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Article ; Online: Combination of UHPLC-Q Exactive-Orbitrap MS, Bioinformatics and Molecular Docking to Reveal the Mechanism of Huan-Lian-Jie-Du Decoction in the Treatment of Diabetic Encephalopathy.

Cao, Dong-Min / Liang, Qing-Feng / Zhang, Zhi-Tong / He, Wen-Jiao / Tang, Dan

2023 Volume 20, Issue 9, Page(s) e202300434

Abstract: Diabetic encephalopathy (DE) is a serious complication of diabetes, which affects patients' quality of life. We aimed to explore HLJDD in the treatment of DE by LC/MS and bioinformatics. UPLC-Q Exactive-Orbitrap MS was employed to clarify the compounds. ... ...

Abstract	Diabetic encephalopathy (DE) is a serious complication of diabetes, which affects patients' quality of life. We aimed to explore HLJDD in the treatment of DE by LC/MS and bioinformatics. UPLC-Q Exactive-Orbitrap MS was employed to clarify the compounds. The modules and hub targets of DE were gained from WGCNA. Subsequently, an Herb-Compound-Target network was constructed and enrichment analysis was used. In addition, a protein-protein interaction (PPI) network was constructed and molecular docking was used to verify the above analysis. As result, 138 compounds and 10 prototypes in brain were identified. In network pharmacology, 8 modules and 5692 hub targets were obtained from WGCNA. An Herb-Compound-Target network was constructed by 4 herbs, 10 compounds and 56 targets. The enrichment analysis showed that the treatment of DE with HLJDD involve oxidative stress and neuroprotection. Beside, SRC, JUN, STAT3, MAPK1 and PIK3R1 were identified and as hub targets of HLJDD in treating DE. Moreover, Molecular docking showed that five hub targets had strong affinity with the corresponding alkaloids. Therefore, we explored the underlying mechanisms of HLJDD in the treatment of DE and to provide the theoretical and scientific basis for subsequent experimental studies and clinical applications.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Drugs, Chinese Herbal/pharmacology ; Chromatography, High Pressure Liquid ; Quality of Life ; Computational Biology ; Diabetes Mellitus/drug therapy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Risk of diabetes in stroke patients who used Bu Yang Huan Wu Tang: A nationwide propensity-score matched study.

Weng, Shu-Wen / Chang, Chuen-Chau / Chen, Ta-Liang / Yeh, Chun-Chieh / Hu, Chaur-Jong / Lane, Hsin-Long / Liao, Chien-Chang / Shih, Chun-Chuan

Phytomedicine : international journal of phytotherapy and phytopharmacology

2020 Volume 80, Page(s) 153376

Abstract: ... for stroke patients in Chinese population, but little is known about the effect of Bu Yang Huan Wu Tang ...

Abstract	Background: The utilization of traditional Chinese medicine is a common therapeutic approach for stroke patients in Chinese population, but little is known about the effect of Bu Yang Huan Wu Tang (BYHWT) on post-stroke diabetes. Purpose: We aimed to evaluate the risk of diabetes in stroke patients who used BYHWT. Study design: A retrospective cohort study based on a real-world database was conducted. Methods: Newly diagnosed stroke patients receiving inpatient care from 2000 to 2004 were identified using a large-scale insurance database in Taiwan. Propensity score matching was used to select eligible stroke patients who did (n = 9849) and did not (n = 9849) receive BYHWT. These two groups were followed up until the end of 2009 to track incident diabetes. Cox proportional hazard models were used to calculate the adjusted hazard rations (HRs) and 95% confidence intervals (CIs) for post-stroke diabetes associated with BYHWT during the follow-up period. Results: Stroke patients who used BYHWT had a reduced incidence of diabetes (14.1% vs. 19.0%, p < 0.0001) and reduced risk of diabetes (HR 0.77; 95% CI 0.72 to 0.83) compared with the control group. The association between BYHWT and reduced risk of post-stroke diabetes was significant across sexe, age group, and stroke subtype. Additionally, the use of BYHWT was associated with a reduced risk of post-stroke diabetes even after excluding the initial three months of diabetes cases in the sensitivity analysis. Conclusions: Stroke patients who received BYHWT therapy had a reduced risk of diabetes, and a positive effect was observed in various subgroups. However, future clinical trials will be necessary to validate the present findings and identify the biochemical mechanism involved.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Diabetes Mellitus/prevention & control ; Drugs, Chinese Herbal/therapeutic use ; Female ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; Stroke/complications ; Stroke/epidemiology ; Taiwan/epidemiology
Chemical Substances	Drugs, Chinese Herbal ; bu-yang-huan-wu-tang
Language	English
Publishing date	2020-10-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2020.153376
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Article: Risk of diabetes in stroke patients who used Bu Yang Huan Wu Tang: A nationwide propensity-score matched study

Weng, Shu-Wen / Chang, Chuen-Chau / Chen, Ta-Liang / Yeh, Chun-Chieh / Hu, Chaur-Jong / Lane, Hsin-Long / Liao, Chien-Chang / Shih, Chun-Chuan

Phytomedicine. 2021 Jan., v. 80

2021

Abstract: ... patients in Chinese population, but little is known about the effect of Bu Yang Huan Wu Tang (BYHWT ...

Abstract	The utilization of traditional Chinese medicine is a common therapeutic approach for stroke patients in Chinese population, but little is known about the effect of Bu Yang Huan Wu Tang (BYHWT) on post-stroke diabetes.We aimed to evaluate the risk of diabetes in stroke patients who used BYHWT.A retrospective cohort study based on a real-world database was conducted.Newly diagnosed stroke patients receiving inpatient care from 2000 to 2004 were identified using a large-scale insurance database in Taiwan. Propensity score matching was used to select eligible stroke patients who did (n = 9849) and did not (n = 9849) receive BYHWT. These two groups were followed up until the end of 2009 to track incident diabetes. Cox proportional hazard models were used to calculate the adjusted hazard rations (HRs) and 95% confidence intervals (CIs) for post-stroke diabetes associated with BYHWT during the follow-up period.Stroke patients who used BYHWT had a reduced incidence of diabetes (14.1% vs. 19.0%, p < 0.0001) and reduced risk of diabetes (HR 0.77; 95% CI 0.72 to 0.83) compared with the control group. The association between BYHWT and reduced risk of post-stroke diabetes was significant across sexe, age group, and stroke subtype. Additionally, the use of BYHWT was associated with a reduced risk of post-stroke diabetes even after excluding the initial three months of diabetes cases in the sensitivity analysis.Stroke patients who received BYHWT therapy had a reduced risk of diabetes, and a positive effect was observed in various subgroups. However, future clinical trials will be necessary to validate the present findings and identify the biochemical mechanism involved.
Keywords	Oriental traditional medicine ; cohort studies ; databases ; diabetes ; insurance ; risk ; risk assessment ; risk reduction ; stroke ; therapeutics ; Taiwan
Language	English
Dates of publication	2021-01
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-light
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2020.153376
Database	NAL-Catalogue (AGRICOLA)

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Article: The effects of Bu Yang Huan Wu Tang on post-stroke epilepsy: a nationwide matched study.

Weng, Shu-Wen / Chen, Ta-Liang / Yeh, Chun-Chieh / Lane, Hsin-Long / Liao, Chien-Chang / Shih, Chun-Chuan

Clinical epidemiology

2018 Volume 10, Page(s) 1839–1850

Abstract: Objective: To compare the long-term risk of epilepsy in stroke patients who use Bu Yang Huan Wu ...

Abstract	Objective: To compare the long-term risk of epilepsy in stroke patients who use Bu Yang Huan Wu Tang (BYHWT) and those who do not. Methods: In the Taiwanese national insurance claims data, we identified newly diagnosed stroke patients receiving inpatient care in the years 2000-2004. Using propensity score-matched pairs to balance the baseline characteristics, we selected eligible stroke patients who did (n=8,971) and did not (n=8,971) receive BYHWT. These two groups were followed up until the end of 2009 to track the occurrence of epilepsy. We used Cox proportional hazard models to calculate the adjusted HRs and 95% CIs for post-stroke epilepsy during the follow-up period according to BYHWT use. Results: Compared with the control group, stroke patients with BYHWT had a reduced risk of epilepsy during the 5-9 years of the follow-up period (HR 0.69, 95% CI 0.61-0.77). The association between BYHWT and reduced post-stroke epilepsy was significant in various subgroups of stroke patients. There was a dose-dependent decrease in the frequency of epilepsy with increasing quantities of BYHWT use from 1 package (HR 0.77, 95% CI 0.66-0.90) to ≥6 packages (HR 0.52, 95% CI 0.42-0.65). Conclusion: Stroke patients who received BYHWT therapy had a reduced long-term risk of epilepsy, and the beneficial effect could be observed in various subgroups. However, future clinical trials will be necessary to corroborate the present findings and identify the biochemical mechanism involved.
Language	English
Publishing date	2018-12-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494772-6
ISSN	1179-1349
ISSN	1179-1349
DOI	10.2147/CLEP.S175677
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Bao pi huan qie yu ai zi bing yu fang

Liang, Hao

bao pi huan qie jiang di HIV gan ran feng xian de tui guang mo shi tan suo

2014

Author's details	Liang Hao zhu bian
MeSH term(s)	HIV Infections/prevention & control ; Circumcision, Male
Language	Chinese
Size	273 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
ISBN	9787504666550 ; 7504666556
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea) as a cerebral-protecting compound.

Watanabe, N / Obuchi, T / Tamai, M / Araki, H / Omura, S / Yang, J S / Yu, D Q / Liang, X T / Huan, J H

Planta medica

1990 Volume 56, Issue 1, Page(s) 48–52

Abstract: Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay ...

Abstract	Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.
MeSH term(s)	Adenosine/analogs & derivatives ; Agaricales/analysis ; Animals ; Brain/drug effects ; Male ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred ICR ; Molecular Structure ; Spectrum Analysis
Chemical Substances	6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine (123369-41-5) ; Adenosine (K72T3FS567)
Language	English
Publishing date	1990-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-2006-960882
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A novel N6-substituted adenosine isolated from Mi Huan Jun (Armillaria mellea) as a cerebral-protecting compound

Watanabe, N / Obuchi, T / Tamai, M / Araki, H / Omura, S / Yang, J.S / Yu, D.Q / Liang, X.T / Huan, J.H

Planta medica. Feb 1990. v. 56 (1)

1990

Keywords	Armillaria mellea ; adenosine ; cytokinins ; mycelium ; plant extracts
Language	English
Dates of publication	1990-02
Size	p. 48-52.
Document type	Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
Database	NAL-Catalogue (AGRICOLA)

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Article: A Novel N6-Substituted Adenosine Isolated from Mi Huan Jun (Armillaria mellea) as a Cerebral-Protecting Compound

Watanabe, Naoharu / Obuchi, Tadashi / Tamai, Masaharu / Araki, Hiroaki / Omura, Sadafumi / Jun-Shan, Yang / De-Quan, Yu / Xiao-Tian, Liang / Jun-Hua, Huan

Planta Medica

1990 Volume 56, Issue 01, Page(s) 48–52

Abstract: Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay ...

Abstract	Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridylmethylamino)-9-β-ribofuranosylpurine (1) on the basis of its UV, mass, 1 H-NMR, and 13 C-NMR spectra.
Keywords	cytokinin ; cerebral-protecting compound
Language	English
Publishing date	1990-02-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-2006-960882
Database	Thieme publisher's database

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Book: Mo huan xian shi zhu yi xiao shuo

Wu, Liang / Zhang, Ping / Zong, Renfa

(Xin shi qi liu pai xiao shuo jing xuan cong shu ; 新时期流派小说精选丛书)

1988

Author's details	Wu liang, zhang ping, zong ren fa bian
Series title	Xin shi qi liu pai xiao shuo jing xuan cong shu 新时期流派小说精选丛书
Keywords	Chinese fiction
Language	Chinese
Size	2, 11, 309 p., 20 cm
Edition	Di 1 ban
Publisher	Shi dai wen yi chu ban she
Publishing place	Chang chun
Document type	Book
ISBN	7538701133 ; 9787538701135
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: IL-2/IL-2R signaling and IL-2Rα-targeted therapy in anaplastic large cell lymphoma.

Liang, Huan-Chang

Pathologie (Heidelberg, Germany)

2022

Abstract: Anaplastic large cell lymphoma (ALCL) is a CD30-positive non-Hodgkin's T‑cell lymphoma. Despite the implementation of CD30 antibody-drug conjugate-targeted therapy into front-line treatment regimens, the prognosis of some subtypes of the disease remains ... ...

Title translation	IL-2/IL-2R-Signalübertragung und gezielte IL-2Rα-Therapie bei anaplastischem großzelligem Lymphom.
Abstract	Anaplastic large cell lymphoma (ALCL) is a CD30-positive non-Hodgkin's T‑cell lymphoma. Despite the implementation of CD30 antibody-drug conjugate-targeted therapy into front-line treatment regimens, the prognosis of some subtypes of the disease remains unsatisfactory. In the relapsed/refractory setting, effective second-line treatment options are still lacking. However, it has been reported that blockade of direct downstream targets of activator protein‑1 (AP-1) transcription factors, which are highly dysregulated in ALCL, results in complete and sustained remission in late-stage relapsed/refractory anaplastic lymphoma kinase (ALK)-positive ALCL patients. Moreover, it has been identified that involvement of the BATF3/AP‑1 module promotes lymphomagenesis via oncogenic BATF3/IL-2/IL-2R signaling through hyperphosphorylation of ERK1/2, STAT1, and STAT5 in ALCL cells regardless of their ALK status. Therefore, targeting BATF3/IL-2/IL-2R signaling may represent a novel therapeutic alternative for ALCL patients.
Language	English
Publishing date	2022-09-12
Publishing country	Germany
Document type	Journal Article
ISSN	2731-7196
ISSN (online)	2731-7196
DOI	10.1007/s00292-022-01108-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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