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  1. Article ; Online: Sotrovimab drives SARS-CoV-2 omicron variant evolution in immunocompromised patients.

    Destras, Grégory / Bal, Antonin / Simon, Bruno / Lina, Bruno / Josset, Laurence

    The Lancet. Microbe

    2022  Volume 3, Issue 8, Page(s) e559

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Humans ; Immunocompromised Host ; SARS-CoV-2/genetics ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; sotrovimab (1MTK0BPN8V)
    Language English
    Publishing date 2022-05-27
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00120-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 spike 340 and 337 mutations in Omicron variants are selected after Sotrovimab infusion in immunocompromised patients

    destras, gregory / bal, antonin / simon, bruno / lina, bruno / josset, laurence

    medRxiv

    Abstract: After monoclonal antibody sotrovimab implementation, Rockett et al have warned on March 9th about two resistant mutations in the spike at position 337 and 340 occurring within the first week in four immunocompromised patients infected by a Delta variant ... ...

    Abstract After monoclonal antibody sotrovimab implementation, Rockett et al have warned on March 9th about two resistant mutations in the spike at position 337 and 340 occurring within the first week in four immunocompromised patients infected by a Delta variant and resulting in viable infection up to 25 days. As sotrovimab is currently the only effective treatment against BA.1 lineage of Omicron variant, we investigated the presence of these mutations in our 22,908 Omicron sequences performed from December 2021 to March 2022. Among 25 Omicron sequences with S:337 and S:340 substitutions, 9 were reported in six patients who had available clinical data and a follow up. All were immunicompromised, and presented a rapid selection of these mutations after sotrovimab monotherapy infusion. With these findings, we underscore that although these mutations are rare, they have been exclusively reported in immunocompromised patients treated with sotrovimab. We urge to consider monoclonal antibody as monotherapy in immunocompromised patients as a risk for escape mutants selection.
    Keywords covid19
    Language English
    Publishing date 2022-04-16
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.04.08.22273513
    Database COVID19

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  3. Article ; Online: Investigation of vaccine breakthrough infections by vaccination scheme during the Delta variant wave in France.

    Bal, Antonin / Destras, Grégory / Simon, Bruno / Giannoli, Jean-Marc / Morfin, Florence / Lina, Bruno / Josset, Laurence

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 7, Page(s) 1032–1034

    MeSH term(s) Communicable Diseases ; France/epidemiology ; Humans ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.02.034
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  4. Article ; Online: Systematic SARS-CoV-2 screening in cerebrospinal fluid during the COVID-19 pandemic.

    Destras, Grégory / Bal, Antonin / Escuret, Vanessa / Morfin, Florence / Lina, Bruno / Josset, Laurence

    The Lancet. Microbe

    2020  Volume 1, Issue 4, Page(s) e149

    MeSH term(s) Antibodies, Viral ; COVID-19/diagnosis ; Humans ; Mass Screening ; Pandemics ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(20)30066-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Detection and prevalence of SARS-CoV-2 co-infections during the Omicron variant circulation in France.

    Bal, Antonin / Simon, Bruno / Destras, Gregory / Chalvignac, Richard / Semanas, Quentin / Oblette, Antoine / Quéromès, Grégory / Fanget, Remi / Regue, Hadrien / Morfin, Florence / Valette, Martine / Lina, Bruno / Josset, Laurence

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6316

    Abstract: From December 2021-February 2022, an intense and unprecedented co-circulation of SARS-CoV-2 variants with high genetic diversity raised the question of possible co-infections between variants and how to detect them. Using 11 mixes of Delta:Omicron ... ...

    Abstract From December 2021-February 2022, an intense and unprecedented co-circulation of SARS-CoV-2 variants with high genetic diversity raised the question of possible co-infections between variants and how to detect them. Using 11 mixes of Delta:Omicron isolates at different ratios, we evaluated the performance of 4 different sets of primers used for whole-genome sequencing and developed an unbiased bioinformatics method for the detection of co-infections involving genetically distinct SARS-CoV-2 lineages. Applied on 21,387 samples collected between December 6, 2021 to February 27, 2022 from random genomic surveillance in France, we detected 53 co-infections between different lineages. The prevalence of Delta and Omicron (BA.1) co-infections and Omicron lineages BA.1 and BA.2 co-infections were estimated at 0.18% and 0.26%, respectively. Among 6,242 hospitalized patients, the intensive care unit (ICU) admission rates were 1.64%, 4.81% and 15.38% in Omicron, Delta and Delta/Omicron patients, respectively. No BA.1/BA.2 co-infections were reported among ICU admitted patients. Among the 53 co-infected patients, a total of 21 patients (39.6%) were not vaccinated. Although SARS-CoV-2 co-infections were rare in this study, their proper detection is crucial to evaluate their clinical impact and the risk of the emergence of potential recombinants.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; COVID-19/epidemiology ; Prevalence ; Coinfection/epidemiology
    Language English
    Publishing date 2022-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33910-9
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  6. Article ; Online: Predictive factors for severe placental damage in pregnant women with SARS-CoV-2 infection.

    Damman, Elise / Trecourt, Alexis / de la Fournière, Benoit / Lebreton, Frédérique / Gaillot-Durand, Lucie / Fichez, Axel / Chauvy, Lauriane / Thonnon, Cyrielle / Destras, Gregory / Devouassoux-Shisheboran, Mojgan / Allias, Fabienne

    Placenta

    2023  Volume 136, Page(s) 1–7

    Abstract: Introduction: SARS-Cov-2 infection during pregnancy can lead to severe placental lesions characterized by massive perivillous fibrin deposition, histiocytic intervillositis and trophoblast necrosis. Diffuse placental damage of this kind is rare, but can ...

    Abstract Introduction: SARS-Cov-2 infection during pregnancy can lead to severe placental lesions characterized by massive perivillous fibrin deposition, histiocytic intervillositis and trophoblast necrosis. Diffuse placental damage of this kind is rare, but can sometimes lead to obstetric complications, such as intrauterine fetal death (IUFD). The objectives of this study were to identify possible predictors of severe placental lesions.
    Methods: We retrospectively studied 96 placentas from SARS-Cov-2 positive pregnant women who gave birth between March 2020 and March 2022. Cases with and without severe placental lesions were compared in terms of clinical and laboratory findings.
    Results: Twelve of the 96 patients had severe placental lesions. There was no significant association with diabetes, obesity or severe clinical maternal disease. In contrast, presence of severe placental lesions was significantly associated with neonatal intensive care, cesarean section, prematurity, IUFD, intrauterine growth restriction (IUGR), gestational age, maternal hypofibrinogenemia and thrombocytopenia. No cases of severe placental lesions were observed in vaccinated patients or in those with the Omicron variant.
    Discussion: In these patients, severe placental lesions due to SARS-Cov-2 were significantly associated with the presence of coagulation abnormalities (hypofibrinogenemia and thrombocytopenia), IUGR and gestational age. These results support laboratory and ultrasound monitoring of these parameters in pregnant women with SARS-Cov-2 infection, especially during the second trimester, to predict potential negative fetal outcomes.
    MeSH term(s) Infant, Newborn ; Female ; Pregnancy ; Humans ; Placenta/pathology ; COVID-19/complications ; COVID-19/pathology ; SARS-CoV-2 ; Pregnant Women ; Cesarean Section/adverse effects ; Retrospective Studies ; Afibrinogenemia/complications ; Afibrinogenemia/pathology ; Stillbirth ; Fetal Death/etiology ; Pregnancy Complications, Infectious/pathology ; Fetal Growth Retardation/pathology
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2023.03.004
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    Zs.A 1578: Show issues Location:
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  7. Article ; Online: Systematic SARS-CoV-2 screening in cerebrospinal fluid during the COVID-19 pandemic

    Grégory Destras / Antonin Bal / Vanessa Escuret / Florence Morfin / Bruno Lina / Laurence Josset

    The Lancet Microbe, Vol 1, Iss 4, Pp e149- (2020)

    2020  

    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A Short COVID-19 Outbreak in an Isolated Pacific Island: A Retrospective Study.

    Couteaux, Clément / Gahetau, Eliuti / Robic, Geneviève / Houillon, Daniel / Lenei, Falakiko / Riou, Olivier / Lhomme, Vincent / Josset, Laurence / Destras, Gregory / Bal, Antonin / Hugues, Isabelle / Roche, Benjamin / Worms, Bernadette / Etard, Jean-François

    Asia-Pacific journal of public health

    2022  Volume 34, Issue 5, Page(s) 586–588

    MeSH term(s) COVID-19 ; Disease Outbreaks/prevention & control ; Humans ; Pacific Islands/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2022-06-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 1025444-4
    ISSN 1941-2479 ; 1010-5395
    ISSN (online) 1941-2479
    ISSN 1010-5395
    DOI 10.1177/10105395221106863
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  9. Article ; Online: Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France.

    Quéromès, Grégory / Destras, Grégory / Bal, Antonin / Regue, Hadrien / Burfin, Gwendolyne / Brun, Solenne / Fanget, Rémi / Morfin, Florence / Valette, Martine / Trouillet-Assant, Sophie / Lina, Bruno / Frobert, Emilie / Josset, Laurence

    Emerging microbes & infections

    2021  Volume 10, Issue 1, Page(s) 167–177

    Abstract: During routine molecular surveillance of SARS-CoV-2 performed at the National Reference Center of Respiratory Viruses (Lyon, France) ( ...

    Abstract During routine molecular surveillance of SARS-CoV-2 performed at the National Reference Center of Respiratory Viruses (Lyon, France) (
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Base Sequence ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; Cross Infection/epidemiology ; Cross Infection/immunology ; Cross Infection/virology ; Cytokines/immunology ; Female ; Frameshift Mutation ; France/epidemiology ; Genetic Variation ; Genome, Viral ; Hospitalization ; Humans ; Immunity ; Inflammation ; Male ; Phylogeny ; SARS-CoV-2/genetics ; Sequence Deletion ; Viral Proteins/genetics ; Viral Proteins/immunology
    Chemical Substances Cytokines ; ORF6 protein, SARS-CoV-2 ; Viral Proteins
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2021.1872351
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  10. Article ; Online: SARS-CoV-2 Omicron Variant, Lineage BA.1, Is Associated with Lower Viral Load in Nasopharyngeal Samples Compared to Delta Variant.

    Sentis, Célia / Billaud, Geneviève / Bal, Antonin / Frobert, Emilie / Bouscambert, Maude / Destras, Gregory / Josset, Laurence / Lina, Bruno / Morfin, Florence / Gaymard, Alexandre / The Covid-Diagnosis Hcl Study Group

    Viruses

    2022  Volume 14, Issue 5

    Abstract: Objectives: High viral load in upper respiratory tract specimens observed for Delta cases might contribute to its increased infectivity compared to the other variant. However, it is not yet documented if the Omicron variant's enhanced infectivity is ... ...

    Abstract Objectives: High viral load in upper respiratory tract specimens observed for Delta cases might contribute to its increased infectivity compared to the other variant. However, it is not yet documented if the Omicron variant's enhanced infectivity is also related to a higher viral load. Our aim was to determine if the Omicron variant's spread is also related to higher viral loads compared to the Delta variant.
    Methods: Nasopharyngeal swabs, 129 (Omicron) and 85 (Delta), from Health Care Workers were collected during December 2021 at the University Hospital of Lyon, France. Cycle threshold (Ct) for the RdRp target of cobas
    Results: Herein, we showed that the RT-PCR Ct values in Health Care Workers sampled within 5 days after symptom onset were significantly higher for Omicron cases than Delta cases (21.7 for Delta variant and 23.8 for Omicron variant,
    Conclusions: This result supports the studies showing that the increased transmissibility of Omicron is related to other mechanisms than higher virus excretion.
    MeSH term(s) COVID-19 ; Humans ; Nasopharynx ; SARS-CoV-2/genetics ; Viral Load
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14050919
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