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  1. Article ; Online: Monitoring Thyroglobulin Following Total Thyroidectomy After Lobectomy-Reply.

    Alameer, Ehab / Eagan, Alana / Ganly, Ian

    JAMA otolaryngology-- head & neck surgery

    2024  Volume 150, Issue 4, Page(s) 357–358

    MeSH term(s) Humans ; Thyroglobulin ; Thyroidectomy/adverse effects ; Thyroid Neoplasms/surgery ; Thyrotropin ; Retrospective Studies ; Neoplasm Recurrence, Local
    Chemical Substances Thyroglobulin (9010-34-8) ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2024.0004
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  2. Article ; Online: New Insights on the Importance of the Extent of Vascular Invasion in Encapsulated Angio-invasive Follicular Thyroid Carcinoma.

    Matsuura, Danielli / Ganly, Ian

    Annals of surgical oncology

    2022  

    Language English
    Publishing date 2022-02-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-11405-7
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    Zs.A 4042: Show issues Location:
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  3. Article ; Online: Paragangliomas of the head and neck.

    Valero, Cristina / Ganly, Ian

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2022  Volume 51, Issue 10, Page(s) 897–903

    Abstract: Paragangliomas are rare neuroendocrine tumors that can be found from the skull base to the pelvis. Head and neck paragangliomas have been historically treated with surgery. However, surgical resection adds risk of injury to vascular structures and ... ...

    Abstract Paragangliomas are rare neuroendocrine tumors that can be found from the skull base to the pelvis. Head and neck paragangliomas have been historically treated with surgery. However, surgical resection adds risk of injury to vascular structures and cranial nerves that can lead to morbidity such as hoarseness, dysarthria, dysphagia, or aspiration. Recently, improved understanding of the behavior of these tumors and increasing experience in non-surgical treatments, such as observation and radiation therapy, have changed the paradigms of management of this entity. Multiple series now show a trend toward a more conservative management, with a higher percentage of patients being observed or treated with radiotherapy. Several factors should be taken into consideration when deciding the most appropriate treatment for head and neck paragangliomas, starting by differentiating carotid body tumors from non-carotid body tumors. In general, surgical resection is normally recommended for carotid body tumors as the complications from treatment are usually minimal. In contrast, for non-carotid body tumors, surgery is often associated with significant functional impairment due to cranial nerve paralysis. As such, non-surgical treatment is now usually recommended for this subset of head and neck paragangliomas. In young patients with no comorbidities and a small to medium carotid body tumors, surgery should be considered. Moreover, surgery should be offered for secreting tumors, malignant tumors, tumors with rapid growth or increase in symptomatology, and when radiotherapy cannot be performed. Conversely, conservative management with active surveillance or radiotherapy can be offered in the remaining cases in order to avoid unnecessary morbidity while still providing acceptable tumor control.
    MeSH term(s) Humans ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/therapy ; Paraganglioma/diagnosis ; Paraganglioma/surgery ; Carotid Body Tumor/diagnosis ; Carotid Body Tumor/surgery ; Paraganglioma, Extra-Adrenal/radiotherapy ; Paraganglioma, Extra-Adrenal/surgery ; Neck ; Retrospective Studies
    Language English
    Publishing date 2022-02-23
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.13286
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    Zs.A 825: Show issues Location:
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  4. Article ; Online: Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.

    Ghossein, Ronald / Ganly, Ian / Tuttle, R Michael / Xu, Bin

    Thyroid : official journal of the American Thyroid Association

    2023  Volume 33, Issue 5, Page(s) 586–592

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Thyroid Neoplasms/radiotherapy ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/drug therapy ; Retrospective Studies ; Iodine Radioisotopes/therapeutic use ; Adenocarcinoma, Follicular/pathology ; Thyroidectomy ; Carcinoma/drug therapy ; Goiter/surgery ; Disease Progression
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2023.0032
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    Zs.A 3307: Show issues Location:
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    Zs.MO 106: Show issues

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  5. Article ; Online: Analysis of growth rate and safety of observation for pleomorphic adenomas in pregnancy: A retrospective case series.

    Subramanian, Tejas / Levyn, Helena / Eagan, Alana / Katabi, Nora / Scholfield, Daniel / Shah, Jatin P / Wong, Richard J / Ganly, Ian / Patel, Snehal G

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2024  Volume 49, Issue 3, Page(s) 349–352

    MeSH term(s) Humans ; Pregnancy ; Female ; Adenoma, Pleomorphic ; Retrospective Studies ; Salivary Gland Neoplasms ; Parotid Neoplasms
    Language English
    Publishing date 2024-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.14144
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    Zs.A 1309: Show issues Location:
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  6. Article ; Online: Papillary thyroid carcinoma tall cell subtype (PTC-TC) and high-grade differentiated thyroid carcinoma tall cell phenotype (HGDTC-TC) have different clinical behaviour: a retrospective study of 1456 patients.

    Ghossein, Ronald / Katabi, Nora / Dogan, Snjezana / Shaha, Ashok R / Tuttle, R Michael / Fagin, James A / Ganly, Ian / Xu, Bin

    Histopathology

    2024  Volume 84, Issue 7, Page(s) 1130–1138

    Abstract: Aims: Papillary thyroid carcinoma, tall cell subtype (PTC-TC) is a potentially aggressive histotype. The latest World Health Organisation (WHO) classification introduced a novel class of tumours; namely, high-grade differentiated thyroid carcinoma ( ... ...

    Abstract Aims: Papillary thyroid carcinoma, tall cell subtype (PTC-TC) is a potentially aggressive histotype. The latest World Health Organisation (WHO) classification introduced a novel class of tumours; namely, high-grade differentiated thyroid carcinoma (HGDTC), characterised by elevated mitotic count and/or necrosis, which can exhibit a tall cell phenotype (HGDTC-TC).
    Methods and results: We analysed the clinical outcomes in a large retrospective cohort of 1456 consecutive thyroid carcinomas with a tall cell phenotype, including PTC-TC and HGDTC-TC. HGDTC-TC is uncommon, accounting for 5.3% (77 of 1379) of carcinomas with tall cell morphology. HGDTC-TC was associated with significantly older age, larger tumour size, angioinvasion, gross extrathyroidal extension, higher AJCC pT stage, positive resection margin and nodal metastasis (P < 0.05). Compared with PTC-TC, HGDTC was associated with a significantly decreased DSS, LRDFS and distant metastasis-free survival (DMFS; P < 0.001). The 10-year DSS was 72 and 99%, the 10-year LRDFS was 61 and 92% and the 10-year DMFS was 53 and 97%, respectively, for HGDTC-TC and PTC-TC. On multivariate analysis, the classification (HGDTC-TC versus PTC-TC) was an independent adverse prognostic factor for DSS, LRDF, and DMFS when adjusted for sex, age, angioinvasion, margin status, AJCC pT and pN stage.
    Conclusions: Compared with PTC-TC, HGDTC-TC is associated with adverse clinicopathological features, a higher frequency of TERT promoter mutations (59% in HGDTC-TC versus 34% in PTC-TC) and incurs a significantly worse prognosis. HGDTC-TC is an independent prognostic factor for carcinoma with tall cell morphology. This validates the concept of HGDTC and the importance of tumour necrosis and high mitotic count for accurate diagnosis and prognosis of differentiated thyroid carcinomas.
    MeSH term(s) Humans ; Thyroid Neoplasms/pathology ; Middle Aged ; Female ; Male ; Retrospective Studies ; Adult ; Thyroid Cancer, Papillary/pathology ; Aged ; Phenotype ; Carcinoma, Papillary/pathology ; Prognosis ; Young Adult ; Aged, 80 and over ; Adolescent ; Neoplasm Grading
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.15157
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    Zs.A 1328: Show issues Location:
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  7. Article ; Online: Response to Letter to the Editor from Jagannath and Mayilvaganan: "Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?"

    Scholfield, Daniel W / Lopez, Joseph / Eagan, Alana / Antal, Zoltan / Tuttle, R Michael / Ghossein, Ronald / LaQuaglia, Michael / Shaha, Ashok R / Shah, Jatin P / Wong, Richard J / Patel, Snehal G / Ganly, Ian

    The Journal of clinical endocrinology and metabolism

    2024  

    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae118
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  8. Article ; Online: Head and neck paragangliomas: 30-year experience.

    Valero, Cristina / Ganly, Ian / Shah, Jatin P

    Head & neck

    2020  Volume 42, Issue 9, Page(s) 2486–2495

    Abstract: Background: We aimed to review our experience and the changing trends in the management of head and neck paragangliomas (HNPG) over the last three decades.: Methods: We retrospectively reviewed 103 patients with HNPG treated at our center (1986-2017). ...

    Abstract Background: We aimed to review our experience and the changing trends in the management of head and neck paragangliomas (HNPG) over the last three decades.
    Methods: We retrospectively reviewed 103 patients with HNPG treated at our center (1986-2017). We included patients treated with surgery, radiotherapy, and patients maintained under active surveillance.
    Results: Of the surgically treated patients (n = 79), 20% (12/59) of the carotid body tumors (CBT) had a cranial nerve deficit as sequela compared to 95% (19/20) of the non-CBT. Radiotherapy controlled growth in all tumors treated with this modality (n = 10). Of the initially observed patients, 70% (14/20) remained stable and did not require additional treatment. Stratifying by decades, there was a progressive increase in patients initially attempted to be observed and a decrease in upfront surgery. No deaths attributable to the HNPG were encountered.
    Conclusions: Surgery is an effective treatment for CBT. Nonsurgical treatment should be considered for non-CBT.
    MeSH term(s) Carotid Body Tumor/surgery ; Head and Neck Neoplasms/therapy ; Humans ; Paraganglioma/therapy ; Paraganglioma, Extra-Adrenal/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26277
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  9. Article ; Conference proceedings: Medial Transorbital Approach in Cranioendoscopic Skull Base Tumor Resections for Locally Advanced Tumors: Technical Considerations and Patient Outcomes

    Scholfield, Daniel W. / Rocca, David Della / Ganly, Ian / Tabar, Viviane / Cohen, Marc

    Journal of Neurological Surgery Part B: Skull Base

    2023  Volume 84, Issue S 01

    Event/congress 32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0043-1762211
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    Zs.A 3425: Show issues Location:
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  10. Article ; Conference proceedings: CAD/CAM-Assisted Surgery and Adjuvant Therapy for Pediatric Head and Neck Skull Base Sarcomas: A Pilot Study

    Lopez, Joseph / Subramanian, Tejas / Woods, Robbie / Scholfield, Daniel / Cohen, Marc / Jatin, Shah / Ganly, Ian

    Journal of Neurological Surgery Part B: Skull Base

    2023  Volume 84, Issue S 01

    Event/congress 32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0043-1762100
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