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  1. Article ; Online: Case formulation of interpersonal patterns and its impact on the therapeutic process: Introduction to the issue.

    Critchfield, Kenneth L / Gazzillo, Francesco / Kramer, Ueli

    Journal of clinical psychology

    2022  Volume 78, Issue 3, Page(s) 379–385

    Abstract: Authors included in this issue of the Journal of Clinical Psychology: In-Session come from diverse theoretical orientations but discuss methods of case conceptualization that share these assumptions: (1) that interpersonal patterns are salient to a good ... ...

    Abstract Authors included in this issue of the Journal of Clinical Psychology: In-Session come from diverse theoretical orientations but discuss methods of case conceptualization that share these assumptions: (1) that interpersonal patterns are salient to a good understanding of patient personality and problems and (2) that an individual formulation is helpful in responsively tailoring in-session processes to meet therapeutic goals. We believe these assumptions resonate with many practitioners working across settings, levels of severity, and theoretical orientations. Each author offers an overview of theory as well as a detailed case description that emphasizes the implications of each formulation for the subsequent process of therapy. A final paper provides commentary across the source papers. The issue is thus evocative not only about clinical practice issues but also of underlying theory. It speaks to the challenges and possibilities of transtheoretical integrated practice and research within our focal domain of common interest, interpersonal relationships.
    MeSH term(s) Humans ; Interpersonal Relations ; Personality ; Personality Disorders ; Psychology, Clinical ; Psychotherapy/methods
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 219160-x
    ISSN 1097-4679 ; 0021-9762
    ISSN (online) 1097-4679
    ISSN 0021-9762
    DOI 10.1002/jclp.23322
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  2. Article ; Online: Non-adherence to WHO's recommended 8-contact model: geospatial analysis of the 2017 Maternal Health Survey.

    Dickson, Kwamena Sekyi / Boateng, Ebenezer N K / Adde, Kenneth Setorwu / Ameyaw, Edward Kwabena / Munro-Kramer, Michelle L

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 192

    Abstract: Introduction: Evidence shows that most women in Ghana do not meet the minimum 8-contact model for antenatal care as recommended by WHO with only 31.2%-41.9% of them meeting the recommendation. To the best of our knowledge, no study in Ghana has examined ...

    Abstract Introduction: Evidence shows that most women in Ghana do not meet the minimum 8-contact model for antenatal care as recommended by WHO with only 31.2%-41.9% of them meeting the recommendation. To the best of our knowledge, no study in Ghana has examined women's noncompliance with the WHO's recommended 8-contact model for antenatal care using geospatial analysis, as this study sets out to do.
    Methods: We sourced data from the recent version of the Ghana Maternal Health Survey which was executed in 2017. A sample of 10,077 women with complete data participated in this study. The link between the explanatory variables and the outcome variable was investigated using binary and multivariate logistic regression models and Spatial analyses such as spatial autocorrelation (Moran's I), hotspot, cluster and outlier analysis, and geographically weighted regression were conducted using ArcMap version 10.7.
    Results: Districts found in the north-eastern and south-western parts of the country were more likely to experience noncompliance with ANC. Women staying within the middle belt without health insurance were more likely (17-29%) to be noncompliant with ANC. Women with low community socioeconomic status were found to be more likely (17-34%) to be noncompliant with ANC in the eastern parts of Ghana.
    Conclusion: The study has shown that in order to achieve targets one and three of Sustainable Development Goal 3, the government of Ghana, the Ministry of Health, together with the Ghana Health Service may have to intensify health education in the identified areas to highlight the importance of adherence to the WHO recommendations on ANC 8-contact model.
    MeSH term(s) Female ; Pregnancy ; Humans ; Maternal Health ; Prenatal Care ; Maternal Health Services ; Health Surveys ; Ghana ; World Health Organization
    Language English
    Publishing date 2023-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-05504-w
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  3. Article ; Online: Physical pain among Indigenous Peoples in Canada: a scoping review.

    Bailey, Nicole G N / Knott, Robbie / Grenier, Georgia / Craig, Kenneth D / Kramer, John L K

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2023  Volume 70, Issue 6, Page(s) 1047–1063

    Abstract: Purpose: Pain is a multifaceted experience shaped by various factors including context of pain, previous life events, and ongoing ethnocultural circumstances. Moreover, the definition of pain is inconsistent across cultures. Western medicine views ... ...

    Title translation La douleur physique chez les peuples autochtones au Canada : une étude de portée.
    Abstract Purpose: Pain is a multifaceted experience shaped by various factors including context of pain, previous life events, and ongoing ethnocultural circumstances. Moreover, the definition of pain is inconsistent across cultures. Western medicine views physical pain (e.g., associated with a bone fracture) and nonphysical mental pain (e.g., depression) as two distinct conditions. Indigenous perspectives are often more wholistic, encompassing mental, spiritual, emotional, and physical hurt. The subjective nature of pain invites ample opportunity for discrimination in both its assessment and management. As such, it is important to consider Indigenous perspectives of pain in research and clinical practice. To investigate which aspects of Indigenous pain knowledge are currently considered by Western research, we conducted a scoping review of the literature on pain in Indigenous Peoples of Canada.
    Source: In June 2021, we searched nine databases and downloaded 8,220 papers after removal of duplicates. Two independent reviewers screened abstracts and full-text articles.
    Principle findings: Seventy-seven papers were included in the analysis. Using grounded theory, five themes emerged: pain measures/scales (n = 7), interventions (n = 13), pharmaceuticals (n = 17), pain expression/experiences (n = 45), and pain conditions (n = 70).
    Conclusion: This scoping review shows that there is a paucity of research on pain measurement in Indigenous Peoples of Canada. This finding is concerning in light of numerous studies reporting that Indigenous Peoples experience their pain as ignored, minimized, or disbelieved. Furthermore, a clear disconnect emerged between pain expression in Indigenous Peoples and assessment in medical professionals. We hope that this scoping review will serve to translate current knowledge to other non-Indigenous academics and to initiate meaningful collaboration with Indigenous partners. Future research led by Indigenous academics and community partners is critically needed to better address pain needs in Canada.
    MeSH term(s) Humans ; Canada ; Indigenous Peoples ; Chest Pain ; Pain Measurement
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-023-02461-y
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  4. Article ; Online: Factors influencing frequency and severity of human-American black bear conflicts in New York, USA.

    Parchizadeh, Jamshid / Kellner, Kenneth F / Hurst, Jeremy E / Kramer, David W / Belant, Jerrold L

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0282322

    Abstract: Free-ranging large carnivores are involved in human-wildlife conflicts which can result in economic costs. Understanding factors that lead to human-wildlife conflicts is important to mitigate these negative effects and facilitate human-carnivore ... ...

    Abstract Free-ranging large carnivores are involved in human-wildlife conflicts which can result in economic costs. Understanding factors that lead to human-wildlife conflicts is important to mitigate these negative effects and facilitate human-carnivore coexistence. We used a human-American black bear (Ursus americanus) conflict database maintained by the New York State Department of Environmental Conservation to determine whether drought, conflicts within the Adirondack and Catskill Parks as compared to outside of these parks, mild severity (Class 3) conflicts early in the year (April-June), and bear harvest in the previous year (as an index of bear abundance), were associated with greater frequency of high or moderate severity (Class 1-2) conflicts later in the year (July-September) across New York, USA. During 2006-2019, we obtained 3,782 mild severity conflict records early in the year, and 1,042 high or moderate severity records later in the year. We found that a one standard deviation increase in the cumulative precipitation difference from mean early in the year (about 7.59 cm) coincided with a 20% decrease in conflicts, and that Wildlife Management Units (WMUs) within the parks were predicted to have 5.61 times as many high or moderate severity conflicts as WMUs outside the parks. We also found that a one standard deviation increase in the frequency of mild severity conflicts (equivalent to 5.68 conflicts) early in the year coincided with an increase in the frequency of high or moderate severity conflicts in a WMU later in the year by 49%, while a one standard deviation increase in the bear abundance index in the previous year (0.14 bears/10 km2) coincided with a 23% increase in high or moderate severity conflicts. To reduce the frequency and severity of conflicts to facilitate human-black bear coexistence, we recommend the following measures to be taken in place consistently and build over time in local communities: (i) further reducing black bear access to anthropogenic foods and other attractants, (ii) non-lethal measures including bear-resistant waste management, (iii) electric fencing, and (iv) modifying placement or configuration of field crops.
    MeSH term(s) Animals ; Humans ; Ursidae ; New York ; Animals, Wild ; Food ; Databases, Factual
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282322
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  5. Article ; Online: Factors influencing frequency and severity of human-American black bear conflicts in New York, USA.

    Jamshid Parchizadeh / Kenneth F Kellner / Jeremy E Hurst / David W Kramer / Jerrold L Belant

    PLoS ONE, Vol 18, Iss 2, p e

    2023  Volume 0282322

    Abstract: Free-ranging large carnivores are involved in human-wildlife conflicts which can result in economic costs. Understanding factors that lead to human-wildlife conflicts is important to mitigate these negative effects and facilitate human-carnivore ... ...

    Abstract Free-ranging large carnivores are involved in human-wildlife conflicts which can result in economic costs. Understanding factors that lead to human-wildlife conflicts is important to mitigate these negative effects and facilitate human-carnivore coexistence. We used a human-American black bear (Ursus americanus) conflict database maintained by the New York State Department of Environmental Conservation to determine whether drought, conflicts within the Adirondack and Catskill Parks as compared to outside of these parks, mild severity (Class 3) conflicts early in the year (April-June), and bear harvest in the previous year (as an index of bear abundance), were associated with greater frequency of high or moderate severity (Class 1-2) conflicts later in the year (July-September) across New York, USA. During 2006-2019, we obtained 3,782 mild severity conflict records early in the year, and 1,042 high or moderate severity records later in the year. We found that a one standard deviation increase in the cumulative precipitation difference from mean early in the year (about 7.59 cm) coincided with a 20% decrease in conflicts, and that Wildlife Management Units (WMUs) within the parks were predicted to have 5.61 times as many high or moderate severity conflicts as WMUs outside the parks. We also found that a one standard deviation increase in the frequency of mild severity conflicts (equivalent to 5.68 conflicts) early in the year coincided with an increase in the frequency of high or moderate severity conflicts in a WMU later in the year by 49%, while a one standard deviation increase in the bear abundance index in the previous year (0.14 bears/10 km2) coincided with a 23% increase in high or moderate severity conflicts. To reduce the frequency and severity of conflicts to facilitate human-black bear coexistence, we recommend the following measures to be taken in place consistently and build over time in local communities: (i) further reducing black bear access to anthropogenic foods and other attractants, (ii) ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 910
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  6. Article ; Online: Transcriptional regulation of the synthesis and secretion of farnesol in the fungus Candida albicans: examination of the Homann transcription regulator knockout collection.

    Gutzmann, Daniel J / Kramer, Jaxon J / Toomey, Brigid M / Boone, Cory H T / Atkin, Audrey L / Nickerson, Kenneth W

    G3 (Bethesda, Md.)

    2023  Volume 13, Issue 10

    Abstract: Candida albicans is an efficient colonizer of human gastrointestinal tracts and skin and is an opportunistic pathogen. C. albicans exhibits morphological plasticity, and the ability to switch between yeast and filamentous morphologies is associated with ... ...

    Abstract Candida albicans is an efficient colonizer of human gastrointestinal tracts and skin and is an opportunistic pathogen. C. albicans exhibits morphological plasticity, and the ability to switch between yeast and filamentous morphologies is associated with virulence. One regulator of this switch is the quorum sensing molecule farnesol that is produced by C. albicans throughout growth. However, the synthesis, secretion, regulation, and turnover of farnesol are not fully understood. To address this, we used our improved farnesol assay to screen a transcription regulator knockout library for differences in farnesol accumulation in whole cultures, pellets, and supernatants. All screened mutants produced farnesol and they averaged 9.2× more farnesol in the pellet than the supernatant. Nineteen mutants had significant differences with ten mutants producing more farnesol than their SN152+ wild-type control strain while nine produced less. Seven mutants exhibited greater secretion of farnesol while two exhibited less. We examined the time course for farnesol accumulation in six mutants with the greatest accumulation differences and found that those differences persisted throughout growth and they were not time dependent. Significantly, two high-accumulating mutants did not exhibit the decay in farnesol levels during stationary phase characteristic of wild-type C. albicans, suggesting that a farnesol modification/degradation mechanism is absent in these mutants. Identifying these transcriptional regulators provides new insight into farnesol's physiological functions regarding cell cycle progression, white-opaque switching, yeast-mycelial dimorphism, and response to cellular stress.
    MeSH term(s) Humans ; Candida albicans/metabolism ; Farnesol/metabolism ; Quorum Sensing/genetics ; Gene Expression Regulation, Fungal
    Chemical Substances Farnesol (4602-84-0)
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkad172
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  7. Article ; Online: Teneurin trans-axonal signaling prunes topographically missorted axons.

    Spead, Olivia / Moreland, Trevor / Weaver, Cory J / Costa, Irene Dalla / Hegarty, Brianna / Kramer, Kenneth L / Poulain, Fabienne E

    Cell reports

    2023  Volume 42, Issue 3, Page(s) 112192

    Abstract: Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. Here, we ... ...

    Abstract Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. Here, we show that trans-axonal signaling mediated by the cell surface molecules Glypican-3, Teneurin-3, and Latrophilin-3 prunes misrouted retinal axons in the visual system. Retinotopic neuron transplantations revealed that pioneer ventral axons that elongate first along the optic tract instruct the pruning of dorsal axons that missort in that region. Glypican-3 and Teneurin-3 are both selectively expressed by ventral retinal ganglion cells and cooperate for correcting missorted dorsal axons. The adhesion G-protein-coupled receptor Latrophilin-3 signals along dorsal axons to initiate the elimination of topographic sorting errors. Altogether, our findings show an essential function for Glypican-3, Teneurin-3, and Latrophilin-3 in topographic tract organization and demonstrate that axonal pruning can be initiated by signaling among axons themselves.
    MeSH term(s) Glypicans/metabolism ; Visual Pathways/physiology ; Axons/metabolism ; Retinal Ganglion Cells/metabolism ; Retina/physiology
    Chemical Substances Glypicans
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112192
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  8. Article ; Online: Quantitative assay for farnesol and the aromatic fusel alcohols from the fungus Candida albicans.

    Boone, Cory H T / Gutzmann, Daniel J / Kramer, Jaxon J / Atkin, Audrey L / Nickerson, Kenneth W

    Applied microbiology and biotechnology

    2022  Volume 106, Issue 19-20, Page(s) 6759–6773

    Abstract: The dimorphic fungus Candida albicans is a commensal and opportunistic fungal pathogen of humans. It secretes at least four small lipophilic molecules, farnesol and three aromatic fusel alcohols. Farnesol has been identified as both a quorum sensing ... ...

    Abstract The dimorphic fungus Candida albicans is a commensal and opportunistic fungal pathogen of humans. It secretes at least four small lipophilic molecules, farnesol and three aromatic fusel alcohols. Farnesol has been identified as both a quorum sensing molecule (QSM) and a virulence factor. Our gas chromatography (GC)-based assay for these molecules exhibits high throughput, prevention of analyte loss by avoiding filtration and rotary evaporation, simultaneous cell lysis and analyte extraction by ethyl acetate, and the ability to compare whole cultures with their cell pellets and supernatants. Farnesol synthesis and secretion were separable phenomena and pellet:supernatant ratios for farnesol were high, up to 12:1. The assay was validated in terms of precision, specificity, ruggedness, accuracy, solution stability, detection limits (DL), quantitation limits (QL), and dynamic range. The DL for farnesol was 0.02 ng/µl (0.09 µM). Measurement quality was assessed by the relative error of the whole culture versus the sum of pellet and supernatant fractions (WPS). C. albicans strain SC5314 grown at 30 °C in complex and defined media (YPD and mRPMI) was assayed in biological triplicate 17 times over 3 days. Farnesol and the three aromatic fusel alcohols can be measured in the same assay. The levels of all four are greatly altered by the growth medium chosen. Significantly, the three fusel alcohols are synthesized during stationary phase, not during growth. They are secreted quickly without being retained in the cell pellet and may accumulate up to mM concentrations. KEY POINTS: • Quantitative analysis of both intra- and extracellular farnesol, and aromatic fusel oils. • High throughput, whole culture assay with simultaneous lysis and extraction. • Farnesol secretion and synthesis are distinct and separate events.
    MeSH term(s) Benzyl Alcohol ; Candida albicans ; Farnesol ; Humans ; Oils ; Quorum Sensing ; Virulence Factors
    Chemical Substances Oils ; Virulence Factors ; Farnesol (4602-84-0) ; Benzyl Alcohol (LKG8494WBH)
    Language English
    Publishing date 2022-09-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-022-12165-w
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    Zs.A 2229: Show issues Location:
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  9. Article ; Online: Teneurin trans-axonal signaling prunes topographically missorted axons

    Olivia Spead / Trevor Moreland / Cory J. Weaver / Irene Dalla Costa / Brianna Hegarty / Kenneth L. Kramer / Fabienne E. Poulain

    Cell Reports, Vol 42, Iss 3, Pp 112192- (2023)

    2023  

    Abstract: Summary: Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. ... ...

    Abstract Summary: Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. Here, we show that trans-axonal signaling mediated by the cell surface molecules Glypican-3, Teneurin-3, and Latrophilin-3 prunes misrouted retinal axons in the visual system. Retinotopic neuron transplantations revealed that pioneer ventral axons that elongate first along the optic tract instruct the pruning of dorsal axons that missort in that region. Glypican-3 and Teneurin-3 are both selectively expressed by ventral retinal ganglion cells and cooperate for correcting missorted dorsal axons. The adhesion G-protein-coupled receptor Latrophilin-3 signals along dorsal axons to initiate the elimination of topographic sorting errors. Altogether, our findings show an essential function for Glypican-3, Teneurin-3, and Latrophilin-3 in topographic tract organization and demonstrate that axonal pruning can be initiated by signaling among axons themselves.
    Keywords CP: Neuroscience ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  10. Article ; Online: Specific sides to multifaceted glycosaminoglycans are observed in embryonic development.

    Kramer, Kenneth L

    Seminars in cell & developmental biology

    2010  Volume 21, Issue 6, Page(s) 631–637

    Abstract: Ubiquitously found in the extracellular matrix and attached to the surface of most cells, glycosaminoglycans (GAGs) mediate many intercellular interactions. Originally described in 1889 as the primary carbohydrate in cartilage and then in 1916 as a ... ...

    Abstract Ubiquitously found in the extracellular matrix and attached to the surface of most cells, glycosaminoglycans (GAGs) mediate many intercellular interactions. Originally described in 1889 as the primary carbohydrate in cartilage and then in 1916 as a coagulation inhibitor from liver, various GAGs have since been identified as key regulators of normal physiology. GAGs are critical mediators of differentiation, migration, tissue morphogenesis, and organogenesis during embryonic development. While GAGs are simple polysaccharide chains, many GAGs acquire a considerable degree of complexity by extensive modifications involving sulfation and epimerization. Embryos that lack specific GAG modifying enzymes have distinct developmental defects, illuminating the importance of GAG complexity. Revealing how these complex molecules specifically function in the embryo has often required additional approaches, the results of which suggest that GAG modifications might instructively mediate embryonic development.
    MeSH term(s) Animals ; Carbohydrate Conformation ; Carbohydrate Sequence ; Embryonic Development ; Extracellular Matrix/chemistry ; Glycosaminoglycans/chemistry ; Glycosaminoglycans/metabolism ; Homeostasis ; Molecular Sequence Data ; Morphogenesis
    Chemical Substances Glycosaminoglycans
    Language English
    Publishing date 2010-07-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2010.06.002
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