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Article ; Online: Three-dimensional Speckle Tracking Echocardiography in Amyloidosis: A New Assessment Method for a Rare Disease.

Markman Filho, Brivaldo

2018 Volume 111, Issue 3, Page(s) 392–393

MeSH term(s)	Amyloidosis ; Echocardiography, Three-Dimensional ; Humans ; Rare Diseases
Language	Portuguese
Publishing date	2018-10-31
Publishing country	Brazil
Document type	Editorial ; Comment
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20180182
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Article ; Online: Speckle-Tracking Echocardiography - Ready for Use in Acute Coronary Syndrome?

Markman Filho, Brivaldo

Arquivos brasileiros de cardiologia

2018 Volume 110, Issue 4, Page(s) 362–363

MeSH term(s)	Acute Coronary Syndrome ; Echocardiography ; Humans ; Reproducibility of Results ; Stroke Volume
Language	Portuguese
Publishing date	2018-05-23
Publishing country	Brazil
Document type	Editorial ; Comment
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20180061
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Article ; Online: Coronary Reperfusion in Acute Myocardial Infarction: Trying the Optimal. Executing the Possible.

Markman Filho, Brivaldo / Lima, Sandro Gonçalves de

Arquivos brasileiros de cardiologia

2021 Volume 117, Issue 1, Page(s) 130–131

Title translation	Reperfusão Coronariana no Infarto Agudo do Miocárdio: Tentar o Ótimo. Executar o Possível.
MeSH term(s)	Humans ; Myocardial Infarction/drug therapy ; Myocardial Reperfusion ; Thrombolytic Therapy
Language	Portuguese
Publishing date	2021-10-11
Publishing country	Brazil
Document type	Editorial ; Comment
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20210500
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Article ; Online: Guidelines, Position Statements, and Standardizations: Documents to Assist Medical Practice.

Sousa, Antônio Carlos Sobral / Corrêa Filho, Harry / Nascimento, Bruno / Issa, Aurora Castro / Vieira, Marcelo Luiz Campos / Markman Filho, Brivaldo

Arquivos brasileiros de cardiologia

2022 Volume 119, Issue 3, Page(s) 496–498

Title translation	Diretrizes, Posicionamentos e Normatizações: Documentos de Auxílio à Prática Médica.
MeSH term(s)	Humans ; Reference Standards
Language	Portuguese
Publishing date	2022-09-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20220001
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Article ; Online: Progression of Myocardial 18F-FDG Uptake in a Patient with Cardiotoxicity.

Berenguer, Diego Rafael Freitas / de Moraes Chaves Becker, Monica / de Oliveira Buril, Roberto / Bertão, Paula Araruna / Markman Filho, Brivaldo / Brandão, Simone Cristina Soares

Arquivos brasileiros de cardiologia

2024 Volume 121, Issue 2, Page(s) e20230276

Abstract: The objective of this case report was to present the progression of chemotherapy-induced cardiotoxicity in a patient with lymphoma, highlighting the importance of myocardial fluor-18-fluorodeoxyglucose (18F-FDG) uptake by positron emission tomography ... ...

Title translation	Evolução da Captação Miocárdica de 18F-FDG em Paciente com Diagnóstico de Cardiotoxicidade.
Abstract	The objective of this case report was to present the progression of chemotherapy-induced cardiotoxicity in a patient with lymphoma, highlighting the importance of myocardial fluor-18-fluorodeoxyglucose (18F-FDG) uptake by positron emission tomography coupled with computed tomography (PET/CT). 43-year-old female patient with uterine lymphoma, who underwent hysterectomy followed by three chemotherapy regimens and radiotherapy. The patient had episodes of acute heart failure two years after chemotherapy. Echocardiogram revealed a reduction in left ventricular ejection fraction (LVEF). A retrospective analysis of 18F-FDG PET/CT showed an increase in myocardial uptake in all tests performed during oncologic treatment. Despite disease remission, the patient developed heart failure with reduced LVEF. During chemotherapy, there was a diffuse, significant increase in myocardial 18F-FDG uptake, which preceded the decrease in myocardial performance and seemed to reflect metabolic changes in cardiomyocytes, related to cardiotoxicity. Would an analysis of myocardial 18F-FDG uptake yield a different cardiac outcome in this patient? This question is relevant, considering that other patients may benefit from the use of PET as an early marker of cardiotoxicity. Imaging tests are essential in the follow-up of patients at risk of cardiotoxicity. Although echocardiography remains the main imaging test in the diagnosis of cardiotoxicity, 18F-FDG PET/CT may be a powerful tool for the early diagnosis of this condition.
MeSH term(s)	Female ; Humans ; Adult ; Fluorodeoxyglucose F18/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Stroke Volume ; Retrospective Studies ; Ventricular Function, Left ; Lymphoma ; Heart Failure/chemically induced ; Heart Failure/diagnostic imaging
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2024-02-23
Publishing country	Brazil
Document type	Case Reports ; Letter
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20230276
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Zs.A 548: Show issues

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Article ; Online: Lutembacher Syndrome with Sinus Venosus-Type Interatrial Communication: An Educational Presentation.

Lordsleem, Andréa Bezerra de Melo da Silveira / Lima, Sandro Gonçalves de / Bezerra, Lucas Soares / Calado, Eveline Barros / Granja, Fabio Antônio Amando / Markman-Filho, Brivaldo

Brazilian journal of cardiovascular surgery

2022 Volume 37, Issue 4, Page(s) 591–594

MeSH term(s)	Heart Septal Defects, Atrial/complications ; Heart Septal Defects, Atrial/diagnostic imaging ; Heart Septal Defects, Atrial/surgery ; Humans ; Lutembacher Syndrome ; Vena Cava, Superior
Language	English
Publishing date	2022-08-16
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2183753-3
ISSN	1678-9741 ; 1678-9741
ISSN (online)	1678-9741
ISSN	1678-9741
DOI	10.21470/1678-9741-2021-0323
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Article: Familial Hypertrophic Cardiomyopathy: Late Potentials and Other Prognostic Markers.

Chaves-Markman, Ândrea / Markman, Manuel / Santos-Veloso, Marcelo Antônio O / Bezerra, Lucas S / Sobral Filho, Dário C / Markman Filho, Brivaldo

Cureus

2020 Volume 12, Issue 1, Page(s) e6530

Abstract: Familial hypertrophic cardiomyopathy is an autosomal dominant genetic disease considered the most common cause of sudden cardiac death in individuals under 35 years old, especially the athletes. This study aimed to investigate the association between the ...

Abstract	Familial hypertrophic cardiomyopathy is an autosomal dominant genetic disease considered the most common cause of sudden cardiac death in individuals under 35 years old, especially the athletes. This study aimed to investigate the association between the presence of late potentials and a family history of sudden death, syncope, and complex ventricular arrhythmias on patients with hypertrophic cardiomyopathy. A case series study was carried out from March 2001 to December 2002, including 22 patients with hypertrophic cardiomyopathy according to transthoracic echocardiogram criteria. Patients on a cardiac pacemaker, right bundle branch block, cardiac transplant, and under no possibilities to realize the exams were excluded. The results showed that asymmetric septal hypertrophy was the most common type (73%), 63% had a positive familial history of hypertrophic cardiomyopathy, 55% sudden cardiac death, and 23% syncope. Also, complex ventricular arrhythmias were detected in 14% and late potentials in 23% of patients. According to this study, the presence of late potentials was not associated with familial sudden death, syncope, and complex ventricular arrhythmias.
Language	English
Publishing date	2020-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.6530
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Article ; Online: ICD indication in hypertrophic cardiomyopathy: which algorithm to use?

Santos-Veloso, Marcelo Antônio Oliveira / Chaves, Ândrea Virgínia Ferreira / Calado, Eveline Barros / Markman, Manuel / Bezerra, Lucas Soares / Lima, Sandro Gonçalves de / Markman Filho, Brivaldo / Oliveira, Dinaldo Cavalcanti de

Revista da Associacao Medica Brasileira (1992)

2022 Volume 68, Issue 8, Page(s) 1059–1063

Abstract: Objective: This study aimed to evaluate the agreement in the indication of implantable cardioverter-defibrillators in patients with Hypertrophic cardiomyopathy, as per the 2014 European Society of Cardiology and 2020 American Heart Association ... ...

Abstract	Objective: This study aimed to evaluate the agreement in the indication of implantable cardioverter-defibrillators in patients with Hypertrophic cardiomyopathy, as per the 2014 European Society of Cardiology and 2020 American Heart Association recommendations, and evaluate fragmented QRS as a predictor of cardiovascular outcome. Methods: Retrospective cohort with 81 patients was evaluated between 2019 and 2021. Patients with hypertrophic cardiomyopathy ≥16 years old were included. Exclusion criteria include secondary myocardiopathy and follow-up <1 year. Kappa coefficient was used to determine the agreement. Survival and incidence curves were determined by Kaplan-Meier method. A p<0.05 was considered significant. Results: The fragmented QRS was identified in 44.4% of patients. There were no differences between patients with and without fragmented QRS regarding clinical parameters, echocardiography, fibrosis, and sudden cardiac death risk. During follow-up of 4.8±3.4 years, there was no sudden cardiac death, but 20.6% patients with implantable cardioverter-defibrillator had at least one appropriate shock. Three of the seven appropriate shocks occurred in European Society of Cardiology low- to moderate-risk patients. Three shocks occurred in moderate-risk patients and four in American Heart Association high-risk patients. Overall recommendations agreement was 64% with a kappa of 0.270 (p=0.007). C-statistic showed no differences regarding the incidence of appropriate shock (p=0.644). Conclusion: sudden cardiac death risk stratification algorithms present discrepancies in implantable cardioverter-defibrillator indication, both with low accuracy.
MeSH term(s)	Adolescent ; Algorithms ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/epidemiology ; Cardiomyopathy, Hypertrophic/therapy ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Humans ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; United States
Language	English
Publishing date	2022-10-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20220199
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Article ; Online: Chemotherapy-induced Cardiac18F-FDG Uptake in Patients with Lymphoma: An Early Metabolic Index of Cardiotoxicity?

Dourado, Mayara L C / Dompieri, Luca T / Leitão, Glauber M / Mourato, Felipe A / Santos, Renata G G / Almeida Filho, Paulo J / Markman Filho, Brivaldo / Melo, Marcelo D T / Brandão, Simone C S

Arquivos brasileiros de cardiologia

2022 Volume 118, Issue 6, Page(s) 1049–1058

Abstract: Background: It is uncertain whether myocardial fluorodeoxyglucose uptake occurs solely due to physiological features or if it represents a metabolic disarrangement under chemotherapy.: Objective: To investigate the chemotherapy effects on the heart ... ...

Title translation	Aumento de Captação Cardíaca de 18F-FDG Induzida por Quimioterapia em Pacientes com Linfoma: Um Marcador Precoce de Cardiotoxicidade?
Abstract	Background: It is uncertain whether myocardial fluorodeoxyglucose uptake occurs solely due to physiological features or if it represents a metabolic disarrangement under chemotherapy. Objective: To investigate the chemotherapy effects on the heart of patients with lymphoma by positron emission tomography associated with computed tomography scans (PET/CT) with 2-deoxy-2[18F] fluoro-D-glucose (18F-FDG PET/CT) before, during and/or after chemotherapy. Methods: Seventy patients with lymphoma submitted to18F-FDG PET/CT were retrospectively analyzed. The level of significance was 5%.18F-FDG cardiac uptake was assessed by three measurements: left ventricular maximum standardized uptake value (SUVmax), heart to blood pool (aorta) ratio, and heart to liver ratio in all the exams. Body weight, fasting blood sugar, post-injection time, and the injected dose of18F-FDG between the scans were also compared. Results: Mean age was 50.4 ± 20.1 years and 50% was female. The analysis was carried out in two groups: baseline vs. interim PET/CT, and baseline vs. post-therapy PET/CT. There was no significant difference in clinical variables or protocol scans variables. We observed an increase in left ventricular (LV) SUVmax from 3.5±1.9 (baseline) to 5.6±4.0 (interim), p=0.01, and from 4.0±2.2 (baseline) to 6.1±4.2 (post-therapy), p<0.001. A percentage increase ≥30% of LV SUVmax occurred in more than half of the sample. The rise of cardiac SUV was accompanied by an increase in LV SUVmax/Aorta SUVmax and LV SUVmean/Liver SUVmean ratios. Conclusion: This study showed a clear increase in cardiac18F-FDG uptake in patients with lymphoma during and/or after chemotherapy. The literature corroborates with these findings and suggests that18F-FDG PET/CT is a sensitive and reliable imaging exam to detect early metabolic signs of cardiotoxicity.
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents/adverse effects ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymphoma/diagnostic imaging ; Lymphoma/drug therapy ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Retrospective Studies
Chemical Substances	Antineoplastic Agents ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	Portuguese
Publishing date	2022-05-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20210463
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Article ; Online: Trends in morbidity and mortality from COPD in Brazil, 2000 to 2016.

Gonçalves-Macedo, Liana / Lacerda, Eliana Mattos / Markman-Filho, Brivaldo / Lundgren, Fernando Luiz Cavalcanti / Luna, Carlos Feitosa

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2019 Volume 45, Issue 6, Page(s) e20180402

Abstract: Objective: To examine the trends in overall COPD mortality, as well as trends in in-hospital morbidity and mortality due to COPD, in Brazil, and to validate predictive models.: Methods: This was a population-based study with a time-series analysis of ...

Abstract	Objective: To examine the trends in overall COPD mortality, as well as trends in in-hospital morbidity and mortality due to COPD, in Brazil, and to validate predictive models. Methods: This was a population-based study with a time-series analysis of cause-specific morbidity and mortality data for individuals ≥ 40 years of age, obtained from national health information systems for the 2000-2016 period. Morbidity and mortality rates, stratified by gender and age group, were calculated for the same period. We used regression analyses to examine the temporal trends and double exponential smoothing in our analysis of the predictive models for 2017. Results: Over the study period, COPD mortality rates trended downward in Brazil. For both genders, there was a downward trend in the southern, southeastern, and central-western regions. In-hospital morbidity rates declined in all regions, more so in the south and southeast. There were significant changes in the number of hospitalizations, length of hospital stay, and hospital expenses. The predictive models for 2017 showed error rates below 9% and were therefore validated. Conclusions: In Brazil, COPD age-adjusted mortality rates have declined in regions with higher socioeconomic indices, where there has been an even sharper decrease in all in-hospital morbidity and mortality variables. In addition to factors such as better treatment adherence and reduced smoking rates, socioeconomic factors appear to be involved in controlling COPD morbidity and mortality. The predictive models estimated here might also facilitate decision making and the planning of health policies aimed at treating COPD.
MeSH term(s)	Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Female ; Geography ; Hospital Mortality/trends ; Humans ; Length of Stay/trends ; Male ; Middle Aged ; Morbidity/trends ; Pulmonary Disease, Chronic Obstructive/mortality ; Sex Distribution ; Socioeconomic Factors ; Time Factors
Language	Portuguese
Publishing date	2019-11-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/1806-3713/e20180402
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