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  1. Article ; Online: Shu Wang.

    Wang, Shu

    Angewandte Chemie (International ed. in English)

    2016  Volume 55, Issue 17, Page(s) 5120

    Language English
    Publishing date 2016-04-18
    Publishing country Germany
    Document type Interview
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201681713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Very natural cancer chemoprevention: A research profile of Li-Shu Wang.

    Wang, Li-Shu

    Food frontiers

    2020  Volume 1, Issue 3, Page(s) 350–351

    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article
    ISSN 2643-8429
    ISSN (online) 2643-8429
    DOI 10.1002/fft2.35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.

    Lv, Xinyan / Bi, Anqi / Zhang, Zhan / Li, Jinyan / Wei, Yingbo / Wan, Meiqi / Wang, Jinyu / Yan, Tingxu / Jia, Ying

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 241, Page(s) 115980

    Abstract: ... have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS ...

    Abstract Ovariectomy (OVX) is usually accompanied by the occurrence of metabolic syndrome. Previous studies have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS) rats. GNS is a traditional Chinese medicine (TCM) prescription which composed of Suanzaoren Decoction and Ganmai Dazao Decoction in "Jingui Yaolue" and Siwu Decoction in "Heji Jufang". Recently, metabolomics analysis has been used to identify slight changes in the metabolic profile and to help understand disease progression and therapeutic interventions in PMS. However, the mechanism of GNS in the treatment of PMS is still unknown. We purposed to study the metabolic characteristics of PMS by serum and fecal metabolomics, and revealed the internal mechanism of GNS regulating ferroptosis against PMS. The PMS model was established by surgical removal of 4/5 ovaries of rats. HPLC-Q-TOF/MS was used to analyze the metabolomics of rat plasma and feces to explore the potential mechanism of GNS in PMS. The expression of ferroptosis-related proteins in rat ovaries was detected by tissue Prussian blue staining, Elisa kit and Western blotting. Cluster analysis of differential metabolites in plasma and feces between the control group and the model group showed that organic acids and their derivatives, lipids and lipid molecules were mainly disturbed during PMS in rats. After GNS administration, 17 differential metabolites were adjusted, involving several major pathways, such as the tricarboxylic acid (TCA) cycle, biosynthesis of amino acids and biosynthesis of unsaturated fatty acids. Further, we found that GNS affected ferroptosis in ovarian cells by regulating endogenous substances in OVX rats. Our study provides new insights into the mechanism of OVX-induced metabolic syndrome based on non-targeted metabolomics. It provides new ideas for the development and application of GNS and the diagnosis and treatment of PMS.
    MeSH term(s) Female ; Rats ; Animals ; Metabolic Syndrome ; Ferroptosis ; Perimenopause ; Metabolomics ; Metabolome ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2024.115980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Erratum for Shu et al., "Transcriptomic-Guided Phosphonate Utilization Analysis Unveils Evidence of Clathrin-Mediated Endocytosis and Phospholipid Synthesis in the Model Diatom, Phaeodactylum tricornutum".

    Shu, Huilin / You, Yanchun / Wang, Hongwei / Wang, Jingtian / Li, Ling / Ma, Jian / Lin, Xin

    mSystems

    2023  Volume 8, Issue 1, Page(s) e0129422

    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.01294-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [A fixation frame for acupuncture and moxibustion of Shu-Mu acupoint combination in rats].

    Wang, Fu-Min / Xiong, Jing / Zeng, Fang / He, Zhao-Xuan

    Zhen ci yan jiu = Acupuncture research

    2022  Volume 47, Issue 10, Page(s) 938–940

    Abstract: Shu-Mu acupoint combination is commonly employed in acupuncture and moxibustion treatment ... moxibustion at Shu-Mu acupoints in rats. The present study designed a device equipped with a fixed plate and ... acupuncture on the back, chest, and abdomen of rats to meet the requirements of the Shu-Mu acupoint ...

    Abstract Shu-Mu acupoint combination is commonly employed in acupuncture and moxibustion treatment. In animal experiments, it is difficult to implement such combination because of the uncontrollable features of animals. Therefore, there is an urgent need to design an experimental device to facilitate the operation of acupuncture and moxibustion at Shu-Mu acupoints in rats. The present study designed a device equipped with a fixed plate and a moxibustion frame for rats. The fixed plate and the moxibustion frame with detachable connection can allow acupuncture on the back, chest, and abdomen of rats to meet the requirements of the Shu-Mu acupoint combination. The moxibustion frame is made of universal hose and equipped with moxa clip, which ensures moxibustion in any direction and performs moxibustion on acupoints in the back, chest, and abdomen simultaneously. This device is unique in structure and convenient in operation, with safety and reliability. It is beneficial to the development of animal experiments related to acupuncture and moxibustion of Shu-Mu acupoint combination in the future.
    MeSH term(s) Rats ; Animals ; Moxibustion ; Acupuncture Points ; Meridians ; Reproducibility of Results ; Acupuncture Therapy
    Language Chinese
    Publishing date 2022-10-27
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
    DOI 10.13702/j.1000-0607.20210256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4364: Show issues Location:
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  6. Article ; Online: Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng-Nian-Shu in perimenopausal syndrome.

    Lv, Xinyan / Xu, Qinghua / Zhang, Zhiqin / Wang, Jinyu / Wan, Meiqi / Zhang, Xiaoying / Wu, Bo / Yan, Tingxu / Jia, Ying

    Journal of separation science

    2023  Volume 46, Issue 17, Page(s) e2300011

    Abstract: Although Geng-Nian-Shu has been shown to be clinically effective in perimenopausal syndrome ... biomarkers of Geng-Nian-Shu in treating perimenopausal syndrome, a total of 135 chemical constituents ... for the PhosphoInositide-3 Kinase/Akt pathway, suggesting that it may be the main regulatory pathway for the Geng-Nian-Shu ...

    Abstract Although Geng-Nian-Shu has been shown to be clinically effective in perimenopausal syndrome, its active components and mechanism have not yet been elucidated. To demonstrate the mechanism-based biomarkers of Geng-Nian-Shu in treating perimenopausal syndrome, a total of 135 chemical constituents including 52 prototype blood constituents were identified via high-performance liquid chromatography-quadrupole-time of flight/mass spectrometry. Then, network pharmacology showed significant enrichment for the PhosphoInositide-3 Kinase/Akt pathway, suggesting that it may be the main regulatory pathway for the Geng-Nian-Shu treatment of the perimenopausal syndrome. Subsequently, multivariate analysis was performed between the Geng-Nian-Shu sham-treated and Geng-Nian-Shu ovariectomy-treated groups and further screened out 18 prototype blood constituents by correlation analysis with plasma estrogen levels to identify potential biomarkers associated with Geng-Nian-Shu treat the ovariectomy-induced perimenopausal syndrome. Finally, the results of pharmacological experimental verification and Pearson correlation analysis indicated that catalpol, ligustilide, paeoniflorin, and gallic acid were selected as biomarkers of Geng-Nian-Shu which were strongly and positively correlated with PhosphoInositide-3 Kinase/Akt signaling pathway. In this study, based on high-performance liquid chromatography-quadrupole-time of flight/mass spectrometry combined with pharmacodynamics, network pharmacology, pharmacology, and other disciplines, we explored the effects and mechanisms of Geng-Nian-Shu in the treatment of perimenopausal syndrome at multiple levels. Using multiplatform technology to investigate the role of Geng-Nian-Shu represents a new strategy for the selection and verification of biomarkers of Geng-Nian-Shu and provides a basis for further development and utilization of Geng-Nian-Shu.
    MeSH term(s) Female ; Humans ; Drugs, Chinese Herbal/analysis ; Perimenopause ; Proto-Oncogene Proteins c-akt ; Biomarkers/analysis ; Phosphatidylinositols
    Chemical Substances Drugs, Chinese Herbal ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Biomarkers ; Phosphatidylinositols
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.202300011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Perforating cutaneous vessels: A key feature of acupoints - Anatomical evidence from five-Shu acupoints in the upper limbs.

    Meng, Shuo / Tang, Zitian / Zhu, Mingsheng / Liang, Xinshuo / Ding, Zhiwei / Wang, Zengtao / Hu, Jinlian

    Clinical anatomy (New York, N.Y.)

    2023  Volume 37, Issue 1, Page(s) 33–42

    Abstract: ... perfusion-fixation method and then examined. The results show that all 30 five-Shu APs in the upper limbs ...

    Abstract Acupuncture has been proven an effective clinical treatment for numerous pathological conditions and malfunctions. However, substantial anatomical evidence for acupuncture points (APs) and meridians is still lacking, so the location of APs is relatively subjective and understanding of the biological mechanisms of acupuncture is limited. All these problems hinder the clinical applications and worldwide acceptance of acupuncture. Our long-term microsurgery experience has indicated that Perforating Cutaneous Vessels (PCVs) are highly relevant to APs but the anatomical evidence is insufficient. To address this lack, two specimens of fresh adult human upper limbs were dissected using an advanced vascular perfusion-fixation method and then examined. The results show that all 30 five-Shu APs in the upper limbs have corresponding PCVs. Both specimens showed a 100% coincidence rate between APs and PCVs, indicating that PCVs could be critical anatomical features of APs. This study also provides an anatomical basis for locating APs objectively via preliminary detection of PCVs. The findings could lead to a better theoretical understanding of mechanisms of acupuncture and the essence of meridians.
    MeSH term(s) Humans ; Acupuncture Points ; Meridians ; Acupuncture Therapy/methods ; Upper Extremity ; Histological Techniques
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.24077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2592: Show issues Location:
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  8. Book: Wang Shu Amateur Attitude

    Shu, Wang

    2013  

    Author's details Wang Shu
    Language German
    Size 280 S, 300 mm x 240 mm
    Publisher Müller, Lars
    Publishing place Zürich
    Document type Book
    ISBN 9783037783375 ; 3037783370
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis.

    Zhao, Yi / Zhao, Linan / Wang, Tao / Liu, Zhenghao / Tang, Suyuan / Huang, Hongxia / Wu, Li / Sun, Youzhi

    Integrative cancer therapies

    2024  Volume 23, Page(s) 15347354241233258

    Abstract: Background: Soothing the liver (called : The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms.: Materials and methods: SGJY herbal combination was extracted ... ...

    Abstract Background: Soothing the liver (called
    The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms.
    Materials and methods: SGJY herbal combination was extracted using water. A breast cancer rat model was developed by chemical DMBA by gavage, then treated with SGJY for 11 weeks. The tumor tissue was preserved for RNA sequencing and analyzed by IPA software. The inhibition effects of SGJY on MCF-7 and T47D breast cancer cells were investigated by SRB assay and cell apoptosis analysis, and the protein expression levels of SNCG, ER-α,
    Results: SGJY significantly reduced the tumor weight and volume, and the level of estradiol in serum. The results of IPA analysis reveal SGJY upregulated 7 canonical pathways and downregulated 16 canonical pathways. Estrogen receptor signaling was the key canonical pathway with 9 genes downregulated. The results of upstream regulator analysis reveal beta-estradiol was the central target; the upstream regulator network scheme showed that 86 genes could affect the expression of the beta-estradiol, including SNCG, CCL21 and MB. Additionally, SGJY was verified to significantly alter the expression of SNCG mRNA, CCL21 mRNA and MB mRNA which was consistent with the data of RNA-Seq. The inhibition effects of SGJY exhibited a dose-dependent response. The apoptosis rates of MCF7 and T47D cells were upregulated. The protein expression of SNCG, ER-α,
    Conclusion: The results demonstrate that SGJY may inhibit the growth of breast cancer. The mechanism might involve downregulating the level of serum estradiol, and suppressing the protein expression in the SNCG/ER-α/AKT-ERK pathway.
    MeSH term(s) Animals ; Female ; Humans ; Rats ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Estradiol ; gamma-Synuclein/genetics ; gamma-Synuclein/metabolism ; MAP Kinase Signaling System ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Estrogen/metabolism ; RNA, Messenger/metabolism ; RNA-Seq
    Chemical Substances Estradiol (4TI98Z838E) ; gamma-Synuclein ; Neoplasm Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Estrogen ; RNA, Messenger ; SNCG protein, human
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182320-0
    ISSN 1552-695X ; 1534-7354
    ISSN (online) 1552-695X
    ISSN 1534-7354
    DOI 10.1177/15347354241233258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Post-marketing safety surveillance and re-evaluaiton of Shu-Xue-Ning injection: a real-world study based on 30,122 cases.

    Xinyao, Jin / Yifan, Zhang / Keyi, Wang / Wentai, Pang / Chunyang, Wang / Hui, Wang / Chunxiang, Liu / Yunhua, Xue / Wenke, Zheng

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1194367

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1194367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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