LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article ; Online: The influencers' era: how the environment shapes chromatin in 3D.

Pudelko, Lorenz / Cabianca, Daphne S

Current opinion in genetics & development

2024 Volume 85, Page(s) 102173

Abstract: Environment-epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms outside of the laboratory are constantly exposed to environmental changes that can influence chromatin regulation at multiple levels, ... ...

Abstract	Environment-epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms outside of the laboratory are constantly exposed to environmental changes that can influence chromatin regulation at multiple levels, potentially impacting on genome function. In this review, we will summarize recent findings on how major external cues impact on 3D chromatin organization in different experimental systems. We will describe environment-induced 3D genome alterations ranging from chromatin accessibility to the spatial distribution of the genome and discuss their role in regulating gene expression.
MeSH term(s)	Chromatin/genetics ; Epigenome ; Metagenomics
Chemical Substances	Chromatin
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077312-5
ISSN	1879-0380 ; 0959-437X
ISSN (online)	1879-0380
ISSN	0959-437X
DOI	10.1016/j.gde.2024.102173
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: An mTOR/RNA pol I axis shapes chromatin architecture in response to fasting.

Al-Refaie, Nada / Padovani, Francesco / Binando, Francesca / Hornung, Johanna / Zhao, Qiuxia / Towbin, Benjamin D / Cenik, Elif Sarinay / Stroustrup, Nicholas / Schmoller, Kurt M / Cabianca, Daphne S

bioRxiv : the preprint server for biology

2023

Abstract: Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom. Yet, how it impacts on 3D genome organization is unknown. Here, we show that fasting induces a reversible and large-scale ...

Abstract	Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom. Yet, how it impacts on 3D genome organization is unknown. Here, we show that fasting induces a reversible and large-scale spatial reorganization of chromatin in
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.22.550032
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism.

Cabianca, Daphne S / Gasser, Susan M

Nucleus (Austin, Tex.)

2016 Volume 7, Issue 3, Page(s) 301–307

Abstract: Multiple layers of regulation are required to ensure appropriate patterns of gene expression for accurate cell differentiation. Interphase chromatin is non-randomly distributed within the nucleus, with highly compacted, transcriptionally silent ... ...

Abstract	Multiple layers of regulation are required to ensure appropriate patterns of gene expression for accurate cell differentiation. Interphase chromatin is non-randomly distributed within the nucleus, with highly compacted, transcriptionally silent heterochromatin enriched at the nuclear and nucleolar periphery. Whether this spatial organization serves a function in organismal physiology, rather than simply being a byproduct of chromatin metabolism, is a fundamental question. Recent work performed in C. elegans embryos characterized the molecular mechanisms that drive the perinuclear anchoring of heterochromatin. Moreover, for the first time it was shown that heterochromatin sequestration helps to restrict cell differentiation programs, while sustaining commitment to a specified fate. Here, we describe and comment on these findings, placing them in a broader context.
MeSH term(s)	Animals ; Euchromatin/metabolism ; Heterochromatin/metabolism ; Histones/chemistry ; Histones/metabolism ; Humans ; Methylation ; Nuclear Envelope/metabolism
Chemical Substances	Euchromatin ; Heterochromatin ; Histones
Language	English
Publishing date	2016-05-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2619626-8
ISSN	1949-1042 ; 1949-1034
ISSN (online)	1949-1042
ISSN	1949-1034
DOI	10.1080/19491034.2016.1187354
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism

Cabianca, Daphne S / Gasser, Susan M

Nucleus. 2016 May 3, v. 7, no. 3

2016

Abstract	Multiple layers of regulation are required to ensure appropriate patterns of gene expression for accurate cell differentiation. Interphase chromatin is non-randomly distributed within the nucleus, with highly compacted, transcriptionally silent heterochromatin enriched at the nuclear and nucleolar periphery. Whether this spatial organization serves a function in organismal physiology, rather than simply being a byproduct of chromatin metabolism, is a fundamental question. Recent work performed in C. elegans embryos characterized the molecular mechanisms that drive the perinuclear anchoring of heterochromatin. Moreover, for the first time it was shown that heterochromatin sequestration helps to restrict cell differentiation programs, while sustaining commitment to a specified fate. Here, we describe and comment on these findings, placing them in a broader context.
Keywords	byproducts ; cell differentiation ; gene expression ; heterochromatin ; interphase ; metabolism ; transcription (genetics)
Language	English
Dates of publication	2016-0503
Size	p. 301-307.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2619626-8
ISSN	1949-1042 ; 1949-1034
ISSN (online)	1949-1042
ISSN	1949-1034
DOI	10.1080/19491034.2016.1187354
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Chromatin states and nuclear organization in development--a view from the nuclear lamina.

Mattout, Anna / Cabianca, Daphne S / Gasser, Susan M

Genome biology

2015 Volume 16, Page(s) 174

Abstract: The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of ... ...

Abstract	The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
MeSH term(s)	Animals ; Cell Differentiation/genetics ; Chromatin/chemistry ; Chromatin/metabolism ; Epigenesis, Genetic ; Genome ; Heterochromatin/metabolism ; Histones/metabolism ; Humans ; Lamins/genetics ; Mice ; Nuclear Lamina/genetics
Chemical Substances	Chromatin ; Heterochromatin ; Histones ; Lamins
Language	English
Publishing date	2015-08-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2040529-7
ISSN	1474-760X ; 1465-6914 ; 1465-6906
ISSN (online)	1474-760X ; 1465-6914
ISSN	1465-6906
DOI	10.1186/s13059-015-0747-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.

Cabianca, Daphne S / Muñoz-Jiménez, Celia / Kalck, Véronique / Gaidatzis, Dimos / Padeken, Jan / Seeber, Andrew / Askjaer, Peter / Gasser, Susan M

Nature

2019 Volume 569, Issue 7758, Page(s) 734–739

Abstract: The execution of developmental programs of gene expression requires an accurate partitioning of the genome into subnuclear compartments, with active euchromatin enriched centrally and silent heterochromatin at the nuclear ... ...

Abstract	The execution of developmental programs of gene expression requires an accurate partitioning of the genome into subnuclear compartments, with active euchromatin enriched centrally and silent heterochromatin at the nuclear periphery
MeSH term(s)	Animals ; Caenorhabditis elegans/anatomy & histology ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/deficiency ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Euchromatin/genetics ; Euchromatin/metabolism ; Gain of Function Mutation ; Genes, Reporter/genetics ; Heterochromatin/genetics ; Heterochromatin/metabolism ; Histone Acetyltransferases/deficiency ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Histones/chemistry ; Histones/metabolism ; Intestines/cytology ; Transcription Factors/deficiency ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	CEC-4 protein, C elegans ; Caenorhabditis elegans Proteins ; Chromatin ; Chromosomal Proteins, Non-Histone ; Euchromatin ; Heterochromatin ; Histones ; MRG-1 protein, C elegans ; Mes-4 protein, C elegans ; Transcription Factors ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Met-1 protein, C elegans (EC 2.1.1.43) ; CBP-1 protein, C elegans (EC 2.3.1.48) ; Histone Acetyltransferases (EC 2.3.1.48)
Language	English
Publishing date	2019-05-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1243-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Chromatin states and nuclear organization in development — a view from the nuclear lamina

Mattout, Anna / Cabianca, Daphne S / Gasser, Susan M

Genome biology. 2015 Dec., v. 16, no. 1

2015

Abstract	The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina–heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
Keywords	cell differentiation ; heterochromatin ; interphase
Language	English
Dates of publication	2015-12
Size	p. 174.
Publishing place	BioMed Central
Document type	Article
Note	Review
ZDB-ID	2040529-7
ISSN	1474-760X ; 1465-6906
ISSN (online)	1474-760X
ISSN	1465-6906
DOI	10.1186/s13059-015-0747-5
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: A novel molecular mechanism in human genetic disease: a DNA repeat-derived lncRNA.

Cabianca, Daphne S / Casa, Valentina / Gabellini, Davide

RNA biology

2012 Volume 9, Issue 10, Page(s) 1211–1217

Abstract: Two thirds of the human genome is composed of repetitive sequences. Despite their prevalence, DNA repeats are largely ignored. The vast majority of our genome is transcribed to produce non protein-coding RNAs. Among these, long non protein-coding RNAs ... ...

Abstract	Two thirds of the human genome is composed of repetitive sequences. Despite their prevalence, DNA repeats are largely ignored. The vast majority of our genome is transcribed to produce non protein-coding RNAs. Among these, long non protein-coding RNAs represent the most prevalent and functionally diverse class. The relevance of the non protein-coding genome to human disease has mainly been studied regarding the altered microRNA expression and function in human cancer. On the contrary, the elucidation of the involvement of long non-coding RNAs in disease is only in its infancy. We have recently found that a chromatin associated, long non protein-coding RNA regulates a Polycomb/Trithorax epigenetic switch at the basis of the repeat associated facioscapulohumeral muscular dystrophy, a common muscle disorder. Based on this, we propose that long non-coding RNAs produced by repetitive sequences contribute in shaping the epigenetic landscape in normal human physiology and in disease.
MeSH term(s)	Chromatin/genetics ; Chromatin/metabolism ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; Epigenesis, Genetic ; Genome, Human ; Histone-Lysine N-Methyltransferase ; Humans ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Dystrophy, Facioscapulohumeral/genetics ; Muscular Dystrophy, Facioscapulohumeral/metabolism ; Muscular Dystrophy, Facioscapulohumeral/pathology ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Polycomb-Group Proteins/genetics ; Polycomb-Group Proteins/metabolism ; RNA, Long Noncoding/chemistry ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Repetitive Sequences, Nucleic Acid
Chemical Substances	Chromatin ; KMT2A protein, human ; Polycomb-Group Proteins ; RNA, Long Noncoding ; Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; DNA (9007-49-2) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
Language	English
Publishing date	2012-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1555-8584
ISSN (online)	1555-8584
DOI	10.4161/rna.21922
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition.

Bonomi, Serena / di Matteo, Anna / Buratti, Emanuele / Cabianca, Daphne S / Baralle, Francisco E / Ghigna, Claudia / Biamonti, Giuseppe

Nucleic acids research

2013 Volume 41, Issue 18, Page(s) 8665–8679

Abstract: Epithelial-to-mesenchymal transition (EMT) is an embryonic program used by cancer cells to acquire invasive capabilities becoming metastatic. ΔRon, a constitutively active isoform of the Ron tyrosine kinase receptor, arises from skipping of Ron exon 11 ... ...

Abstract	Epithelial-to-mesenchymal transition (EMT) is an embryonic program used by cancer cells to acquire invasive capabilities becoming metastatic. ΔRon, a constitutively active isoform of the Ron tyrosine kinase receptor, arises from skipping of Ron exon 11 and provided the first example of an alternative splicing variant causatively linked to the activation of tumor EMT. Splicing of exon 11 is controlled by two adjacent regulatory elements, a silencer and an enhancer of splicing located in exon 12. The alternative splicing factor and oncoprotein SRSF1 directly binds to the enhancer, induces the production of ΔRon and activates EMT leading to cell locomotion. Interestingly, we now find an important role for hnRNP A1 in controlling the activity of the Ron silencer. HnRNP A1 is able to antagonize the binding of SRSF1 and prevent exon skipping. Notably, hnRNP A1, by inhibiting the production of ΔRon, activates the reversal program, namely the mesenchymal-to-epithelial transition, which instead occurs at the final metastasis sites. Also, hnRNP A1 affects Ron splicing by regulating the expression level of hnRNP A2/B1, which similarly to SRSF1 can promote ΔRon production. These results shed light on how splicing regulation contributes to the tumor progression and provide potential targets to develop anticancer therapies.
MeSH term(s)	Alternative Splicing ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Exons ; HEK293 Cells ; HeLa Cells ; Heterogeneous Nuclear Ribonucleoprotein A1 ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/physiology ; Humans ; Nonsense Mediated mRNA Decay ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Regulatory Sequences, Ribonucleic Acid
Chemical Substances	Heterogeneous Nuclear Ribonucleoprotein A1 ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B ; Regulatory Sequences, Ribonucleic Acid ; RON protein (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2013-07-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkt579
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.

Gonzalez-Sandoval, Adriana / Towbin, Benjamin D / Kalck, Veronique / Cabianca, Daphne S / Gaidatzis, Dimos / Hauer, Michael H / Geng, Liqing / Wang, Li / Yang, Teddy / Wang, Xinghao / Zhao, Kehao / Gasser, Susan M

Cell

2015 Volume 163, Issue 6, Page(s) 1333–1347

Abstract: Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 methylation is necessary to silence and to anchor repeat-rich heterochromatin ... ...

Abstract	Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 methylation is necessary to silence and to anchor repeat-rich heterochromatin at the nuclear periphery. In a screen for perinuclear anchors of heterochromatin, we identified a previously uncharacterized C. elegans chromodomain protein, CEC-4. CEC-4 binds preferentially mono-, di-, or tri-methylated H3K9 and localizes at the nuclear envelope independently of H3K9 methylation and nuclear lamin. CEC-4 is necessary for endogenous heterochromatin anchoring, but not for transcriptional repression, in contrast to other known H3K9 methyl-binders in worms, which mediate gene repression but not perinuclear anchoring. When we ectopically induce a muscle differentiation program in embryos, cec-4 mutants fail to commit fully to muscle cell fate. This suggests that perinuclear sequestration of chromatin during development helps restrict cell differentiation programs by stabilizing commitment to a specific cell fate. PAPERCLIP.
MeSH term(s)	Amino Acid Sequence ; Animals ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Differentiation ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromosomal Proteins, Non-Histone/chemistry ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Heterochromatin ; Histone Code ; Molecular Sequence Data ; Sequence Alignment
Chemical Substances	CEC-4 protein, C elegans ; Caenorhabditis elegans Proteins ; Chromosomal Proteins, Non-Histone ; Heterochromatin
Language	English
Publishing date	2015-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2015.10.066
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito