Article ; Online: Evidence for Biologic Drug Modifying Anti-Rheumatoid Drugs and Association with Cardiovascular Disease Risk Mitigation in Inflammatory Arthritis.
Rheumatic diseases clinics of North America
2024 Volume 49, Issue 1, Page(s) 165–178
Abstract: Systemic auto-immune inflammatory arthritides are associated with increased cardiovascular (CV) risk compared to those without these conditions, and is a leading cause of morbidity and mortality. Newer biologic drug modifying antirheumatoid drugs (bDMARD) ...
Abstract | Systemic auto-immune inflammatory arthritides are associated with increased cardiovascular (CV) risk compared to those without these conditions, and is a leading cause of morbidity and mortality. Newer biologic drug modifying antirheumatoid drugs (bDMARD) and small molecules have transformed treatment paradigms enabling tighter control of disease activity and in some cases, remission. There is evidence to suggest that the majority of bDMARDs may also reduce cardiovascular risk, although prospective interventional data remain sparse. Additionally, recent results raise concern for treatments targeting specific pathways that may negatively affect cardiovascular risk. This review will cover key biologic pathways targeted in rheumatoid arthritis, psoriatic arthritis, and spondyloarthropathies. |
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MeSH term(s) | Humans ; Antirheumatic Agents/adverse effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Prospective Studies ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/complications ; Biological Products/adverse effects |
Chemical Substances | Antirheumatic Agents ; Biological Products |
Language | English |
Publishing date | 2024-02-02 |
Publishing country | United States |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 92118-x |
ISSN | 1558-3163 ; 0889-857X |
ISSN (online) | 1558-3163 |
ISSN | 0889-857X |
DOI | 10.1016/j.rdc.2022.08.005 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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