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Article ; Online: Current aspects of Fabry's disease.

Torregrosa, José-Vicente

2018 Volume 151, Issue 5, Page(s) 196–197

Title translation	Aspectos actuales de la enfermedad de Fabry.
MeSH term(s)	Biomarkers/blood ; Fabry Disease/diagnosis ; Fabry Disease/epidemiology ; Fabry Disease/genetics ; Fabry Disease/therapy ; Glycolipids/blood ; Humans ; Incidence ; Mutation ; Prevalence ; Sphingolipids/blood ; Trihexosylceramides/metabolism ; alpha-Galactosidase/genetics
Chemical Substances	Biomarkers ; Glycolipids ; Sphingolipids ; Trihexosylceramides ; globotriaosyl lysosphingolipid (126550-86-5) ; globotriaosylceramide (71965-57-6) ; alpha-Galactosidase (EC 3.2.1.22)
Language	Spanish
Publishing date	2018-03-06
Publishing country	Spain
Document type	Editorial
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2018.01.025
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Article ; Online: The 'Phosphorus Week': involvement of Spanish nephrologists in the control of phosphorus blood levels.

Álvarez, Emilio Sánchez / Xipell, Marc / Gallardo, Anna / Astudillo, Elena / Torregrosa, Jose-Vicente

Nefrologia

2023 Volume 43, Issue 2, Page(s) 232–238

Abstract: Background: The adequate control of phosphorus levels is a major concern for professionals involved in the care of patients with chronic kidney disease (CKD), since high phosphorus levels are directly related to an increase in mortality.: Objectives: ...

Abstract	Background: The adequate control of phosphorus levels is a major concern for professionals involved in the care of patients with chronic kidney disease (CKD), since high phosphorus levels are directly related to an increase in mortality. Objectives: To know the perception and involvement of Spanish nephrologists on the control of phosphorus levels, the so-called 'Phosphorus Week' was organized (November 13-17, 2017). Methods: All members of the Spanish Society of Nephrology were invited to participate in an online survey, which included questions on aspects related to phosphorus control in patients with advanced CKD (aCKD) (glomerular filtration rate <30 ml/min/1, 73 m Results: 72 data entries were obtained in the survey with an inclusion of 7463 patients. Of them, 35.4% were on HD, 34.8% were KT, 24.2% had aCKD and 5.5% were on PD. The serum phosphorus level target for the four groups of patients was 4.5 mg/dl, with minimal variations depending on the area of the national territory. The patients with better control of phosphataemia were patients with KT (93.3% had phosphorus values <4.5 mg/dl), followed by patients with aCKD (65.6% with phosphorus <4.5 mg/dl). Only 53.6% of the patients on HD and 39.4% of those on PD reached the phosphorus goal <4.5 mg/dl. The group of patients on dialysis was the one in whom phosphorus binders prescribed the most (73.5% and 75.6% in HD and PD, respectively), being less frequent in patients with patients with aCKD (39.9%) and only 4.5 % in KT. Conclusions: The objectives of the Spanish nephrologists are in line with those recommended by the national and international clinical guidelines; however, there is still a wide room for improvement to achieve these goals, especially in HD and PD patients.
MeSH term(s)	Humans ; Phosphorus ; Nephrologists ; Renal Dialysis ; Peritoneal Dialysis ; Renal Insufficiency, Chronic/therapy
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-07-11
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2023.07.001
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Article ; Online: Cardiovascular calcifications in kidney transplant recipients.

Podestà, Manuel Alfredo / Cucchiari, David / Ciceri, Paola / Messa, Piergiorgio / Torregrosa, José-Vicente / Cozzolino, Mario

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2021 Volume 37, Issue 11, Page(s) 2063–2071

Abstract: Vascular and valvular calcifications are highly prevalent in kidney transplant recipients (KTRs) and are associated with an increased risk of cardiovascular events, which represent the leading cause of long-term mortality in these patients. However, ... ...

Abstract	Vascular and valvular calcifications are highly prevalent in kidney transplant recipients (KTRs) and are associated with an increased risk of cardiovascular events, which represent the leading cause of long-term mortality in these patients. However, cardiovascular calcification has been traditionally considered as a condition mostly associated with advanced chronic kidney disease stages and dialysis, and comparatively fewer studies have assessed its impact after kidney transplantation. Despite partial or complete resolution of uraemia-associated metabolic derangements, KTRs are still exposed to several pro-calcifying stimuli that favour the progression of pre-existing vascular calcifications or their de novo development. Traditional risk factors, bone mineral disorders, inflammation, immunosuppressive drugs and deficiency of calcification inhibitors may all play a role, and strategies to correct or minimize their effects are urgently needed. The aim of this work is to provide an overview of established and putative mediators involved in the pathogenesis of cardiovascular calcification in kidney transplantation, and to describe the clinical and radiological features of these forms. We also discuss current evidence on preventive strategies to delay the progression of cardiovascular calcifications in KTRs, as well as novel therapeutic candidates to potentially prevent their long-term deleterious effects.
MeSH term(s)	Humans ; Cardiovascular Diseases/etiology ; Kidney Transplantation/adverse effects ; Renal Dialysis/adverse effects ; Risk Factors ; Transplant Recipients ; Vascular Calcification/complications
Language	English
Publishing date	2021-01-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfab053
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Article ; Online: Calciphylaxis in patients with chronic kidney disease: A disease which is still bewildering and potentially fatal.

Cucchiari, David / Torregrosa, Jose-Vicente

Nefrologia

2018 Volume 38, Issue 6, Page(s) 579–586

Abstract: Calciphylaxis, also known as calcific uraemic arteriolopathy, is a rare syndrome that typically causes skin necrosis and usually affects dialysis patients. Its pathogenesis is multifactorial and is the consequence of many factors causing ectopic ... ...

Title translation	Calcifilaxis en pacientes con enfermedad renal crónica: una enfermedad todavía desconcertante y potencialmente mortal.
Abstract	Calciphylaxis, also known as calcific uraemic arteriolopathy, is a rare syndrome that typically causes skin necrosis and usually affects dialysis patients. Its pathogenesis is multifactorial and is the consequence of many factors causing ectopic calcifications in patients with chronic kidney disease, such as calcium-phosphate metabolism disorders, hyper- or hypo-parathyroidism, diabetes, obesity, systemic inflammation and the use of vitamin K antagonists, among others. From a clinical point of view, calciphylaxis may progress from painful purpura to extensive areas of skin necrosis that can potentially lead to superinfection and the death of the patient due to sepsis. Treatment is primarily based on managing the wounds, eliminating all the possible precipitating factors of ectopic calcification and administering agents which are capable of inhibiting the process of calcification.
MeSH term(s)	Calciphylaxis/diagnosis ; Calciphylaxis/etiology ; Calciphylaxis/therapy ; Humans ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Risk Factors
Language	Spanish
Publishing date	2018-11-08
Document type	Journal Article ; Review
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefro.2018.05.007
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Article ; Online: Correction to: Panel Discussion: Some Aspects of the Management of Patients with X-Linked Hypophosphataemic Rickets.

Torregrosa, José-Vicente / Sánchez Del Pozo, Jaime / Luiz Yanes, María Isabel / Muñoz Torres, Manuel

Advances in therapy

2020 Volume 37, Issue 8, Page(s) 3642

Abstract: In the original article, there is an error in age related reference. ...

Abstract	In the original article, there is an error in age related reference.
Language	English
Publishing date	2020-06-16
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-020-01406-x
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Article ; Online: Correction to: Panel Discussion: Some Aspects of the Management of Patients with X-Linked Hypophosphataemic Rickets.

Torregrosa, José-Vicente / Sánchez Del Pozo, Jaime / Luis Yanes, María Isabel / Muñoz Torres, Manuel

Advances in therapy

2020 Volume 37, Issue 7, Page(s) 3432

Abstract: In the original article, third author name has been published incorrectly. ...

Abstract	In the original article, third author name has been published incorrectly.
Language	English
Publishing date	2020-05-23
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-020-01370-6
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Article: Dramatic increase in parathyroid hormone and hypocalcaemia after denosumab in a kidney transplanted patient.

Torregrosa, Jose-Vicente

Clinical kidney journal

2012 Volume 6, Issue 1, Page(s) 122

Language	English
Publishing date	2012-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfs158
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Article ; Online: Panel Discussion: Some Aspects of the Management of Patients with X-Linked Hypophosphataemic Rickets.

Torregrosa, José-Vicente / Sánchez Del Pozo, Jaime / Luiz Yanes, María Isabel / Muñoz Torres, Manuel

Advances in therapy

2020 Volume 37, Issue Suppl 2, Page(s) 121–126

Abstract: X-linked hypophosphataemia (XLH) rickets is a rare disease frequently misdiagnosed and mismanaged. Despite having clinical guidelines that offers some therapeutic recommendations based on the clinical experience of experts, physicians still have ... ...

Abstract	X-linked hypophosphataemia (XLH) rickets is a rare disease frequently misdiagnosed and mismanaged. Despite having clinical guidelines that offers some therapeutic recommendations based on the clinical experience of experts, physicians still have questions about some important aspects of the diagnosis and treatment of XLH, such as when the disease should be suspected, who should be in charge of the diagnosis, what should be done once the disease is diagnosed, or what therapeutic options are currently available. The objective of this paper is to answer some of the more frequent questions related to the management of patients with XLH by a group of experts participating in a scientific conference on XLH held in Madrid.
MeSH term(s)	Adolescent ; Antibodies, Monoclonal/therapeutic use ; Child ; Child, Preschool ; Drug Dosage Calculations ; Drug Therapy/standards ; Familial Hypophosphatemic Rickets/diagnosis ; Familial Hypophosphatemic Rickets/drug therapy ; Female ; Humans ; Male ; Practice Guidelines as Topic
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2020-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-019-01208-w
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Article ; Online: Management of hypercalcemia after renal transplantation.

Torregrosa, José-Vicente / Barros, Xoana

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2013 Volume 33, Issue 6, Page(s) 751–757

Abstract: Post-transplant hypercalcemia due to persistent secondary hyperparathyroidism (HPT) has a high prevalence in the first 3 months after surgery and decreases during the first year, but it persists over time in around 5-10% of renal transplant patients. The ...

Abstract	Post-transplant hypercalcemia due to persistent secondary hyperparathyroidism (HPT) has a high prevalence in the first 3 months after surgery and decreases during the first year, but it persists over time in around 5-10% of renal transplant patients. The increased bone resorption and tubular reabsorption of calcium due to the action of the parathyroid hormone (PTH) appear to be the main mechanisms involved in hypercalcemia. At the time of the renal transplantation (RT), PTH is the factor that determines the development of post-RT hypercalcemia, although it is sometimes masked in patients who are well controlled with medical treatment. The number of dialysis patients receiving treatment with cinacalcet for secondary HPT is increasing. The withdrawal of the calcimimetic at the time of renal transplantation results in a higher prevalence of hypercalcaemia and hyperparathyroidism in these patients. In patients with PTH well controlled with cinacalcet before transplantation, there is a direct relationship between the dose and the subsequent development of hypercalcemia, probably because it indicates the presence of a more severe secondary HPT. Hypercalcemia may have deleterious effects on the renal graft, resulting in tubulointerstitial calcification. Persistent hypercalcemia is a marker of an increased risk of bone disease deterioration in these patients. Nowadays, the first treatment option is cinacalcet and if there is no response, we consider performing a parathyroidectomy. In this review, we propose an algorithm for management of post-RT hypercalcemia.
MeSH term(s)	Algorithms ; Bone Resorption/etiology ; Bone Resorption/prevention & control ; Calcimimetic Agents/therapeutic use ; Calcium/metabolism ; Calcium/therapeutic use ; Cinacalcet Hydrochloride ; Humans ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Hypercalcemia/physiopathology ; Hyperparathyroidism, Secondary/drug therapy ; Hyperparathyroidism, Secondary/etiology ; Hyperparathyroidism, Secondary/surgery ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/therapy ; Kidney Transplantation ; Naphthalenes/therapeutic use ; Parathyroid Hormone/blood ; Parathyroidectomy/methods ; Postoperative Complications/physiopathology ; Postoperative Complications/therapy ; Renal Dialysis/adverse effects ; Vitamin D/therapeutic use
Chemical Substances	Calcimimetic Agents ; Naphthalenes ; Parathyroid Hormone ; Vitamin D (1406-16-2) ; Cinacalcet Hydrochloride (1K860WSG25) ; Calcium (SY7Q814VUP)
Language	Spanish
Publishing date	2013-11-13
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
DOI	10.3265/Nefrologia.pre2013.Aug.11888
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Zs.MO 56: Show issues

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Article ; Online: Recommendations of the Spanish Society of Nephrology for the management of mineral and bone metabolism disorders in patients with chronic kidney disease: 2021 (SEN-MM).

Torregrosa, José-Vicente / Bover, Jordi / Rodríguez Portillo, Mariano / González Parra, Emilio / Dolores Arenas, María / Caravaca, Francisco / González Casaus, María-Luisa / Martín-Malo, Alejandro / Navarro-González, Juan Francisco / Lorenzo, Víctor / Molina, Pablo / Rodríguez, Minerva / Cannata Andia, Jorge

Nefrologia

2023 Volume 43 Suppl 1, Page(s) 1–36

Abstract: As in 2011, when the Spanish Society of Nephrology (SEN) published the Spanish adaptation to the Kidney Disease: Improving Global Outcomes (KDIGO) universal Guideline on Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD), this document contains ... ...

Abstract	As in 2011, when the Spanish Society of Nephrology (SEN) published the Spanish adaptation to the Kidney Disease: Improving Global Outcomes (KDIGO) universal Guideline on Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD), this document contains an update and an adaptation of the 2017 KDIGO guidelines to our setting. In this field, as in many other areas of nephrology, it has been impossible to irrefutably answer many questions, which remain pending. However, there is no doubt that the close relationship between the CKD-MBD/cardiovascular disease/morbidity and mortality complex and new randomised clinical trials in some areas and the development of new drugs have yielded significant advances in this field and created the need for this update. We would therefore highlight the slight divergences that we propose in the ideal objectives for biochemical abnormalities in the CKD-MBD complex compared to the KDIGO suggestions (for example, in relation to parathyroid hormone or phosphate), the role of native vitamin D and analogues in the control of secondary hyperparathyroidism and the contribution of new phosphate binders and calcimimetics. Attention should also be drawn to the adoption of important new developments in the diagnosis of bone abnormalities in patients with kidney disease and to the need to be more proactive in treating them. In any event, the current speed at which innovations are taking place, while perhaps slower than we might like, globally drives the need for more frequent updates (for example, through Nefrología al día).
MeSH term(s)	Humans ; Chronic Kidney Disease-Mineral and Bone Disorder/therapy ; Chronic Kidney Disease-Mineral and Bone Disorder/complications ; Nephrology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/diagnosis ; Bone Diseases, Metabolic/drug therapy ; Bone Diseases, Metabolic/etiology ; Bone Diseases, Metabolic/diagnosis ; Minerals/therapeutic use ; Phosphates
Chemical Substances	Minerals ; Phosphates
Language	English
Publishing date	2023-05-16
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2023.03.003
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