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  1. Article: Saturated fatty acids differently affect mitochondrial function and the intestinal epithelial barrier depending on their chain length in the

    Guerbette, Thomas / Rioux, Vincent / Bostoën, Mégane / Ciesielski, Vincent / Coppens-Exandier, Hugo / Buraud, Marine / Lan, Annaïg / Boudry, Gaëlle

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1266842

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1266842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Special section involvement of lipids in the occurrence of COVID-19.

    Rioux, Vincent / Record, Michel

    Biochimie

    2020  Volume 179, Page(s) 228

    MeSH term(s) COVID-19/epidemiology ; COVID-19/metabolism ; Humans ; Lipid Metabolism ; Pandemics
    Keywords covid19
    Language English
    Publishing date 2020-11-06
    Publishing country France
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2020.11.007
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.135: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Impact of bilingual face, arm, speech, time (FAST) public awareness campaigns on emergency medical services (EMS) activation in a large Canadian metropolitan area.

    Brissette, Vincent / Rioux, Bastien / Choisi, Thérésa / Poppe, Alexandre Y

    CJEM

    2023  Volume 25, Issue 5, Page(s) 403–410

    Abstract: Background and aims: Face, arm, speech, time (FAST) public awareness campaigns improve stroke recognition in the general population. Whether this translates into improved emergency medical services (EMS) activation remains unclear. We assessed the ... ...

    Abstract Background and aims: Face, arm, speech, time (FAST) public awareness campaigns improve stroke recognition in the general population. Whether this translates into improved emergency medical services (EMS) activation remains unclear. We assessed the association of five consecutive FAST campaigns with EMS calls for suspected strokes in a large urban area of Quebec, Canada.
    Methods: We conducted an observational study to assess data collected between June 2015 and December 2019 by the public EMS agency covering the cities of Laval and Montreal (Quebec, Canada). Five FAST campaigns were held over this period (mean duration: 9 weeks). We compared daily EMS calls before and after all FAST campaigns (2015 vs 2019) with t tests and Mann-Whitney U tests. We used single-group, univariate interrupted time series to measure changes in daily EMS calls for suspected strokes following each FAST campaign (stroke categories: any, symptom onset < 5 h, Cincinnati Prehospital Stroke Scale [CPSS] 3/3). Calls for headache served as negative control.
    Results: After five FAST campaigns, mean daily EMS calls increased by 28% (p < 0.001) for any suspected stroke and by 61% (p < 0.001) for stroke with symptom onset < 5 h, compared to 10.1% for headache (p = 0.012). Significant increases in daily EMS calls were observed after three campaigns (highest OR = 1.26; 95% CI 1.11, 1.43; p < 0.001). There were no significant changes in calls after individual campaigns for suspected stroke with symptom onset < 5 h, or suspected stroke with CPSS 3/3.
    Conclusions: We observed an inconsistent impact of individual FAST campaigns on EMS calls for any suspected stroke, and did not observe significant EMS call changes after individual campaigns for acute (< 5 h) and severe (CPSS 3/3) strokes. These results may help stakeholders identify potential benefits and limitations of public awareness campaigns using the FAST acronym.
    MeSH term(s) Humans ; Arm ; Speech ; Canada ; Emergency Medical Services ; Stroke/diagnosis ; Stroke/therapy ; Stroke/epidemiology
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Observational Study ; Journal Article
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-023-00482-6
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  4. Article ; Online: Les lipides ne doivent plus être diabolisés… ni chez l’adulte, ni chez l’enfant.

    Legrand, Philippe / Catheline, Daniel / Rioux, Vincent

    Medecine sciences : M/S

    2021  Volume 37, Issue 1, Page(s) 41–46

    Abstract: Following a long and dogmatic period, which has demonized the dietary lipids, a cautious review of the literature led the scientists to propose a new paradigm and rehabilitation for lipids. French guidelines have endorsed it since 2010, and recent data ... ...

    Title translation Lipids should not be demonized in adults and in infants.
    Abstract Following a long and dogmatic period, which has demonized the dietary lipids, a cautious review of the literature led the scientists to propose a new paradigm and rehabilitation for lipids. French guidelines have endorsed it since 2010, and recent data confirm this new and necessary approach, especially for infants.
    MeSH term(s) Adult ; Child ; Diet/psychology ; Diet/standards ; Dietary Fats/metabolism ; Dietary Fats/pharmacology ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; France ; Humans ; Infant ; Lipid Metabolism/physiology ; Lipids/physiology ; Nutrition Policy/trends
    Chemical Substances Dietary Fats ; Lipids
    Language French
    Publishing date 2021-01-25
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020257
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Fatty Acid Desaturase 3 (FADS3) Is a Specific ∆13-Desaturase of Ruminant trans-Vaccenic Acid.

    Rioux, Vincent / Legrand, Philippe

    Lifestyle genomics

    2019  Volume 12, Issue 1-6, Page(s) 18–24

    Abstract: In mammalian species, the Fatty Acid Desaturase (FADS) gene cluster includes FADS1 (∆5-desaturase), FADS2 (∆6-desaturase), and a third gene member, named FADS3. According to its high degree of nucleotide sequence homology with both FADS1and FADS2, FADS3 ... ...

    Abstract In mammalian species, the Fatty Acid Desaturase (FADS) gene cluster includes FADS1 (∆5-desaturase), FADS2 (∆6-desaturase), and a third gene member, named FADS3. According to its high degree of nucleotide sequence homology with both FADS1and FADS2, FADS3 was promptly suspected by researchers in the field to code for a new mammalian membrane-bound fatty acid desaturase. However, no catalytic activity was attributed to the FADS3 protein for a decade, until the rat FADS3 protein was shown in vitro to be able to catalyze the unexpected ∆13-desaturation of trans-vaccenic acid, producing the trans11,cis13-conjugated linoleic acid isomer. This review summarizes the recent investigations establishing the FADS3 enzyme as a reliable mammalian trans-vaccenate ∆13-desaturase in vivo and tries to identify further unresolved issues that need to be addressed.
    Language English
    Publishing date 2019-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2946059-1
    ISSN 2504-3188 ; 2504-3161
    ISSN (online) 2504-3188
    ISSN 2504-3161
    DOI 10.1159/000502356
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    In stock of ZB MED Bonn / Germany

    Z 7783: Show issues

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  7. Article ; Online: A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.

    Yang, Ziping / Rioux, Nathalie / Vincent, Ludwig / Jones, Hannah M / Cha, David / Plummer, Andrew / Wilfret, David / Kearney, Brian P

    CPT: pharmacometrics & systems pharmacology

    2023  Volume 12, Issue 10, Page(s) 1553–1564

    Abstract: Pomotrelvir is a new chemical entity and potent direct-acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)-mediated drug-drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, ... ...

    Abstract Pomotrelvir is a new chemical entity and potent direct-acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)-mediated drug-drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, starting with in vitro assays followed by the basic static model assessment. The identified CYP3A4-mediated potential DDIs were evaluated clinically at a supratherapeutic dose of 1050 mg twice daily (b.i.d.) of pomotrelvir, including pomotrelvir coadministration with ritonavir (strong inhibitor of CYP3A4) or midazolam (sensitive substrate of CYP3A4). Furthermore, a physiologically-based pharmacokinetic (PBPK) model was developed within the Simcyp Population-based Simulator using in vitro and in vivo information and validated with available human pharmacokinetic (PK) data. The PBPK model was simulated to assess the DDI potential for CYP isoforms that pomotrelvir has shown a weak to moderate DDI in vitro and for CYP3A4 at the therapeutic dose of 700 mg b.i.d. To support the use of pomotrelvir in women of childbearing potential, the impact of pomotrelvir on the exposure of the representative oral hormonal contraceptive drugs ethinyl estradiol and levonorgestrel was assessed using the PBPK model. The overall assessment suggested weak inhibition of pomotrelvir on CYP3A4 and minimal impact of a strong CYP3A4 inducer or inhibitor on pomotrelvir PK. Therefore, pomotrelvir is not anticipated to have clinically meaningful DDIs at the clinical dose. These comprehensive in vitro, in clinic, and in silico efforts indicate that the DDI potential of pomotrelvir is minimal, so excluding patients on concomitant medicines in clinical studies would not be required.
    MeSH term(s) Humans ; Female ; Cytochrome P-450 CYP3A ; Antiviral Agents/pharmacology ; Hepatitis C, Chronic ; Cytochrome P-450 Enzyme System ; Drug Interactions ; Protein Isoforms ; Models, Biological ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Computer Simulation
    Chemical Substances Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Antiviral Agents ; Cytochrome P-450 Enzyme System (9035-51-2) ; Protein Isoforms ; Cytochrome P-450 CYP3A Inhibitors
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.13034
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  8. Article ; Online: Special section involvement of lipids in the occurrence of COVID-19

    Rioux, Vincent / Record, Michel

    Biochimie ; ISSN 0300-9084

    2020  

    Keywords Biochemistry ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.biochi.2020.11.007
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Special Section Involvement of lipids in the occurrence of COVID-19

    Rioux, Vincent, / Record, Michel

    ISSN: 0300-9084 ; Biochimie ; https://hal.archives-ouvertes.fr/hal-03001625 ; Biochimie, Elsevier, 2020, ⟨10.1016/j.biochi.2020.11.007⟩

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV]Life Sciences [q-bio] ; covid19
    Language English
    Publishing date 2020-11-05
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Special Section Involvement of lipids in the occurrence of COVID-19

    Rioux, Vincent, / Record, Michel

    ISSN: 0300-9084 ; Biochimie ; https://hal.archives-ouvertes.fr/hal-03001625 ; Biochimie, Elsevier, 2020, ⟨10.1016/j.biochi.2020.11.007⟩

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV]Life Sciences [q-bio] ; covid19
    Language English
    Publishing date 2020-11-05
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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