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Article: High production

de Andrade, Lorena Viana / de Souza Sá, Mirela Vanessa / Vasconcelos, Beatriz / Vasconcelos, Luydson Richardson Silva / Khouri, Ricardo / de Souza, Carlos Dornels Freire / Armstrong, Anderson da Costa / do Carmo, Rodrigo Feliciano

Heliyon

2023 Volume 10, Issue 1, Page(s) e23670

Abstract: Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association ... ...

Abstract	Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23670
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Article ; Online: High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients

Lorena Viana de Andrade / Mirela Vanessa de Souza Sá / Beatriz Vasconcelos / Luydson Richardson Silva Vasconcelos / Ricardo Khouri / Carlos Dornels Freire de Souza / Anderson da Costa Armstrong / Rodrigo Feliciano do Carmo

Heliyon, Vol 10, Iss 1, Pp e23670- (2024)

A retrospective cohort study

1481

Abstract	Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization and clinical worsening in patients with COVID-19. A total of 550 patients with COVID-19 were included (94 non-hospitalized and 456 hospitalized). Polymorphisms in MBL2 exon 1 (codons 52, 54 and 57) and promoter region (−550, −221, and +4) were determined by real-time PCR. MBL and complement proteins were measured by Luminex. A higher frequency of the H/H genotype and the HYPA haplotype was observed in non-hospitalized patients when compared to hospitalized. In addition, critically ill patients carrying haplotypes associated with high MBL levels (HYPA/HYPA + HYPA/LYPA + HYPA/LYQA + LYPA/LYQA + LYPA/LYPA + LYQA/LYQA + LXPA/HYPA + LXPA/LYQA + LXPA/LYPA) were protected against lower oxygen saturation levels (P = 0.02), use of invasive ventilation use (P = 0.02, OR 0.38), and shock (P = 0.01, OR 0.40), independent of other potential confounders adjusted by multivariate analysis. Our results suggest that variants in MBL2 associated with high MBL levels may play a protective role in the clinical course of COVID-19.
Keywords	Innate immunity ; Complement system ; Mannose-binding lectin ; Mannan-binding lectin ; Polymorphism ; SARS-CoV-2 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Health in prison: coronavirus disease 2019's challenges in the Brazilian criminal justice system.

Paiva, João Paulo Silva de / Leal, Thiago Cavalcanti / Silva, Leonardo Feitosa da / Santos, Lucas Gomes / Santana, Gibson Barros de Almeida / Machado, Michael Ferreira / Souza, Carlos Dornels Freire de

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 1, Page(s) 186–190

MeSH term(s)	Humans ; Prisons ; Criminal Law ; Brazil ; COVID-19
Language	English
Publishing date	2023-01-09
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20210889
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Article ; Online: Disseminated cutaneous tuberculosis in an immunocompetent patient: a clinical challenge in the public health system in Brazil.

Amorim, José Roberto / Nunes, Bruno Eduardo Bastos Rolim / Silva, Francisco Wellington Dos Santos da / Magalhães, Ariana Carla Sousa de / Moreno de Oliveira Fernandes, Tânia Rita / do Carmo, Rodrigo Feliciano / de Souza, Carlos Dornels Freire

International journal of dermatology

2022 Volume 61, Issue 6, Page(s) 771–773

MeSH term(s)	Brazil ; Granuloma ; Humans ; Immunocompetence ; Public Health ; Skin ; Tuberculosis, Cutaneous/diagnosis ; Tuberculosis, Cutaneous/drug therapy ; Tuberculosis, Miliary
Language	English
Publishing date	2022-01-30
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16108
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Article ; Online: Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility.

Moraes, Ana Clara Cadidé Gonzaga / da Luz, Renata Clesia Feitosa Viana / Fernandes, André Luís Magalhães / Barbosa, Milena Xavier Silva / de Andrade, Lorena Viana / Armstrong, Anderson da Costa / de Souza, Carlos Dornels Freire / do Carmo, Rodrigo Feliciano

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 853

Abstract: Background: Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various ... ...

Abstract	Background: Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this study was to evaluate the association of PTX3 gene polymorphisms and PTX3 plasma levels with susceptibility to leprosy and clinical characteristics. Methods: Patients with leprosy from a hyperendemic area in the Northeast Region of Brazil were included. Healthy household contacts and healthy blood donors from the same geographical area were recruited as a control group. The rs1840680 and rs2305619 polymorphisms of PTX3 were determined by real-time PCR. Plasma levels of PTX3 were determined by ELISA. Results: A total of 512 individuals were included. Of these, 273 were patients diagnosed with leprosy; 53 were household contacts, and 186 were healthy blood donors. No association was observed between PTX3 polymorphisms and susceptibility to leprosy or development of leprosy reaction or physical disability. On the other hand, plasma levels of PTX3 were significantly higher in patients with leprosy when compared to household contacts (p = 0.003) or blood donors (p = 0.04). It was also observed that PTX3 levels drop significantly after multidrug therapy (p < 0.0001). Conclusions: Our results suggest that PTX3 may play an important role in the pathogenesis of leprosy and point to the potential use of this molecule as an infection marker.
MeSH term(s)	Humans ; Drug Therapy, Combination ; Leprostatic Agents ; C-Reactive Protein/genetics ; C-Reactive Protein/analysis ; Biomarkers ; Leprosy/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	PTX3 protein (148591-49-5) ; Leprostatic Agents ; C-Reactive Protein (9007-41-4) ; Biomarkers
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08862-0
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Article ; Online: Leprosy transmission in Bahia, 2001-2015: modeling based on Jointpoint regression and spatial scan statistics.

Souza, Carlos Dornels Freire de / Luna, Carlos Feitosa / Magalhães, Mônica de Avelar Figueiredo Mafra

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

2019 Volume 28, Issue 1, Page(s) e2018065

Abstract: Objective: to describe the trend and the spatial distribution of leprosy in the state of Bahia, Brazil, 2001-2015.: Methods: this was a mixed ecological study of epidemiological indicators of leprosy; Jointpoint regression was used for the temporal ... ...

Title translation	Transmissão da hanseníase na Bahia, 2001-2015: modelagem a partir de regressão por pontos de inflexão e estatística de varredura espacial.
Abstract	Objective: to describe the trend and the spatial distribution of leprosy in the state of Bahia, Brazil, 2001-2015. Methods: this was a mixed ecological study of epidemiological indicators of leprosy; Jointpoint regression was used for the temporal analysis, while spatial scan statistics were used to identify clusters of the disease; the trend was classified as stationary, increasing or decreasing; we calculated the annual percent change (APC) and average annual percent change (AAPC). Results: there was a reduction in prevalence (AAPC = -5.6; p<0,001), treatment dropout (AAPC = -13.7; p<0.001), and females with leprosy (AAPC = -0.6; p<0.001); the new grade II case coefficient (AAPC = 2.7; p<0.001) and the proportion of multibacillary cases (AAPC = 2,2; p<0.001) showed a growing trend; spatial distribution was heterogeneous and concentrated in three regions in particular (north, west and south of the state), with variation between the indicators. Conclusion: persisting leprosy transmission in the state, late diagnosis and high hidden prevalence is suggested.
MeSH term(s)	Adolescent ; Brazil/epidemiology ; Cluster Analysis ; Delayed Diagnosis ; Female ; Humans ; Leprosy/diagnosis ; Leprosy/epidemiology ; Leprosy/transmission ; Male ; Models, Statistical ; Prevalence ; Regression Analysis ; Spatial Analysis
Language	Portuguese
Publishing date	2019-04-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2880588-4
ISSN	2237-9622 ; 1679-4974
ISSN (online)	2237-9622
ISSN	1679-4974
DOI	10.5123/S1679-49742019000100015
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Article ; Online: Spatial modeling of leprosy in the state of Bahia and its social determinants: a study of health inequities.

Souza, Carlos Dornels Freire de / Luna, Carlos Feitosa / Magalhães, Mônica de Avelar Figueiredo Mafra

Anais brasileiros de dermatologia

2019 Volume 94, Issue 2, Page(s) 182–191

Abstract: Background: Leprosy is a neglected disease caused by Mycobacterium leprae. Brazil has the second largest number of cases in the world.: Objectives: To analyze the spatial distribution of leprosy in the state of BAHIA, Brazil, and the association ... ...

Abstract	Background: Leprosy is a neglected disease caused by Mycobacterium leprae. Brazil has the second largest number of cases in the world. Objectives: To analyze the spatial distribution of leprosy in the state of BAHIA, Brazil, and the association between his occurrence and the synthetic indicators of municipal socioeconomic performance, social vulnerability and income inequality. Methods: An ecological study with secondary data obtained from the National System of Notifiable Diseases. Dependent variables: coefficient of detection in the general population and in the population under 15 years old and the rate of grade II of physical disability. Independent variables: Synthetic indicators of socioeconomic performance, social vulnerability and income inequality. Results: The highest coefficients of detection of new cases in the general population and in children under 15 years old are concentrated in the north-west axis and in the southern region of the state. On the other hand, the highest rates of degree II of physical incapacity are concentrated in the north, northeast and south regions. Only the Index of Social and Economic Performance(IPESE)-Economy and Finance composed the final regression model of the general detection coefficients and in children under 15 years old. The municipalities with the highest indexes had the highest detection coefficients, reflecting the capacity to diagnose new cases. Study limitations: The use of synthetic indicators is a limitation of the study. Conclusions: Leprosy presents a heterogeneous spatial pattern in the state of BAHIA, and the IPESE-Economics and Finance indicator is the only one with explanatory potential of the disease.
MeSH term(s)	Adolescent ; Age Distribution ; Bayes Theorem ; Brazil/epidemiology ; Cities/epidemiology ; Demography/methods ; Disabled Persons/statistics & numerical data ; Endemic Diseases/statistics & numerical data ; Health Status Indicators ; Humans ; Leprosy/epidemiology ; Social Determinants of Health/statistics & numerical data ; Socioeconomic Factors ; Spatial Analysis ; Vulnerable Populations/statistics & numerical data
Language	English
Publishing date	2019-05-09
Publishing country	Spain
Document type	Journal Article
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1590/abd1806-4841.20197554
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Book ; Online: Spatiotemporal evolution of case fatality rates of COVID-19 in Brazil, 2020

Souza, Carlos Dornels Freire de / Paiva, João Paulo Silva de / Leal, Thiago Cavalcanti / Silva, Leonardo Feitosa da / Santos, Lucas Gomes

Jornal Brasileiro de Pneumologia v.46 n.4 2020

2020

Keywords	covid19
Language	English
Publishing date	2020-01-01
Publisher	Sociedade Brasileira de Pneumologia e Tisiologia
Publishing country	br
Document type	Book ; Online
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Article ; Online: Urbanization and cardiovascular health among Indigenous groups in Brazil.

Armstrong, Anderson da Costa / de Souza, Carlos Dornels Freire / Santos, Juracy Marques Dos / Carmo, Rodrigo Feliciano do / Armstrong, Dinani Matoso Fialho de Oliveira / Pereira, Vanessa Cardoso / Ladeia, Ana Marice / Correia, Luis Claudio Lemos / Barral-Netto, Manoel / Lima, Joao Augusto Costa

Communications medicine

2023 Volume 3, Issue 1, Page(s) 17

Abstract: ... among Indigenous populations (Projeto de Aterosclerose em Indígenas; PAI) is a cross-sectional study conducted in Northeast ...

Abstract	Background: We described the prevalence of cardiovascular risk factors in groups of Brazilian Indigenous people at different degrees of urbanization. Methods: The Project of Atherosclerosis among Indigenous populations (Projeto de Aterosclerose em Indígenas; PAI) is a cross-sectional study conducted in Northeast Brazil between August 2016-June 2017. It included three populations: Fulni-ô Indigenous people (lowest degree of urbanization), Truká Indigenous people (greater urbanization), and a highly urbanized non-Indigenous local cohort (control group). Participants were assessed to register sociodemographic, anthropometric, as well as clinical and laboratory-derived cardiovascular (CV) risk parameters. Age-adjusted prevalence of hypertension was also computed. Nonparametric tests were used for group comparisons. Results: Here we included 999 participants, with a predominance of females in all three groups (68.3% Control group, 65.0% Fulni-ô indigenous group, and 60.1% Truká indigenous group). Obesity was present in 45.6% of the urban non-Indigenous population, 37.7% Truká and in 27.6% Fulni-ô participants. The prevalence of hypertension was 29.1% (n = 297) with lower prevalence in the less urbanized Fulni-ô people (Fulni-ô - 18.2%; Truká - 33.9%; and Control - 33.8%; p < 0.001). In the elderly male population, the prevalence of hypertension was 18.7% in the Fulni-ô, 45.8% in the Truká, and 54.5% in the control group. Of the 342 participants that self-reported hypertension, 37.5% (n = 68) showed uncontrolled blood pressure (BP). Uncontrolled BP was more prevalent among Truká people when compared to Fulni-ô people and non-Indigenous participants (45.4%, 22.9%, and 40.7%, respectively; p < 0.001). Conclusions: We found a higher cardiovascular risk in communities with a higher degree of urbanization, suggesting that living in towns and cities may have a negative impact on these aspects of cardiovascular health.
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-023-00239-3
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Article ; Online: Epidemiological monitoring of leprosy indicators in Sergipe (2001-2015): segmented regression analysis.

Souza, Carlos Dornels Freire de / Leal, Thiago Cavalcanti / Paiva, João Paulo Silva de / Santos, Victor Santana

Anais brasileiros de dermatologia

2020 Volume 95, Issue 4, Page(s) 508–510

Abstract: This study analyzed the trend of leprosy indicators in Sergipe, between 2001 and 2015. It was a time series study that analyzed the trend for general detection coefficient, children under 15 years of age, and new cases with grade 2 disability. The ... ...

Abstract	This study analyzed the trend of leprosy indicators in Sergipe, between 2001 and 2015. It was a time series study that analyzed the trend for general detection coefficient, children under 15 years of age, and new cases with grade 2 disability. The joinpoint model was used. Two (2.6%) municipalities had an increasing trend in general detection coefficient, five (6.6%) had an increasing trend in detection rate in children under 15, and 19 (25.3%) had an increasing trend in detection coefficient of new leprosy cases with grade 2 disability. The findings suggest maintenance of the chain of transmission.
MeSH term(s)	Brazil/epidemiology ; Child ; Cities ; Disabled Persons ; Epidemiological Monitoring ; Humans ; Leprosy/epidemiology ; Regression Analysis
Language	English
Publishing date	2020-05-19
Publishing country	Spain
Document type	Case Reports
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1016/j.abd.2019.07.015
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