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Article ; Online: Drug-Induced Liver Injury Secondary to Turmeric Use.

Ajitkumar, Ashika / Mohan, Gaurav / Ghose, Medha / Yarrarapu, Sivanaga / Afiniwala, Swara

European journal of case reports in internal medicine

2023 Volume 10, Issue 5, Page(s) 3845

Abstract: Turmeric is a herbal medication and spice which has been used for thousands of years in traditional Eastern medicine for its flavour, colour, and purported anti-inflammatory, antioxidant, antineoplastic and antimicrobial properties. It has recently ... ...

Abstract	Turmeric is a herbal medication and spice which has been used for thousands of years in traditional Eastern medicine for its flavour, colour, and purported anti-inflammatory, antioxidant, antineoplastic and antimicrobial properties. It has recently garnered interest and popularity worldwide for these reasons. While turmeric supplements are generally safe, some reports of toxicity are emerging. Compounds like piperine are added to turmeric to enhance its bioavailability, potentially contributing to its toxicity. Here, we describe a 55-year-old woman with progressive jaundice and elevated bilirubin and liver enzymes but no evidence of acute liver failure. She was treated with N-acetyl cysteine (NAC) for 24 hours and liver function tests (LFTs) were closely monitored. As a downtrend in LFTs was noted and the patient remained asymptomatic, she was discharged with close outpatient follow-up. LFTs eventually normalized 2 months after the initial presentation. Clinicians must keep this differential in mind when evaluating acute liver injury. With our case report, we question the utility of NAC in non-acetaminophen-related liver injury and encourage further studies. Learning points: Eliciting information on recent drug or supplement use should be part of comprehensive history-taking to evaluate acute liver injury.Turmeric supplements which may contain piperine to enhance bioavailability are a potential source of acute liver injury.The role of N-acetyl cysteine in managing non-acetaminophen-related liver injury is unclear and further studies are required.
Language	English
Publishing date	2023-04-21
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2023_003845
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Article: Corpus alienum (foreign body) embedded in the oral cavity of children: An agony of parents and diagnostic dilemma among clinicians.

Ray, Jay G / Kashyap, Nikita / Ghose, Sandip / Das, Monalisa

Journal of oral and maxillofacial pathology : JOMFP

2023 Volume 27, Issue 4, Page(s) 765–767

Abstract: Aspiration or ingestion of foreign bodies by children is a common problem globally. Corpus alienum or foreign bodies, embedded in the palate or other areas of the oral cavity, are unusual findings that can occasionally be muddled with other oral lesions. ...

Abstract	Aspiration or ingestion of foreign bodies by children is a common problem globally. Corpus alienum or foreign bodies, embedded in the palate or other areas of the oral cavity, are unusual findings that can occasionally be muddled with other oral lesions. Studies reveal that the majority of cases occur in children, wherein 50% of the children lack a proper history. Since infants or very young children fail to provide proper history and are extremely scared of repeated oral examination clinical diagnosis is all the more difficult. The risks of respiratory obstruction, mucosal tear, nasopharyngeal inflammation, and gastrointestinal bleeding make these non-invasive foreign bodies potentially fatal.
Language	English
Publishing date	2023-12-20
Publishing country	India
Document type	Case Reports
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.jomfp_381_23
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Article: Comparative conformational studies on the tryptic digestion fragments of human ummunoglobulins M and G.

Ghose, A C

Biochemical and biophysical research communications

1971 Volume 45, Issue 5, Page(s) 1144–1150

MeSH term(s)	Binding Sites ; Circular Dichroism ; Humans ; Hydrogen-Ion Concentration ; Immunochemistry ; Immunoglobulin G ; Immunoglobulins ; Protein Conformation ; Protein Hydrolysates ; Trypsin ; Waldenstrom Macroglobulinemia/immunology
Chemical Substances	Immunoglobulin G ; Immunoglobulins ; Protein Hydrolysates ; Trypsin (EC 3.4.21.4)
Language	English
Publishing date	1971-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/0006-291x(71)90138-0
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Article ; Online: Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea.

Tao, Gabriel / Dagher, Fatima / Li, Li / Singh, Rashim / Hu, Ming / Ghose, Romi

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 166, Page(s) 113246

Abstract: Irinotecan is a first-line treatment for colorectal cancer and the prodrug of 7-ethyl-10-hydroxy-camptothecin (SN-38). However, its fatal gastrointestinal (GI) toxicity raises serious concern. In liver, irinotecan generates its inactive metabolite, SN- ... ...

Abstract	Irinotecan is a first-line treatment for colorectal cancer and the prodrug of 7-ethyl-10-hydroxy-camptothecin (SN-38). However, its fatal gastrointestinal (GI) toxicity raises serious concern. In liver, irinotecan generates its inactive metabolite, SN-38G via UDP-glucuronosyltransferase (UGT)1A1. Subsequently, SN-38G is excreted into GI tract where it is reactivated by microbiome to yield the toxic metabolite, SN-38. Activation of toll-like receptor (TLR)/myeloid differentiation primary response 88 (MyD88) by bacterial endotoxin decreases drug-metabolizing enzymes. In this study, we treated C57BL6/J mice with 50 mg/kg irinotecan once daily until observing grade 4 diarrhea. Mice were sacrificed on day0, day2 and day8. Based on the finding in C57BL6/J mice, we repeated the treatment in Tlr2
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Camptothecin/toxicity ; Diarrhea/chemically induced ; Diarrhea/metabolism ; Glucuronosyltransferase/metabolism ; Irinotecan/adverse effects ; Mice ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism ; Uridine Diphosphate
Chemical Substances	Adaptor Proteins, Signal Transducing ; Antineoplastic Agents, Phytogenic ; Myd88 protein, mouse ; Myeloid Differentiation Factor 88 ; Tlr4 protein, mouse ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Uridine Diphosphate (58-98-0) ; Irinotecan (7673326042) ; UGT1A1 enzyme (EC 2.4.1.-) ; Glucuronosyltransferase (EC 2.4.1.17) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2022-06-18
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113246
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Zs.A 529: Show issues

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Article ; Online: Corrigendum to "Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea" [Food Chem. Toxicol. 166 (2022) 113246].

Tao, Gabriel / Dagher, Fatima / Li, Li / Singh, Rashim / Hu, Ming / Ghose, Romi

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 171, Page(s) 113547

Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Published Erratum
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113547
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Article ; Online: Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.

Chithra, Yogeshachar / Dey, Gourav / Ghose, Vivek / Chandramohan, Vivek / Gowthami, Niya / Vasudev, V / Srinivas Bharath, M M

Neurochemical research

2023 Volume 48, Issue 8, Page(s) 2360–2389

Abstract: Mitochondrial dysfunction and oxidative stress are critical to neurodegeneration in Parkinson's disease (PD). Mitochondrial dysfunction in PD entails inhibition of the mitochondrial complex I (CI) in the dopaminergic neurons of substantia nigra. The ... ...

Abstract	Mitochondrial dysfunction and oxidative stress are critical to neurodegeneration in Parkinson's disease (PD). Mitochondrial dysfunction in PD entails inhibition of the mitochondrial complex I (CI) in the dopaminergic neurons of substantia nigra. The events contributing to CI inhibition and downstream pathways are not completely elucidated. We conducted proteomic analysis in a dopaminergic neuronal cell line exposed individually to neurotoxic CI inhibitors: rotenone (Rot), paraquat (Pq) and 1-methyl-4-phenylpyridinium (MPP
MeSH term(s)	Humans ; Dopaminergic Neurons/metabolism ; Parkinson Disease/metabolism ; Proteomics ; Cell Death ; Paraquat/toxicity ; 1-Methyl-4-phenylpyridinium/toxicity ; Rotenone/toxicity ; Electron Transport Complex I/metabolism
Chemical Substances	Paraquat (PLG39H7695) ; 1-Methyl-4-phenylpyridinium (R865A5OY8J) ; Rotenone (03L9OT429T) ; Electron Transport Complex I (EC 7.1.1.2)
Language	English
Publishing date	2023-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-023-03907-x
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Zs.A 1368: Show issues

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Article: Impact of Obesity on In-Hospital Morbidity and Mortality Among Patients Admitted for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD).

Bhide, Poorva / Bapaye, Jay / Mohan, Gaurav / Ghose, Medha / Ravilla, Jayashree / Yarrarapu, Siva Naga S / Du, Doantrang

Cureus

2023 Volume 15, Issue 2, Page(s) e35138

Abstract: Background Obesity has been considered to be a risk factor for increased morbidity and mortality among patients with cardiopulmonary diseases. The burden of chronic obstructive pulmonary disease (COPD) and obesity is very high in the United States. We ... ...

Abstract	Background Obesity has been considered to be a risk factor for increased morbidity and mortality among patients with cardiopulmonary diseases. The burden of chronic obstructive pulmonary disease (COPD) and obesity is very high in the United States. We aimed to use the National Inpatient Sample (NIS) to evaluate the impact of obesity on the outcomes of patients hospitalized with COPD exacerbation. Materials & Methods This is a retrospective cohort study from the NIS database involving adult patients hospitalized for COPD exacerbation in the year 2019 obtained using the international classification of diseases, 10
Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.35138
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Article ; Online: A longitudinal examination of psychosocial mechanisms linking discrimination with objective and subjective sleep.

Dautovich, Natalie D / Reid, Morgan P / Ghose, Sarah M / Kim, Giyeon / Tighe, Caitlan A / Shoji, Kristy D / Kliewer, Wendy

Sleep health

2023 Volume 9, Issue 5, Page(s) 654–661

Abstract: Objective: Although chronic discrimination negatively impacts sleep, the cross-sectional nature of most research limits the understanding of how changes in discrimination over time are associated with sleep health. Therefore, the aims of this study were ...

Abstract	Objective: Although chronic discrimination negatively impacts sleep, the cross-sectional nature of most research limits the understanding of how changes in discrimination over time are associated with sleep health. Therefore, the aims of this study were to explore the: (1) longitudinal association between daily discrimination and subjective and objective sleep; (2) mediating roles of anxiety and social well-being; and (3) moderating role of change in discrimination over time. Methods: An archival analysis was completed using data from the Midlife in the United States study across 3 timepoints. Participants were primarily female-identifying, white, and college-educated. Measures included Pittsburgh Sleep Quality Index (N = 958), sleep diaries (N = 307), and actigraphy (N = 304). Daily discrimination, the Social Well-Being Scale, and the Mood and Anxiety Symptom Questionnaire were also administered. Moderated parallel mediations were performed using the PROCESS macro controlling for depressive symptoms. Results: More discrimination at time 1 was associated with worse global sleep quality (b = 0.10 and p = .001) and daily sleep quality (b = 0.03 and p = .02) and worse objective sleep-onset latency (b = 0.93 and p = .02), wake after sleep onset (b = 1.09 and p = .002), and sleep efficiency (b = -0.52 and p < .001) at time 3. Social well-being mediated the associations between discrimination and subjective global sleep quality 95% CI [0.00, 0.03] and daily sleep quality 95% CI [0.00, 0.01] and objective TST 95% CI [0.00, 0.96] when discrimination was increasing or chronic. Anxiety mediated the discrimination-global sleep quality association regardless of changes in discrimination. Conclusions: Discrimination showed durable associations with a broad array of sleep outcomes across a 10-year period. Anxiety and social well-being linked discrimination to subjective sleep outcomes, illustrating the importance of psychosocial well-being for sleep health in those experiencing discrimination.
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2813299-3
ISSN	2352-7226 ; 2352-7218
ISSN (online)	2352-7226
ISSN	2352-7218
DOI	10.1016/j.sleh.2023.06.007
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Article ; Online: Evaluating increases in sensitivity from NORDIC for diverse fMRI acquisition strategies.

Dowdle, Logan T / Vizioli, Luca / Moeller, Steen / Akçakaya, Mehmet / Olman, Cheryl / Ghose, Geoffrey / Yacoub, Essa / Uğurbil, Kâmil

NeuroImage

2023 Volume 270, Page(s) 119949

Abstract: As the neuroimaging field moves towards detecting smaller effects at higher spatial resolutions, and faster sampling rates, there is increased attention given to the deleterious contribution of unstructured, thermal noise. Here, we critically evaluate ... ...

Abstract	As the neuroimaging field moves towards detecting smaller effects at higher spatial resolutions, and faster sampling rates, there is increased attention given to the deleterious contribution of unstructured, thermal noise. Here, we critically evaluate the performance of a recently developed reconstruction method, termed NORDIC, for suppressing thermal noise using datasets acquired with various field strengths, voxel sizes, sampling rates, and task designs. Following minimal preprocessing, statistical activation (t-values) of NORDIC processed data was compared to the results obtained with alternative denoising methods. Additionally, we examined the consistency of the estimates of task responses at the single-voxel, single run level, using a finite impulse response (FIR) model. To examine the potential impact on effective image resolution, the overall smoothness of the data processed with different methods was estimated. Finally, to determine if NORDIC alters or removes temporal information important for modeling responses, we employed an exhaustive leave-p-out cross validation approach, using FIR task responses to predict held out timeseries, quantified using R
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Functional Neuroimaging/methods ; Research Design ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.119949
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Lifestyle Factors and Sleep Health across the Lifespan.

Dzierzewski, Joseph M / Sabet, Sahar M / Ghose, Sarah M / Perez, Elliottnell / Soto, Pablo / Ravyts, Scott G / Dautovich, Natalie D

International journal of environmental research and public health

2021 Volume 18, Issue 12

Abstract: ... factors (e.g., daily social media use, sedentary activity, fast food consumption, etc.) were ...

Abstract	Sleep health, operationalized as a multidimensional construct consisting of sleep regularity, satisfaction, alertness, timing, efficiency, and duration, is an emerging concept in the field of sleep medicine which warrants further investigation. The purpose of the present study was to: (1) compare sleep health across the lifespan, (2) determine lifestyle factors associated with sleep health, and (3) examine whether lifestyle factors associated with sleep health varied between and within age groups. Participants consisted of 3284 individuals (Mean age = 42.70; 45% male) who participated in a cross-sectional online survey of sleep and health. Sleep health was measured using the RU-SATED scale, while demographic and lifestyle factors (e.g., daily social media use, sedentary activity, fast food consumption, etc.) were all self-reported. Sleep health was the highest among older adults (
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Fast Foods ; Female ; Humans ; Life Style ; Longevity ; Male ; Middle Aged ; Sleep
Language	English
Publishing date	2021-06-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18126626
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