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  1. Book ; Online ; E-Book: The Breast

    Klimberg, V. Suzanne / Gradishar, William J. / Bland, Kirby I. / Korourian, Soheila / White, Julia / Copeland, Edward M.

    comprehensive management of benign and malignant diseases

    2024  

    Title variant Bland and Copeland's the breast
    Author's details edited by V. Suzanne Klimberg, William J. Gradishar, Kirby I. Bland, Soheila Korourian, Julia White, Edward M. Copeland III
    Language English
    Size 1 Online-Ressource (3200 Seiten), Illustrationen
    Edition Sixth edition
    Publisher Elsevier
    Publishing place Philadelphia
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021829140
    ISBN 9780323833660 ; 9780323833653 ; 0323833667 ; 0323833659
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Modifying the antiviral innate immune response by selective writing, erasing, and reading of m

    Aufgebauer, Caroline J / Bland, Katherine M / Horner, Stacy M

    Cell chemical biology

    2024  Volume 31, Issue 1, Page(s) 100–109

    Abstract: Viral infection and the antiviral innate immune response are regulated by the RNA modification m ...

    Abstract Viral infection and the antiviral innate immune response are regulated by the RNA modification m
    MeSH term(s) Humans ; RNA ; Reading ; Immunity, Innate ; Virus Diseases ; Antiviral Agents/pharmacology ; RNA, Viral/genetics
    Chemical Substances RNA (63231-63-0) ; Antiviral Agents ; RNA, Viral
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: The breast

    Bland, Kirby I. / Klimberg, V. Suzanne / Copeland, Edward M. / Gradishar, William J.

    comprehensive management of benign and malignant diseases

    2018  

    Author's details senior editors, Kirby I. Bland, MD, V. Suzanne Klimberg MD, Edward M. Copeland III,MD William J. Gradishar, MD; associate editors, Julia White, MD Soheila Korourian, MD
    Keywords Breast Diseases / therapy ; Breast Neoplasms / therapy
    Language English
    Size xxii, 1114 Seiten, Illustrationen
    Edition Fifth edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note 2. bis 4. Auflage in 2 Bänden ; Zugang zur Online-Ausgabe über Code
    HBZ-ID HT019485925
    ISBN 978-0-323-35955-9 ; 9780323511872 ; 0-323-35955-8 ; 0323511872
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 89 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Article ; Online: Mechanisms of synergistic suppression of ALK-positive lung cancer cell growth by the combination of ALK and SHP2 inhibitors.

    Berry, M A / Bland, A R / Ashton, J C

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10041

    Abstract: Lung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment for patients with ALK-positive lung cancer, but the survival rate beyond 2-3 years is low. Co-targeting secondary oncogenic drivers such as SHP2 is a ... ...

    Abstract Lung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment for patients with ALK-positive lung cancer, but the survival rate beyond 2-3 years is low. Co-targeting secondary oncogenic drivers such as SHP2 is a potential strategy for improving drug efficacy. This is because SHP2 is expressed ubiquitously, but ALK expression is largely restricted to cancer cells. Thus, the combination of ALK and SHP2 inhibitors may provide a way to restrict synergistic cytotoxicity to cancer cells only, by reducing the dose of SHP2 inhibitors required for anticancer action and minimising SHP2-dependent systemic toxicity. The objective of this study was to investigate whether the combination of a SHP2 inhibitor (SHP099) with alectinib would synergistically suppress the growth of ALK-positive lung cancer cells. Our results demonstrated that the drug combination significantly and synergistically decreased cell viability at relatively low concentrations in ALK-positive H3122 and H2228 cells, due to G1 cell cycle arrest and increased apoptosis because of suppressed downstream RAS/MAPK signalling. The drug combination also induced the expression of mediators of the intrinsic apoptotic pathway, Bim and cleaved caspase-3, and modulated the expression of cell cycle mediators cyclin D1, cyclin B1, and phosphorylated CDK1.
    MeSH term(s) Humans ; Anaplastic Lymphoma Kinase/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Signal Transduction ; Cell Line, Tumor
    Chemical Substances Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37006-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Name-bearing types of butterflies (Lepidoptera, Papilionoidea), in the National Museums of Scotland, Edinburgh.

    Bland, Keith P

    Zootaxa

    2019  Volume 4559, Issue 1, Page(s) 57–89

    Abstract: ... originates from H. Carcasson (1), M. Cock (1), J. B. Godart (7), W. J. Kaye (1), O. Kudrna (3) and M. B ... Euphaedra COOKSONI, Mycalesis HAROLDI; H.H. Druce (1869-1922) Cyclopides COOKSONI, Spindasis KALLIMON; H.J ... Elwes (1846-1922) Parnassius delphius ssp. INFERNALIS; J.C. Fabricius (1745-1808) Papilio COCALIA ...

    Abstract This article documents 91 species-group names of Butterflies (Lepidoptera: Papilionoidea) for which either primary or secondary type material is present in the collections of the National Museums of Scotland, Edinburgh. The describers and the 76 nominal taxa they descibed are as follows: H. Druce (1846-1913) Euphaedra COOKSONI, Mycalesis HAROLDI; H.H. Druce (1869-1922) Cyclopides COOKSONI, Spindasis KALLIMON; H.J. Elwes (1846-1922) Parnassius delphius ssp. INFERNALIS; J.C. Fabricius (1745-1808) Papilio COCALIA ("neotype"), Papilio MARDANIA ("neotype"); H. Fruhstorfer (1866-1922) Parnassius mnemosyne ssp. MELAINA; D.R. Gifford (1918-1981) Leptomyrina HANDMANI, Alaena LAMBORNI, Deudorix (Virachola) MAGDA, Papilio ophidicephalus ssp. MKUWADZI; J.B. Godart (1775-1825) Idea AGELIA, Danais ALCATHOE, Cethosia ALIPHERA, Danais ALOPIA, Danais BAUDINIANA, Papilio BITIAS, Argynnis BRIAREA, Heliconia CLEOBAEA, Danais CLEOPHILE, Danais CLEOTHERA, Heliconia CYRBIA, Pieris DOXO, Pieris EPICHARIS, Pieris ERIPHIA, Heliconia ETHILLA, Heliconia EUCLEA, Papilio EURYMAS, Pieris GIDICA, Argynnis HEGEMONE, Satyrus HYSIUS, Papilio IMERIUS, Acraea JANISCA, Pieris JOSEPHINA, Vanessa LAODORA, Papilio LEUCASPIS, Papilio LYCORAEUS, Vanessa LYTREA, Heliconia MEGARA, Heliconia MELPHIS, Libythea MYRRHA, Acraea OZOMENE, Pieris PHISADIA, Papilio POLYMETUS, Danais PROTHOE, Argynnis PYGMAEA, Pieris PYRO, Pieris SALACIA, Acraea SERVONA, Papilio TEMENES, Papilio TEREAS, Libythea TERENA, Biblis THADANA, Argynnis THAROSSA, Papilio TRIOPAS, Pieris VENILIA, Vanessa VULCANIA, Acraea ZETHEA, Acraea ZIDORA, Acraea ZOSTERIA; C.W.N. Holmes (1916-2018) Bebearia paludicola ssp. BLANDI, Bebearia cocalioides ssp. HECQI, Bebearia orientis ssp. MALAWIENSIS, Bebearia PALUDICOLA; E.G. Honrath (1837-1893) Parnassius bremeri ssp. GRAESERI, Parnassius nordmanni var. MINIMA; W.J. Kaye (1875-1967) Hesperocharis LAMONTI; F. Moore (1830-1907) Neptis ADARA, Abisara ANGULATA, Lebadea ATTENUATA, Ixias CITRINA, Euploea LIMBORGII, Papilio ONPAPE, Cirrhochroa SURYA; W.F.H. Rosenberg G. Talbot (1914) Dismorphia orise ssp. DENIGRATA.        The secondary type material (number of species in brackets) originates from H. Carcasson (1), M. Cock (1), J. B. Godart (7), W. J. Kaye (1), O. Kudrna (3) and M. B. Usher (2).
    MeSH term(s) Animals ; Butterflies ; Heliconiaceae ; Lepidoptera ; Museums ; Scotland
    Language English
    Publishing date 2019-02-18
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4559.1.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Life-saving effect of pulmonary surfactant in premature babies.

    Raj, J Usha / Bland, Richard D / Bhattacharya, Jahar / Rabinovitch, Marlene / Matthay, Michael A

    The Journal of clinical investigation

    2024  Volume 134, Issue 9

    Abstract: The discovery and replacement of lung surfactant have helped increase survival rates for neonatal respiratory distress syndrome in extremely premature infants. ...

    Abstract The discovery and replacement of lung surfactant have helped increase survival rates for neonatal respiratory distress syndrome in extremely premature infants.
    MeSH term(s) Humans ; Infant, Newborn ; Pulmonary Surfactants/metabolism ; Respiratory Distress Syndrome, Newborn ; Infant, Premature ; Infant, Extremely Premature
    Chemical Substances Pulmonary Surfactants
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI179948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: How to use autoantibodies in suspected paediatric rheumatic disease.

    Keightley, Jaclyn / Walsh, Jo / Bland, Ruth M

    Archives of disease in childhood. Education and practice edition

    2022  Volume 107, Issue 4, Page(s) 236–241

    Abstract: Autoantibodies can be an important indicator of paediatric rheumatic disease and useful in establishing a diagnosis. However, autoantibodies may be requested in cases where the patient does not have clinical features strongly suggestive of a rheumatic ... ...

    Abstract Autoantibodies can be an important indicator of paediatric rheumatic disease and useful in establishing a diagnosis. However, autoantibodies may be requested in cases where the patient does not have clinical features strongly suggestive of a rheumatic disease. This can lead to further unnecessary investigations, specialist referral and undue anxiety for the family. The aim of this article is to provide guidance for when it is appropriate to request autoantibodies, which ones to perform and how to interpret the results.
    MeSH term(s) Autoantibodies ; Child ; Humans ; Rheumatic Diseases/diagnosis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2148818-6
    ISSN 1743-0593 ; 1743-0585
    ISSN (online) 1743-0593
    ISSN 1743-0585
    DOI 10.1136/archdischild-2021-323212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.106 -E.P.Ed.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Evaluation of Dalbavancin in Vancomycin Allergic Patients: A Case Series.

    Jones, Bruce M / Freeman, Kennedy J / Cleveland, Kerry O / Bland, Christopher M

    Clinical therapeutics

    2022  Volume 44, Issue 12, Page(s) e59–e63

    Abstract: Purpose: There is a paucity of data regarding dalbavancin use in patients with a vancomycin allergy because of potential cross-reactivity between the 2 glycopeptide antibiotics.: Methods: A retrospective medical record review was performed between ... ...

    Abstract Purpose: There is a paucity of data regarding dalbavancin use in patients with a vancomycin allergy because of potential cross-reactivity between the 2 glycopeptide antibiotics.
    Methods: A retrospective medical record review was performed between February 2016 and February 2021 in patients with a listed vancomycin allergy who received dalbavancin as an outpatient infusion and had a listed vancomycin allergy in the electronic health record.
    Findings: There were 559 unique patients during the study period who received dalbavancin as an outpatient infusion, 10 of whom had a documented vancomycin allergy in the electronic health record. Four of the 10 patients had a history of a type I IgE-mediated reaction to vancomycin, 1 patient reported delayed rash, 2 patients reported a vancomycin infusion reaction, 2 patients reported acute kidney injury, and 1 patient reported intolerance with general malaise. All 10 patients received at least 1 dose of dalbavancin with no reported adverse events.
    Implications: This case series displays that all patients who received dalbavancin tolerated the infusion well with no adverse events reported. Dalbavancin may be a viable option for patients with a listed vancomycin allergy.
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2022.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1435: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 404: Show issues

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  9. Article: Existential Givens in the COVID-19 Crisis

    Bland, Andrew M.

    J. Hum. Psychol.

    Abstract: COVID-19 confronts humanity with an undeniable, unprecedented crisis. The focus of this article is the opportunities it offers for a proverbial pressing of the reset button by prompting pause and reflection on habitual patterns and serving as an “urgent ... ...

    Abstract COVID-19 confronts humanity with an undeniable, unprecedented crisis. The focus of this article is the opportunities it offers for a proverbial pressing of the reset button by prompting pause and reflection on habitual patterns and serving as an “urgent experience” with the potential to spark revitalizing intentionality. Using Greening’s four dialectical existential givens—life/death, community/isolation, freedom/determinism, and meaning/absurdity—as a guiding framework, I explore imbalances in aspects of life in the United States that have been illuminated by COVID-19. Then, I employ existential–humanistic theorizing and research as a vision of how these dialectical forces can be transcended by confronting paradoxes posed by these givens (vs. simplistically overemphasizing either their positive or their negative aspects) and by activating the creative potential therein. Specifically, COVID-19 offers opportunities for individuals to relinquish an unsustainable and ineffective way of being inherent in and reinforced by the U.S. cultural narrative; to embrace ambiguity and tragedy; to actively identify, remediate, and reconcile underacknowledged and underactualized human capacities; and therefore to heal false dichotomies and become more capable of living fully, authentically, and flexibly. Accordingly, COVID-19 also provides opportunities for collective co-creation of a cultural narrative involving evolution toward enhanced senses of consciousness and caring.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #639163
    Database COVID19

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  10. Article: Instrumental Texture Differentiation of Channel (

    Bland, John M / Ardoin, Ryan / Li, Carissa H / Bechtel, Peter J

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 13

    Abstract: An analysis of instrumental texture differences between channel (Ictalurus punctatus) and hybrid (female channel × male blue, I. furcatus) catfish fillets is presented. Factors including cold-storage type (fresh, frozen, or individually quick frozen (IQF) ...

    Abstract An analysis of instrumental texture differences between channel (Ictalurus punctatus) and hybrid (female channel × male blue, I. furcatus) catfish fillets is presented. Factors including cold-storage type (fresh, frozen, or individually quick frozen (IQF)) and gender were included in the comparisons. Texture was measured at eight positions per fillet by a texture profile analysis (TPA) method that provided seven texture attributes: firmness, toughness, cohesiveness, adhesiveness, chewiness, resilience, and springiness, plus the thickness of the fillets (238 total). All attributes except adhesiveness were found to be statistically different (p < 0.05) between channel and hybrid fillets, with channels having the highest value in each attribute. When cold-storage type was included in the analysis, channels still produced the highest attribute values, but the number of attributes differed with firmness, toughness, and chewiness most associated with the differences in the type of catfish, while the other attributes were affected by cold-storage type. Thickness was found to be a strong covariant to some of the texture attributes, especially toughness, but the determination of difference between channels and hybrids was not affected and TPA profiles provided high levels of differentiation between catfish types.
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11131875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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