Article: Spatial distribution of uranium in mice kidneys detected by laser ablation inductively coupled plasma mass spectrometry.
Journal of applied bioanalysis
2017 Volume 3, Issue 3, Page(s) 43–48
Abstract: The aim of the study is to better understand where uranium deposits in mice kidneys. The spatial distribution of uranium was examined in the kidneys of C57BL/6 mice using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Mice were ... ...
| Abstract | The aim of the study is to better understand where uranium deposits in mice kidneys. The spatial distribution of uranium was examined in the kidneys of C57BL/6 mice using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Mice were exposed to varying levels of uranyl nitrate in their drinking water. Calibration standards were developed to allow for semi-quantitative measurement of uranium in the cortical and medullary regions of mice kidney by LA-ICP-MS. Scanning electron microscopy was used to image the ablation patterns on the kidney. Uranium levels were observed to increase in kidney tissue as uranyl nitrate treatment exposure levels increased. A trend towards a higher uranium concentration in the medullary versus cortical region of the kidneys was observed. These results show the usefulness of LA-ICP-MS in toxicity studies by providing a quantitative, spatial assessment of uranium deposition in a target organ. |
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| Language | English |
| Publishing date | 2017-11-15 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2835003-0 |
| ISSN | 2405-710X |
| ISSN | 2405-710X |
| DOI | 10.17145/jab.17.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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