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Article ; Online: Cardiac response to water activities in children with Long QT syndrome type 1

Anna Lundström / Urban Wiklund / Annika Winbo / Håkan Eliasson / Marcus Karlsson / Annika Rydberg

PLoS ONE, Vol 18, Iss

2023 Volume 12

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cardiac response to water activities in children with Long QT syndrome type 1.

Lundström, Anna / Wiklund, Urban / Winbo, Annika / Eliasson, Håkan / Karlsson, Marcus / Rydberg, Annika

PloS one

2023 Volume 18, Issue 12, Page(s) e0295431

Abstract: Background: Swimming is a genotype-specific trigger in long QT syndrome type 1 (LQT1).: Objective: To examine the autonomic response to water activities in children and adolescents with LQT1.: Methods: In this cross-sectional study, LQT1 patients ... ...

Abstract	Background: Swimming is a genotype-specific trigger in long QT syndrome type 1 (LQT1). Objective: To examine the autonomic response to water activities in children and adolescents with LQT1. Methods: In this cross-sectional study, LQT1 patients were age and sex matched to one healthy control subject. Electrocardiograms (ECGs) were recorded during face immersion (FI), swimming, diving, and whole-body submersion (WBS). Heart rate (HR) and heart rate variability (HRV) was measured. The high frequency (HF) component of HRV was interpreted to reflect parasympathetic activity, while the low frequency (LF) component was interpreted as reflecting the combined influence of sympathetic and parasympathetic activity on autonomic nervous modulation of the heart. Results: Fifteen LQT1 patients (aged 7-19 years, all on beta-blocker therapy) and fifteen age and sex matched non-medicated controls were included. No significant ventricular arrhythmias were observed in the LQT1 population during the water activities. Out of these 15 matched pairs, 12 pairs managed to complete FI and WBS for more than 10 seconds and were subsequently included in HR and HRV analyses. In response to FI, the LQT1 group experienced a drop in HR of 48 bpm, compared to 67 bpm in the control group (p = 0.006). In response to WBS, HR decreased by 48 bpm in the LQT1 group and 70 bpm in the control group (p = 0.007). A significantly lower PTOT (p < 0.001) and HF (p = 0.011) component was observed before, during and after FI in LQT1 patients compared with the controls. Before, during and after WBS, a significantly lower total power (p < 0.001), LF (p = 0.002) and HF (p = 0.006) component was observed in the LQT1 patients. Conclusion: A significantly lower HR decrease in response to water activities was observed in LQT1 subjects on beta-blocker therapy, compared to matched non-medicated controls. The data suggests an impaired parasympathetic response in LQT1 children and adolescents. An aberrant autonomic nervous system (ANS) response may cause an autonomic imbalance in this patient group.
MeSH term(s)	Adolescent ; Child ; Humans ; Romano-Ward Syndrome ; Cross-Sectional Studies ; Heart ; Autonomic Nervous System ; Electrocardiography ; Heart Rate/physiology ; Long QT Syndrome
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0295431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Screening och utredning – risk för både över- och underdiagnostik.

Hirvikoski, Tatja / Billstedt, Eva / Lundström, Sebastian / Brar, Annika

Lakartidningen

2022 Volume 119

Abstract: ADHD in adults is commonly associated with severe impairments in many major life activities, and an adequate diagnosis is a first step towards treatment and support. Negative consequences follow both underdiagnosis and overdiagnosis of adult ADHD, which ... ...

Title translation	Screening and diagnostic assessment of ADHD in adults - risks associated with both underdiagnosis and overdiagnosis.
Abstract	ADHD in adults is commonly associated with severe impairments in many major life activities, and an adequate diagnosis is a first step towards treatment and support. Negative consequences follow both underdiagnosis and overdiagnosis of adult ADHD, which can be confused with other psychiatric diagnoses and sometimes overlooked in people with high intellectual capacity, and in women in general. In a clinical practice, most physicians meet adults with ADHD - with or without a diagnosis - and therefore need competence in screening of ADHD in adults. Experienced clinicians conduct the consequent diagnostic assessment, to reduce risk of both underdiagnosis and overdiagnosis. Several national and international clinical guidelines summarize evidence-based practices for adults with ADHD. European Network Adult ADHD, ENAA, revised consensus statement recommends pharmacological treatment and psychoeducation as a first step after ADHD diagnosis in adulthood.
MeSH term(s)	Humans ; Adult ; Female ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Overdiagnosis ; Consensus ; Physicians ; Diagnostic and Statistical Manual of Mental Disorders
Language	Swedish
Publishing date	2022-02-22
Publishing country	Sweden
Document type	English Abstract ; Journal Article
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: ACE-2 och coronavirus – en fråga om balans och dynamik?

Lundström, Annika / Sandén, Per

Lakartidningen

2020 Volume 117

Abstract: The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was ... ...

Title translation	ACE2 and coronavirus - a question of balance and dynamics?
Abstract	The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.
MeSH term(s)	Angiotensin II/physiology ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus ; Coronavirus Infections/virology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/virology ; Renin-Angiotensin System/physiology ; Risk Factors ; SARS-CoV-2
Chemical Substances	Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	Swedish
Publishing date	2020-04-17
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article: Editorial: Platelet Function in COVID-19.

Lundström, Annika / Sandén, Per / Mitroulis, Ioannis / van der Meijden, Paola E J

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 912472

Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.912472
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Article ; Online: Corrigendum to "Aberrant autonomic pattern during the post-exercise recovery phase in Long QT syndrome patients" [Auton. Neurosci. 236 (2021) 102897].

Lundström, Anna / Wiklund, Urban / Law, Lucy / Jensen, Steen / Karlsson, Marcus / Rydberg, Annika

Autonomic neuroscience : basic & clinical

2022 Volume 238, Page(s) 102931

Language	English
Publishing date	2022-01-06
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2021.102931
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Zs.A 1533: Show issues

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Article ; Online: IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden.

Ziegler, Louise / Lundström, Annika / Havervall, Sebastian / Thålin, Charlotte / Gigante, Bruna

Cytokine

2022 Volume 159, Page(s) 156020

Abstract: Background: COVID-19 disease severity and need for intensive care has been associated with profound immune disturbances in which interleukin 6 (IL-6) is central. IL-6 signals through two pathways: classical IL-6 signalling with C-reactive protein (CRP) ... ...

Abstract	Background: COVID-19 disease severity and need for intensive care has been associated with profound immune disturbances in which interleukin 6 (IL-6) is central. IL-6 signals through two pathways: classical IL-6 signalling with C-reactive protein (CRP) as a product is pivotal in the acute immune response against pathogens while IL-6 trans-signalling is involved in prolonged inflammation. We measured biomarkers of the IL-6 classical and trans-signalling pathways in patients with moderate or severe COVID-19 in the first wave of the COVID-19 pandemic. Method: In a longitudinal cohort study including patients admitted to Danderyd hospital, Stockholm, Sweden, with COVID-19 (n = 112), plasma IL-6 mirroring activity in both pathways, CRP as marker of classical signalling and the soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130) as markers of trans-signalling were analysed at baseline. Potential differences in biomarker levels between groups of moderate and severe COVID-19 defined by care level, level of respiratory support and one-month mortality was analysed, as was correlations between biomarkers. In addition, levels 4 months after hospital admission were compared to those at baseline. Results: Levels of IL-6 and CRP were increased in severe COVID-19 whereas IL-6 trans-signalling markers (sIL-6R, sgp130) did not differ between the groups. CRP correlated positively with IL-6 in all patients while correlation with IL-6 could not be demonstrated for sIL-6R and sgp130 in either group. Levels of IL-6, CRP and sIL-6R were significantly decreased after 4 months whereas sgp130 levels increased. Conclusion: Classical signalling is the dominating IL-6 pathway in moderate-severe COVID-19.
MeSH term(s)	Biomarkers ; C-Reactive Protein ; COVID-19 ; Cytokine Receptor gp130/metabolism ; Humans ; Hyperplasia ; Interleukin-6 ; Longitudinal Studies ; Pandemics ; Receptors, Interleukin-6/metabolism ; SARS-CoV-2 ; Sweden/epidemiology
Chemical Substances	Biomarkers ; IL6 protein, human ; Interleukin-6 ; Receptors, Interleukin-6 ; Cytokine Receptor gp130 (133483-10-0) ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-08-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2022.156020
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Zs.A 2840: Show issues

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Article: ACE-2 och coronavirus en fråga om balans och dynamik?/ [ACE2 and coronavirus - a question of balance and dynamics?]

Lundström, Annika / Sandén, Per

Lakartidningen

Abstract	The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32314329
Database	COVID19

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Article ; Online: Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection.

Petersson, Ida / Hansen, Bjorn M / Svenningsson, Anders / Lundstrom, Annika

BMJ case reports

2022 Volume 15, Issue 9

Abstract: A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after ... ...

Abstract	A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated white matter hyperintensities on T2-weighted Fluid Attenuated Inversion Recovery (T2-FLAIR) and many small areas with impaired diffusion in primarily supratentorial and infratentorial white matter on Diffusion-Weighted Imaging (DWI). In the following months, the patient made a remarkable clinical recovery. Despite clinical improvement, an MRI after 7 months showed that white matter hyperintensities had progressed and become confluent. Both MRIs demonstrated findings resembling CSVD, which could relate to a COVID-19-specific process affecting cerebral microvasculature.
MeSH term(s)	Brain Injuries, Traumatic ; COVID-19 ; Diffusion Magnetic Resonance Imaging ; Humans ; Magnetic Resonance Imaging ; Male ; White Matter/diagnostic imaging
Language	English
Publishing date	2022-09-13
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-249156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editor's Choice - Nationwide Outcome Analysis of Primary Carotid Endarterectomy in Symptomatic Patients Depending on Closure Technique and Patch Type.

Jonsson, Magnus / Hammar, Kimberley / Lindberg, Malin / Lundström, Annika / Franko, Mikael A / Laska, Ann-Charlotte / Wester, Per / Mani, Kevin

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2023 Volume 65, Issue 4, Page(s) 467–473

Abstract: Objective: Current European guidelines recommend both eversion carotid endarterectomy (CEA) and conventional CEA with routine patch closure, rather than routine primary closure. Polyester and polytetrafluoroethylene (PTFE) have been used as patch ... ...

Abstract	Objective: Current European guidelines recommend both eversion carotid endarterectomy (CEA) and conventional CEA with routine patch closure, rather than routine primary closure. Polyester and polytetrafluoroethylene (PTFE) have been used as patch material for a long time. More recently, bovine pericardium has been used; however, there are few studies comparing long term results between bovine pericardium and other patch types. The aim of this study was to investigate the short and long term results after CEA depending on surgical technique and patch material. Methods: A registry based study on all primary CEAs (n = 9 205) performed for symptomatic carotid artery stenosis in Sweden from July 2008 to December 2019, cross linked with data from the Swedish stroke registry, Riksstroke, and chart review for evaluation of any events occurring during follow up. The primary endpoint was ipsilateral stroke < 30 days. Secondary endpoints included re-operations due to neck haematoma and < 30 day ipsilateral stroke, > 30 day ipsilateral stroke, all stroke > 30 days, and all cause mortality. Results: 2 495 patients underwent eversion CEA and 6 710 conventional CEA for symptomatic carotid stenosis. The most commonly used patch material was Dacron (n = 3 921), followed by PTFE (n = 588) and bovine pericardium (n = 413). A total of 1 788 patients underwent conventional CEA with primary closure. Two hundred and seventy-three patients (3.0%) had a stroke < 30 days. Primary closure was associated with an increased risk of ipsilateral stroke and stroke or death <30 days: odds ratio 1.7 (95% confidence interval [CI] 1.2 - 2.4, p = .002); and 1.5 (95% CI 1.2 - 2.0), respectively. During follow up (median 4.2 years), 592 patients had any form of stroke and 1 492 died. There was no significant difference in long term risk of ipsilateral stroke, all stroke, or death depending on surgical technique or patch material. Conclusion: There was an increased risk of ipsilateral stroke < 30 days in patients operated on with primary closure compared with eversion CEA and patch angioplasty. There was no difference between primary closure, different patch types, or eversion after the peri-operative phase.
Language	English
Publishing date	2023-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2022.12.033
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