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Article: The evolution of clinical immunology and allergy in Australia.

Basten, Antony

2007 Volume 86, Issue 1, Page(s) 16–21

MeSH term(s)	Acquired Immunodeficiency Syndrome/immunology ; Allergy and Immunology/education ; Allergy and Immunology/history ; Allergy and Immunology/manpower ; Allergy and Immunology/trends ; Australia ; Biomedical Research/history ; Biomedical Research/manpower ; Biomedical Research/trends ; Biotechnology/trends ; Cell- and Tissue-Based Therapy/history ; Cell- and Tissue-Based Therapy/trends ; History, 20th Century ; Humans ; Immunotherapy/trends ; Immunotherapy, Active/history ; Immunotherapy, Active/trends ; Interdisciplinary Communication ; Research/history
Language	English
Publishing date	2007-11-27
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1038/sj.icb.7100138
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Article ; Online: Genetic and structural basis of the human anti-α-galactosyl antibody response.

Langley, David B / Schofield, Peter / Nevoltris, Damien / Jackson, Jennifer / Jackson, Katherine J L / Peters, Tim J / Burk, Melanie / Matthews, Jacqueline M / Basten, Antony / Goodnow, Christopher C / van Nunen, Sheryl / Reed, Joanne H / Christ, Daniel

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 28, Page(s) e2123212119

Abstract: Humans lack the capacity to produce the Galα1-3Galβ1-4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria parasites, cetuximab, and tick ... ...

Abstract	Humans lack the capacity to produce the Galα1-3Galβ1-4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria parasites, cetuximab, and tick proteins. Here we use X-ray crystallographic analysis of antibodies from α-gal knockout mice and humans in complex with the glycan to reveal a common binding motif, centered on a germline-encoded tryptophan residue at Kabat position 33 (W33) of the complementarity-determining region of the variable heavy chain (CDRH1). Immunoglobulin sequencing of anti-α-gal B cells in healthy humans and tick-induced mammalian meat anaphylaxis patients revealed preferential use of heavy chain germline IGHV3-7, encoding W33, among an otherwise highly polyclonal antibody response. Antigen binding was critically dependent on the presence of the germline-encoded W33 residue for all of the analyzed antibodies; moreover, introduction of the W33 motif into naive IGHV3-23 antibody phage libraries enabled the rapid selection of α-gal binders. Our results outline structural and genetic factors that shape the human anti-α-galactosyl antibody response, and provide a framework for future therapeutics development.
MeSH term(s)	Anaphylaxis/immunology ; Animals ; Antibodies/chemistry ; Antibodies/genetics ; Antibody Formation/genetics ; Antigen-Antibody Complex/chemistry ; Crystallography, X-Ray ; Food Hypersensitivity/immunology ; Humans ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/chemistry ; Immunoglobulin Variable Region/immunology ; Mice ; Mice, Knockout ; Peptide Library ; Protein Conformation ; Tick-Borne Diseases/immunology ; Trisaccharides/genetics ; Trisaccharides/immunology
Chemical Substances	Antibodies ; Antigen-Antibody Complex ; Immunoglobulin Heavy Chains ; Immunoglobulin Variable Region ; Peptide Library ; Trisaccharides ; alpha-galactosyl epitope
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2123212119
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Book ; Thesis: Reaktogenität und Immunogenität eines DTPa-HBV-Hib-Kombinationsimpfstoffes

Basten, Karin Antonie

1996

Author's details	vorgelegt von Karin Antonie Basten
Language	German
Size	107 Bl.
Edition	[Mikrofiche-Ausg.]
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Mainz, Univ., Diss., 1996
Note	Mikrofiche-Ausg.: 2 Mikrofiches : 24x
HBZ-ID	HT007910054
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1997 MB 1743	order for loan	Magazin

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Article ; Online: B-cell tolerance: mechanisms and implications.

Basten, Antony / Silveira, Pablo A

Current opinion in immunology

2010 Volume 22, Issue 5, Page(s) 566–574

Abstract: Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens ...

Abstract	Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens in the B-cell repertoire. In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases.
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; Autoimmunity/immunology ; B-Lymphocytes/immunology ; Humans ; Immune Tolerance/immunology
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2010.08.001
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Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 13: Show issues

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Article: Special regulatory T-cell review: T-cell dependent suppression revisited

Basten, Antony / Fazekas de St Groth, Barbara

Immunology. 2008 Jan., v. 123, no. 1

2008

Abstract: The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When ... ...

Abstract	The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system. Cannon to right of them, Cannon to left of them, Cannon in front of them Volley'd and thunder'd Storm'd at with shot and shell, Boldly they rode and well, Into the jaws of Death, Into the mouth of Hell, Rode the six hundred (suppressionists). (Adapted from The Charge of the Light Brigade, Alfred, Lord Tennyson)
Language	English
Dates of publication	2008-01
Size	p. 33-39.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/j.1365-2567.2007.02772.x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Special regulatory T-cell review: T-cell dependent suppression revisited.

Basten, Antony / Fazekas de St Groth, Barbara

Immunology

2007 Volume 123, Issue 1, Page(s) 33–39

Abstract	The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system. Cannon to right of them, Cannon to left of them, Cannon in front of them Volley'd and thunder'd Storm'd at with shot and shell, Boldly they rode and well, Into the jaws of Death, Into the mouth of Hell, Rode the six hundred (suppressionists). (Adapted from The Charge of the Light Brigade, Alfred, Lord Tennyson)
MeSH term(s)	Allergy and Immunology/history ; Anemia, Hemolytic, Autoimmune/immunology ; Animals ; History, 20th Century ; Humans ; Immune Tolerance/immunology ; Immunoglobulin G/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2007-12-20
Publishing country	England
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/j.1365-2567.2007.02772.x
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Ud II Zs.181: Show issues

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Article ; Online: CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

Suan, Dan / Kräutler, Nike J / Maag, Jesper L V / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Avery, Danielle T / Young, Clara / Statham, Aaron / Elliott, Michael / Dinger, Marcel E / Basten, Antony / Tangye, Stuart G / Brink, Robert

Immunity

2017 Volume 47, Issue 6, Page(s) 1142–1153.e4

Abstract: Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC ...

Abstract	Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in both mouse and human GCs. CCR6
MeSH term(s)	Animals ; B7-2 Antigen/genetics ; B7-2 Antigen/immunology ; Cell Differentiation ; Cell Lineage/immunology ; Gene Expression Profiling ; Gene Expression Regulation ; Germinal Center/cytology ; Germinal Center/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; Immunophenotyping ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenotype ; Plasma Cells/cytology ; Plasma Cells/immunology ; Positive Regulatory Domain I-Binding Factor 1/genetics ; Positive Regulatory Domain I-Binding Factor 1/immunology ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/immunology ; Receptors, CCR6/genetics ; Receptors, CCR6/immunology ; Receptors, CXCR4/genetics ; Receptors, CXCR4/immunology ; Signal Transduction
Chemical Substances	B7-2 Antigen ; CCR6 protein, mouse ; CXCR4 protein, mouse ; Cd86 protein, mouse ; Prdm1 protein, mouse ; Receptors, CCR6 ; Receptors, CXCR4 ; Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-)
Language	English
Publishing date	2017--19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2017.11.022
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

Kräutler, Nike J / Suan, Dan / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Chan, Tyani D / Sundling, Christopher / Kaplan, Warren / Schofield, Peter / Jackson, Jennifer / Basten, Antony / Christ, Daniel / Brink, Robert

The Journal of experimental medicine

2017 Volume 214, Issue 5, Page(s) 1259–1267

Abstract: Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying ... ...

Abstract	Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of the GC. Initiation of differentiation required signals delivered upon engagement with intact antigen. Signals delivered by T follicular helper cells were not required to initiate differentiation but were essential to complete the differentiation process and drive migration of maturing PCs through the dark zone and out of the GC. This bipartite or two-signal mechanism has likely evolved to both sustain protective immunity and avoid autoantibody production.
MeSH term(s)	Animals ; Antigens, Differentiation, B-Lymphocyte/physiology ; B-Lymphocytes/physiology ; Cell Differentiation/physiology ; Germinal Center/physiology ; Mice ; Mice, Inbred C57BL ; Plasma Cells/physiology ; T-Lymphocytes, Helper-Inducer/physiology
Chemical Substances	Antigens, Differentiation, B-Lymphocyte
Language	English
Publishing date	2017-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20161533
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

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Article ; Online: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

Gardam, Sandra / Sierro, Frederic / Basten, Antony / Mackay, Fabienne / Brink, Robert

Immunity

2008 Volume 28, Issue 3, Page(s) 391–401

Abstract: Tumor necrosis factor receptor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in mature B cells. In ... ...

Abstract	Tumor necrosis factor receptor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in mature B cells. In the absence of this suppressive activity, B cells developed independently of the obligatory B cell survival factor, BAFF (B cell-activating factor of the tumor necrosis factor family). However, deletion of either TRAF2 or TRAF3 from the T cell lineage did not promote T cell survival, despite causing extensive NF-kappaB2 activation. This constitutive, lineage-specific suppression of B cell survival by TRAF2 and TRAF3 determines the requirement for BAFF to sustain B cell development in vivo. Binding of BAFF to BAFF receptor reversed TRAF2-TRAF3-mediated suppression of B cell survival by triggering the depletion of TRAF3 protein. This process was TRAF2 dependent, revealing dual roles for TRAF2 in regulating B cell homeostasis.
MeSH term(s)	Animals ; B-Cell Activation Factor Receptor/immunology ; B-Cell Activation Factor Receptor/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cell Survival/immunology ; Flow Cytometry ; Gene Expression ; Gene Expression Profiling ; Mice ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Signal Transduction/immunology ; TNF Receptor-Associated Factor 2/immunology ; TNF Receptor-Associated Factor 2/metabolism ; TNF Receptor-Associated Factor 3/immunology ; TNF Receptor-Associated Factor 3/metabolism
Chemical Substances	B-Cell Activation Factor Receptor ; TNF Receptor-Associated Factor 2 ; TNF Receptor-Associated Factor 3
Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2008.01.009
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Tuberculosis and treatment with infliximab.

Riminton, Sean / Pearce, Nicholas / Antony, Basten

The New England journal of medicine

2002 Volume 346, Issue 8, Page(s) 623–626

MeSH term(s)	Animals ; Antibodies, Monoclonal/adverse effects ; Disease Susceptibility/immunology ; Humans ; Infliximab ; Mice ; Mice, Inbred C57BL ; Mortality ; Tuberculosis/chemically induced ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/deficiency
Chemical Substances	Antibodies, Monoclonal ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2002-02-21
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
Database	MEDical Literature Analysis and Retrieval System OnLINE

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