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  1. Article ; Online: Achieving Curative Ablation Outcomes: It Is All about the Imaging.

    Soulen, Michael C / Sofocleous, Constantinos T

    Radiology

    2020  Volume 298, Issue 1, Page(s) 219–220

    MeSH term(s) Colorectal Neoplasms ; Humans ; Liver Neoplasms ; Radiofrequency Ablation ; Retrospective Studies
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020203930
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  2. Article ; Online: Image-Guided Thermal Ablation for Colorectal Liver Metastases.

    Vasiniotis Kamarinos, N / Kaye, E A / Sofocleous, C T

    Techniques in vascular and interventional radiology

    2020  Volume 23, Issue 2, Page(s) 100672

    Abstract: Image-guided percutaneous thermal ablation is a widely acceptable local therapy for patients with colorectal liver metastases who are noneligible for surgery or present with recurrence after hepatectomy. The increasing knowledge of factors that affect ... ...

    Abstract Image-guided percutaneous thermal ablation is a widely acceptable local therapy for patients with colorectal liver metastases who are noneligible for surgery or present with recurrence after hepatectomy. The increasing knowledge of factors that affect oncologic outcomes has allowed selected patients with resectable small volume colorectal liver metastases to be treated by thermal ablation with curative intent. The continuous technological evolutions in imaging and image-guidance and the wide implementation of microwave ablation that overcomes most of the limitations of radiofrequency ablation have contributed to this paradigm shift. The importance of patient selection, ablation margin evaluation, and confirmation of complete tumor ablation (A0) are discussed in this article.
    MeSH term(s) Biopsy ; Clinical Decision-Making ; Colorectal Neoplasms/pathology ; Cryosurgery/adverse effects ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Laser Therapy/adverse effects ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Margins of Excision ; Metastasectomy/adverse effects ; Microwaves/adverse effects ; Microwaves/therapeutic use ; Patient Selection ; Positron Emission Tomography Computed Tomography ; Predictive Value of Tests ; Radiofrequency Ablation/adverse effects ; Radiopharmaceuticals/administration & dosage ; Surgery, Computer-Assisted/adverse effects ; Treatment Outcome ; Tumor Burden
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2170922-1
    ISSN 1557-9808 ; 1089-2516
    ISSN (online) 1557-9808
    ISSN 1089-2516
    DOI 10.1016/j.tvir.2020.100672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Thermal Ablation of Metastatic Colon Cancer to the Liver.

    Camacho, Juan C / Petre, Elena N / Sofocleous, Constantinos T

    Seminars in interventional radiology

    2019  Volume 36, Issue 4, Page(s) 310–318

    Abstract: Colorectal cancer (CRC) is responsible for approximately 10% of cancer-related deaths in the Western world. Liver metastases are frequently seen at the time of diagnosis and throughout the course of the disease. Surgical resection is often considered as ... ...

    Abstract Colorectal cancer (CRC) is responsible for approximately 10% of cancer-related deaths in the Western world. Liver metastases are frequently seen at the time of diagnosis and throughout the course of the disease. Surgical resection is often considered as it provides long-term survival; however, few patients are candidates for resection. Percutaneous ablative therapies are also used in the management of this patient population. Different thermal ablation (TA) technologies are available including radiofrequency ablation, microwave ablation (MWA), laser, and cryoablation. There is growing evidence about the role of interventional oncology and image-guided percutaneous ablation in the management of metastatic colorectal liver disease. This article aims to outline the technical considerations, outcomes, and rational of TA in the management of patients with CRC liver metastases, focusing on the emerging role of MWA.
    Language English
    Publishing date 2019-10-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0039-1698754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Importance of Optimal Thermal Ablation Margins in Colorectal Liver Metastases: A Systematic Review and Meta-Analysis of 21 Studies.

    Chlorogiannis, David-Dimitris / Sotirchos, Vlasios S / Georgiades, Christos / Filippiadis, Dimitrios / Arellano, Ronald S / Gonen, Mithat / Makris, Gregory C / Garg, Tushar / Sofocleous, Constantinos T

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Background: Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the US. Thermal ablation (TA) can be a comparable alternative to partial hepatectomy for selected cases when eradication of all visible tumor with an ... ...

    Abstract Background: Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the US. Thermal ablation (TA) can be a comparable alternative to partial hepatectomy for selected cases when eradication of all visible tumor with an ablative margin of greater than 5 mm is achieved. This systematic review and meta-analysis aimed to encapsulate the current clinical evidence concerning the optimal TA margin for local cure in patients with colorectal liver metastases (CLM).
    Methods: MEDLINE, EMBASE, and the CENTRAL databases were systematically searched from inception until 1 May 2023, in accordance with the PRISMA Guidelines. Measure of effect included the risk ratio (RR) with 95% confidence interval (CI) using the random-effects model.
    Results: Overall, 21 studies were included, comprising 2005 participants and 2873 ablated CLMs. TA with margins less than 5 mm were associated with a 3.6 times higher risk for LTP (n = 21 studies, RR: 3.60; 95% CI: 2.58-5.03;
    Conclusions: This meta-analysis solidifies that a minimal ablation margin over 5 mm is the minimum critical endpoint required, whereas a minimal margin of at least 10 mm yields optimal local tumor control after TA of CLMs.
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245806
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  5. Article ; Online: Liver-Directed and Systemic Therapies for Colorectal Cancer Liver Metastases.

    Kemeny, Nancy / Kurilova, Ieva / Li, Jia / Camacho, Juan C / Sofocleous, Constantinos T

    Cardiovascular and interventional radiology

    2019  Volume 42, Issue 9, Page(s) 1240–1254

    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-019-02284-9
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  6. Article: Thermal Ablation of Metastatic Colon Cancer to the Liver

    Camacho, Juan C. / Petre, Elena N. / Sofocleous, Constantinos T.

    Seminars in Interventional Radiology

    (Ablative Therapy: Part 1)

    2019  Volume 36, Issue 04, Page(s) 310–318

    Abstract: Colorectal cancer (CRC) is responsible for approximately 10% of cancer-related deaths in the Western world. Liver metastases are frequently seen at the time of diagnosis and throughout the course of the disease. Surgical resection is often considered as ... ...

    Series title Ablative Therapy: Part 1
    Abstract Colorectal cancer (CRC) is responsible for approximately 10% of cancer-related deaths in the Western world. Liver metastases are frequently seen at the time of diagnosis and throughout the course of the disease. Surgical resection is often considered as it provides long-term survival; however, few patients are candidates for resection. Percutaneous ablative therapies are also used in the management of this patient population. Different thermal ablation (TA) technologies are available including radiofrequency ablation, microwave ablation (MWA), laser, and cryoablation. There is growing evidence about the role of interventional oncology and image-guided percutaneous ablation in the management of metastatic colorectal liver disease. This article aims to outline the technical considerations, outcomes, and rational of TA in the management of patients with CRC liver metastases, focusing on the emerging role of MWA.
    Keywords metastatic colon cancer ; liver metastasis ; thermal ablation ; survival
    Language English
    Publishing date 2019-10-01
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0039-1698754
    Database Thieme publisher's database

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  7. Article ; Online: Reply to: "Regarding 'PET/CT Imaging Characteristics After Radioembolization of Hepatic Metastasis from Breast Cancer'".

    Deipolyi, Amy R / England, Ryan W / Ridouani, Fourat / Riedl, Christopher C / Kunin, Henry S / Boas, F Edward / Yarmohammadi, Hooman / Sofocleous, Constantinos T

    Cardiovascular and interventional radiology

    2020  Volume 43, Issue 5, Page(s) 799

    MeSH term(s) Brachytherapy ; Breast Neoplasms ; Humans ; Liver Neoplasms ; Positron Emission Tomography Computed Tomography ; Yttrium Radioisotopes
    Chemical Substances Yttrium Radioisotopes
    Language English
    Publishing date 2020-02-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-020-02428-2
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  8. Article: Real-Time Split-Dose PET/CT-Guided Ablation Improves Colorectal Liver Metastasis Detection and Ablation Zone Margin Assessments without the Need for Repeated Contrast Injection.

    Zirakchian Zadeh, Mahdi / Yeh, Randy / Kunin, Henry S / Kirov, Assen S / Petre, Elena N / Gönen, Mithat / Silk, Mikhail / Cornelis, Francois H / Soares, Kevin C / Ziv, Etay / Solomon, Stephen B / Sotirchos, Vlasios S / Sofocleous, Constantinos T

    Cancers

    2022  Volume 14, Issue 24

    Abstract: Background: Real-time split-dose PET can identify the targeted colorectal liver metastasis (CLM) and eliminate the need for repeated contrast administration before and during thermal ablation (TA). This study aimed to assess the added value of pre- ... ...

    Abstract Background: Real-time split-dose PET can identify the targeted colorectal liver metastasis (CLM) and eliminate the need for repeated contrast administration before and during thermal ablation (TA). This study aimed to assess the added value of pre-ablation real-time split-dose PET when combined with non-contract CT in the detection of CLM for ablation and the evaluation of the ablation zone and margins.
    Methods: A total of 190 CLMs/125 participants from two IRB-approved prospective clinical trials using PET/CT-guided TA were analyzed. Based on detection on pre-TA imaging, CLMs were categorized as detectable, non-detectable, and of poor conspicuity on CT alone, and detectable, non-detectable, and low FDG-avidity on PET/CT after the initial dose. Ablation margins around the targeted CLM were evaluated using a 3D volumetric approach.
    Results: We found that 129/190 (67.9%) CLMs were detectable on CT alone, and 61/190 CLMs (32.1%) were undetectable or of poor conspicuity, not allowing accurate depiction and targeting by CT alone. Thus, the theoretical 5- and 10-mm margins could not be defined in these tumors (32.1%) using CT alone. When TA intraprocedural PET/CT images are obtained and inspected (fused PET/CT), only 4 CLM (2.1%) remained undetectable or had a low FDG avidity.
    Conclusions: The addition of PET to non-contrast CT improved CLM detection for ablation targeting, margin assessments, and continuous depiction of the FDG avid CLMs during the ablation without the need for multiple intravenous contrast injections pre- and intra-procedurally.
    Language English
    Publishing date 2022-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14246253
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  9. Article ; Online: Safety and Efficacy of Hepatic Artery Embolization in Heavily Treated Patients with Intrahepatic Cholangiocarcinoma: Analysis of Clinicopathological and Radiographic Parameters Associated with Better Overall Survival.

    Velayati, Sara / Elsakka, Ahmed / Zhao, Ken / Erinjeri, Joseph P / Marinelli, Brett / Soliman, Mohamed / Chevallier, Olivier / Ziv, Etay / Brody, Lynn A / Sofocleous, Constantinos T / Solomon, Stephen B / Harding, James J / Abou-Alfa, Ghassan K / D'Angelica, Michael I / Wei, Alice C / Kingham, Peter T / Jarnagin, William R / Yarmohammadi, Hooman

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 10, Page(s) 9181–9191

    Abstract: The safety and efficacy of hepatic artery embolization (HAE) in treating intrahepatic cholangiocarcinoma (IHC) was evaluated. Initial treatment response, local tumor progression-free survival (L-PFS), and overall survival (OS) were evaluated in 34 IHC ... ...

    Abstract The safety and efficacy of hepatic artery embolization (HAE) in treating intrahepatic cholangiocarcinoma (IHC) was evaluated. Initial treatment response, local tumor progression-free survival (L-PFS), and overall survival (OS) were evaluated in 34 IHC patients treated with HAE. A univariate survival analysis and a multivariate Cox proportional hazard analysis to identify independent factors were carried out. Objective response (OR) at 1-month was 79.4%. Median OS and L-PFS from the time of HAE was 13 (CI = 95%, 7.4-18.5) and 4 months (CI = 95%, 2.09-5.9), respectively. Tumor burden < 25% and increased tumor vascularity on preprocedure imaging and surgical resection prior to embolization were associated with longer OS (
    MeSH term(s) Humans ; Treatment Outcome ; Hepatic Artery/diagnostic imaging ; Hepatic Artery/pathology ; Cholangiocarcinoma/diagnostic imaging ; Cholangiocarcinoma/therapy ; Bile Ducts, Intrahepatic/diagnostic imaging ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/diagnostic imaging ; Bile Duct Neoplasms/therapy
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30100663
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  10. Article ; Online: Correction to: Optimizing

    Maxwell, Aaron W P / Mendoza, Humberto G / Sellitti, Matthew J / Camacho, Juan C / Deipolyi, Amy R / Ziv, Etay / Sofocleous, Constantinos T / Yarmohammadi, Hooman / Maybody, Majid / Humm, John L / Schwartz, Jazmin / Juluru, Krishna / Dunphy, Mark P / Boas, F Edward

    Cardiovascular and interventional radiology

    2022  Volume 45, Issue 7, Page(s) 1055

    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03171-6
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