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Article: Qian-Zheng-San

Wang, Zhi-Yong / Qin, Li-Hua / Zhang, Wei-Guang / Zhang, Pei-Xun / Jiang, Bao-Guo

2019 Volume 14, Issue 4, Page(s) 683–691

Abstract: Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx ... However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury ... by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian ...

Abstract	Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx Batryticatus, Scorpio, has been found to play an active therapeutic role in central nervous system diseases. However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury. Therefore, we used Sprague-Dawley rats to investigate this. A sciatic nerve crush injury model was induced by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian-Zheng-San (1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were not administered Qian-Zheng-San. Rats in sham group did not undergo surgery and systemic therapy. Footprint analysis was used to assess nerve motor function. Electrophysiological experiments were used to detect nerve conduction function. Immunofluorescence staining was used to assess axon counts and morphological analysis. Immunohistochemical staining was used to observe myelin regeneration of the sciatic nerve and the number of motoneurons in the anterior horn of the spinal cord. At 2 and 4 weeks postoperatively, the sciatic nerve function index, nerve conduction velocity, the number of distant regenerated axons and the axon diameter of the sciatic nerve increased in the Qian-Zheng-San treatment group compared with the control group. At 2 weeks postoperatively, nerve fiber diameter, myelin thickness, and the number of motor neurons in the lumbar spinal cord anterior horn increased in the Qian-Zheng-San treatment group compared with the control group. These results indicate that Qian-Zheng-San has a positive effect on peripheral nerve regeneration.
Language	English
Publishing date	2019-01-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.247472
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Qian et al. Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways.

Qian, Kaiyu / Wang, Gang / Cao, Rui / Liu, Tao / Qian, Guofeng / Guan, Xinyuan / Guo, Zhongqiang / Xiao, Yu / Wang, Xinghuan

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: During the course of a review of our publications, an inadvertent error in the article [ ... ]. ...

Abstract	During the course of a review of our publications, an inadvertent error in the article [...].
Language	English
Publishing date	2022-10-09
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196731
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Article: Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.

Qian, Lichao / Ren, Shuai / Xu, Zhongchi / Zheng, Yawei / Wu, Lihua / Yang, Ying / Wang, Yixuan / Li, Jie / Yan, Shihai / Fang, Zhuyuan

Frontiers in pharmacology

2021 Volume 12, Page(s) 667433

Abstract: ... nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats ...

Abstract	Protection against hypoxia injury is an important therapeutic strategy for treating hypertensive nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats fed with high salt diet and HEK293T cells exposed to hypoxia were investigated. After eight weeks' treatment of QYYY, blood pressure, serum creatinine, serum cystatin C, blood urea nitrogen, urinary β2-microglobulin, urinary N-acetyl-β-glucosaminidase, and urinary microalbumin were assessed. The changes of hypoxia-inducible factor-1α (HIF-1α), pyruvate kinase M2 (PKM2), glucose transport 1 (GLUT1), lactate dehydrogenase A (LDH-A), connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), ATP, lactate, pyruvate, and pathology were also assessed
Language	English
Publishing date	2021-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.667433
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Article ; Online: Reply to the Letter from Qian Ren and Yanjun Wang About the Article, "LI-RADS Morphological Type Predicts Prognosis of Patients with Hepatocellular Carcinoma After Radical Resection".

Zhang, Chunhui / Yang, Rui / Wang, Xinxin / Tao, Yuqing / Tang, Shuli / Tian, Zhennan / Zhou, Yang

Annals of surgical oncology

2023 Volume 31, Issue 3, Page(s) 1849–1850

MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Contrast Media ; Magnetic Resonance Imaging ; Prognosis
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-14557-2
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Article ; Online: Exploring the mechanism of action of Qian Lie Xing Fang during the treatment of benign prostatic hyperplasia via network pharmacology and molecular dynamics simulation analyses.

Xiang, Jingjing / Li, Zefei / Wang, Chaoyang

Medicine

2023 Volume 102, Issue 42, Page(s) e35540

Abstract: ... with Qian Lie Xing Fang (QLXF) via the warming and tonifying of kidney yang, promotion of blood circulation ...

Abstract	This study aimed to explore the historical research progress on benign prostatic hyperplasia from the perspective of traditional Chinese medicine theory and the treatment of benign prostatic hyperplasia (BPH) with Qian Lie Xing Fang (QLXF) via the warming and tonifying of kidney yang, promotion of blood circulation, and clearing of meridians. First, network pharmacology analysis was used to screen and identify possible pathways for BPH treatment with QLXF. Subsequently, molecular docking analysis helped explore the mechanism of action by which the components of QLXF affected androgen receptor (AR) and type 5 phosphodiesterase inhibitor (PDE-5) levels. Targets for treatment with QLXF were identified from the online Mendelian inheritance in man and DisGeNET databases. BPH-related genes were identified using GeneCards and online Mendelian inheritance in man databases, and their intersection was used to construct a protein-protein interaction network analysis graph. Subsequently, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were performed. The semiflexible docking of the ingredients of QLXF acting on the 2 targets was performed via molecular docking and molecular dynamics simulation, to elucidate the mechanism of action by which the active ingredients affect AR and PDE-5 levels further. This enabled us to explore the pattern of interactions between small active ingredient molecules, the target protein, and the stability after binding at the microscopic level. Gene ontology enrichment analysis showed that QLXF affected several processes, such as DNA transcription factor binding, kinase binding, protein homodimerization activity, protein structure domain-specific binding, and protein-coupled amine receptor activity in BPH patients. KEGG results showed that chemical carcinogenic reactive oxidative species and the JAK-STAT, Pl3k-Akt, FoxO, NF-κB, and other pathways were significantly enriched. Conducting molecular docking studies to investigate the interaction of active components from QLXF with AR and PDE-5, it was found that MOL002260 may possess the potential to inhibit PDE-5 activity, while MOL010578 may exhibit the capability to inhibit AR activity. QLXF is closely associated with various biological processes and KEGG signaling pathways related to BPH. The active ingredients of QLXF were investigated for their interactions with AR and PDE-5, with a primary focus on the small molecules MOL002260 and MOL010578.
MeSH term(s)	Humans ; Male ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Network Pharmacology ; Prostatic Hyperplasia/drug therapy ; Prostatic Hyperplasia/genetics ; Databases, Genetic ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035540
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Article ; Online: Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

Ma, Siqi / Xu, Junyao / Zheng, Yawei / Li, Yin / Wang, Yixuan / Li, Haitao / Fang, Zhuyuan / Li, Jie

Journal of ethnopharmacology

2022 Volume 302, Issue Pt A, Page(s) 115878

Abstract: Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history ...

Abstract	Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history in the treatment of hypertensive renal damage (HRD) in China. Clinical studies have found that QYYYG stabilizes blood pressure and prevents early renal damage. However, the exact mechanism is not entirely clear. Aim of the study: To evaluate the therapeutic effect and further explore the therapeutic mechanism of QYYYG against HRD. Materials and methods: The efficacy of QYYYG in treating HRD was assessed in spontaneous hypertension rats (SHR). Renal autophagy and the TRPC6-CaMKKβ-AMPK pathway in rats were evaluated. The regulatory role of QYYYG in angiotensin II (Ang II) induced abnormal autophagy in rat podocytes was determined by detecting autophagy-related proteins, intracellular Ca Results: QYYYG alleviated HRD and reversed the abnormal expression of autophagy-related genes in the SHR. In vitro, QYYYG protected against Ang II-induced podocyte damage. Furthermore, treatment of podocytes with QYYYG reversed Ang II-induced autophagy and inhibited Ang II-stimulated TRPC6 activation, Ca Conclusions: The present study suggested that QYYYG may exert its HRD protective effects in part by regulating the abnormal autophagy of podocytes through the TRPC6-CaMKKβ-AMPK-mTOR pathway.
MeSH term(s)	Animals ; Rats ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; TRPC6 Cation Channel/metabolism ; AMP-Activated Protein Kinases/metabolism ; Calcium/metabolism ; Autophagy ; TOR Serine-Threonine Kinases/metabolism ; Podocytes ; Angiotensin II/metabolism ; Hypertension/drug therapy ; Hypertension/metabolism ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; TRPC Cation Channels/pharmacology
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; TRPC6 Cation Channel ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; qian yang yu yin granule ; Calcium (SY7Q814VUP) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Angiotensin II (11128-99-7) ; mTOR protein, rat (EC 2.7.1.1) ; Trpc6 protein, rat ; TRPC Cation Channels
Language	English
Publishing date	2022-10-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115878
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Article ; Online: Effects of Fusu mixture (Wen-Shen-Qian-Yang Method) on sepsis-induced acute respiratory distress syndrome.

Zhang, Li / Long, Kunlan / Wang, Chunxia / Zhang, Xuemei / Yang, Hongjing / Chen, Jun / Li, Xue / Gao, Peiyang / Zhang, Song

Medicine

2020 Volume 99, Issue 29, Page(s) e21066

Abstract: Introduction: Sepsis is the most common etiology of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Capillary leakage caused by lung endothelial injury is the central cause of ARDS. The results of research in modern medicine in ... ...

Abstract	Introduction: Sepsis is the most common etiology of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Capillary leakage caused by lung endothelial injury is the central cause of ARDS. The results of research in modern medicine in reducing endothelial damage and restoring endothelial functions are limited. In the previous clinical observations, we found that the Fusu mixture not only improves the clinical symptoms but also reduces the leakage of pulmonary capillaries. Therefore, the purpose of this study is to determine the clinical efficacy of the Fusu mixture combined with Western medicine in the treatment of ARDS caused by sepsis and to explore the mechanism of traditional Chinese medicine. Methods: This is a prospective, single-center, randomized, single-blind, and controlled clinical study involving 620 eligible patients. The patients will be randomly divided into 2 groups: the Western medicine treatment group and the combination of Chinese and Western medicine treatment group. After 14 days of intervention, the clinical efficacy and safety of the Fusu mixture on sepsis-induced ARDS patients will be observed. The primary outcome will be measured as 28-day mortality. The secondary outcome indices include inflammatory markers (CRP, PCT, IL-6, TNF - α), APACHE II score, SOFA score, days without a ventilator, blood gas analysis (Lac, PaO2 / FiO2), intensive care unit hospital stay time, intensive care unit mortality. Simultaneously, the analysis of the exploratory results will be carried out to analyze the possible mechanism of Fusu mixture in the treatment of sepsis-induced ARDS by the high-throughput sequencing and bioinformatics. Discussion: The purpose of this study is to evaluate the clinical efficacy of Fusu mixture in the treatment of sepsis-induced ARDS and explore its possible mechanism of action. If successful, it will provide evidence-based adjuvant therapy for the clinical treatment of ARDS.
MeSH term(s)	Adult ; Blood Gas Analysis ; Capillary Leak Syndrome/complications ; Capillary Leak Syndrome/etiology ; Female ; Humans ; Male ; Medicine, Chinese Traditional/methods ; Medicine, Chinese Traditional/standards ; Middle Aged ; Prospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/physiopathology ; Sepsis/complications ; Sepsis/drug therapy ; Sepsis/physiopathology ; Single-Blind Method ; Treatment Outcome
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000021066
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Article: Cost-Effectiveness Analysis of a Sponge City Construction Based on the Life Cycle Cost Theory—A Case Study of the Yanshan South Road Area of Qian’an City, China

Wang, Mengjie / Wang, Xiaoyue / Yi, Caihui / Ge, Xiaoyu

Water. 2022 Aug. 27, v. 14, no. 17

2022

Abstract: ... results in urban water scarcity. In 2014, Hebei Province’s Qian’an city was ranked among the first group ... and its surrounding area in Qian’an, focusing on the cost of resolving an urban water problem. Using ...

Abstract	In semi-humid regions of China, annual precipitation is not evenly distributed. Heavy, summertime rainfall with a short duration frequently causes urban flooding, and annual rainfall less than evaporation results in urban water scarcity. In 2014, Hebei Province’s Qian’an city was ranked among the first group of sponge city pilot cities. This paper investigates the historically flooded section of Yanshan South Road and its surrounding area in Qian’an, focusing on the cost of resolving an urban water problem. Using the storm flood management model (SWMM) and the life cycle cost (LCC) method, the waterlogging reduction effect and life-cycle cost of various low impact development (LID) scenarios were evaluated. Six rainfall design scenarios were simulated and calculated so that the hydrological performance and cost-effectiveness could be comprehensively evaluated to establish the economic value and effectiveness of implementing LID facilities. This study found that the cost-effectiveness values of sunken green space (SG), SG + infiltration ponds (IP) (3:1), SG + IP (1:1), and SG + IP (1:3) scenarios for infiltration LID schemes were relatively high, up to 2.10. In the infiltration-storage LID scheme, the cost-effectiveness of the SG + reservoirs (RE) (1:1) was grater, which was 1.84. In semi-humid regions, the regulation and storage of rainwater, regarding its collection and use, can be widely applied to the construction of sponge cities.
Keywords	case studies ; cost effectiveness ; economic valuation ; evaporation ; flood control ; green infrastructure ; life cycle costing ; models ; rain ; storms ; summer ; water ; water shortages ; China
Language	English
Dates of publication	2022-0827
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w14172647
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Qian lie an suppository (prostant) for chronic prostatitis: A systematic review and meta-analysis of randomized controlled trials.

Hui-Juan, Cao / Shi-Bing, Liang / Jian-Ping, Liu / Bin, Wang / Hai-Song, Li / Ji-Sheng, Wang / Si-Qi, Guan / Yu-Tian, Zhu / Heng-Heng, Dai / Chun-Yu, Zhou

Medicine

2019 Volume 98, Issue 14, Page(s) e15072

Abstract: ... for the treatment of CP is limited.: Objectives: This review evaluated the effectiveness and safety of Qian Lie ...

Abstract	Background: Chronic prostatitis (CP) is an inflammation of the prostate gland that seriously affects the quality of life of patients. The existing evidence of antibiotics and α-blockers for the treatment of CP is limited. Objectives: This review evaluated the effectiveness and safety of Qian Lie An Suppository (Prostant) in treating CP. Methods: Randomized controlled trials comparing Prostant (alone or plus the control) with placebo, conventional drugs, or nonpharmaceutical therapies for CP were included in this article through searching from 6 databases. Data were analyzed using RevMan 5.3 software. Meta-analysis was performed when the clinical or statistical heterogeneity was found acceptable among trials. Estimate effects were present with risk ratio (RR) or mean difference and their 95% confidence interval (CI) for dichotomies or continuous variables. Quality of the evidence for each primary outcome was assessed using GRADE criteria. Results: Totally 21 trials involving 3359 participants were included. There were 2 included trials had unclear risk of bias, and the remaining trials had high risk of bias. Meta-analyses showed the number of cured patients in the Prostant group was 2 times more than that of the placebo (RR 2.05, 95%CI 1.10 to 3.81) or antibiotics (RR 1.95, 95%CI 1.18 to 3.23) groups. Similar results were found when Prostant in combination with antibiotics or hyperthermia compared with the antibiotics (RR 1.78, 95% CI 1.10-2.89) or hyperthermia (RR 1.72, 95% CI 1.23-2.40) alone. However, there was no difference in the number of cured patients between Prostant and α-blockers or hyperthermia therapy. No severe adverse event was reported in all included trials. The main adverse events in Prostant group were reported (in 8 included trials) as diarrhea and anal discomfort. Conclusions: Low-quality evidence showed that the Prostant may have add-on effect for patients with CP on increasing the number of cured patients, relieving pain, and improving the quality of life. There is not sufficient evidence to determine the effectiveness and safety of Prostant for the treatment of CP compared with placebo, antibiotics, α-blockers or the hyperthermia therapy.
MeSH term(s)	Administration, Rectal ; Anti-Bacterial Agents/therapeutic use ; Chronic Disease ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Humans ; Male ; Prostatitis/drug therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Suppositories
Chemical Substances	Anti-Bacterial Agents ; Drugs, Chinese Herbal ; Suppositories ; prostant
Language	English
Publishing date	2019-04-03
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000015072
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Book ; Online: CHARACTERISTIC OF DROUGHT AND FLOOD IN THE DIAN-QIAN-GUI KARST AREAS BASED ON TRMM-Z INDEX

Wang, Y. F. / Liang, L. S. / Jing, J. L. / Luo, F. L. / Wang, A. N.

eISSN: 2194-9034

2020

Abstract: ... in Dian-Qian-Gui Karst Areas of China, TRMM 3B43 precipitation data from 1998 to 2017 and 72 rain gauge ...

Abstract	In order to study the spatial and temporal variation of characteristics of drought and flood in Dian-Qian-Gui Karst Areas of China, TRMM 3B43 precipitation data from 1998 to 2017 and 72 rain gauge station data from 1998 to 2012 were used to verify the TRMM 3B43 data on monthly scale by correlation coefficient and relative deviation. The TRMM-Z index was taken as an index of drought and flood to quantitatively analyze the drought and flood characteristics. The results show that: (1) there was a significant positive correlation between TRMM 3B43 precipitation data and the measured data of meteorological stations on the monthly scale, with a correlation coefficient of 0.92, passing the significance test of 0.01 level. The calculated result of relative Bias is -0.058, indicating that TRMM 3B43 precipitation is slightly higher than the actual precipitation. (2) From 1998 to 2017, the TRMM-Z index in the research area fluctuated between −1.160 and 1.678, among which the Z index in July 1999 reached the maximum value of 1.678, and in February 2010 the Z index reached the minimum value of −1.160. (3) During the past 20 years, the flood months in the study areas were 47 months, accounting for 19.58% of the study time, and 40 months were drought months, accounting for 16.67% of the study time. Floods mainly occurred in the summer with abundant rainfall, while droughts mainly occurred in the winter with less rainfall. (4) Taking 2008–2009 as typical representative of drought and flood, the spatial variation of drought and flood were researched.
Subject code	910
Language	English
Publishing date	2020-02-09
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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