in pre-/diabetes prevalence's are likely to have.
MeSH term(s)	Female ; Humans ; Male ; Cross-Sectional Studies ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Follow-Up Studies ; Hand Strength ; Longitudinal Studies ; Middle Aged ; Aged
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-03871-9
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Article ; Online: Shared decision making reimagined.

Haidet, Paul / Melro, Carolyn M / Fecile, Mary Lynn E / Jarecke, Jodi L T / Moniz, Tracy / Cooper, Amanda B

Patient education and counseling

2024 Volume 123, Page(s) 108249

MeSH term(s)	Humans ; Decision Making, Shared ; Decision Making ; Physician-Patient Relations ; Patient Participation
Language	English
Publishing date	2024-03-12
Publishing country	Ireland
Document type	Editorial
ZDB-ID	605590-4
ISSN	1873-5134 ; 0738-3991
ISSN (online)	1873-5134
ISSN	0738-3991
DOI	10.1016/j.pec.2024.108249
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Article ; Online: Examining the role of attention during feature binding in visuospatial working memory.

Goldenhaus-Manning, David T / Cooper, Nicholas R / Loaiza, Vanessa M

Attention, perception & psychophysics

2023 Volume 86, Issue 1, Page(s) 354–365

Abstract: The current experiments address the enduring debate regarding the role of attention in feature binding in visuospatial working memory by considering the nature of the to-be-bound features, i.e., whether they are intrinsic (integrated within the object, ... ...

Abstract	The current experiments address the enduring debate regarding the role of attention in feature binding in visuospatial working memory by considering the nature of the to-be-bound features, i.e., whether they are intrinsic (integrated within the object, such as its color and shape) or extrinsic (not part of the object, such as its spatial location). Specifically, arrays of different-colored shapes in different locations were followed by probed recall: One feature of the probed object prompted recall of one of its remaining two features (e.g., a shape probe prompts recall of color, with the probe displayed at the center of the screen (i.e., without spatial information)) to test the retention of intrinsic (shape, color) and extrinsic (location) features. During the retention interval, we manipulated attention via disruption (Experiment 1) and retro-cues (Experiment 2) to determine their impacts on binding errors, as estimated from a three-parameter mixture model fit to recall error (i.e., the distance between the target and response). Disrupting central versus peripheral attention in Experiment 1 did not respectively increase extrinsic and intrinsic binding errors as predicted, but disrupting central attention reduced target memory of the extrinsic feature relative to a no-disruption baseline. Guiding attention via extrinsic and intrinsic retro-cues in Experiment 2 did not respectively reduce extrinsic and intrinsic binding errors as predicted, but we observed retro-cue benefits to target memory that did not distinguish between extrinsic and intrinsic features. Thus, this work highlights that attentional resources aid target memory, with no consistent distinction between intrinsic and extrinsic features.
MeSH term(s)	Humans ; Memory, Short-Term/physiology ; Attention/physiology ; Cues ; Mental Recall/physiology ; Visual Perception/physiology
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2464550-3
ISSN	1943-393X ; 1943-3921
ISSN (online)	1943-393X
ISSN	1943-3921
DOI	10.3758/s13414-023-02655-y
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