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  1. Article ; Online: Can a writing intervention using mainstream Assistive Technology software compensate for dysgraphia and support reading comprehension for people with aphasia?

    Moss, Becky / Marshall, Jane / Woolf, Celia / Hilari, Katerina

    International journal of language & communication disorders

    2023  

    Abstract: Background: Stroke profoundly affects quality of life (QOL), including loss of employment, reduced social activity, shrinking social networks and low mood. Dysgraphia (impaired writing) is a common symptom of aphasia yet is rarely targeted in ... ...

    Abstract Background: Stroke profoundly affects quality of life (QOL), including loss of employment, reduced social activity, shrinking social networks and low mood. Dysgraphia (impaired writing) is a common symptom of aphasia yet is rarely targeted in rehabilitation. Recent technological advances might challenge this, since much communication is now conducted digitally through writing. The rehabilitation of writing may therefore help to address the wider consequences of stroke and aphasia.
    Aims: Can assistive technology (AT) training for people with dysgraphia: (1) improve written output, and are gains achieved only with AT? (2) improve reading comprehension scores, and are gains achieved only with AT? and (3) affect social participation, mood or QOL METHODS AND PROCEDURES: DESIGN: A mixed-methods, repeated measures, small group study design was adopted (qualitative outcomes will be reported elsewhere).
    Participants: Recruited from community settings, for example, Stroke Association communication support groups.
    Inclusion criteria: over 18 years old, aphasia due to stroke, acquired dysgraphia, writing more impaired than speech, fluent English prior to stroke, access to computer and Internet.
    Exclusion criteria: currently receiving speech and language therapy, significant cognitive impairment, neuromuscular/motor-speech impairments/structural abnormalities, developmental dyslexia, uncorrected visual/auditory impairments.
    Procedures: Screening and diagnostic assessments at time T1 (first baseline). Outcome measures at T1; repeated at T2 (second baseline), T3 (end of intervention), T4 (3-month follow up). Social participation assessment and cognitive monitoring at T2, T3, T4.
    Intervention: Seven-ten hours individual therapy weekly and additional email support. Participants were trained to operate Dragon NaturallySpeaking (speech to text package) and ClaroRead (read writing aloud). Outcome measures were administered on pen and paper (control) and on computer, with AT enabled only at T3, T4.
    Outcomes and results: Computer narrative writing was significantly improved by AT training (Friedman's χ
    Conclusion and implications: The customisable AT training was acceptable to participants and resulted in significantly improved narrative writing. Compensatory AT interventions are a useful adjunct to remediatory writing interventions and may particularly support functional writing.
    What this paper adds: What is already known on this subject Writing is rarely spared in aphasia and may present as the most impaired communication modality. Yet, people with aphasia report that writing is seldom included in their rehabilitation. Many communication activities are now conducted digitally through writing, therefore rehabilitation of this is more important than ever before. This study sought to address whether an assistive technology (AT) software package can improve writing and whether any changes were compensatory or remediatory. What this study adds to existing knowledge This group study found that AT training led to gains in written discourse and social network in people with aphasia and dysgraphia. Gains were not replicated in handwritten tasks, suggesting this was a compensatory therapeutic approach. What are the clinical implications of this work? AT programs such as this may present speech and language therapists with a practical, pragmatic adjunct to writing or typing therapy, particularly for clients with chronic, intractable impairments for whom remediatory therapy may have a low chance of success.
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415919-3
    ISSN 1460-6984 ; 1368-2822
    ISSN (online) 1460-6984
    ISSN 1368-2822
    DOI 10.1111/1460-6984.12975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multi-biobank summary data Mendelian randomisation does not support a causal effect of IL-6 signalling on risk of pulmonary arterial hypertension.

    Woolf, Benjamin / Perry, James A / Hong, Charles C / Wilkins, Martin R / Toshner, Mark / Gill, Dipender / Burgess, Stephen / Rhodes, Christopher J

    The European respiratory journal

    2024  Volume 63, Issue 4

    MeSH term(s) Humans ; Interleukin-6/genetics ; Pulmonary Arterial Hypertension ; Biological Specimen Banks ; Risk Factors ; Familial Primary Pulmonary Hypertension ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02031-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Selective modification of ascending spinal outputs in acute and neuropathic pain states.

    Yarmolinsky, David A / Zeng, Xiangsunze / MacKinnon-Booth, Natalie / Greene, Caitlin / Kim, Chloe / Woolf, Clifford J

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Pain hypersensitivity arises from the plasticity of peripheral and spinal somatosensory neurons, which modifies nociceptive input to the brain and alters pain perception. We utilized chronic calcium imaging of spinal dorsal horn neurons to determine how ... ...

    Abstract Pain hypersensitivity arises from the plasticity of peripheral and spinal somatosensory neurons, which modifies nociceptive input to the brain and alters pain perception. We utilized chronic calcium imaging of spinal dorsal horn neurons to determine how the representation of somatosensory stimuli in the anterolateral tract, the principal pathway transmitting nociceptive signals to the brain, changes between distinct pain states. In healthy conditions, we identify stable, narrowly tuned outputs selective for cooling or warming, and a neuronal ensemble activated by intense/noxious thermal and mechanical stimuli. Induction of an acute peripheral sensitization with capsaicin selectively and transiently retunes nociceptive output neurons to encode low-intensity stimuli. In contrast, peripheral nerve injury-induced neuropathic pain results in a persistent suppression of innocuous spinal outputs coupled with activation of a normally silent population of high-threshold neurons. These results demonstrate the differential modulation of specific spinal outputs to the brain during nociceptive and neuropathic pain states.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.08.588581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Methods to increase response to postal and electronic questionnaires.

    Edwards, Philip James / Roberts, Ian / Clarke, Mike J / DiGuiseppi, Carolyn / Woolf, Benjamin / Perkins, Chloe

    The Cochrane database of systematic reviews

    2023  Volume 11, Page(s) MR000008

    Abstract: Background: Self-administered questionnaires are widely used to collect data in epidemiological research, but non-response reduces the effective sample size and can introduce bias. Finding ways to increase response to postal and electronic ... ...

    Abstract Background: Self-administered questionnaires are widely used to collect data in epidemiological research, but non-response reduces the effective sample size and can introduce bias. Finding ways to increase response to postal and electronic questionnaires would improve the quality of epidemiological research.
    Objectives: To identify effective strategies to increase response to postal and electronic questionnaires.
    Search methods: We searched 14 electronic databases up to December 2021 and manually searched the reference lists of relevant trials and reviews. We contacted the authors of all trials or reviews to ask about unpublished trials; where necessary, we also contacted authors to confirm the methods of allocation used and to clarify results presented.
    Selection criteria: Randomised trials of methods to increase response to postal or electronic questionnaires. We assessed the eligibility of each trial using pre-defined criteria.
    Data collection and analysis: We extracted data on the trial participants, the intervention, the number randomised to intervention and comparison groups and allocation concealment. For each strategy, we estimated pooled odds ratios (OR) and 95% confidence intervals (CI) in a random-effects model. We assessed evidence for selection bias using Egger's weighted regression method and Begg's rank correlation test and funnel plot. We assessed heterogeneity amongst trial odds ratios using a Chi
    Main results: Postal We found 670 eligible trials that evaluated over 100 different strategies of increasing response to postal questionnaires. We found substantial heterogeneity amongst trial results in half of the strategies. The odds of response almost doubled when: using monetary incentives (odds ratio (OR) 1.86; 95% confidence interval (CI) 1.73 to 1.99; heterogeneity I
    Authors' conclusions: Researchers using postal and electronic questionnaires can increase response using the strategies shown to be effective in this Cochrane review.
    MeSH term(s) Male ; Humans ; Surveys and Questionnaires ; Reminder Systems ; Sample Size ; Smartphone ; Electronics
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.MR000008.pub5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Implementation of a Drug Screening Platform to Target

    Cronin, Shane J F / Davidow, Lance S / Arvanites, Anthony C / Rubin, Lee L / Penninger, Josef M / Woolf, Clifford J

    Bio-protocol

    2023  Volume 13, Issue 9, Page(s) e4666

    Abstract: Management of neuropathic pain is notoriously difficult; current analgesics, including anti-inflammatory- and opioid-based medications, are generally ineffective and can pose serious side effects. There is a need to uncover non-addictive and safe ... ...

    Abstract Management of neuropathic pain is notoriously difficult; current analgesics, including anti-inflammatory- and opioid-based medications, are generally ineffective and can pose serious side effects. There is a need to uncover non-addictive and safe analgesics to combat neuropathic pain. Here, we describe the setup of a phenotypic screen whereby the expression of an algesic gene,
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ethnic differences in success at application for consultant posts among United Kingdom physicians from 2011 to 2019: a retrospective cross-sectional observational study.

    Harvey, P R / Phillips, C / Newbery, N / Nagamoottoo, D / Woolf, K / Trudgill, N J

    Journal of the Royal Society of Medicine

    2022  Volume 115, Issue 8, Page(s) 300–312

    Abstract: Objectives: To identify associations between success following application for consultant physician posts and demographic factors.: Design: Logistic regression analysis of nationwide survey data.: Setting: United Kingdom (UK) physicians with a ... ...

    Abstract Objectives: To identify associations between success following application for consultant physician posts and demographic factors.
    Design: Logistic regression analysis of nationwide survey data.
    Setting: United Kingdom (UK) physicians with a recent certificate of completion of training (CCT).
    Participants: All UK trainee physicians who received a CCT between 2010 and 2019 were surveyed. Respondents were excluded if they had not applied for a consultant post or if application data were incomplete.
    Main outcome measures: The primary outcome measure was success over the entire consultant application process, i.e. shortlisted and offered the post following the first application. Secondary outcomes were: shortlisted following first application and offered a consultant post at first interview.
    Results: From 7037 CCT holders surveyed, 50.7% responded. While 1198 (59.7%) respondents were white, 760 (37.9%) were from minority ethnic groups and 50 (3.5%) were of unknown ethnicity. Primary medical qualification (PMQ) country was the UK in 75.3% (n = 1512). On multivariable logistic regression analysis the independent negative associations with success were: minority ethnicity (odds ratio [OR] 0.55, 95% confidence interval [CI] 0.43-0.71);
    Conclusions: Minority ethnic group candidates for consultant physician posts had lower success rates compared to white candidates after correction for important variables including specialty, time from and country of PMQ. This finding requires further evaluation to identify the causes for this variation.
    MeSH term(s) Consultants ; Cross-Sectional Studies ; Humans ; Medicine ; Physicians ; Retrospective Studies ; United Kingdom
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/01410768221085691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Lives Lost to Inequities: Avertable Deaths From Neurologic Diseases in the Past Decade.

    Woolf, Steven H / Chapman, Derek A / Lee, Jong Hyung / Johnston, Karen C / Benson, Richard T / Trevathan, Edwin / Smith, Wally R / Gaskin, Darrell J

    Neurology

    2023  Volume 101, Issue 7 Suppl 1, Page(s) S9–S16

    Abstract: Background and objectives: Mortality rates for neurologic diseases are increasing in the United States, with large disparities across geographical areas and populations. Racial and ethnic populations, notably the non-Hispanic (NH) Black population, ... ...

    Abstract Background and objectives: Mortality rates for neurologic diseases are increasing in the United States, with large disparities across geographical areas and populations. Racial and ethnic populations, notably the non-Hispanic (NH) Black population, experience higher mortality rates for many causes of death, but the magnitude of the disparities for neurologic diseases is unclear. The objectives of this study were to calculate mortality rates for neurologic diseases by race and ethnicity and-to place this disparity in perspective-to estimate how many US deaths would have been averted in the past decade if the NH Black population experienced the same mortality rates as other groups.
    Methods: Mortality rates for deaths attributed to neurologic diseases, as defined by the International Classification of Diseases, were calculated for 2010 to 2019 using death and population data obtained from the Centers for Disease Control and Prevention and the US Census Bureau. Avertable deaths were calculated by indirect standardization: For each calendar year of the decade, age-specific death rates of NH White persons in 10 age groups were multiplied by the NH Black population in each age group. A secondary analysis used Hispanic and NH Asian populations as the reference groups.
    Results: In 2013, overall age-adjusted mortality rates for neurologic diseases began increasing, with the NH Black population experiencing higher rates than NH White, NH American Indian and Alaska Native, Hispanic, and NH Asian populations (in decreasing order). Other populations with higher mortality rates for neurologic diseases included older adults, the male population, and adults older than 25 years without a high school diploma. The gap in mortality rates for neurologic diseases between the NH Black and NH White populations widened from 4.2 individuals per 100,000 in 2011 to 7.0 per 100,000 in 2019. Over 2010 to 2019, had the NH Black population experienced the neurologic mortality rates of NH White, Hispanic, or NH Asian populations, 29,986, 88,407, or 117,519 deaths, respectively, would have been averted.
    Discussion: Death rates for neurologic diseases are increasing. Disproportionately higher neurologic mortality rates in the NH Black population are responsible for a large number of excess deaths, making research and policy efforts to address the systemic causes increasingly urgent.
    MeSH term(s) Aged ; Humans ; Male ; Asian ; Black People ; Ethnicity ; Hispanic or Latino ; Nervous System Diseases/epidemiology ; Nervous System Diseases/ethnology ; Nervous System Diseases/mortality ; United States/epidemiology ; Health Status Disparities ; Healthcare Disparities/ethnology ; Healthcare Disparities/statistics & numerical data ; White People ; American Indian or Alaska Native ; Female
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterization of a Musculoskeletal Syndrome of Enthesitis and Arthritis in Patients With Atopic Dermatitis Treated With Dupilumab, an Interleukin-4/13 Inhibitor.

    Hughes, Catherine D / Nathan, Joseph / Mathew, Libin / Pink, Andrew E / Woolf, Richard T / Smith, Catherine / Menon, Bina / Kirkham, Bruce

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 10, Page(s) 1793–1797

    Abstract: Objective: To characterize the presentation and outcomes of patients with atopic dermatitis (AD) who developed musculoskeletal symptoms after treatment with dupilumab, a human IgG4 monoclonal antibody that blocks the functions of interleukin-4 (IL-4) ... ...

    Abstract Objective: To characterize the presentation and outcomes of patients with atopic dermatitis (AD) who developed musculoskeletal symptoms after treatment with dupilumab, a human IgG4 monoclonal antibody that blocks the functions of interleukin-4 (IL-4) and IL-13, key pathologic pathways in AD.
    Methods: This article reports an observational cohort of patients receiving dupilumab who developed new-onset musculoskeletal symptoms after dupilumab therapy at our center. All patients had a comprehensive rheumatologic history and examination, with imaging by ultrasonography (US) or magnetic resonance imaging (MRI) in most patients.
    Results: Between October 2018 and February 2021, we recorded 470 patients with AD commencing dupilumab treatment from routine clinical care records. Of 36 patients referred for rheumatologic assessment, we identified 26 patients (14 male, 12 female) with a musculoskeletal syndrome of inflammatory enthesitis, arthritis, and/or tenosynovitis. Clinical findings were confirmed by US and MRI. All patients had very good response to dupilumab treatment, and no specific predictors of musculoskeletal syndrome were noted. Symptoms were mild in 16 patients, moderate in 6 patients, and severe in 4 patients. Receipt of nonsteroidal antiinflammatory drugs or cyclooxygenase 2 inhibitors, reduction of dupilumab dose/frequency, and cessation of dupilumab therapy led to improvement, but moderate or severe symptoms persisted for many months.
    Conclusion: We report a new musculoskeletal syndrome of inflammatory enthesitis/arthritis/tenosynovitis in some patients receiving the IL-4 receptor antagonist dupilumab. This response to a cytokine-targeting therapy provides key insights into the pathogenesis of enthesitis.
    MeSH term(s) Humans ; Male ; Female ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/diagnosis ; Interleukin-4/therapeutic use ; Interleukin Inhibitors ; Tenosynovitis ; Arthritis, Rheumatoid ; Treatment Outcome ; Severity of Illness Index
    Chemical Substances dupilumab (420K487FSG) ; Interleukin-4 (207137-56-2) ; Interleukin Inhibitors
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42558
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  9. Article: Macrophages protect against sensory axon degeneration in diabetic neuropathy.

    Hakim, Sara / Jain, Aakanksha / Petrova, Veselina / Indajang, Jonathan / Kawaguchi, Riki / Wang, Qing / Duran, Elif Sude / Nelson, Drew / Adamson, Stuart S / Greene, Caitlin / Woolf, Clifford J

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss and debilitating neuropathic ... ...

    Abstract Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss and debilitating neuropathic pain
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.30.577801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A study demonstrating users' preference for the adapted-REQUITE patient-reported outcome questionnaire over PRO-CTCAE

    Jordan, Thomas / Nuamek, Thitikorn / Fornacon-Wood, Isabella / Califano, Raffaele / Coote, Joanna / Harris, Margaret / Mistry, Hitesh / Taylor, Paul / Woolf, David / Faivre-Finn, Corinne

    Frontiers in oncology

    2024  Volume 14, Page(s) 1328871

    Abstract: Introduction: The use of patient-reported outcomes (PROs) has been shown to enhance the accuracy of symptom collection and improve overall survival and quality of life. This is the first study comparing concordance and patient preference for two PRO ... ...

    Abstract Introduction: The use of patient-reported outcomes (PROs) has been shown to enhance the accuracy of symptom collection and improve overall survival and quality of life. This is the first study comparing concordance and patient preference for two PRO tools: Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE
    Materials and methods: Patients with lung cancer were recruited to the study while attending outpatient clinics at a tertiary cancer centre. Clinician-reported outcomes were generated through initial patient assessment with CTCAE v4.03. Participants then completed the PRO-CTCAE
    Results: Out of 74 patients approached, 65 provided written informed consent to participate in the study. 63 (96.9%) patients completed both PRO-CTCAE
    Conclusion: The adapted-REQUITE questionnaire has shown a superior correlation to clinician-reported outcomes and higher patient preference than the PRO-CTCAE
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1328871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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