Result 1 - 10 of total 608
Contemporary British History
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #610442 |
| Database | COVID19 |
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2017 Volume 28, Issue 1, Page(s) 110–142
Abstract: This article explores the relationship between emotions, space and politics in 1980s London, using the Greater London Council, childcare, and racial harassment as particular foci. It brings together political history, the history of emotions, and ... ...
| Abstract | This article explores the relationship between emotions, space and politics in 1980s London, using the Greater London Council, childcare, and racial harassment as particular foci. It brings together political history, the history of emotions, and geography to offer a new way of thinking about political culture, as well as contributing to the history of the 1980s. It is based upon archival sources. |
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| Language | English |
| Publishing date | 2017-03-01 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2077480-1 |
| ISSN | 1477-4674 ; 0955-2359 |
| ISSN (online) | 1477-4674 |
| ISSN | 0955-2359 |
| DOI | 10.1093/tcbh/hww055 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of the American Medical Informatics Association : JAMIA
2023 Volume 30, Issue 12, Page(s) 2064–2071
Abstract: Objectives: A scoping review identified interventions for optimizing hospital medication alerts post-implementation, and characterized the methods used, the populations studied, and any effects of optimization.: Materials and methods: A structured ... ...
| Abstract | Objectives: A scoping review identified interventions for optimizing hospital medication alerts post-implementation, and characterized the methods used, the populations studied, and any effects of optimization. Materials and methods: A structured search was undertaken in the MEDLINE and Embase databases, from inception to August 2023. Articles providing sufficient information to determine whether an intervention was conducted to optimize alerts were included in the analysis. Snowball analysis was conducted to identify additional studies. Results: Sixteen studies were identified. Most were based in the United States and used a wide range of clinical software. Many studies used inpatient cohorts and conducted more than one intervention during the trial period. Alert types studied included drug-drug interactions, drug dosage alerts, and drug allergy alerts. Six types of interventions were identified: alert inactivation, alert severity reclassification, information provision, use of contextual information, threshold adjustment, and encounter suppression. The majority of interventions decreased alert quantity and enhanced alert acceptance. Alert quantity decreased with alert inactivation by 1%-25.3%, and with alert severity reclassification by 1%-16.5% in 6 of 7 studies. Alert severity reclassification increased alert acceptance by 4.2%-50.2% and was associated with a 100% acceptance rate for high-severity alerts when implemented. Clinical errors reported in 4 studies were seen to remain stable or decrease. Discussion: Post-implementation medication optimization interventions have positive effects for clinicians when applied in a variety of settings. Less well reported are the impacts of these interventions on the clinical care of patients, and how endpoints such as alert quantity contribute to changes in clinician and pharmacist perceptions of alert fatigue. Conclusion: Well conducted alert optimization can reduce alert fatigue by reducing overall alert quantity, improving clinical acceptance, and enhancing clinical utility. |
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| MeSH term(s) | Humans ; Medical Order Entry Systems ; Medication Errors/prevention & control ; Drug Interactions ; Drug Hypersensitivity ; Software ; Decision Support Systems, Clinical |
| Language | English |
| Publishing date | 2023-10-09 |
| Publishing country | England |
| Document type | Review ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1205156-1 |
| ISSN | 1527-974X ; 1067-5027 |
| ISSN (online) | 1527-974X |
| ISSN | 1067-5027 |
| DOI | 10.1093/jamia/ocad193 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4128: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 312: Show issues |
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The lancet. HIV
2020 Volume 7, Issue 7, Page(s) e454–e455
| MeSH term(s) | Cities ; Epidemics ; HIV ; HIV Infections/epidemiology ; Humans ; Models, Economic ; United States |
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| Language | English |
| Publishing date | 2020-03-05 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Comment |
| ISSN | 2352-3018 |
| ISSN (online) | 2352-3018 |
| DOI | 10.1016/S2352-3018(20)30051-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024 Volume 166, Page(s) 112056
Abstract: Falls are a major public health concern, with older women being at the greatest risk to experience a fall. Step descent increases the likelihood of a fall injury, yet the influence of age and fall history on lower extremity kinematics have not been ... ...
| Abstract | Falls are a major public health concern, with older women being at the greatest risk to experience a fall. Step descent increases the likelihood of a fall injury, yet the influence of age and fall history on lower extremity kinematics have not been extensively studied. The purpose of this study was to examine lower extremity and foot kinematics of women with and without a fall history during single step descent. Hip, knee, and foot kinematics of young women (n = 15, age = 22.6 ± 3.2 years), older women with no recent falls (n = 15, age = 71.6 ± 4.4 years), and older women with a fall history (n = 15, age = 71.5 ± 5.0 years) as they descended a 17 cm step were examined. Differences in initial contact angles and ROM during landing were examined with between group MANOVA tests. Distal foot initial contact angles were not significant between groups. For range of motion, both older groups went through greater hip extension (p = 0.003, partial η |
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| MeSH term(s) | Humans ; Female ; Aged ; Young Adult ; Adult ; Biomechanical Phenomena ; Foot ; Lower Extremity ; Knee ; Knee Joint ; Range of Motion, Articular |
| Language | English |
| Publishing date | 2024-03-19 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 218076-5 |
| ISSN | 1873-2380 ; 0021-9290 |
| ISSN (online) | 1873-2380 |
| ISSN | 0021-9290 |
| DOI | 10.1016/j.jbiomech.2024.112056 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 700: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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The American journal of cardiology
2023 Volume 205, Page(s) 524–526
| MeSH term(s) | Humans ; Urea ; Heart Failure/drug therapy |
|---|---|
| Chemical Substances | omecamtiv mecarbil (2M19539ERK) ; Urea (8W8T17847W) |
| Language | English |
| Publishing date | 2023-09-04 |
| Publishing country | United States |
| Document type | Letter ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 80014-4 |
| ISSN | 1879-1913 ; 0002-9149 |
| ISSN (online) | 1879-1913 |
| ISSN | 0002-9149 |
| DOI | 10.1016/j.amjcard.2023.08.013 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui IV Zs.73: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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International journal of dermatology
2022 Volume 62, Issue 3, Page(s) 387–396
Abstract: Since Merkel cell polyomavirus (MCPyV) was linked as the predominant etiology of Merkel cell carcinoma (MCC) in 2008, three additional human polyomaviruses (HPyV) have been definitively linked to cutaneous diseases-trichodysplasia spinulosa virus (TSPyV) ...
| Abstract | Since Merkel cell polyomavirus (MCPyV) was linked as the predominant etiology of Merkel cell carcinoma (MCC) in 2008, three additional human polyomaviruses (HPyV) have been definitively linked to cutaneous diseases-trichodysplasia spinulosa virus (TSPyV) and human polyomavirus 6 and 7 (HPyV6, HPyV7). TSPyV contributes to the development of trichodysplasia spinulosa (TS), and HPyV6/7 is associated closely with the eruption of pruritic and dyskeratotic dermatoses (PDD). Clinically, MCC is treated with surgical excision and radiation with adjuvant chemotherapy, although newer treatment options include immune checkpoint inhibition. These novel immunotherapies hold promise for the treatment of metastatic MCC, but resistance and side effects prevent a significant proportion of patients from realizing their benefits. Based on previous case reports, the standard of care for the less deadly but disfiguring cutaneous disease TS include immunosuppressant (IS) reduction, the use of antivirals such as cidofovir (CDV) or valganciclovir (VGCV), or a combination of these treatments. Similar treatments were attempted for PDD, but oral acitretin was found to be most effective. As MCC, TS, and PDD are rare diseases, further research is required for effective treatments. In this review, we summarize clinical trials, preclinical studies, and case reports that present outcomes and side effects of current and emerging treatments for HPyV-associated cutaneous diseases, offering a comprehensive resource for clinical application and prospective clinical trials. |
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| MeSH term(s) | Humans ; Prospective Studies ; Polyomavirus ; Polyomavirus Infections ; Carcinoma, Merkel Cell ; Skin Diseases ; Skin Neoplasms |
| Language | English |
| Publishing date | 2022-12-28 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 412254-9 |
| ISSN | 1365-4632 ; 0011-9059 ; 1461-1244 |
| ISSN (online) | 1365-4632 |
| ISSN | 0011-9059 ; 1461-1244 |
| DOI | 10.1111/ijd.16534 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui VI Zs.189: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Behavioral ecology : official journal of the International Society for Behavioral Ecology
2023 Volume 35, Issue 1, Page(s) arad093
Abstract: Geographic differences in vocalizations provide strong evidence for animal culture, with patterns likely arising from generations of social learning and transmission. Most studies on the evolution of avian vocal variation have predominantly focused on ... ...
| Abstract | Geographic differences in vocalizations provide strong evidence for animal culture, with patterns likely arising from generations of social learning and transmission. Most studies on the evolution of avian vocal variation have predominantly focused on fixed repertoire, territorial song in passerine birds. The study of vocal communication in open-ended learners and in contexts where vocalizations serve other functions is therefore necessary for a more comprehensive understanding of vocal dialect evolution. Parrots are open-ended vocal production learners that use vocalizations for social contact and coordination. Geographic variation in parrot vocalizations typically take the form of either distinct regional variations known as dialects or graded variation based on geographic distance known as clinal variation. In this study, we recorded monk parakeets ( |
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| Language | English |
| Publishing date | 2023-11-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1496189-1 |
| ISSN | 1465-7279 ; 1045-2249 |
| ISSN (online) | 1465-7279 |
| ISSN | 1045-2249 |
| DOI | 10.1093/beheco/arad093 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Clinical and experimental dermatology
2023 Volume 48, Issue 8, Page(s) 903–908
Abstract: Background: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine cutaneous carcinoma aetiologically linked to the Merkel cell polyomavirus (MCPyV). Immune checkpoint inhibitors are currently the first-line therapy for metastatic MCC; ... ...
| Abstract | Background: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine cutaneous carcinoma aetiologically linked to the Merkel cell polyomavirus (MCPyV). Immune checkpoint inhibitors are currently the first-line therapy for metastatic MCC; however, the treatment is effective in only about half of patients, highlighting the need for alternative therapies. Selinexor (KPT-330) is a selective inhibitor of nuclear exportin 1 (XPO1) and has been shown to inhibit MCC cell growth in vitro, but the pathogenesis has not been established. Decades of research have established that cancer cells significantly upregulate lipogenesis to meet an increased demand for fatty acids and cholesterol. Treatments that inhibit lipogenic pathways may halt cancer cell proliferation. Aim: To determine the effect of increasing doses of selinexor on fatty acid and cholesterol synthesis in MCPyV-positive MCC (MCCP) cell lines and aid in elucidating the mechanism by which selinexor prevents and reduces MCC growth. Methods: MKL-1 and MS-1 cell lines were treated with increasing doses of selinexor for 72 h. Protein expression quantification was determined using chemiluminescent Western immunoblotting and densitometric analysis. Fatty acids and cholesterol were quantified using free fatty acid assay and cholesterol ester detection kits. Results: Selinexor causes statistically significant reductions of the lipogenic transcription factors sterol regulatory element-binding proteins 1 and 2, and lipogenic enzymes acetyl-CoA carboxylase, fatty acid synthase, squalene synthase and 3β-hydroxysterol Δ-24-reductase in a dose-dependent manner in two MCCP cell lines. Although inhibiting the fatty acid synthesis pathway results in meaningful decreases in fatty acids, the cellular cholesterol levels did not demonstrate such reductions. Conclusion: For patients with metastatic MCC refractory to immune checkpoint inhibitors, selinexor may provide clinical benefit through the inhibition of the lipogenesis pathway; however, further research and clinical trials are needed to evaluate these findings. |
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| MeSH term(s) | Humans ; Carcinoma, Merkel Cell/pathology ; Immune Checkpoint Inhibitors ; Lipogenesis ; Cell Line ; Skin Neoplasms/pathology ; Fatty Acids |
| Chemical Substances | selinexor (31TZ62FO8F) ; Immune Checkpoint Inhibitors ; Fatty Acids |
| Language | English |
| Publishing date | 2023-05-16 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 195504-4 |
| ISSN | 1365-2230 ; 0307-6938 |
| ISSN (online) | 1365-2230 |
| ISSN | 0307-6938 |
| DOI | 10.1093/ced/llad081 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1278: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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microPublication biology
2019 Volume 2019
| Language | English |
|---|---|
| Publishing date | 2019-07-04 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2578-9430 |
| ISSN (online) | 2578-9430 |
| DOI | 10.17912/micropub.biology.000128 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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