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  1. Article ; Online: Special dermatological presentation of paediatric multisystem inflammatory syndrome related to COVID-19: erythema multiforme.

    Bapst, Thomas / Romano, Fabrizio / Müller, Marie / Rohr, Marie

    BMJ case reports

    2020  Volume 13, Issue 6

    MeSH term(s) Adolescent ; Anti-Bacterial Agents/administration & dosage ; Azithromycin/administration & dosage ; Betacoronavirus/isolation & purification ; COVID-19 ; Ceftriaxone/administration & dosage ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Diagnosis, Differential ; Erythema Multiforme/diagnosis ; Erythema Multiforme/etiology ; Erythema Multiforme/therapy ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/etiology ; Male ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/etiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription.

    Bapst, Andreas M / Dahl, Sophie L / Knöpfel, Thomas / Wenger, Roland H

    Biochimica et biophysica acta. Gene regulatory mechanisms

    2020  Volume 1863, Issue 8, Page(s) 194568

    Abstract: One of the widely used applications of the popular Cre-loxP method for targeted recombination is the permanent activation of marker genes, such as reporter genes or antibiotic resistance genes, by excision of a preceding transcriptional stop signal. The ... ...

    Abstract One of the widely used applications of the popular Cre-loxP method for targeted recombination is the permanent activation of marker genes, such as reporter genes or antibiotic resistance genes, by excision of a preceding transcriptional stop signal. The STOP cassette consists of three identical SV40-derived poly(A) signal repeats and is flanked by two loxP sites. We found that in addition to complete loxP-mediated recombination, limiting levels of the Cre recombinase also cause incomplete recombination of the STOP cassette. Partial recombination leads to the loss of only one or two of the three identical poly(A) repeats with recombination breakpoints always precisely matching the end/start of each poly(A) signal repeat without any relevant similarity to the canonical or known cryptic loxP sequences, suggesting that this type of Cre-mediated recombination is loxP-independent. Incomplete deletion of the STOP cassette results in partial read-through transcription, explaining at least some of the variability often observed in marker gene expression from an otherwise identical locus.
    MeSH term(s) Animals ; CHO Cells ; Cricetulus ; Female ; Gene Expression ; Genes, Reporter/genetics ; Genetic Markers ; Integrases/genetics ; Integrases/metabolism ; Kidney ; Male ; Mice ; Recombination, Genetic ; Transcriptome
    Chemical Substances Genetic Markers ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2020-04-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918786-2
    ISSN 1876-4320 ; 1874-9399
    ISSN (online) 1876-4320
    ISSN 1874-9399
    DOI 10.1016/j.bbagrm.2020.194568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Special dermatological presentation of paediatric multisystem inflammatory syndrome related to COVID-19: erythema multiforme

    Bapst, Thomas / Romano, Fabrizio / Müller, Marie / Rohr, Marie

    BMJ case reports

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #618659
    Database COVID19

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  4. Article ; Online: Special dermatological presentation of paediatric multisystem inflammatory syndrome related to COVID-19

    Bapst, Thomas / Romano, Fabrizio / Müller, Marie / Rohr, Marie

    BMJ Case Reports

    erythema multiforme

    2020  Volume 13, Issue 6, Page(s) e236986

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ISSN 1757-790X
    DOI 10.1136/bcr-2020-236986
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.

    Ruiz-Serrano, Amalia / Boyle, Christina N / Monné Rodríguez, Josep M / Günter, Julia / Jucht, Agnieszka E / Pfundstein, Svende / Bapst, Andreas M / Lutz, Thomas A / Wenger, Roland H / Scholz, Carsten C

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the ... ...

    Abstract Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the treatment of metabolically driven diseases. We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear. Here, we report that the induced global deletion of OTUB1 in adult mice (
    MeSH term(s) Adenosine Triphosphate/metabolism ; Adenylate Kinase/metabolism ; Animals ; Blood Glucose ; Body Weight ; Cell Size ; Cells, Cultured ; Cysteine Endopeptidases/genetics ; Cysteine Endopeptidases/metabolism ; Energy Metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Deletion ; Insulin/administration & dosage ; Insulin/adverse effects ; Insulin Resistance/genetics ; Mice ; Mixed Function Oxygenases/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances Blood Glucose ; Insulin ; Adenosine Triphosphate (8L70Q75FXE) ; Mixed Function Oxygenases (EC 1.-) ; factor inhibiting hypoxia-inducible factor 1, mouse (EC 1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Adenylate Kinase (EC 2.7.4.3) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Otub1 protein, mouse (EC 3.4.22.-)
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin-producing cells.

    Bapst, Andreas M / Knöpfel, Thomas / Nolan, Karen A / Imeri, Faik / Schuh, Claus D / Hall, Andrew M / Guo, Jia / Katschinski, Dörthe M / Wenger, Roland H

    Journal of cellular physiology

    2022  Volume 237, Issue 5, Page(s) 2420–2433

    Abstract: In adult mammals, the kidney is the main source of circulating erythropoietin (Epo), the master regulator of erythropoiesis. In vivo data in mice demonstrated multiple subtypes of interstitial renal Epo-producing (REP) cells. To analyze the ... ...

    Abstract In adult mammals, the kidney is the main source of circulating erythropoietin (Epo), the master regulator of erythropoiesis. In vivo data in mice demonstrated multiple subtypes of interstitial renal Epo-producing (REP) cells. To analyze the differentiation plasticity of fibroblastoid REP cells, we used a transgenic REP cell reporter mouse model to generate conditionally immortalized REP-derived (REPD) cell lines. Under nonpermissive conditions, REPD cells ceased from proliferation and acquired a stem cell-like state, with strongly enhanced hypoxia-inducible factor 2 (HIF-2α), stem cell antigen 1 (SCA-1), and CD133 expression, but also enhanced alpha-smooth muscle actin (αSMA) expression, indicating myofibroblastic signaling. These cells maintained the "on-off" nature of Epo expression observed in REP cells in vivo, whereas other HIF target genes showed a more permanent regulation. Like REP cells in vivo, REPD cells cultured in vitro generated long tunneling nanotubes (TNTs) that aligned with endothelial vascular structures, were densely packed with mitochondria and became more numerous under hypoxic conditions. Although inhibition of mitochondrial oxygen consumption blunted HIF signaling, removal of the TNTs did not affect or even enhance the expression of HIF target genes. Apart from pericytes, REPD cells readily differentiated into neuroglia but not adipogenic, chondrogenic, or osteogenic lineages, consistent with a neuronal origin of at least a subpopulation of REP cells. In summary, these results suggest an unprecedented combination of differentiation features of this unique cell type.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line ; Erythropoiesis ; Erythropoietin/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Kidney/metabolism ; Mammals/metabolism ; Mice ; Mice, Transgenic ; Pericytes/metabolism
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1, alpha Subunit ; Erythropoietin (11096-26-7)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30677
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    Uc I Zs.212: Show issues Location:
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  7. Book ; Audio / Video ; Online: Zweinutzungsrassen

    Alföldi, Thomas / Bieber, Anna / Spengler Neff, Anet / Bapst, Beat

    Alter Zopf oder neue Chance? (Video)

    2018  

    Abstract: ... fassen Anna Bieber, FiBL und Beat Bapst, Qualitas AG die Ergebnisse zusammen und die Teilnehmer ...

    Abstract Die Schweizer Partner der beiden CORE Organic Projekte "2-Org-Cows" und "OrganicDairyHealth" präsentierten kürzlich ihre Ergebnisse vor Vertretern von Zuchtorganisationen und Landwirten. In diesem Video fassen Anna Bieber, FiBL und Beat Bapst, Qualitas AG die Ergebnisse zusammen und die Teilnehmer des Workshops äussern sich über die Zukunft von Zweinutzungsrinder.
    Keywords Dairy cattle ; Beef cattle ; Breeding and genetics ; Health and welfare
    Language German
    Publishing date 2018-04-24
    Publishing country dk
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Audio / Video ; Online: Dual-purpose breeds - an outdated custom or a new opportunity? (Video)

    Alföldi, Thomas / Bieber, Anna / Spengler Neff, Anet / Bapst, Beat

    2018  

    Abstract: ... Bieber and Beat Bapst summarize the results and workshop participants share their views on dual-purpose ...

    Abstract The Swiss partners of the two CORE Organic projects “2-Org-Cows” and “OrganicDairyHealth” recently presented their findings to representatives of breeding organizations and farmers. In this video, Anna Bieber and Beat Bapst summarize the results and workshop participants share their views on dual-purpose cattle.
    Keywords Dairy cattle ; Beef cattle ; Breeding and genetics ; Health and welfare
    Language English
    Publishing date 2018-04-24
    Publishing country dk
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism

    Amalia Ruiz-Serrano / Christina N. Boyle / Josep M. Monné Rodríguez / Julia Günter / Agnieszka E. Jucht / Svende Pfundstein / Andreas M. Bapst / Thomas A. Lutz / Roland H. Wenger / Carsten C. Scholz

    International Journal of Molecular Sciences, Vol 23, Iss 1536, p

    2022  Volume 1536

    Abstract: Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the ... ...

    Abstract Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the treatment of metabolically driven diseases. We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear. Here, we report that the induced global deletion of OTUB1 in adult mice ( Otub1 iKO) elevated energy expenditure, reduced age-dependent body weight gain, facilitated blood glucose clearance and lowered basal plasma insulin levels. The respiratory exchange ratio was maintained, indicating an unaltered nutrient oxidation. In addition, Otub1 deletion in cells enhanced AKT activity, leading to a larger cell size, higher ATP levels and reduced AMPK phosphorylation. AKT is an integral part of insulin-mediated signaling and Otub1 iKO mice presented with increased AKT phosphorylation following acute insulin administration combined with insulin hypersensitivity. We conclude that OTUB1 is an important regulator of metabolic homeostasis.
    Keywords deubiquitinating enzyme ; energy expenditure ; insulin ; liver ; ubiquitin system ; FIH ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study.

    Kremer, Stéphane / Lersy, François / de Sèze, Jérome / Ferré, Jean-Christophe / Maamar, Adel / Carsin-Nicol, Béatrice / Collange, Olivier / Bonneville, Fabrice / Adam, Gilles / Martin-Blondel, Guillaume / Rafiq, Marie / Geeraerts, Thomas / Delamarre, Louis / Grand, Sylvie / Krainik, Alexandre / Caillard, Sophie / Constans, Jean Marc / Metanbou, Serge / Heintz, Adrien /
    Helms, Julie / Schenck, Maleka / Lefèbvre, Nicolas / Boutet, Claire / Fabre, Xavier / Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Lacalm, Audrey / Oesterlé, Hélène / Bolognini, Federico / Messié, Julien / Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Bapst, Blanche / Megdiche, Imen / Henry Feugeas, Marie-Cécile / Khalil, Antoine / Gaudemer, Augustin / Jager, Lavinia / Nesser, Patrick / Talla Mba, Yannick / Hemmert, Céline / Feuerstein, Philippe / Sebag, Nathan / Carré, Sophie / Alleg, Manel / Lecocq, Claire / Schmitt, Emmanuelle / Anxionnat, René / Zhu, François / Comby, Pierre-Olivier / Ricolfi, Frédéric / Thouant, Pierre / Desal, Hubert / Boulouis, Grégoire / Berge, Jérome / Kazémi, Apolline / Pyatigorskaya, Nadya / Lecler, Augustin / Saleme, Suzana / Edjlali-Goujon, Myriam / Kerleroux, Basile / Zorn, Pierre-Emmanuel / Matthieu, Muriel / Baloglu, Seyyid / Ardellier, François-Daniel / Willaume, Thibault / Brisset, Jean Christophe / Boulay, Clotilde / Mutschler, Véronique / Hansmann, Yves / Mertes, Paul-Michel / Schneider, Francis / Fafi-Kremer, Samira / Ohana, Mickael / Meziani, Ferhat / David, Jean-Stéphane / Meyer, Nicolas / Anheim, Mathieu / Cotton, François

    Radiology

    2020  Volume 297, Issue 2, Page(s) E242–E251

    Abstract: Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus ... ...

    Abstract Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus disease 2019 (COVID-19) infection. Materials and Methods This was a retrospective study of patients evaluated from March 23, 2020, to April 27, 2020, at 16 hospitals. Inclusion criteria were (
    MeSH term(s) Adolescent ; Adult ; Aged ; Betacoronavirus ; Brain/diagnostic imaging ; Brain/pathology ; COVID-19 ; Child ; Cohort Studies ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/pathology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/pathology ; Retrospective Studies ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020202222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.106: Show issues Location:
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