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Article: Tandem MutSβ binding to long extruded DNA trinucleotide repeats underpins pathogenic expansions.

Li, Jun / Wang, Huaibin / Yang, Wei

bioRxiv : the preprint server for biology

2023

Abstract: Expansion of trinucleotide repeats causes Huntington's disease, Fragile X syndrome and over twenty other monogenic ... ...

Abstract	Expansion of trinucleotide repeats causes Huntington's disease, Fragile X syndrome and over twenty other monogenic disorders
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.12.571350
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Article ; Online: Impact on urban river water quality and pollution control of water environmental management projects based on SMS-Mike21 coupled simulation.

Wei, Huaibin / Rao, Yiding / Liu, Jing / Wang, Yao / Cao, Yongxiao

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6492

Abstract: To explore the impact of expanding Nanyang Sewage Purification Center (NSPC) on the main sewage discharge area of Bai River, we constructed a 2D hydrodynamic-water quality model based on surface water modeling system (SMS) and Mike21. Simulating three ... ...

Abstract	To explore the impact of expanding Nanyang Sewage Purification Center (NSPC) on the main sewage discharge area of Bai River, we constructed a 2D hydrodynamic-water quality model based on surface water modeling system (SMS) and Mike21. Simulating three sewage discharge conditions in wet, normal, and dry season, we evaluated three indicators (COD, NH
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57201-z
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Article: FAK loss reduces BRAF

Gao, Chenxi / Ge, Huaibin / Kuan, Shih-Fan / Cai, Chunhui / Lu, Xinghua / Esni, Farzad / Schoen, Robert / Wang, Jing / Chu, Edward / Hu, Jing

Research square

2024

Abstract: ... ...

Abstract	BRAF
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2531119/v2
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Article ; Online: Characteristics of overlying strata and mechanisms of arch beam failure in shallowly buried thick bedrock coal seams

Changxiang Wang / Huaibin Li / Meng Zhang / Changlong Liao / Shaojie Zhang

Energy Science & Engineering, Vol 11, Iss 10, Pp 3317-

A case study in western China

2023 Volume 3331

Abstract: Abstract The Yangjiacun coal mine, located in western China, exhibits distinctive characteristics, such as its shallow depth, thick bedrock, thin loose layer, and unique roof strata breaking movement. In this research, a comprehensive analysis of ... ...

Abstract	Abstract The Yangjiacun coal mine, located in western China, exhibits distinctive characteristics, such as its shallow depth, thick bedrock, thin loose layer, and unique roof strata breaking movement. In this research, a comprehensive analysis of previous exploration data, subsequent mechanical testing, key stratum theory, natural equilibrium arch theory, and simulation tests and numerical simulations has been conducted to investigate the failure behavior of the overlying rock strata in the Yangjiacun Coal Mine. Specifically, the load‐bearing capacity of the key stratum structure in the bedrock and the morphological properties of the arch‐beam structure have been thoroughly examined. A mechanical model of the roof rock arch‐beam structure has been established, and an analytical formula for the limit size and stability criterion of the arch‐beam structure has been derived. The mining‐induced rock arch‐beam structure plays a crucial role in transferring the load of the upper strata to the surrounding goaf, thereby preventing subsidence and deformation of the overlying strata. However, the arch‐beam structure periodically experiences instability during the advancement of the working face, gradually progressing towards the upper layer until the main key stratum is breached and the arch‐beam structure collapses. Based on the characteristics of weathered rock and the arch‐beam failure model in the Yangjiacun Coal Mine, quantitative backfilling mining methods have been proposed to either compensate for the mining void created by coal extraction or limit the size of exposed key strata through strip mining, ensuring the stability of the R6 key stratum. This study represents a significant contribution to understanding the intricate failure behavior of overlying rock strata in coal mines and provides a valuable framework for the responsible and efficient extraction of coal resources in similar environments.
Keywords	arch beam structure ; key layer structure ; shallow buried depth ; stability analysis ; Technology ; T ; Science ; Q
Subject code	950
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration.

Wang, Xin / Chen, Xi / Liu, Guangdong / Cai, Huaibin / Le, Weidong

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: The degeneration of midbrain dopaminergic (mDA) neurons, particularly in the substantia nigra pars compacta (SNc), is one of the most prominent pathological hallmarks of Parkinson's disease (PD). To uncover the pathogenic mechanisms of mDA neuronal death ...

Abstract	The degeneration of midbrain dopaminergic (mDA) neurons, particularly in the substantia nigra pars compacta (SNc), is one of the most prominent pathological hallmarks of Parkinson's disease (PD). To uncover the pathogenic mechanisms of mDA neuronal death during PD may provide therapeutic targets to prevent mDA neuronal loss and slow down the disease's progression. Paired-like homeodomain transcription factor 3 (Pitx3) is selectively expressed in the mDA neurons as early as embryonic day 11.5 and plays a critical role in mDA neuron terminal differentiation and subset specification. Moreover, Pitx3-deficient mice exhibit some canonical PD-related features, including the profound loss of SNc mDA neurons, a dramatic decrease in striatal dopamine (DA) levels, and motor abnormalities. However, the precise role of Pitx3 in progressive PD and how this gene contributes to mDA neuronal specification during early stages remains unclear. In this review, we updated the latest findings on Pitx3 by summarizing the crosstalk between Pitx3 and its associated transcription factors in mDA neuron development. We further explored the potential benefits of Pitx3 as a therapeutic target for PD in the future. To better understand the transcriptional network of Pitx3 in mDA neuron development may provide insights into Pitx3-related clinical drug-targeting research and therapeutic approaches.
MeSH term(s)	Animals ; Mice ; Dopamine ; Dopaminergic Neurons/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Mesencephalon/metabolism ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Dopamine (VTD58H1Z2X) ; Homeodomain Proteins ; Transcription Factors ; homeobox protein PITX3
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108614
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Article ; Online: Effects of Valproic Acid Therapy on Rats with Spinal Cord Injury: A Systematic Review and Meta-Analysis.

Yang, Qinglin / Zhang, Huaibin / Jin, Zhuanmei / Zhang, Baolin / Wang, Yongping

World neurosurgery

2023 Volume 182, Page(s) 12–28

Abstract: Objective: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the risk of clinical conversion and provide a valuable reference for future animal and clinical studies.: Methods: We searched ... ...

Abstract	Objective: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the risk of clinical conversion and provide a valuable reference for future animal and clinical studies. Methods: We searched scientific databases, including PubMed, Ovid-Embase, Web of Science, and Scopus databases. The relevant literature was searched from the establishment date of the database to June 28, 2023. The search results were screened, data were extracted, and the quality of the literature was evaluated independently by 2 reviewers. Results: Among 656 nonduplicated references, 14 articles were included for meta-analysis. The summary results showed that the overall Basso, Beattie and Bresnahan scores of the VPA intervention group were significantly higher than those in the control group at 1-6 weeks after VPA intervention. Subgroup analysis showed that the injury model, administration dose, rat strain, country of study, or follow-up duration had no significant effect on the efficacy of VPA on rats with SCI. In addition, mesh analysis showed that high doses of the VPA group had a better effect on SCI rats, compared with the low dose group and the medium dose group. Conclusions: To date, this is the first systematic evaluation of the potential effects of VPA on motor recovery in rats with SCI. We concluded that VPA can promote motor recovery in rats with SCI, and higher doses of VPA seem to be more effective in rats with SCI. However, the limited quality and sample of included studies reduced the application of this meta-analysis. In the future, more high-quality, direct comparative studies are needed to explore this issue in depth.
MeSH term(s)	Rats ; Animals ; Valproic Acid/therapeutic use ; Spinal Cord Injuries/drug therapy ; Spinal Cord ; Recovery of Function ; Disease Models, Animal
Chemical Substances	Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.10.135
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Zs.A 1159: Show issues

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Article ; Online: Correction: Elaborating the interplay between the detecting unit and emitting unit in infrared quantum dot up-conversion photodetectors.

Xua, Qiulei / Yang, Xinxin / Liu, Jiao Jiao / Li, Fei / Chang, Ruiguang / Wang, Lei / Wang, A Qiang / Wu, Zhenghui / Shen, Huaibin / Du, Zuliang

Nanoscale

2024 Volume 16, Issue 2, Page(s) 941

Abstract: Correction for 'Elaborating the interplay between the detecting unit and emitting unit in infrared quantum dot up-conversion photodetectors' by Qiulei ... ...

Abstract	Correction for 'Elaborating the interplay between the detecting unit and emitting unit in infrared quantum dot up-conversion photodetectors' by Qiulei Xu
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Published Erratum
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr90227g
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Article ; Online: Spatiotemporally Controlled Photolabeling of Genetically Unmodified Proteins in Live Cells.

Yu, Huaibin / Wang, Shuangshuang / Fu, Yu / Wagner, Manfred / Weil, Tanja / Liu, Shaoqin / Zhao, Weining / Zhong, Fangrui / Wu, Yuzhou

Analytical chemistry

2024 Volume 96, Issue 5, Page(s) 1932–1940

Abstract: Selective labeling of the protein of interest (POI) in genetically unmodified live cells is crucial for understanding protein functions and kinetics in their natural habitat. In particular, spatiotemporally controlled installation of the labels on a POI ... ...

Abstract	Selective labeling of the protein of interest (POI) in genetically unmodified live cells is crucial for understanding protein functions and kinetics in their natural habitat. In particular, spatiotemporally controlled installation of the labels on a POI under light control without affecting their original activity is in high demand but is a tremendous challenge. Here, we describe a novel ligand-directed photoclick strategy for spatiotemporally controlled labeling of endogenous proteins in live cells. It was realized with a designer labeling reagent skillfully integrating the photochemistries of 2-nitrophenylpropyloxycarbonyl and 3-hydroxymethyl-2-naphthol with an affinity ligand. Highly electrophilic
MeSH term(s)	Ligands ; Proteins/chemistry ; Naphthols/chemistry ; Fluorescein
Chemical Substances	3-(hydroxymethyl)-2-naphthol ; Ligands ; Proteins ; Naphthols ; Fluorescein (TPY09G7XIR)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04099
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Zs.A 4033: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss.

Wang, Huaibin / Liu, Zhao / Meng, Lijun / Zhang, Xiujun

Human fertility (Cambridge, England)

2022 Volume 26, Issue 5, Page(s) 1015–1022

Abstract: Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics ... ...

Abstract	Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE165004 from the Gene Expression Omnibus (GEO). Gene ontology (GO) analysis and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analyses were performed on selected genes by using the R Programming Language. A protein-protein interaction (PPI) network was constructed with the Retrieval of Interacting Genes (STRING). Our analysis revealed that 1,869 genes were differentially expressed in RPL and control groups. GO analysis revealed that the interferon type 1 and the glycoprotein-related biological processes played irreplaceable roles, meanwhile KEGG enrichment analysis also revealed that the cAMP signalling pathway and the prolactin signalling pathway played important roles. In the following study, we found that there were many DEGs in the RPL group that were closely related to endometrial decidualization, such as IL17RD, IL16, SOX4, CREBBP, and POFUT1 as well as Notch1 and RBPJ in the Notch signalling pathway family were down-regulated in the RPL group. The results provided valuable information on the pathogenesis of RPL.
MeSH term(s)	Female ; Pregnancy ; Humans ; Gene Expression Profiling/methods ; Computational Biology/methods ; SOXC Transcription Factors
Chemical Substances	SOX4 protein, human ; SOXC Transcription Factors
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2086960-5
ISSN	1742-8149 ; 1464-7273
ISSN (online)	1742-8149
ISSN	1464-7273
DOI	10.1080/14647273.2022.2045636
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Zs.A 5775: Show issues

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Article: Increasing contributions of airborne route in SARS-CoV-2 omicron variant transmission compared with the ancestral strain.

Ji, Shuyi / Xiao, Shenglan / Wang, Huaibin / Lei, Hao

Building and environment

2022 Volume 221, Page(s) 109328

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant lineage worldwide. Experimental studies have shown that SARS-CoV-2 Omicron variant is more stable on various environmental surfaces than the ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant lineage worldwide. Experimental studies have shown that SARS-CoV-2 Omicron variant is more stable on various environmental surfaces than the ancestral strains of SARS-CoV-2. However, the influences on the role of the contact route in SARS-CoV-2 transmission are still unknown. In this study, we built a Markov chain model to simulate the transmission of the Omicron and ancestral strains of SARS-CoV-2 within a household over a 1-day period from multiple pathways; that is, airborne, droplet, and contact routes. We assumed that there were two adults and one child in the household, and that one of the adults was infected with SARS-CoV-2. We assumed two scenarios. (1) Asymptomatic/presymptomatic infection, and (2) symptomatic infection. During asymptomatic/presymptomatic infection, the contact route contributing the most (37%-45%), followed by the airborne (34%-38%) and droplet routes (21%-28%). During symptomatic infection, the droplet route was the dominant pathway (48%-71%), followed by the contact route (25%-42%), with the airborne route playing a negligible role (<10%). Compared to the ancestral strain, although the contribution of the contact route increased in Omicron variant transmission, the increase was slight, from 25%-41% to 30%-45%. With the growing concern about the increase in the proportion of asymptomatic/presymptomatic infection in Omicron strain transmissions, the airborne route, rather than the fomite route, should be of focus. Our findings suggest the importance of ventilation in the SARS-CoV-2 Omicron variant prevention in building environment.
Language	English
Publishing date	2022-06-26
Publishing country	England
Document type	Journal Article
ISSN	0360-1323
ISSN	0360-1323
DOI	10.1016/j.buildenv.2022.109328
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