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  1. Article ; Online: Anal Cancer and Anal Cancer Screening.

    Cohen, Camryn M / Clarke, Megan A

    Clinical obstetrics and gynecology

    2023  Volume 66, Issue 3, Page(s) 516–533

    Abstract: This chapter provides an overview of anal cancer and contemporary approaches for anal precancer detection, beginning with a discussion of the biology and natural history of anal squamous cell carcinoma, the predominant human papillomavirus -associated ... ...

    Abstract This chapter provides an overview of anal cancer and contemporary approaches for anal precancer detection, beginning with a discussion of the biology and natural history of anal squamous cell carcinoma, the predominant human papillomavirus -associated histologic subtype of anal cancer. This section is followed by a description of the epidemiology of anal cancer, including trends in incidence and mortality, a discussion of populations with elevated risk for anal cancer and an overview of associated risk factors. The remainder of the chapter provides the most up-to-date evidence on tools and approaches for anal cancer prevention, screening, and early detection; including, the role of human papillomavirus vaccination for primary prevention; anal cytology, high resolution anoscopy and novel biomarkers for secondary prevention; and digital anal-rectal examination for early detection.
    MeSH term(s) Humans ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/prevention & control ; Early Detection of Cancer ; Papillomavirus Vaccines/therapeutic use ; Anal Canal/pathology ; Anus Neoplasms/diagnosis ; Anus Neoplasms/epidemiology ; Anus Neoplasms/prevention & control ; Papillomaviridae
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of State Funding for Comprehensive Reproductive Health Care With Use of Contraception Among Latina Patients and Non-Latina Patients in Oregon.

    Cohen, Megan A / Boniface, Emily R / Skye, Megan / Linz, Rachel / Pedhiwala, Nisreen / Rodriguez, Maria I

    JAMA health forum

    2023  Volume 4, Issue 7, Page(s) e232144

    Abstract: Importance: There are well-documented racial and ethnic disparities in effective contraceptive use due to multiple factors. A key contributor may be differential insurance coverage and patient costs. The Oregon Reproductive Health Equity Act (RHEA), ... ...

    Abstract Importance: There are well-documented racial and ethnic disparities in effective contraceptive use due to multiple factors. A key contributor may be differential insurance coverage and patient costs. The Oregon Reproductive Health Equity Act (RHEA), enacted in 2017, ensures full coverage of reproductive health care without cost sharing for all Oregonians with low income.
    Objective: To assess whether removing financial barriers to accessing contraceptive care is associated with an improvement in use of moderately and highly effective contraceptive methods among Latina women compared with non-Latina women.
    Design, setting, and participants: This cohort study included women aged 12 to 51 years who sought contraceptive care in the Oregon Health Authority Reproductive Health Program from April 2016 to March 2020. Patients using permanent contraception, those missing data on ethnicity, and non-Oregon residents were excluded. Data analysis was performed in January 2021.
    Exposures: Contraceptive care in the Reproductive Health Program after RHEA implementation.
    Main outcomes and measures: The main outcome was prevalence of use of moderately effective methods (contraceptive pills, patch, ring, or injection) or highly effective methods (long-acting reversible contraceptives) at the time of the contraceptive visit. Difference-in-differences analysis was used to compare moderately and highly effective contraception use between Latina and non-Latina patients. Secondary outcomes were proportions of adoption or continuation of moderately and highly effective methods, prevalence of highly effective methods, and adoption or continuation of highly effective methods. The unit of analysis was at the clinic visit level.
    Results: The study sample consisted of 295 604 evaluable clinic visits, in which 28.4% of individuals identified as Latina and 71.6% of individuals identified as non-Latina. The mean (SD) age was 25.5 (8.1) years. With difference-in-differences analysis, there was a significant adjusted 1.9 percentage point (95% CI, 0.2-3.6 percentage points) increase in prevalence of moderately or highly effective contraceptive methods for Latina patients compared with non-Latina patients. There were no significant differences for other outcomes of interest.
    Conclusions: This cohort study found that in Oregon, legislation removing financial barriers to accessing contraceptive care was associated with significant mitigation in disparate moderately and highly effective contraceptive method prevalence for Latina patients compared with non-Latina patients. The findings suggest that state funds successfully supplanted federal funds to enable continued robust comprehensive family planning services after withdrawal from Title X.
    MeSH term(s) Humans ; Female ; Cohort Studies ; Reproductive Health ; Contraception/methods ; Contraceptive Agents/therapeutic use ; Family Planning Services
    Chemical Substances Contraceptive Agents
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.2144
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  3. Article ; Online: Global Preconception and Contraception Care: Using a Life-Course Approach to Improve Health Outcomes in Lower-Resource Settings.

    Cohen, Megan A / Kumar, Somesh / Hathaway, Mark

    Obstetrics and gynecology clinics of North America

    2022  Volume 49, Issue 4, Page(s) 647–663

    Abstract: A life-course approach incorporating appropriate preconception and contraception care is key to achieving optimal maternal, neonatal, and child health outcomes. In low- and middle-income countries (LMIC), there is a large unmet need for contraception and ...

    Abstract A life-course approach incorporating appropriate preconception and contraception care is key to achieving optimal maternal, neonatal, and child health outcomes. In low- and middle-income countries (LMIC), there is a large unmet need for contraception and an estimated 49% of pregnancies are unintended. In this article, we discuss preconception and contraception care in LMIC settings including key recommendations for content and service delivery. We discuss barriers and facilitators to contraceptive provision, discuss considerations for providers who may practice in LMIC settings, and highlight strategies for achieving increased contraceptive uptake including several examples of successful programs.
    MeSH term(s) Pregnancy ; Child ; Female ; Infant, Newborn ; Humans ; Family Planning Services ; Contraception ; Contraceptive Agents ; Life Change Events ; Outcome Assessment, Health Care ; Contraception Behavior
    Chemical Substances Contraceptive Agents
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1004315-9
    ISSN 1558-0474 ; 0889-8545
    ISSN (online) 1558-0474
    ISSN 0889-8545
    DOI 10.1016/j.ogc.2022.07.003
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  4. Article: Using CDC's Worksite Health ScoreCard to Evaluate Nutrition and Physical Activity Interventions in Priority Communities in New York State, 2015-2020.

    Archibald, Abbie / Murphy, Megan / Cohen, Theresa / Lowenfels, Ann

    Health promotion practice

    2022  Volume 23, Issue 1_suppl, Page(s) 34S–43S

    Abstract: The aim of our study was to evaluate a statewide obesity prevention program, designed to improve two social determinants of health (access to healthy foods and opportunities for physical activity) by changing worksite policies, systems, and environments. ...

    Abstract The aim of our study was to evaluate a statewide obesity prevention program, designed to improve two social determinants of health (access to healthy foods and opportunities for physical activity) by changing worksite policies, systems, and environments. We used data on social determinants of health to identify priority communities and funded 25 contractors to recruit and engage worksites in those communities. We employed a pre/post quasi-experimental design and used the Centers for Disease Control and Prevention's Worksite Health ScoreCard to assess implementation of nutrition and physical activity strategies. Contractors collaborated with partners to conduct pre- and postassessments at 313 worksites. Worksites were successful at implementing all except one strategy; implementation doubled for eight strategies and tripled for three. We used weighted scores to incorporate strength of the evidence-base and level of impact into our analysis; increases in strategy implementation were statistically significant in worksites that provided places to purchase food and beverages and in those that did not. Our study revealed several important recommendations for practice. Use available data to prioritize communities experiencing health disparities and identify PSE change strategies to increase access to nutritious foods and physical activity opportunities. Engage with reputable community-based partners from different sectors when designing and implementing programs. Use standardized tools, such as the Worksite Health ScoreCard, to evaluate public health initiatives.
    MeSH term(s) Humans ; United States ; Workplace ; Health Promotion ; New York ; Centers for Disease Control and Prevention, U.S. ; Exercise
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036801-X
    ISSN 1552-6372 ; 1524-8399
    ISSN (online) 1552-6372
    ISSN 1524-8399
    DOI 10.1177/15248399221114338
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  5. Article ; Online: Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception.

    Cohen, Megan A / Edelman, Alison / Paynter, Robin / Henderson, Jillian T

    The Cochrane database of systematic reviews

    2023  Volume 1, Page(s) CD014908

    Abstract: Background: The novel coronavirus disease (COVID-19) has led to significant mortality and morbidity, including a high incidence of related thrombotic events. There has been concern regarding hormonal contraception use during the COVID-19 pandemic, as ... ...

    Abstract Background: The novel coronavirus disease (COVID-19) has led to significant mortality and morbidity, including a high incidence of related thrombotic events. There has been concern regarding hormonal contraception use during the COVID-19 pandemic, as this is an independent risk factor for thrombosis, particularly with estrogen-containing formulations. However, higher estrogen levels may be protective against severe COVID-19 disease. Evidence for risks of hormonal contraception use during the COVID-19 pandemic is sparse. We therefore conducted a living systematic review that will be updated as new data emerge on the risk of thromboembolism with hormonal contraception use in patients with COVID-19.
    Objectives: To determine if use of hormonal contraception increases risk of venous and arterial thromboembolism in women with COVID-19. To determine if use of hormonal contraception increases other markers of COVID-19 severity including hospitalization in the intensive care unit, acute respiratory distress syndrome, intubation, and mortality. A secondary objective is to maintain the currency of the evidence, using a living systematic review approach.
    Search methods: ⁠⁠⁠⁠⁠⁠We searched CENTRAL, MEDLINE, Embase, CINAHL, LILACS, Global Health, and Scopus from inception to search update in March 2022. For the living systematic review, we monitored the literature monthly.
    Selection criteria: We included all published and ongoing studies of patients with COVID-19 comparing outcomes of those on hormonal contraception versus those not on hormonal contraception. This included case series and non-randomized studies of interventions (NRSI).
    Data collection and analysis: One review author extracted study data and this was checked by a second author. Two authors individually assessed risk of bias for the comparative studies using the ROBINS-I tool and a third author helped reconcile differences. For the living systematic review, we will publish updates to our synthesis every six months. In the event that we identify a study with a more rigorous study design than the current included evidence prior to the planned six-month update, we will expedite the synthesis publication.
    Main results: We included three comparative NRSIs with 314,704 participants total and two case series describing 13 patients. The three NRSIs had serious to critical risk of bias in several domains and low study quality. Only one NRSI ascertained current use of contraceptives based on patient report; the other two used diagnostic codes within medical records to assess hormonal contraception use, but did not confirm current use nor indication for use. None of the NRSIs included thromboembolism as an outcome. Studies were not similar enough in terms of their outcomes, interventions, and study populations to combine with meta-analyses. We therefore narratively synthesized all included studies. Based on results from one NRSI, there may be little to no effect of combined hormonal contraception use on odds of mortality for COVID-19 positive patients (odds ratio (OR) 1.00, 95% confidence interval (CI) 0.41 to 2.40; 1 study, 18,892 participants; very low-certainty evidence). Two NRSIs examined hospitalization rates for hormonal contraception users versus non-users. Based on results from one NRSI, the odds of hospitalization for COVID-19 positive combined hormonal contraception users may be slightly decreased compared with non-users for patients with body mass index (BMI) under 35 kg/m
    Authors' conclusions: There are no comparative studies assessing risk of thromboembolism in COVID-19 patients who use hormonal contraception, which was the primary objective of this review. Very little evidence exists examining the risk of increased COVID-19 disease severity for combined hormonal contraception users compared to non-users of hormonal contraception, and the evidence that does exist is of very low certainty. The odds of hospitalization for COVID-19 positive users of combined hormonal contraceptives may be slightly decreased compared with those of hormonal contraceptive non-users, but the evidence is very uncertain as this is based on one study restricted to patients with BMI under 35 kg/m
    MeSH term(s) Female ; Humans ; Contraceptive Agents/adverse effects ; COVID-19/epidemiology ; Estrogens/adverse effects ; Hormonal Contraception/adverse effects ; Pandemics ; Thrombosis/epidemiology ; Venous Thromboembolism/epidemiology
    Chemical Substances Contraceptive Agents ; Estrogens
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD014908.pub2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identifying opportunities for informatics-supported suicide prevention: the case of Caring Contacts.

    Burkhardt, Hannah A / Laine, Megan / Kerbrat, Amanda / Cohen, Trevor / Comtois, Katherine A / Hartzler, Andrea

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2023  Volume 2022, Page(s) 309–318

    Abstract: Suicide is the tenth leading cause of death in the United States. Caring Contacts (CC) is a suicide prevention intervention involving care teams sending brief messages expressing unconditional care to patients at risk of suicide. Despite solid evidence ... ...

    Abstract Suicide is the tenth leading cause of death in the United States. Caring Contacts (CC) is a suicide prevention intervention involving care teams sending brief messages expressing unconditional care to patients at risk of suicide. Despite solid evidence for its effectiveness, CC has not been broadly adopted by healthcare organizations. Technology has the potential to facilitate CC if barriers to adoption were better understood. This qualitative study assessed the needs of organizational stakeholders for a CC informatics tool through interviews that investigated barriers to adoption, workflow challenges, and participant-suggested design opportunities. We identified contextual barriers related to environment, intervention parameters, and technology use. Workflow challenges included time-consuming simple tasks, risk assessment and management, the cognitive demands of authoring follow-up messages, accessing and aggregating information across systems, and team communication. To address these needs, we propose design considerations that focus on automation, cognitive support, and data and workflow integration. Future work will incorporate these findings to design informatics tools supporting broader adoption of Caring Contacts.
    MeSH term(s) Humans ; United States ; Suicide ; Suicide Prevention ; Informatics ; Communication ; Qualitative Research
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1942-597X
    ISSN (online) 1942-597X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inflammatory Bowel Disease Hospitalizations Are Similar for Patients Receiving Televisit-Delivered Outpatient Care and Those Receiving Traditional In-Person Care.

    Cohen-Mekelburg, Shirley / Valicevic, Autumn / Lin, Lewei Allison / Saini, Sameer D / Kim, Hyungjin Myra / Adams, Megan A

    The American journal of gastroenterology

    2024  

    Abstract: Introduction: The coronavirus disease 2019 pandemic resulted in widespread expansion of telehealth. However, there are concerns that telehealth-delivered outpatient care may limit opportunities for managing complications and preventing hospitalizations ... ...

    Abstract Introduction: The coronavirus disease 2019 pandemic resulted in widespread expansion of telehealth. However, there are concerns that telehealth-delivered outpatient care may limit opportunities for managing complications and preventing hospitalizations for patients with inflammatory bowel disease (IBD). We aimed to assess the association between outpatient IBD care delivered through televisit (video or phone) and IBD-related hospitalizations.
    Methods: We conducted a case-control study of patients with IBD who had an IBD-related index hospitalization between April 2021 and July 2022 and received their care in the Veterans Health Administration. We matched these hospitalized patients to controls who were not hospitalized based on age, sex, race, Charlson comorbidity index, IBD type, IBD-related emergency department use, IBD-related hospitalizations, and outpatient gastroenterology visits in the preceding year. The variable of interest was the percentage of total clinic visits delivered through televisit in the year before the index hospitalization. We compared the risk of IBD-related hospitalization by exposure to televisit-delivered care using conditional logistic regression.
    Results: We identified 534 patients with an IBD-related hospitalization and 534 matched controls without an IBD-related hospitalization during the study period. Patients with IBD with a higher percentage of televisit-delivered (vs in-person) outpatient care were less likely to be hospitalized during the study period (for every 10% increase in televisit use, odds ratio 0.97, 95% confidence interval 0.94-1.00; P = 0.03).
    Discussion: Televisit-delivered outpatient IBD care is not associated with higher risk of IBD-related hospitalization. These findings may reassure clinicians that televisit-delivered outpatient care is appropriate for patients with complex chronic diseases such as IBD.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002703
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  8. Article ; Online: Abortion Care Beyond 13 Weeks' Gestation: A Global Perspective.

    Cohen, Megan A / Kapp, Nathalie / Edelman, Alison

    Clinical obstetrics and gynecology

    2021  Volume 64, Issue 3, Page(s) 460–474

    Abstract: The majority of abortions are performed early in pregnancy, but later abortion accounts for a large proportion of abortion-related morbidity and mortality. People who need this care are often the most vulnerable-the poor, the young, those who experience ... ...

    Abstract The majority of abortions are performed early in pregnancy, but later abortion accounts for a large proportion of abortion-related morbidity and mortality. People who need this care are often the most vulnerable-the poor, the young, those who experience violence, and those with significant health issues. In settings with access to safe care, studies demonstrate significant declines in abortion-related morbidity and mortality. This review focuses on evidence-based practices for induced abortion beyond 13 weeks' gestation and post-abortion care in both high- and low-resource settings. We also highlight key programmatic issues to consider when expanding the gestational age for abortion services.
    MeSH term(s) Abortion, Induced ; Abortion, Legal ; Abortion, Spontaneous ; Female ; Gestational Age ; Humans ; Population Surveillance ; Pregnancy
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000631
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  9. Article ; Online: Assessing ChatGPT's Responses to Otolaryngology Patient Questions.

    Carnino, Jonathan M / Pellegrini, William R / Willis, Megan / Cohen, Michael B / Paz-Lansberg, Marianella / Davis, Elizabeth M / Grillone, Gregory A / Levi, Jessica R

    The Annals of otology, rhinology, and laryngology

    2024  , Page(s) 34894241249621

    Abstract: Objective: This study aims to evaluate ChatGPT's performance in addressing real-world otolaryngology patient questions, focusing on accuracy, comprehensiveness, and patient safety, to assess its suitability for integration into healthcare.: Methods: ... ...

    Abstract Objective: This study aims to evaluate ChatGPT's performance in addressing real-world otolaryngology patient questions, focusing on accuracy, comprehensiveness, and patient safety, to assess its suitability for integration into healthcare.
    Methods: A cross-sectional study was conducted using patient questions from the public online forum Reddit's r/AskDocs, where medical advice is sought from healthcare professionals. Patient questions were input into ChatGPT (GPT-3.5), and responses were reviewed by 5 board-certified otolaryngologists. The evaluation criteria included difficulty, accuracy, comprehensiveness, and bedside manner/empathy. Statistical analysis explored the relationship between patient question characteristics and ChatGPT response scores. Potentially dangerous responses were also identified.
    Results: Patient questions averaged 224.93 words, while ChatGPT responses were longer at 414.93 words. The accuracy scores for ChatGPT responses were 3.76/5, comprehensiveness scores were 3.59/5, and bedside manner/empathy scores were 4.28/5. Longer patient questions did not correlate with higher response ratings. However, longer ChatGPT responses scored higher in bedside manner/empathy. Higher question difficulty correlated with lower comprehensiveness. Five responses were flagged as potentially dangerous.
    Conclusion: While ChatGPT exhibits promise in addressing otolaryngology patient questions, this study demonstrates its limitations, particularly in accuracy and comprehensiveness. The identification of potentially dangerous responses underscores the need for a cautious approach to AI in medical advice. Responsible integration of AI into healthcare necessitates thorough assessments of model performance and ethical considerations for patient safety.
    Language English
    Publishing date 2024-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/00034894241249621
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  10. Article ; Online: Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception: a Cochrane systematic review.

    Hansen, Katie / Cohen, Megan A / Ramanadhan, Shaalini / Paynter, Robin / Edelman, Alison / Henderson, Jillian T

    BMJ sexual & reproductive health

    2023  Volume 49, Issue 3, Page(s) 201–209

    Abstract: Background: The coronavirus disease COVID-19 is associated with an increased risk of thrombotic events. Individuals with COVID-19 using hormonal contraception could be at additional risk for thromboembolism, but evidence is sparse.: Methods: We ... ...

    Abstract Background: The coronavirus disease COVID-19 is associated with an increased risk of thrombotic events. Individuals with COVID-19 using hormonal contraception could be at additional risk for thromboembolism, but evidence is sparse.
    Methods: We conducted a systematic review on the risk of thromboembolism with hormonal contraception use in women aged 15-51 years with COVID-19. We searched multiple databases through March 2022, including all studies comparing outcomes of patients with COVID-19 using or not using hormonal contraception. We applied standard risk of bias tools to evaluate studies and GRADE methodology to assess certainty of evidence. Our primary outcomes were venous and arterial thromboembolism. Secondary outcomes included hospitalisation, acute respiratory distress syndrome, intubation, and mortality.
    Results: Of 2119 studies screened, three comparative non-randomised studies of interventions (NRSIs) and two case series met the inclusion criteria. All studies had serious to critical risk of bias and low study quality. Overall, there may be little to no effect of combined hormonal contraception (CHC) use on odds of mortality for COVID-19-positive patients (OR 1.0, 95% CI 0.41 to 2.4). The odds of hospitalisation for COVID-19-positive CHC users may be slightly decreased compared with non-users for patients with body mass index <35 kg/m
    Conclusions: Not enough evidence exists to draw conclusions regarding risk of thromboembolism in patients with COVID-19 using hormonal contraception. Evidence suggests there may be little to no or slightly decreased odds of hospitalisation, and little to no effect on odds of mortality for hormonal contraception users versus non-users with COVID-19.
    MeSH term(s) Humans ; Female ; COVID-19/epidemiology ; Hormonal Contraception ; Thromboembolism/epidemiology ; Thromboembolism/etiology
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Systematic Review ; Journal Article
    ISSN 2515-2009
    ISSN (online) 2515-2009
    DOI 10.1136/bmjsrh-2023-201792
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