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Article ; Online: Comment on Tuten Dal S et al.

Khan, Sujoy

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2024 Volume 35, Issue 3, Page(s) e14107

Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Letter
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.14107
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Article ; Online: Safety and immunogenicity of booster vaccination and fractional dosing with Ad26.COV2.S or BNT162b2 in Ad26.COV2.S-vaccinated participants.

Riou, Catherine / Bhiman, Jinal N / Ganga, Yashica / Sawry, Shobna / Ayres, Frances / Baguma, Richard / Balla, Sashkia R / Benede, Ntombi / Bernstein, Mallory / Besethi, Asiphe S / Cele, Sandile / Crowther, Carol / Dhar, Mrinmayee / Geyer, Sohair / Gill, Katherine / Grifoni, Alba / Hermanus, Tandile / Kaldine, Haajira / Keeton, Roanne S /

Kgagudi, Prudence / Khan, Khadija / Lazarus, Erica / Le Roux, Jean / Lustig, Gila / Madzivhandila, Mashudu / Magugu, Siyabulela F J / Makhado, Zanele / Manamela, Nelia P / Mkhize, Qiniso / Mosala, Paballo / Motlou, Thopisang P / Mutavhatsindi, Hygon / Mzindle, Nonkululeko B / Nana, Anusha / Nesamari, Rofhiwa / Ngomti, Amkele / Nkayi, Anathi A / Nkosi, Thandeka P / Omondi, Millicent A / Panchia, Ravindre / Patel, Faeezah / Sette, Alessandro / Singh, Upasna / van Graan, Strauss / Venter, Elizabeth M / Walters, Avril / Moyo-Gwete, Thandeka / Richardson, Simone I / Garrett, Nigel / Rees, Helen / Bekker, Linda-Gail / Gray, Glenda / Burgers, Wendy A / Sigal, Alex / Moore, Penny L / Fairlie, Lee

PLOS global public health

2024 Volume 4, Issue 4, Page(s) e0002703

Abstract: We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 ... in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S ... were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or ...

Abstract	We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine. B cell responses (binding, neutralization and antibody dependent cellular cytotoxicity-ADCC), and spike-specific T-cell responses were evaluated at baseline, 2, 12 and 24 weeks post-boost. Antibody and T-cell immunity targeting the Ad26 vector was also evaluated. No vaccine-associated serious adverse events were recorded. The full- and half-dose BNT162b2 boosted anti-SARS-CoV-2 binding antibody levels (3.9- and 4.5-fold, respectively) and neutralizing antibody levels (4.4- and 10-fold). Binding and neutralizing antibodies following half-dose Ad26.COV2.S were not significantly boosted. Full-dose Ad26.COV2.S did not boost binding antibodies but slightly enhanced neutralizing antibodies (2.1-fold). ADCC was marginally increased only after a full-dose BNT162b2. T-cell responses followed a similar pattern to neutralizing antibodies. Six months post-boost, antibody and T-cell responses had waned to baseline levels. While we detected strong anti-vector immunity, there was no correlation between anti-vector immunity in Ad26.COV2.S recipients and spike-specific neutralizing antibody or T-cell responses post-Ad26.COV2.S boosting. Overall, in the context of hybrid immunity, boosting with heterologous full- or half-dose BNT162b2 mRNA vaccine demonstrated superior immunogenicity 2 weeks post-vaccination compared to homologous Ad26.COV2.S, though rapid waning occurred by 12 weeks post-boost. Trial Registration: The study has been registered to the South African National Clinical Trial Registry (SANCTR): DOH-27-012022-7841. The approval letter from SANCTR has been provided in the up-loaded documents.
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0002703
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Article ; Online: Children’s Balneotherapy and Physiotherapy

Maya A. Khan / Irena V. Pogonchenkova / Maria S. Petrova

Вестник восстановительной медицины, Vol 21, Iss 4, Pp 10-

Yesterday, Today, Tomorrow: a Review

2023 Volume 16

Abstract: INTRODUCTION. One of the most important directions of the development of children’s balneology is ... s balneology:the problems of adaptation of children’s bodies to contrasting climatic conditions are ... the history of the formation of children’s balneology and physiotherapy and to assess its current state ...

Abstract	INTRODUCTION. One of the most important directions of the development of children’s balneology is the improvement of sanatoriumresorttreatment of children. On November 26, 2018, the Russian Government approved the Strategy for the Development of theRussian Sanatorium-Resort Complex, which aims to increase the availability of health resort treatment; development of therapeuticareas and resorts; effective use of natural therapeutic resources; and improvement of the material and technical base of health resortorganizations. In recent years there has been a tendency towards intensifying scientific research in the field of children’s balneology:the problems of adaptation of children’s bodies to contrasting climatic conditions are being brought up to date; questions of medicalclimatology concerning the specific features of meteopathological reactions and the development of methods of their correctionand prevention using both natural factors and hardware physiotherapy technologies are being actively studied; scientific research onbalneotherapy – a traditionally widely used method of resort therapy – is being revived;AIM. To analyze the history of the formation of children’s balneology and physiotherapy and to assess its current state.CONCLUSION. An important area of pediatric physiotherapy is the development of personalized physiotherapy based on the provisionon the maximum effectiveness of physical treatment methods applied taking into account the individual characteristics of the youngpatient’s body. Today, innovative physiotherapy technologies are widely included in individual medical rehabilitation programs forchildren with various diseases. Thus, nowadays, children’s balneology and physiotherapy have a good theoretical, methodological andpersonnel base for the effective solution of urgent problems in pediatrics. Advances in the study of the mechanism of therapeutic actionof natural and artificial physical factors open up new prospects in the development of innovative technologies of resort pediatrics ...
Keywords	children’s balneology ; physiotherapy ; health resort treatment ; medical rehabilitation ; Medicine (General) ; R5-920 ; Sports medicine ; RC1200-1245
Subject code	360
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology
Document type	Article ; Online
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Article ; Online: Pinholin S

Ahammad, Tanbir / Khan, Rasal H / Sahu, Indra D / Drew, Daniel L / Faul, Emily / Li, Tianyan / McCarrick, Robert M / Lorigan, Gary A

Biochimica et biophysica acta. Biomembranes

2021 Volume 1863, Issue 12, Page(s) 183771

Abstract: ... of this process. Pinholin S ...

Abstract	The bacteriophage infection cycle is terminated at a predefined time to release the progeny virions via a robust lytic system composed of holin, endolysin, and spanin proteins. Holin is the timekeeper of this process. Pinholin S
MeSH term(s)	Bacteriophages/chemistry ; Bacteriophages/genetics ; Biological Transport ; Cell Death/genetics ; Endopeptidases/chemistry ; Endopeptidases/genetics ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Mutation/genetics ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Virion/chemistry ; Virion/genetics
Chemical Substances	Membrane Proteins ; Viral Proteins ; pinholin S(21) protein, phage phi21 ; Endopeptidases (EC 3.4.-) ; endolysin (EC 3.4.99.-)
Language	English
Publishing date	2021-09-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	60-7
ISSN	1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamem.2021.183771
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Article ; Online: M. S. Swaminathan (1925-2023).

Khan, Sameen Ahmed / Deshmukh, Sanjay Vasant

Science (New York, N.Y.)

2023 Volume 382, Issue 6673, Page(s) 886

Abstract: Architect of India's green revolution. ...

Abstract	Architect of India's green revolution.
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adl3574
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Book ; Online: S-ADDOPT

Qureshi, Muhammad I. / Xin, Ran / Kar, Soummya / Khan, Usman A.

Decentralized stochastic first-order optimization over directed graphs

2020

Abstract: ... algorithm. In particular, we propose the S-ADDOPT algorithm that assumes a stochastic first-order oracle ... we show that S-ADDOPT reaches the exact solution sublinearly at $\mathcal{O}(1/k)$ and its convergence is ... asymptotically network-independent. Thus the asymptotic behavior of S-ADDOPT is comparable to the centralized ...

Abstract	In this report, we study decentralized stochastic optimization to minimize a sum of smooth and strongly convex cost functions when the functions are distributed over a directed network of nodes. In contrast to the existing work, we use gradient tracking to improve certain aspects of the resulting algorithm. In particular, we propose the S-ADDOPT algorithm that assumes a stochastic first-order oracle at each node and show that for a constant step-size $\alpha$, each node converges linearly inside an error ball around the optimal solution, the size of which is controlled by $\alpha$. For decaying step-sizes $\mathcal{O}(1/k)$, we show that S-ADDOPT reaches the exact solution sublinearly at $\mathcal{O}(1/k)$ and its convergence is asymptotically network-independent. Thus the asymptotic behavior of S-ADDOPT is comparable to the centralized stochastic gradient descent. Numerical experiments over both strongly convex and non-convex problems illustrate the convergence behavior and the performance comparison of the proposed algorithm.
Keywords	Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control ; Statistics - Machine Learning
Subject code	510
Publishing date	2020-05-15
Publishing country	us
Document type	Book ; Online
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Article ; Online: It’s complicated

Foster, Allison / Khan, Zohaib / Siddiqui, Aisha / Singh, Sukhdev / Atere, Muhammed / Nfonoyim, Jay M

SAGE Open Medical Case Reports

A case report on a COVID-19-positive HIV patient presenting with rhabdomyolysis and acute kidney injury

2020 Volume 8, Page(s) 2050313X2096542

Abstract: The SARS-Cov-2/COVID-19 pandemic in early 2020 has had a devastating impact on health systems around the world. While viral pneumonia remains the most common complication, reports are surfacing of cases with neurological, cardiac, and renal involvement. ... ...

Abstract	The SARS-Cov-2/COVID-19 pandemic in early 2020 has had a devastating impact on health systems around the world. While viral pneumonia remains the most common complication, reports are surfacing of cases with neurological, cardiac, and renal involvement. Even less is known about the implications in special high-risk populations. In this report, we discuss a unique case of an HIV-positive patient in New York City who presented with a 2-week history of worsening fatigue, cough, dyspnea, and myalgias and was found to have COVID-19 pneumonia and acute kidney injury. He was managed for severe uremic metabolic acidosis and electrolyte abnormalities with emergent hemodialysis and supportive therapy with subsequent improvement. Direct involvement of SARS-CoV-2 and pneumonia-induced rhabdomyolysis were identified as the precipitating factors of his acute kidney injury. The pathophysiologic mechanisms of acute kidney injury, SARS-CoV-2 renal tropism, and the impact of highly active antiretroviral therapy on COVID-19 pneumonia are discussed. We highlight the importance of clinician awareness of this potentially fatal complication of COVID-19 pneumonia, particularly in the HIV-positive population as early recognition and management can have favorable outcomes.
Keywords	covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313x20965423
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Article ; Online: Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment.

Khan, Mohd Faiyaz / Ahmad, Niyaz / Alkholifi, Faisal K / Ullah, Zabih / Khalid, Mohammed Saifuddin / Akhtar, Sultan / Farooqui, Sadaf / Khan, Nazia / Chaudhary, Anis Ahmad / Alawam, Abdullah S / Ali, Mohamed A M

RSC advances

2024 Volume 14, Issue 1, Page(s) 160–180

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra05933b
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Article: Healthcare Access Among Individuals of Asian Descent in the U.S.

Al Rifai, Mahmoud / Kianoush, Sina / Jain, Vardhmaan / Minhas, Abdul Mannan Khan / Hussain, Aliza / Krittanawong, Chayakrit / Patel, Jaideep / Agarwala, Anandita / Hanif, Bashir / Samad, Zainab / Yang, Eugene / Virani, Salim S

Kansas journal of medicine

2022 Volume 15, Page(s) 352–357

Abstract: ... of atherosclerotic cardiovascular disease (ASCVD) compared with other groups in the U.S. Barriers in accessing ... statistically significant.: Conclusions: Among Asians living in the U.S. with cardiovascular risk factors or ...

Abstract	Introduction: Some groups of Asian Americans, especially Asian Indians, experience higher rates of atherosclerotic cardiovascular disease (ASCVD) compared with other groups in the U.S. Barriers in accessing medical care partly may explain this higher risk as a result of delayed screening for cardiovascular risk factors and timely initiation of preventive treatment. Methods: Cross-sectional data were utilized from the 2006 to 2015 National Health Interview Survey (NHIS). Barriers to accessing medical care included no place to seek medical care when needed, no healthcare coverage, no care due to cost, delayed care due to cost, inability to afford medication, or not seeing a doctor in the past 12 months. Results: The study sample consisted of 18,150 Asian individuals, of whom 20.5% were Asian Indian, 20.5% were Chinese, 23.4% were Filipino, and 35.6% were classified as "Other Asians". The mean (standard error) age was 43.8 (0.21) years and 53% were women. Among participants with history of hypertension, diabetes mellitus, or ASCVD (prevalence = 25%), Asian Indians were more likely to report delayed care due to cost (2.58 (1.14,5.85)), while Other Asians were more likely to report no care due to cost (2.43 (1.09,5.44)) or delayed care due to cost (2.35 (1.14,4.86)), compared with Chinese. Results among Filipinos were not statistically significant. Conclusions: Among Asians living in the U.S. with cardiovascular risk factors or ASCVD, Asian Indians and Other Asians are more likely to report delayed care or no care due to cost compared with Chinese.
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article
ISSN	1948-2035
ISSN	1948-2035
DOI	10.17161/kjm.vol15.17942
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Article ; Online: Innovative dual-active sites in interfacially engineered interfaces for high-performance S-scheme solar-driven CO

Miao, Baoji / Cao, Yange / Khan, Imran / Chen, Qiuling / Khan, Salman / Zada, Amir / Shahyan, Muhammad / Ali, Sharafat / Ullah, Rizwan / Bai, Jinbo / Rizwan, Muhammad / Alhuthali, Abdullah M S

Journal of colloid and interface science

2024 Volume 661, Page(s) 544–563

Abstract: The realization of 2D/2D Van der Waals (VDW) heterojunctions represents an advanced approach to achieving superior photocatalytic efficiency. However, electron transfer through Van der Waals heterojunctions formed via ex-situ assembly encounters ... ...

Abstract	The realization of 2D/2D Van der Waals (VDW) heterojunctions represents an advanced approach to achieving superior photocatalytic efficiency. However, electron transfer through Van der Waals heterojunctions formed via ex-situ assembly encounters significant challenges at the interface due to contrasting morphologies and potential barriers among the nanocomposite substituents. Herein, a novel approach is presented, involving the insertion of a phosphate group between copper phthalocyanine (CuPc) and B-doped and N-deficient g-C
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.01.168
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