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Article: Inhibitory effect of chemical and natural anti-browning agents on polyphenol oxidase from ginger (Z

Lim, Win Yee / Wong, Chen Wai

2018 Volume 55, Issue 8, Page(s) 3001–3007

Abstract: Food browning is undesirable as it causes deterioration in food quality and appearance. This phenomenon was related to polyphenol oxidase (PPO), which catalyzes conversion of phenolic compounds ... ...

Abstract	Food browning is undesirable as it causes deterioration in food quality and appearance. This phenomenon was related to polyphenol oxidase (PPO), which catalyzes conversion of phenolic compounds into
Language	English
Publishing date	2018-05-19
Publishing country	India
Document type	Journal Article
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-018-3218-7
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Article ; Online: Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload.

Ye, Lei / Su, Liping / Wang, Chenxu / Loo, Szejie / Tee, Guizhen / Tan, Shihua / Khin, Sandar Win / Ko, Shijie / Su, Boyang / Cook, Stuart A

PloS one

2018 Volume 13, Issue 7, Page(s) e0201498

Abstract: ... dysfunction when subjected to pressure-loading. However, the effects of TTNtv of the Z-disc are largely ... with TTNtv of the Z-disc were randomly assigned to TAC (Z-TAC) or sham-surgery (Z-Sham) and wildtype (WT ... PV loops. Diastolic function was impaired in Z-disc TTNtv rats at baseline as compared to WT and ...

Abstract	Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic dysfunction when subjected to pressure-loading. However, the effects of TTNtv of the Z-disc are largely unexplored. A rat model of pressure-loaded heart is developed by trans-aortic constriction (TAC). Rats with TTNtv of the Z-disc were randomly assigned to TAC (Z-TAC) or sham-surgery (Z-Sham) and wildtype (WT) littermates served as controls (WT-TAC or WT-Sham). Left ventricular (LV) function was assessed by echocardiography. Pressure volume (PV) loops, histology and molecular profiling were performed eight months after surgery. Pressure-load by TAC increased LV mass in all cases when compared with Sham animals. Notably, systolic function was preserved in TAC animals throughout the study period, which was confirmed by terminal PV loops. Diastolic function was impaired in Z-disc TTNtv rats at baseline as compared to WT and became impaired further after TAC (dp/dtmin, mmHg/s): Z-TAC = -3435±763, WT-TAC = -6497±1299 (p<0.01). Z-TAC animals had greater cardiac fibrosis, with elevated collagen content and decreased vascular density as compared to WT-TAC animals associated with enhanced apoptosis of myocyte and non-myocyte populations. In the context of pressure overload, Z-disc TTNtv is associated with cardiac fibrosis, diastolic dysfunction, and capillary rarefaction in the absence of overt systolic dysfunction.
MeSH term(s)	Animals ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/genetics ; Aortic Valve Stenosis/physiopathology ; Connectin/chemistry ; Connectin/genetics ; Fibrosis/genetics ; Fibrosis/physiopathology ; Genetic Predisposition to Disease ; Heart Failure/complications ; Heart Failure/genetics ; Hypertension/complications ; Hypertension/genetics ; Male ; Phenotype ; Polymorphism, Genetic ; Protein Interaction Domains and Motifs/genetics ; Protein Isoforms/genetics ; Rats ; Rats, Inbred F344 ; Rats, Transgenic ; Ventricular Dysfunction, Left/genetics ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left/genetics ; Ventricular Function, Left/physiology
Chemical Substances	Connectin ; Protein Isoforms ; Ttn protein, rat
Language	English
Publishing date	2018-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0201498
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Article: Relationship Between Glycolytic Potential and Meat Quality of Duroc Pigs with Consideration of Carcass Chilling System / ZwiÄzek potencjaÅu glikolitycznego z cechami jakoÅci miÄsa tucznikÃ³w rasy Duroc, z uwzglÄdnieniem systemu chÅodzenia tusz

Zybert, Andrzej / Halina Sieczkowska / Katarzyna Antosik / ElÅ¼bieta KrzÄcio-Nieczyporuk / Grzegorz Adamczyk / Maria KoÄwin-PodsiadÅa

Annals of animal science. 2013 Aug. 01, v. 13, no. 3

2013

Abstract: The objective of this study was to determine phenotypic relations between glycolytic potential (GP) measured 45 min postmortem and meat quality traits of stress-resistant fatteners, with consideration of carcass chilling system. The investigations ... ...

Abstract	The objective of this study was to determine phenotypic relations between glycolytic potential (GP) measured 45 min postmortem and meat quality traits of stress-resistant fatteners, with consideration of carcass chilling system. The investigations involved 35 Duroc fattening pigs whose left halfcarcasses were chilled conventionally (4ÂºC for 24 h) and right half-carcasses were rapidly chilled in a three-phase chilling tunnel (-10ÂºC for 15 min, -15ÂºC for 25 min and -5ÂºC for 40 min with air velocity of 3 m/s). In this study we showed that rapid chilling significantly slows the rate of pH fall from 2 to 96 h after slaughter. The negative relationship between glycolytic potential and pH (especially 24 h postmortem) was stronger for conventionally chilled carcasses but the regression coefficient (b) does not suggest increased rate of pH fall in meat of conventionally chilled carcasses (especially compared to rapid chilling) at the later stages of conversion of muscle to meat (from 24 to 144 h after slaughter). In this investigation GP was positively correlated to drip loss at 48 h postmortem, and a stronger correlation was noted for rapidly chilled carcasses. Moreover, the regression coefficient indicates that rapid chilling to 48 h postmortem can cause a slightly higher drip loss from meat than when the carcasses are chilled conventionally (0.55 vs. 0.46 percentage points per 10 Î¼mol/g GP). At the later stages of conversion of muscle to meat (96 and 144 h postmortem) the correlation and regression coefficients were the same regardless of the chilling system.
Keywords	Duroc ; air ; cold treatment ; correlation ; drip loss ; finishing ; glycolysis ; meat ; meat quality ; muscles ; pH ; phenotype ; regression analysis ; slaughter ; swine
Language	English
Dates of publication	2013-0801
Size	p. 645-654.
Publishing place	Versita
Document type	Article
ZDB-ID	1500291-3
ISSN	0137-1657 ; 1642-3402
ISSN	0137-1657 ; 1642-3402
DOI	10.2478/aoas-2013-0028
Database	NAL-Catalogue (AGRICOLA)

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Article: Feasibility study of Glucagon-like peptide-1 analogues for the optimization of Outcomes in obese patients undergoing AbLation for Atrial Fibrillation (GOAL-AF) protocol.

Win, Kyaw Z / Armstrong, Matthew / Steeds, Richard P / Kalla, Manish

Pilot and feasibility studies

2024 Volume 10, Issue 1, Page(s) 36

Abstract: Background: Catheter ablation for atrial fibrillation is recommended for symptomatic patients after failed medical therapy. Ablation has a higher failure rate in obese patients, and both the prevalence of atrial fibrillation and obesity are increasingly ...

Abstract	Background: Catheter ablation for atrial fibrillation is recommended for symptomatic patients after failed medical therapy. Ablation has a higher failure rate in obese patients, and both the prevalence of atrial fibrillation and obesity are increasingly globally. The outcome of ablation can be improved if obese patients can achieve goal-oriented weight reduction prior to ablation. Conventional weight loss strategies, however, can be difficult to access and can delay ablation, thereby risking a lower chance of maintaining sinus rhythm. Effective weight-loss medications, such as the glucagon-like peptide inhibitor-1 drugs, offer the potential for incremental impact on weight loss over a shorter period of time as a bridging therapy. The aim of this study is to assess the feasibility of using liraglutide, a glucagon-like peptide inhibitor-1, in producing weight loss in obese patients before catheter ablation. Methods: The study is an open-label, uncontrolled, prospective single-centre feasibility study of daily liraglutide injections in the treatment of obese patients for at least 13 weeks before and 52 weeks after AF ablation. Adult patients with symptomatic AF whose body mass index ≥ 30 will be recruited from those planning to undergo ablation. Feasibility will be determined based on the recruitment rate, adherence to the medication, and the amount of weight loss achieved over the study period. Exploratory outcomes include changes in atrial structure, function, and fibrosis with weight loss evaluated by cardiac magnetic resonance imaging, electroanatomic mapping, and patient-reported outcome measure. Discussion: This study will allow us to determine whether the use of liraglutide in obese patients with atrial fibrillation undergoing ablation is feasible with adequate recruitment. The additional information on adherence and average weight loss over the study period will inform the design of a future definitive randomized controlled trial. Trial registration: ClinicalTrials.gov ( NCT05221229 ). Registered on 2 February 2022. Trial funding: Metchley Park Medical Society and University of Birmingham Starter Fellowship, British Heart Foundation Accelerator Grant, Abbott Investigator-Initiated Study Grant.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2809935-7
ISSN	2055-5784
ISSN	2055-5784
DOI	10.1186/s40814-024-01454-y
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Article ; Online: A Sticky Situation: An Uncommon Cardiac Complication of Cyanoacrylate Glue Injection.

Sindhi, Rithik Mohan Singh / Win, Kyaw Z / Zafar, Athesham / Steeds, Richard P

JACC. Case reports

2023 Volume 17, Page(s) 101886

Abstract: This case report describes an uncommon cardiac complication related to the endoscopic injection of cyanoacrylate glue to treat gastric variceal bleeding. The presentation and management options are reviewed and compared with our step-by-step approach in ... ...

Abstract	This case report describes an uncommon cardiac complication related to the endoscopic injection of cyanoacrylate glue to treat gastric variceal bleeding. The presentation and management options are reviewed and compared with our step-by-step approach in a patient requiring a liver transplant. (
Language	English
Publishing date	2023-07-05
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2023.101886
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Article ; Online: Challenges for Zika prevention in Myanmar.

Win, A Z

QJM : monthly journal of the Association of Physicians

2017 Volume 110, Issue 8, Page(s) 481–482

MeSH term(s)	Humans ; Myanmar/epidemiology ; Public Health ; Travel ; Zika Virus/genetics ; Zika Virus Infection/epidemiology ; Zika Virus Infection/prevention & control ; Zika Virus Infection/transmission ; Zika Virus Infection/virology
Language	English
Publishing date	2017-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcx130
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Article ; Online: Mobile apps used for people living with multiple sclerosis: A scoping review.

Howard, Zahli / Win, Khin Than / Guan, Vivienne

Multiple sclerosis and related disorders

2023 Volume 73, Page(s) 104628

Abstract: Background: Multiple Sclerosis (MS) is a chronic neurodegenerative disorder. People living with MS (plwMS) require long-term, multidisciplinary care in both clinical and community settings. MS-specific mHealth interventions have advanced in the form of ... ...

Abstract	Background: Multiple Sclerosis (MS) is a chronic neurodegenerative disorder. People living with MS (plwMS) require long-term, multidisciplinary care in both clinical and community settings. MS-specific mHealth interventions have advanced in the form of clinical treatments, rehabilitation, disease monitoring and self-management of disease. However, mHealth interventions for plwMS appear to have limited proof of clinical efficacy. As native mobile apps target specific mobile operating systems, they tend to have better interactive designs leveraging platform-specific guidelines. Thus, to improve such efficacy, it is pivotal to explore the design characteristics of native mobile apps used for plwMS. Objectives: This study aimed to explore the design characteristics of native mobile apps used for adults living with MS in academic settings. Methods: A scoping review of studies was conducted. A literature search was performed through PubMed, CINAHL, MEDLINE and Cochrane Library. Per native mobile apps, characteristics, persuasive technology elements and evaluations were summarized. Results: A total of 14 native mobile apps were identified and 43% of the identified apps were used for data collection (n=6). Approximately 70% of the included apps involved users (plwMS) whilst developing (n=10). A total of three apps utilized embedded sensors. Videos or photos were used for physical activity interventions (n=2) and gamification principles were applied for cognitive and/or motor rehabilitation interventions (n=3). Behavior change theories were integrated into the design of the apps for fatigue management and physical activity. Regarding persuasive technology, the design principles of primary support were applied across all identified apps. The elements of dialogue support and social support were the least applied. The methods for evaluating the identified apps were varied. Conclusion: The findings suggest that the identified apps were in the early stages of development and had a user-centered design. By applying the persuasive systems design model, interaction design qualities and features of the identified mobile apps in academic settings were systematically evaluated at a deeper level. Identifying the digital functionality and interface design of mobile apps for plwMS will help researchers to better understand interactive design and how to incorporate these concepts in mHealth interventions for improvement of clinical efficacy.
MeSH term(s)	Adult ; Humans ; Mobile Applications ; Multiple Sclerosis/therapy ; Chronic Disease ; Exercise ; Self-Management
Language	English
Publishing date	2023-03-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2023.104628
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Article ; Online: Comparison of UK's Minor Ailments Scheme and US's retail clinic model: a narrative review.

Win, Aung Z

Primary health care research & development

2016 Volume 17, Issue 6, Page(s) 622–627

Abstract: There is a raising demand for unscheduled care in the United Kingdom. Minor Ailments Schemes (MAS) were introduced to reduce the burden of minor ailments on higher cost settings such as general practices and emergency departments. The number of visits ... ...

Abstract	There is a raising demand for unscheduled care in the United Kingdom. Minor Ailments Schemes (MAS) were introduced to reduce the burden of minor ailments on higher cost settings such as general practices and emergency departments. The number of visits for minor ailments at GPs often declined following the implementation of MAS. Retail clinics in America employ nurse practitioners (NPs) and physician assistants (PAs) who can diagnose and treat minor illness, and minor injuries. Similar to the retail clinics, MAS can merge with walk-in centres. PAs and NPs can take over some primary care workload from pharmacists to prevent the pharmacists from being overwhelmed with all their current duties. MAS can also initiate the development of telehealth service to accommodate the home-bound patients. MAS must continue to change and evolve to meet the current and future demands of health care.
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2027892-5
ISSN	1477-1128 ; 1463-4236
ISSN (online)	1477-1128
ISSN	1463-4236
DOI	10.1017/S1463423616000086
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Article: Mitochondrial genomic integrity and the nuclear epigenome in health and disease.

Morin, Amanda L / Win, Phyo W / Lin, Angela Z / Castellani, Christina A

Frontiers in endocrinology

2022 Volume 13, Page(s) 1059085

Abstract: Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear genome and ... ...

Abstract	Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear genome and contribute to health and disease. Evidence shows that mtDNA-CN and heteroplasmic variation are associated with aging, complex disease, and all-cause mortality. Further, the nuclear epigenome may mediate the effects of mtDNA variation on disease. In this way, mitochondria act as an environmental biosensor translating vital information about the state of the cell to the nuclear genome. Cellular communication between mtDNA variation and the nuclear epigenome can be achieved by modification of metabolites and intermediates of the citric acid cycle and oxidative phosphorylation. These essential molecules (e.g. ATP, acetyl-CoA, ɑ-ketoglutarate and S-adenosylmethionine) act as substrates and cofactors for enzymes involved in epigenetic modifications. The role of mitochondria as an environmental biosensor is emerging as a critical modifier of disease states. Uncovering the mechanisms of these dynamics in disease processes is expected to lead to earlier and improved treatment for a variety of diseases. However, the influence of mtDNA-CN and heteroplasmy variation on mitochondrially-derived epigenome-modifying metabolites and intermediates is poorly understood. This perspective will focus on the relationship between mtDNA-CN, heteroplasmy, and epigenome modifying cofactors and substrates, and the influence of their dynamics on the nuclear epigenome in health and disease.
MeSH term(s)	Genome, Mitochondrial/genetics ; Epigenome ; DNA, Mitochondrial/genetics ; Mitochondria/genetics ; Genomics
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1059085
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Article: Pediatric resident training in Myanmar.

Win, Zaw

The Southeast Asian journal of tropical medicine and public health

2014 Volume 45 Suppl 1, Page(s) 16

MeSH term(s)	Curriculum ; Educational Measurement ; Humans ; Internship and Residency/organization & administration ; Myanmar ; Pediatrics/education
Language	English
Publishing date	2014
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	800646-5
ISSN	0125-1562 ; 0038-3619
ISSN	0125-1562 ; 0038-3619
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