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Article ; Online: m

Lence, Tina / Akhtar, Junaid / Bayer, Marc / Schmid, Katharina / Spindler, Laura / Ho, Cheuk Hei / Kreim, Nastasja / Andrade-Navarro, Miguel A / Poeck, Burkhard / Helm, Mark / Roignant, Jean-Yves

Nature

2016 Volume 540, Issue 7632, Page(s) 242–247

Abstract: ... ...

Abstract	N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Alternative Splicing ; Animals ; Behavior, Animal/physiology ; Drosophila Proteins/chemistry ; Drosophila Proteins/deficiency ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/enzymology ; Drosophila melanogaster/physiology ; Female ; Male ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Nervous System/metabolism ; Neurons/physiology ; Nuclear Proteins/chemistry ; Nuclear Proteins/deficiency ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phenotype ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; RNA-Binding Proteins/genetics ; Sex Determination Processes/genetics ; Sex Determination Processes/physiology
Chemical Substances	Drosophila Proteins ; NITO protein, Drosophila ; Nuclear Proteins ; Protein Subunits ; RNA-Binding Proteins ; Sxl protein, Drosophila ; Ythdc1 protein, Drosophila ; N-methyladenosine (CLE6G00625) ; Methyltransferases (EC 2.1.1.-) ; mRNA (2'-O-methyladenosine-N6-)-methyltransferase (EC 2.1.1.62) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2016-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature20568
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Article ; Online: The plant cytosolic m

Vicente, Alexandre Magno / Manavski, Nikolay / Rohn, Paul Torben / Schmid, Lisa-Marie / Garcia-Molina, Antoni / Leister, Dario / Seydel, Charlotte / Bellin, Leo / Möhlmann, Torsten / Ammann, Gregor / Kaiser, Stefanie / Meurer, Jörg

Plant communications

2023 Volume 4, Issue 6, Page(s) 100634

Abstract: The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis, growth, and crop yield. Here, we showed that three abiotic perturbations-heat, cold, and high light-triggered considerable changes in ... ...

Abstract	The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis, growth, and crop yield. Here, we showed that three abiotic perturbations-heat, cold, and high light-triggered considerable changes in the expression signatures of 42 epitranscriptomic factors (writers, erasers, and readers) with putative chloroplast-associated functions that formed clusters of commonly expressed genes in Arabidopsis. The expression changes under all conditions were reversible upon deacclimation, identifying epitranscriptomic players as modulators in acclimation processes. Chloroplast dysfunctions, particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOME UNCOUPLED-independent manner, triggered retrograde signals to remodel chloroplast-associated epitranscriptomic expression patterns. N
MeSH term(s)	RNA/metabolism ; Epigenome ; Light ; Photosynthesis/genetics ; Chloroplasts/genetics ; Chloroplasts/metabolism ; Arabidopsis/metabolism
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2023-06-07
Publishing country	China
Document type	Journal Article
ISSN	2590-3462
ISSN (online)	2590-3462
DOI	10.1016/j.xplc.2023.100634
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Book ; Online: M&M Mix

Xiong, Xuehan / Arnab, Anurag / Nagrani, Arsha / Schmid, Cordelia

A Multimodal Multiview Transformer Ensemble

2022

Abstract: ... MTV (M&M) models varying backbone sizes and input modalities. Our approach achieved 52.8% Top-1 ...

Abstract	This report describes the approach behind our winning solution to the 2022 Epic-Kitchens Action Recognition Challenge. Our approach builds upon our recent work, Multiview Transformer for Video Recognition (MTV), and adapts it to multimodal inputs. Our final submission consists of an ensemble of Multimodal MTV (M&M) models varying backbone sizes and input modalities. Our approach achieved 52.8% Top-1 accuracy on the test set in action classes, which is 4.1% higher than last year's winning entry. Comment: Technical report for Epic-Kitchens challenge 2022
Keywords	Computer Science - Computer Vision and Pattern Recognition
Publishing date	2022-06-20
Publishing country	us
Document type	Book ; Online
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Article ; Online: Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.

Berthold, Frank / Rosswog, Carolina / Christiansen, Holger / Frühwald, Michael / Hemstedt, Nadine / Klingebiel, Thomas / Fröhlich, Birgit / Schilling, Freimut H / Schmid, Irene / Simon, Thorsten / Hero, Barbara / Fischer, Matthias / Ernst, Angela

Pediatric blood & cancer

2021 Volume 68, Issue 8, Page(s) e29038

Abstract: Introduction: The survival of children with stage 4(M) neuroblastoma without MYCN amplification ... Between 1990 and 2015, 177 patients with stage 4(M) MYCN nonamplified neuroblastoma aged less than 18 ... predictive in the investigated subcohort.: Conclusion: The outcome of patients with stage 4(M ...

Abstract	Introduction: The survival of children with stage 4(M) neuroblastoma without MYCN amplification and below the age of 18 months is considered better than the still dismal outcome of older high-risk neuroblastoma patients. This study analyzes the impact of clinical and molecular characteristics on the long-term outcome. Patients and methods: Clinical presentation, survival, and recurrence patterns of patients enrolled onto trials NB90, NB97, and NB2004 were retrospectively analyzed. Gene expression signatures based on RNA microarrays (TH10) were investigated if tumor material was available. Results: Between 1990 and 2015, 177 patients with stage 4(M) MYCN nonamplified neuroblastoma aged less than 18 months at diagnosis were eligible. After a median follow-up of 9.7 years (IQR 5.0, 13.4), the proportions of 10-year event-free survival (EFS) and overall survival (OS) were 73% (95% confidence interval [CI] 67-79%) and 86% (95% CI 80-92%), respectively. Of the 27 neuroblastoma recurrences, 44% occurred in more than one site. Four additional patients presented histologically mature ganglioneuroma at recurrence. Six patients developed a secondary malignancy. The secondary 5-year EFS and OS of the 27 patients with neuroblastoma recurrence were 44% and 59%, respectively. TH10 gene expression signature was not prognostically predictive in the investigated subcohort. Conclusion: The outcome of patients with stage 4(M) neuroblastoma aged less than 18 months is favorable when treated with high-risk or otherwise intensive therapy. The development of secondary malignancies and the potential of maturation to ganglioneuroma call for a controlled stepwise reduction of treatment intensity.
MeSH term(s)	Disease-Free Survival ; Ganglioneuroma/genetics ; Ganglioneuroma/pathology ; Gene Amplification ; Humans ; Infant ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Staging ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Prognosis ; Retrospective Studies
Chemical Substances	MYCN protein, human ; N-Myc Proto-Oncogene Protein
Language	English
Publishing date	2021-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.29038
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Article: 2014 M&A roundup

Schmid, Alexandra S / Goldberg, Stephen R / Sanchez, Carol M

The journal of corporate accounting & finance Vol. 25, No. 2 (2013/14), p. 3-10

what is the board's role?

2014 Volume 25, Issue 2, Page(s) 3–10

Author's details	Alexandra S. Schmid, Carol M. Sanchez, and Stephen R. Goldberg
Language	English
Publisher	Wiley
Publishing place	Hoboken, NJ
Document type	Article
ZDB-ID	1113073-8 ; 2054493-5
ISSN	1097-0053 ; 1044-8136
ISSN (online)	1097-0053
ISSN	1044-8136
Database	ECONomics Information System

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Book: Notfallmedizin für Heilpraktikerinnen und Heilpraktiker

Schmid, Markus

2023

Author's details	Markus Schmid - Staatlich examinierter Rettungsassistent und später Notfallsanitäter - Seit 2005 Heilpraktiker - 2005¿2020 Dozent in einer der größten Heilprakitkerschulen Münchens - Seit 2009 Berufsschullehrer für Rettungsassistenten / Notfallsanitäter an einer Rettungsdienstschule in München - Seit 2010 In-House-Notfallschulungen für Arzt-, HP-, Physio- und Osteopathiepraxen im ganzen Bundesgebiet - Seit 2013 Dozent für den bayerischen und deutschen Hausärzteverband; Weiterbildung medizinischer Fachangestellter - Seit 2019 eigene Heilpraktikerschule, "D2HP" in Miesbach. Hier setzt er ein neues, erfolgreiches Lernsystem für die Vorbereitung auf die amtsärztliche Überprüfung um
Keywords	Notfallmedizin ; Notfälle ; Notfallmedizin für Heilpraktiker ; Notfallmaßnahmen Heilpraktikerprüfung ; Notfallmaßnahmen Heilpraktikerpraxis ; Notfall Heilpraktikerausbildung ; Prüfungstraining Notfallmedizin ; Notfälle in der Heilpraktikerpraxis ; < ; P> ; Notfälle in der Heilpraktikerpraxis< ; /P>
Language	German
Size	206 p.
Publisher	Urban & Fischer
Document type	Book
Note	PDA Manuell_23
Format	214 x 271 x 12
ISBN	9783437551932 ; 3437551930
Database	PDA

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Article: Analysing radon accumulation in the home by flexible M-quantile mixed effect regression

Borgoni, R / A. Carcagní / N. Salvati / T. Schmid

Stochastic environmental research and risk assessment. 2019 Feb., v. 33, no. 2

2019

Abstract: ... concentrations. In this paper, a semiparametric random-effect M-quantile model is introduced to model radon ...

Abstract	Radon is a noble gas that occurs in nature as a decay product of uranium. Radon is the principal contributor to natural background radiation and is considered to be one of the major leading causes of lung cancer. The main concern revolves around indoor environments where radon accumulates and reaches high concentrations. In this paper, a semiparametric random-effect M-quantile model is introduced to model radon concentration inside a building, and a way to estimate the model within the framework of robust maximum likelihood is presented. Using data collected in a monitoring survey carried out in the Lombardy Region (Italy) in 2003–2004, we investigate the impact of a number of factors, such as geological typologies of the soil and building characteristics, on indoor concentration. The proposed methodology permits the identification of building typologies prone to a high concentration of the pollutant. It is shown how these effects are largely not constant across the entire distribution of indoor radon concentration, making the suggested approach preferable to ordinary regression techniques since high concentrations are usually of concern. Furthermore, we demonstrate how our model provides a natural way of identifying those areas more prone to high concentration, displaying them by thematic maps. Understanding how buildings’ characteristics affect indoor concentration is fundamental both for preventing the gas from accumulating in new buildings and for mitigating those situations where the amount of radon detected inside a building is too high and has to be reduced.
Keywords	buildings ; data collection ; models ; monitoring ; neoplasms ; pollutants ; radon ; soil ; statistical analysis ; surveys ; thematic maps ; uranium ; Italy
Language	English
Dates of publication	2019-02
Size	p. 375-394.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1481263-0
ISSN	1436-3259 ; 1435-151X ; 1436-3240 ; 0931-1955
ISSN (online)	1436-3259 ; 1435-151X
ISSN	1436-3240 ; 0931-1955
DOI	10.1007/s00477-018-01643-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Short-term high altitude exposure at 3454 m is well tolerated in patients with stable heart failure.

Schmid, Jean-Paul / Nobel, Daniel / Brugger, Nicolas / Novak, Jan / Palau, Patricia / Trepp, Anja / Wilhelm, Matthias / Saner, Hugo

European journal of heart failure

2015 Volume 17, Issue 2, Page(s) 182–186

Abstract: ... at 540 and 3454 m after an ascent using public transport. Assessments of exercise capacity ... at high altitude. Mean resting heart rate increased from 74.3 ± 12.3 to 83.3 ± 13.4 b.p.m., P < 0.001. No ... statistically significant difference in premature ventricular contractions (92 ± 150/h at 540 m vs. 111 ± 196/h ...

Abstract	Aims: High altitude exposure for the purpose of tourism is very popular in mountainous regions and is considered to be safe for patients with stable CAD and preserved LV function. The purpose of this study was to evaluate the haemodynamic response to exercise and electrical stability by Holter monitoring in patients with chronic heart failure (HF) and an EF <40%. Methods and results: We studied 29 HF patients with a peak VO2 >50% of the predicted (25 men, age 60.0 ± 8.9 years, EF 28.8 ± 5.4%) at 540 and 3454 m after an ascent using public transport. Assessments of exercise capacity (cardiopulmonary exercise test), haemodynamic response (inert gas rebreathing system), and susceptibility to arrhythmias (Holter ECG recording) were performed. None of the patients (19 with ischaemic heart disease, 11 with an implantable cardioverter defibrillator) had to return prematurely to the lowland site. Two patients presented symptoms of mild mountain sickness, and one patient developed a self-limited ventricular tachycardia during maximal exercise at high altitude. Mean peak VO2 at the lowland site was 18.5 ± 3.6 mL/min/kg and decreased by 22.2% (P < 0.001) at high altitude. Mean resting heart rate increased from 74.3 ± 12.3 to 83.3 ± 13.4 b.p.m., P < 0.001. No statistically significant difference in premature ventricular contractions (92 ± 150/h at 540 m vs. 111 ± 196/h at 3454 m, P = 0.284) was noted. Conclusion: Patients with stable chronic HF and a peak VO2 >50% of the predicted tolerate a short exposure to an altitude of 3454 m well, even during exercise. However, it cannot be excluded that the susceptibility to ventricular tachyarrhythmias during exercise is increased in some subjects.
MeSH term(s)	Adult ; Aged ; Altitude Sickness/physiopathology ; Cardiac Output ; Electrocardiography, Ambulatory ; Exercise Test/methods ; Exercise Tolerance/physiology ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Oxygen Consumption ; Prospective Studies ; Ultrasonography
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.227
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Article ; Online: Modulation of Ambient Temperature-Dependent Flowering in Arabidopsis thaliana by Natural Variation of FLOWERING LOCUS M.

Lutz, Ulrich / Posé, David / Pfeifer, Matthias / Gundlach, Heidrun / Hagmann, Jörg / Wang, Congmao / Weigel, Detlef / Mayer, Klaus F X / Schmid, Markus / Schwechheimer, Claus

PLoS genetics

2015 Volume 11, Issue 10, Page(s) e1005588

Abstract: ... this ambient temperature pathway has gained increasing importance. In Arabidopsis thaliana, FLOWERING LOCUS M ...

Abstract	Plants integrate seasonal cues such as temperature and day length to optimally adjust their flowering time to the environment. Compared to the control of flowering before and after winter by the vernalization and day length pathways, mechanisms that delay or promote flowering during a transient cool or warm period, especially during spring, are less well understood. Due to global warming, understanding this ambient temperature pathway has gained increasing importance. In Arabidopsis thaliana, FLOWERING LOCUS M (FLM) is a critical flowering regulator of the ambient temperature pathway. FLM is alternatively spliced in a temperature-dependent manner and the two predominant splice variants, FLM-ß and FLM-δ, can repress and activate flowering in the genetic background of the A. thaliana reference accession Columbia-0. The relevance of this regulatory mechanism for the environmental adaptation across the entire range of the species is, however, unknown. Here, we identify insertion polymorphisms in the first intron of FLM as causative for accelerated flowering in many natural A. thaliana accessions, especially in cool (15°C) temperatures. We present evidence for a potential adaptive role of this structural variation and link it specifically to changes in the abundance of FLM-ß. Our results may allow predicting flowering in response to ambient temperatures in the Brassicaceae.
MeSH term(s)	Alternative Splicing/genetics ; Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis Proteins/biosynthesis ; Arabidopsis Proteins/genetics ; Flowers/genetics ; Gene Expression Regulation, Plant ; Global Warming ; MADS Domain Proteins/biosynthesis ; MADS Domain Proteins/genetics ; Mutagenesis, Insertional/genetics ; Polymorphism, Genetic ; Seasons ; Temperature
Chemical Substances	Arabidopsis Proteins ; FLM protein, Arabidopsis ; MADS Domain Proteins
Language	English
Publishing date	2015-10-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1005588
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Article ; Online: Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells.

Schwertheim, Suzan / Wein, Frederik / Lennartz, Klaus / Worm, Karl / Schmid, Kurt Werner / Sheu-Grabellus, Sien-Yi

Journal of cancer research and clinical oncology

2017 Volume 143, Issue 7, Page(s) 1143–1154

Abstract: ... cell differentiation and tumor progression. Curcumin arrested cell growth at the G2/M phase.: Conclusions: Curcumin ... increases the expression of redifferentiation markers and induces G2/M arrest, apoptosis, and downregulation ...

Abstract	Purpose: The therapy of unresectable advanced thyroid carcinomas shows unfavorable outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently contributes to therapeutic resistance; the radioiodine therapy often fails due to the loss of differentiated functions in advanced thyroid carcinomas. Curcumin is known for its anticancer properties in a series of cancers, but only few studies have focused on thyroid cancer. Our aim was to evaluate curcumin's molecular mechanisms and to estimate if curcumin could be a new therapeutic option in advanced thyroid cancer. Methods: Human thyroid cancer cell lines TPC-1 (papillary), FTC-133 (follicular), and BHT-101 (anaplastic) were treated with curcumin. Using real-time PCR analysis, we investigated microRNA (miRNA) and mRNA expression levels. Cell cycle, Annexin V/PI staining, and caspase-3 activity analysis were performed to detect apoptosis. NF-κB p65 activity and cell proliferation were analyzed using appropriate ELISA-based colorimetric assay kits. Results: Treatment with 50 μM curcumin significantly increased the mRNA expression of the differentiation genes thyroglobulin (TG) and sodium iodide symporter (NIS) in all three cell lines and induced inhibition of cell proliferation, apoptosis, and decrease of NF-κB p65 activity. The miRNA expression analyses showed a significant deregulation of miRNA-200c, -21, -let7c, -26a, and -125b, known to regulate cell differentiation and tumor progression. Curcumin arrested cell growth at the G2/M phase. Conclusions: Curcumin increases the expression of redifferentiation markers and induces G2/M arrest, apoptosis, and downregulation of NF-κB activity in thyroid carcinoma cells. Thus, curcumin appears to be a promising agent to overcome resistance to the conventional cancer therapy.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Blotting, Western ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Curcumin/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Gene Expression Profiling ; Humans ; NF-kappa B/antagonists & inhibitors ; Real-Time Polymerase Chain Reaction ; Thyroid Neoplasms/pathology ; Transcriptome
Chemical Substances	Antineoplastic Agents ; NF-kappa B ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2017-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-017-2380-z
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