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  1. Article ; Online: Characterization, taxonomic classification, and genomic analysis of two newly isolated bacteriophages with potential to infect

    Nazir, Amina / Li, Lulu / Li, Fei / Tong, Yigang / Liu, Yuqing / Chen, Yibao

    Microbiology spectrum

    2024  , Page(s) e0223023

    Abstract: Escherichia ... ...

    Abstract Escherichia coli
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02230-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genome Sequence of Novel Clostridium perfringens Bacteriophage vB_CpeS-17DYC, Isolated from Wastewater in China.

    Nazir, Amina / Zhang, Qing / Liu, Yuqing / Chen, Yibao

    Microbiology resource announcements

    2023  Volume 12, Issue 7, Page(s) e0030023

    Abstract: Phage vB_CpeS-17DYC was isolated from wastewater from a poultry market using Clostridium perfringens strain DYC. The vB_CpeS-17DYC genome is 39,184 bp long, with 65 open reading frames and a GC content of 30.6%. It shared 93.95% nucleotide identity, with ...

    Abstract Phage vB_CpeS-17DYC was isolated from wastewater from a poultry market using Clostridium perfringens strain DYC. The vB_CpeS-17DYC genome is 39,184 bp long, with 65 open reading frames and a GC content of 30.6%. It shared 93.95% nucleotide identity, with 70% query coverage, with
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00300-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genome sequence of Shiga toxin-producing

    Wang, Xiaoqian / Wei, Xiaotian / Zhang, Qing / Li, Lulu / Liu, Zhengjie / Chen, Yibao / Liu, Yuqing / Cai, Yumei

    Microbiology resource announcements

    2024  Volume 13, Issue 2, Page(s) e0114523

    Abstract: Bacteriophage vB_EcoM_JNE01 was isolated from chicken farm sewage ... ...

    Abstract Bacteriophage vB_EcoM_JNE01 was isolated from chicken farm sewage using
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.01145-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimicrobial Resistance and Molecular Characterization of

    Li, Lulu / Zhao, Xiaonan / Zhang, Qing / Luo, Yanbo / Guo, Genglin / Hu, Ming / Chen, Yibao / Liu, Yuqing

    Foodborne pathogens and disease

    2024  

    Abstract: Antimicrobial resistance (AMR) is a great threat to animal and public health. Here, we conducted a surveillance ... ...

    Abstract Antimicrobial resistance (AMR) is a great threat to animal and public health. Here, we conducted a surveillance of
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2148479-X
    ISSN 1556-7125 ; 1535-3141
    ISSN (online) 1556-7125
    ISSN 1535-3141
    DOI 10.1089/fpd.2023.0120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7517: Show issues

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  5. Article ; Online: Disarm The Bacteria: What Temperate Phages Can Do.

    Zhou, Shiyue / Liu, Zhengjie / Song, Jiaoyang / Chen, Yibao

    Current issues in molecular biology

    2023  Volume 45, Issue 2, Page(s) 1149–1167

    Abstract: In the field of phage applications and clinical treatment, virulent phages have been in the spotlight whereas temperate phages received, relatively speaking, less attention. The fact that temperate phages often carry virulent or drug-resistant genes is a ...

    Abstract In the field of phage applications and clinical treatment, virulent phages have been in the spotlight whereas temperate phages received, relatively speaking, less attention. The fact that temperate phages often carry virulent or drug-resistant genes is a constant concern and drawback in temperate phage applications. However, temperate phages also play a role in bacterial regulation. This review elucidates the biological properties of temperate phages based on their life cycle and introduces the latest work on temperate phage applications, such as on host virulence reduction, biofilm degradation, genetic engineering and phage display. The versatile use of temperate phages coupled with their inherent properties, such as economy, ready accessibility, wide variety and host specificity, make temperate phages a solid candidate in tackling bacterial infections.
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45020076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Phage-Derived Depolymerase: Its Possible Role for Secondary Bacterial Infections in COVID-19 Patients.

    Nazir, Amina / Song, Jiaoyang / Chen, Yibao / Liu, Yuqing

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: As of 29 July 2022, there had been a cumulative 572,239,451 confirmed cases of COVID-19 worldwide, including 6,390,401 fatalities. COVID-19 patients with severe symptoms are usually treated with a combination of virus- and drug-induced immuno-suppression ...

    Abstract As of 29 July 2022, there had been a cumulative 572,239,451 confirmed cases of COVID-19 worldwide, including 6,390,401 fatalities. COVID-19 patients with severe symptoms are usually treated with a combination of virus- and drug-induced immuno-suppression medicines. Critical clinical complications of the respiratory system due to secondary bacterial infections (SBIs) could be the reason for the high mortality rate in COVID-19 patients. Unfortunately, antimicrobial resistance is increasing daily, and only a few options are available in our antimicrobial armory. Hence, alternative therapeutic options such as enzymes derived from bacteriophages can be considered for treating SBIs in COVID-19 patients. In particular, phage-derived depolymerases have high antivirulent potency that can efficiently degrade bacterial capsular polysaccharides, lipopolysaccharides, and exopolysaccharides. They have emerged as a promising class of new antibiotics and their therapeutic role for bacterial infections is already confirmed in animal models. This review provides an overview of the rising incidence of SBIs among COVID-19 patients. We present a practicable novel workflow for phage-derived depolymerases that can easily be adapted for treating SBIs in COVID-19 patients.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phage Engineering for Targeted Multidrug-Resistant

    Song, Jiaoyang / Liu, Zhengjie / Zhang, Qing / Liu, Yuqing / Chen, Yibao

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: The lytic bacteriophages have potential application value in the treatment of bacterial infections. However, the narrow host spectrum of these phages limits their range of clinical application. Here, we demonstrate the use of scarless Cas9-assisted ... ...

    Abstract The lytic bacteriophages have potential application value in the treatment of bacterial infections. However, the narrow host spectrum of these phages limits their range of clinical application. Here, we demonstrate the use of scarless Cas9-assisted recombination (no-SCAR) gene-editing technology to regulate phage-host range. We used phage PHB20 as the scaffold to create agents targeting different multidrug-resistant
    MeSH term(s) Bacteriophages/genetics ; Escherichia coli/genetics ; Gene Editing ; Bacteria/genetics ; Drug Resistance, Multiple, Bacterial/genetics
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Phage Endolysins: Advances in the World of Food Safety.

    Nazir, Amina / Xu, Xiaohui / Liu, Yuqing / Chen, Yibao

    Cells

    2023  Volume 12, Issue 17

    Abstract: As antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell ... ...

    Abstract As antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell walls. They have emerged as promising antibacterial agents suitable for integration into food processing systems. Their application as food preservatives can effectively regulate pathogens, thus contributing to an overall improvement in food safety. This review summarizes the latest techniques considering endolysins' potential for food safety. These techniques include native and engineered endolysins for controlling bacterial contamination at different points within the food production chain. However, we find that characterizing endolysins through in vitro methods proves to be time consuming and resource intensive. Alternatively, the emergence of advanced high-throughput sequencing technology necessitates the creation of a robust computational framework to efficiently characterize recently identified endolysins, paving the way for future research. Machine learning encompasses potent tools capable of analyzing intricate datasets and pattern recognition. This study briefly reviewed the use of these industry 4.0 technologies for advancing the research in food industry. We aimed to provide current status of endolysins in food industry and new insights by implementing these industry 4.0 strategies revolutionizes endolysin development. It will enhance food safety, customization, efficiency, transparency, and collaboration while reducing regulatory hurdles and ensuring timely product availability.
    MeSH term(s) Endopeptidases ; Anti-Bacterial Agents ; Bacteriophages ; Food Safety
    Chemical Substances endolysin (EC 3.4.99.-) ; Endopeptidases (EC 3.4.-) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12172169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Phage Engineering for Targeted Multidrug-Resistant Escherichia coli

    Jiaoyang Song / Zhengjie Liu / Qing Zhang / Yuqing Liu / Yibao Chen

    International Journal of Molecular Sciences, Vol 24, Iss 2459, p

    2023  Volume 2459

    Abstract: The lytic bacteriophages have potential application value in the treatment of bacterial infections. However, the narrow host spectrum of these phages limits their range of clinical application. Here, we demonstrate the use of scarless Cas9-assisted ... ...

    Abstract The lytic bacteriophages have potential application value in the treatment of bacterial infections. However, the narrow host spectrum of these phages limits their range of clinical application. Here, we demonstrate the use of scarless Cas9-assisted recombination (no-SCAR) gene-editing technology to regulate phage–host range. We used phage PHB20 as the scaffold to create agents targeting different multidrug-resistant Escherichia coli by replacing its phage tail fiber gene (ORF40). The engineered phages were polyvalent and capable of infecting both the original host bacteria and new targets. Phage-tail fiber genes can be amplified by PCR to construct a recombinant phage PHB20 library that can deal with multidrug-resistant bacteria in the future. Our results provide a better understanding of phage–host interactions, and we describe new anti-bacterial editing methods.
    Keywords CRISPR/Cas9 ; engineering phage ; phage tail fibers ; multidrug resistant bacteria ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Repeated (

    Jiang, Yubin / Wang, Xingming / Chen, Jiawei / Zhang, Yibao / Hashimoto, Kenji / Yang, Jian-Jun / Zhou, Zhiqiang

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2310603

    Abstract: Chronic pain is commonly linked with diminished working memory. This study explores the impact of the anesthetic ( ...

    Abstract Chronic pain is commonly linked with diminished working memory. This study explores the impact of the anesthetic (
    MeSH term(s) Mice ; Animals ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Brain-Derived Neurotrophic Factor/pharmacology ; Memory, Short-Term ; Gastrointestinal Microbiome ; Chronic Pain/drug therapy ; RNA, Ribosomal, 16S ; Hippocampus/metabolism ; Memory Disorders/drug therapy ; Butyrates/pharmacology
    Chemical Substances Ketamine (690G0D6V8H) ; Brain-Derived Neurotrophic Factor ; RNA, Ribosomal, 16S ; Butyrates
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2310603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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