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Article: Initial spinal epidural hematoma symptoms mimic artery dissection.

Yabuki, Shunya / Hirai, Hiroyuki / Miyajima, Masayuki / Moro, Takatomo

2024 Volume 12, Issue 3, Page(s) e8652

Abstract: An elderly patient with upper back pain and hypertension was diagnosed as having spontaneous spinal epidural hematoma (SSEH) after excluding artery dissection. The initial symptoms of SSEH mimic those of artery dissection, and the symptoms of spinal ... ...

Abstract	An elderly patient with upper back pain and hypertension was diagnosed as having spontaneous spinal epidural hematoma (SSEH) after excluding artery dissection. The initial symptoms of SSEH mimic those of artery dissection, and the symptoms of spinal damage frequently appear later. Physicians should, therefore, be mindful of SSEH.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8652
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Article: Financial Burden as a Potential Barrier to Vaccine Completion in Post-hematopoietic Stem Cell Transplant Patients in Japan.

Ogawa, Taku / Hirai, Nobuyasu / Fujikura, Hiroyuki / Imakita, Natsuko / Kasahara, Kei

Cureus

2024 Volume 16, Issue 3, Page(s) e56842

Abstract: Introduction The administration of routine vaccinations to patients following hematopoietic stem cell transplantation (HSCT) is highly recommended. However, studies examining reasons for not completing vaccination in post-HSCT patients are lacking. ... ...

Abstract	Introduction The administration of routine vaccinations to patients following hematopoietic stem cell transplantation (HSCT) is highly recommended. However, studies examining reasons for not completing vaccination in post-HSCT patients are lacking. Method We reviewed the medical records of patients who sought vaccination following HSCT from January 2012 to December 2018 at the Center for Infectious Diseases, Nara Medical University. Results Information regarding patients' backgrounds, administered vaccines, and reasons for not administering recommended vaccines was collected for the study. Thirty-five patients (22 men and 13 women) with a median time from HSCT to the first visit of 25 months were enrolled. Vaccine coverage was highest for diphtheria, tetanus, and acellular pertussis (DTaP) at 89% (31 patients), followed by 23-valent pneumococcal, measles/rubella/mumps, and Japanese encephalitis at 71% (25 patients), 71% (25 patients), and 63% (22 persons), respectively. However, vaccine coverage for hepatitis B, 13-valent pneumococcal, and Hib was low at 26% (three patients), 11% (four patients), and 40% (14 patients), respectively. The reason for not completing the recommended vaccination series was not provided for most cases; however, the economic barrier was cited for all vaccines. Discussion This study identified several cases in Japan where individuals stopped completing post-HSCT vaccinations due to financial constraints. Larger-scale studies may be necessary in Japan in the future for further investigation.
Language	English
Publishing date	2024-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56842
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Article: Concurrent bacterial liver abscess and mild encephalitis/encephalopathy with reversible splenial lesion in a patient with poorly controlled type 2 diabetes.

Sekikawa, Naohiro / Hirai, Hiroyuki / Sugimoto, Kazuhiro / Kusano, Yoshiro

Diabetology international

2023 Volume 14, Issue 3, Page(s) 312–317

Abstract: A 34-year-old man with poorly controlled type 2 diabetes was admitted to our hospital because of fever, headache, vomiting, and impaired consciousness. His hemoglobin A1c level was as high as 11.0%. Abdominal computed tomography revealed a bacterial ... ...

Abstract	A 34-year-old man with poorly controlled type 2 diabetes was admitted to our hospital because of fever, headache, vomiting, and impaired consciousness. His hemoglobin A1c level was as high as 11.0%. Abdominal computed tomography revealed a bacterial liver abscess, while head magnetic resonance imaging simultaneously showed a high-signal lesion on diffusion-weighted imaging and a low-signal lesion on the apparent diffusion coefficient map of the splenium of the corpus callosum. No significant findings were detected in the cerebrospinal fluid. The latter findings led to a diagnosis of mild encephalitis/encephalopathy with reversible splenial lesions. His impaired consciousness resolved on Day 5 after treatment with ceftriaxone and metronidazole infusion and intensive insulin therapy; magnetic resonance imaging on Day 20 showed that the lesion in the splenium of the corpus callosum had disappeared. We propose that when a person with poorly controlled diabetes develops a bacterial infection and presents with impaired consciousness and headache, clinicians should consider the complications of mild encephalitis/encephalopathy with reversible splenial lesion.
Language	English
Publishing date	2023-05-15
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2574501-3
ISSN	2190-1686 ; 2190-1678
ISSN (online)	2190-1686
ISSN	2190-1678
DOI	10.1007/s13340-023-00635-z
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Article ; Online: Effect of Enoxaparin and Daikenchuto Coadministration on Hepatic Disorder Markers in Gynecological Cancer Patients after Abdominal Surgery.

Watanabe, Hiroaki / Hirai, Keita / Nakazawa, Yuka / Koike, Ayaka / Tsuchiya, Hiroyuki / Naito, Takafumi

Biological & pharmaceutical bulletin

2024 Volume 47, Issue 4, Page(s) 758–763

Abstract: Enoxaparin and daikenchuto are commonly administered to prevent venous thromboembolism and intestinal obstruction after gynecological malignancy surgery. However, the effects of their combined use on hepatic function are not well studied. This study ... ...

Abstract	Enoxaparin and daikenchuto are commonly administered to prevent venous thromboembolism and intestinal obstruction after gynecological malignancy surgery. However, the effects of their combined use on hepatic function are not well studied. This study aimed to clarify the effects of the coadministration of enoxaparin and daikenchuto on hepatic function. First, Japanese Adverse Drug Event Report (JADER) data were analyzed to identify signals of hepatic disorders. Second, a retrospective observational study of patients who underwent surgery for gynecological malignancies was conducted. This study defined hepatic disorders as an increase in aspartate aminotransferase (AST) or alanine aminotransaminase (ALT) levels above the reference values, using 1-h postoperative values as the baseline. The analysis of JADER data revealed an increased risk for hepatic disorders with the coadministration of enoxaparin and daikenchuto. An observational study also showed higher odds ratios (95% confidence intervals) for the occurrence of hepatic disorders in the coadministration group (4.27; 2.11-8.64) and enoxaparin alone group (2.48; 1.31-4.69) than in the daikenchuto alone group. The median increase in the ALT level was also higher in the coadministration group (34; 15-59) than in the enoxaparin alone (19; 6-38) and daikenchuto alone groups (8; 3-33). In conclusion, our study suggests that compared with the use of enoxaparin or daikenchuto alone, enoxaparin and daikenchuto coadministration increases the risk of hepatic disorders, with more significant increases in AST and ALT levels. Healthcare workers need to be aware of these potential side effects when combining these drugs after surgery for gynecological malignancies.
MeSH term(s)	Female ; Humans ; Enoxaparin/adverse effects ; Genital Neoplasms, Female/surgery ; Genital Neoplasms, Female/drug therapy ; Panax ; Zanthoxylum ; Anticoagulants/adverse effects ; Postoperative Complications/prevention & control ; Postoperative Complications/chemically induced ; Postoperative Complications/drug therapy ; Plant Extracts ; Zingiberaceae
Chemical Substances	Enoxaparin ; dai-kenchu-to ; Anticoagulants ; Plant Extracts
Language	English
Publishing date	2024-04-02
Publishing country	Japan
Document type	Observational Study ; Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b24-00026
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Zs.A 1474: Show issues

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Article ; Online: Combination of serum 5-S-cysteinyldopa, melanoma inhibitory activity and IL-8 improves the diagnostic accuracy of malignant melanoma compared with individual markers.

Katoh, Yuki / Hara, Hiroyuki / Harada, Tomonori / Hirai, Shuichi

Medicine

2022 Volume 101, Issue 35, Page(s) e30471

Abstract: Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient mortality. However, current clinical and histological variables show limited accuracy in diagnosis. Serum or urine level of 5-S-cysteinyldopa (5-S-CD) is a ... ...

Abstract	Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient mortality. However, current clinical and histological variables show limited accuracy in diagnosis. Serum or urine level of 5-S-cysteinyldopa (5-S-CD) is a commonly used melanoma biomarker in Japan owing to its increased sensitivity compared with other melanoma markers. However, its use as a diagnostic marker has shown some limitations. Therefore, here we examined the combination of 5-S-CD with melanoma inhibitory activity, which showed sensitivity in detecting melanoma comparable with that of 5-S-CD, and interleukin-8, a cytokine linked with melanoma progression, in a cohort of Japanese patients with melanoma. Our results revealed that the triple combination of 5-S-CD, melanoma inhibitory activity, and interleukin-8 showed high diagnostic accuracy in detecting melanoma compared with each of the individual factors. Importantly, the triple marker showed specificity and utility in detecting early-stage melanoma. Our results suggest the utility of the triple marker as a diagnostic biomarker for melanoma patients.
MeSH term(s)	Biomarkers, Tumor ; Cysteinyldopa ; Cytokines ; Humans ; Interleukin-8 ; Melanoma/pathology ; Skin Neoplasms ; Melanoma, Cutaneous Malignant
Chemical Substances	Biomarkers, Tumor ; Cytokines ; Interleukin-8 ; Cysteinyldopa (19641-92-0)
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030471
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Ua VI Zs.171: Show issues

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Article ; Online: Changes in lung sounds after bronchodilator inhalation in acute bronchiolitis.

Matsushita, Takashi / Ichinose, Mami / Kuramochi, Yu / Hirai, Kota / Niimura, Fumio / Kato, Masahiko / Mochizuki, Hiroyuki

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15676

MeSH term(s)	Humans ; Infant ; Bronchodilator Agents/therapeutic use ; Respiratory Sounds/etiology ; Bronchiolitis/diagnosis ; Bronchiolitis/drug therapy ; Lung ; Administration, Inhalation ; Respiratory Syncytial Virus Infections/drug therapy ; Bronchiolitis, Viral
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	2023-10-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15676
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Zs.A 848: Show issues

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Article: Gastric ectopic pancreas with a pseudocyst.

Furukawa, Kazuhiro / Furune, Satoshi / Hirose, Takashi / Hirai, Keiko / Suzuki, Takahiro / Hida, Emiko / Shibata, Hiroyuki / Kawashima, Hiroki

Revista espanola de enfermedades digestivas

2024

Abstract: Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular connections to the normal pancreas. EP is generally asymptomatic and is detected incidentally during endoscopy. However, due to pseudocyst formation, inflammation, or ...

Abstract	Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular connections to the normal pancreas. EP is generally asymptomatic and is detected incidentally during endoscopy. However, due to pseudocyst formation, inflammation, or malignant transformation, it may cause non-specific gastrointestinal symptoms, such as abdominal pain, abdominal discomfort, nausea, vomiting, and bleeding. Pseudocyst formation in EP may result from the retention of exocrine secretions in the absence of connections between the glandular epithelium and gastric lumen. We herein report a case of EP with a pseudocyst associated with epigastric pain. EP with a pseudocyst, although rare, needs to be considered in a differential diagnosis of cystic lesions of the stomach.
Language	English
Publishing date	2024-03-07
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2024.10339/2024
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Zs.B 199: Show issues

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Article ; Online: Synergy Effect of Plasmonic Field Enhancement and Light Confinement in Mesoporous Titania-Coated Aluminum Nanovoid Photoelectrode.

Kawamura, Go / Hirai, Daiki / Yamauchi, Shingo / Tan, Wai Kian / Muto, Hiroyuki / Matsuda, Atsunori

The journal of physical chemistry letters

2023 Volume 14, Issue 51, Page(s) 11691–11696

Abstract: Photoelectrochemical (PEC) water splitting is a highly demanded technology for the realization of sustainable society. Various types of photoanodes have been developed to achieve high efficiency of PEC water splitting. Plasmonic field enhancement and ... ...

Abstract	Photoelectrochemical (PEC) water splitting is a highly demanded technology for the realization of sustainable society. Various types of photoanodes have been developed to achieve high efficiency of PEC water splitting. Plasmonic field enhancement and light confinement effects are often adopted to improve PEC performance. However, their synergistic effects have not been studied. In this work, a mesoporous TiO
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03150
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Article ; Online: Effect of wheeze and lung function on lung sound parameters in children with asthma.

Sakama, Takashi / Ichinose, Mami / Obara, Takeru / Shibata, Mayuko / Kagawa, Takanori / Takakura, Hiromitsu / Hirai, Kota / Furuya, Hiroyuki / Kato, Masahiko / Mochizuki, Hiroyuki

Allergology international : official journal of the Japanese Society of Allergology

2023 Volume 72, Issue 4, Page(s) 545–550

Abstract: Background: In children with asthma, there are many cases in which wheeze is confirmed by auscultation with a normal lung function, or in which the lung function is decreased without wheeze. Using an objective lung sound analysis, we examined the effect ...

Abstract	Background: In children with asthma, there are many cases in which wheeze is confirmed by auscultation with a normal lung function, or in which the lung function is decreased without wheeze. Using an objective lung sound analysis, we examined the effect of wheeze and the lung function on lung sound parameters in children with asthma. Methods: A total of 114 children with asthma (males to females = 80: 34, median age 10 years old) were analyzed for their lung sound parameters using conventional methods, and wheeze and the lung function were checked. The effects of wheeze and the lung function on lung sound parameters were examined. Results: The patients with wheeze or decreased forced expiratory flow and volume in 1 s (FEV Conclusions: Our data suggest that bronchial constriction in the asthmatic children with wheeze similarly exists in the asthmatic children with a decreased lung function. A lung sound analysis is likely to enable an accurate understanding of airway conditions.
MeSH term(s)	Male ; Female ; Humans ; Child ; Respiratory Sounds ; Forced Expiratory Volume ; Asthma/diagnosis ; Respiratory Function Tests ; Lung
Language	English
Publishing date	2023-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2023.03.001
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Zs.A 5248: Show issues

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Article ; Online: Clinical application of a lung sound analysis in infants with respiratory syncytial virus acute bronchiolitis.

Ichinose, Mami / Obara, Takeru / Shibata, Mayuko / Kagawa, Takanori / Sakama, Takashi / Takakura, Hiromitsu / Hirai, Kota / Furuya, Hiroyuki / Kato, Masahiko / Mochizuki, Hiroyuki

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15605

Abstract: Background: Objective investigation of the characteristics of acute bronchiolitis in infants is important for its diagnosis and treatment.: Methods: Lung sound data of 50 patients diagnosed with respiratory syncytial virus (RSV) acute bronchiolitis ( ... ...

Abstract	Background: Objective investigation of the characteristics of acute bronchiolitis in infants is important for its diagnosis and treatment. Methods: Lung sound data of 50 patients diagnosed with respiratory syncytial virus (RSV) acute bronchiolitis (m:f = 29:21, median of age 7 months), 20 patients with RSV acute respiratory tract infections without acute bronchiolitis (m:f = 10:10, 5 months) and 38 age-matched control infants (m:f = 23:15, 8 months) were analyzed using a conventional method and compared. Furthermore, the relationships between lung sound parameters and clinical symptoms (clinical score, length of hospital stay and SpO Results: Results of lung sound analysis showed that the inspiratory sound power of patients with RSV respiratory tract infections was low and the expiratory sound power was high compared with those of the controls. When the patients with RSV respiratory tract infections were divided into the bronchiolitis and non-bronchiolitis groups, the expiratory/inspiratory ratio of the bronchiolitis patients was greater than that of the non-bronchiolitis patients. There was no difference in the clinical symptoms, clinical score and length of hospital stay between the bronchiolitis and non-bronchiolitis patients, except for the SpO Conclusion: Lung sound analysis confirmed that patients with RSV acute bronchiolitis present with marked airway narrowing. Considering these results as a characteristic of acute bronchiolitis, it would be meaningful to reflect it in the improvement of diagnosis, treatment and subsequent management.
MeSH term(s)	Humans ; Infant ; Child, Preschool ; Respiratory Sounds ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/therapy ; Bronchiolitis/diagnosis ; Bronchiolitis/therapy ; Hospitalization ; Respiratory Syncytial Viruses ; Respiratory Syncytial Virus, Human
Language	English
Publishing date	2023-08-24
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15605
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Zs.A 848: Show issues

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