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  1. Article ; Online: Preparing for kidney replacement therapy in pediatric advanced CKD: a review of literature and defining a multi-disciplinary clinical approach to patient-caregiver education.

    Millner, Rachel / Crawford, Brendan / Ranabothu, Saritha / Blaszak, Richard

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 12, Page(s) 3901–3908

    Abstract: Pediatric patients with progressive chronic kidney disease (CKD) approaching kidney replacement therapy (KRT) make up a small population but carry significant morbidity and mortality. Patients and caregivers require comprehensive kidney failure education ...

    Abstract Pediatric patients with progressive chronic kidney disease (CKD) approaching kidney replacement therapy (KRT) make up a small population but carry significant morbidity and mortality. Patients and caregivers require comprehensive kidney failure education to ensure a smooth start to KRT. Choice of KRT modality can be influenced by medical comorbidities, patient/caregiver comprehension, and comfort with a particular modality, social and economic factors, and/or implicit bias of the health care team. As KRT modality can influence morbidity, mortality, and quality of life, we created a pediatric advanced CKD clinic to provide comprehensive KRT education and to promote informed decision-making for our advanced CKD patients and their caregivers.
    MeSH term(s) Humans ; Child ; Caregivers ; Quality of Life ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/epidemiology ; Renal Replacement Therapy ; Renal Insufficiency
    Language English
    Publishing date 2023-04-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05953-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of pre-emptive rituximab on EBV DNA levels and prevention of post-transplant lymphoproliferative disorder in pediatric kidney transplant recipients: A case series from the pediatric nephrology research consortium.

    Ashoor, Isa F / Al-Akash, Samhar / Kizilbash, Sarah / Moudgil, Asha / Puliyanda, Dechu / Ranabothu, Saritha / Shi, Yi / Dharnidharka, Vikas

    Pediatric transplantation

    2024  Volume 28, Issue 3, Page(s) e14743

    Abstract: Background: There are scant data on the effect of rituximab on EBV DNA levels and prevention of post-transplant lymphoproliferative disorder (PTLD) in pediatric kidney transplant recipients with EBV DNAemia.: Methods: Kidney transplant recipients ... ...

    Abstract Background: There are scant data on the effect of rituximab on EBV DNA levels and prevention of post-transplant lymphoproliferative disorder (PTLD) in pediatric kidney transplant recipients with EBV DNAemia.
    Methods: Kidney transplant recipients with EBV DNAemia treated with rituximab to prevent PTLD between 7/1999 and 7/2019 at five pediatric centers were included. Those with confirmed PTLD at the onset of rituximab were excluded. Primary outcomes included percentage change in EBV DNAemia and occurrence of PTLD post rituximab.
    Results: Twenty-six pediatric kidney transplant recipients were included. Median age at transplant was 4 years (IQR 2.1-10.3). EBV DNA load monitoring by qPCR was performed at 1-3 month intervals. EBV DNAemia onset occurred at a median of 73 days post-transplant (IQR 52-307), followed by DNAemia peak at a median of 268 days (IQR 112-536). Rituximab was administered at a median of 9 days post peak (IQR 0-118). Rituximab regimens varied; median dose 375 mg/m
    Conclusions: In the largest pediatric kidney transplant recipient case series with EBV DNAemia given rituximab to prevent PTLD, rituximab achieved a short-term reduction in DNA load; however, recurrent DNAemia is common.
    MeSH term(s) Humans ; Child ; Child, Preschool ; Rituximab/therapeutic use ; Herpesvirus 4, Human/genetics ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/prevention & control ; Epstein-Barr Virus Infections/drug therapy ; Kidney Transplantation/adverse effects ; Nephrology ; DNA, Viral ; Lymphoproliferative Disorders/etiology ; Lymphoproliferative Disorders/prevention & control ; Lymphoproliferative Disorders/drug therapy ; Transplant Recipients ; Viral Load
    Chemical Substances Rituximab (4F4X42SYQ6) ; DNA, Viral
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rocky road-an uncommon reason for kidney allograft dysfunction: Questions.

    Ranabothu, Saritha / Blaszak, Richard / Larsen, Chris / Crawford, Brendan

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 6, Page(s) 1457–1459

    Language English
    Publishing date 2020-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04683-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rocky road-an uncommon reason for kidney allograft dysfunction: Answers.

    Ranabothu, Saritha / Blaszak, Richard / Larsen, Chris / Crawford, Brendan

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 6, Page(s) 1461–1463

    Language English
    Publishing date 2020-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04688-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Utilization Pattern for Eculizumab Among Children With Hemolytic Uremic Syndrome.

    Ranabothu, Saritha / Brown, Clare C / Blaszak, Richard / Millner, Rachel / Moore, Kristen Rice / Prodhan, Parthak

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 733042

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.733042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Industry Payments to Nephrologists in the United States.

    Pakanati, Abhinandan R / Kovvuru, Karthik / Thombre, Vaishali / Kanduri, Swetha Rani / Nalleballe, Krishna / Ranabothu, Saritha

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17057

    Abstract: Background Industry payments to physicians raise concerns about conflicts of interest that have the potential to impact patient care. In this study, we explored nonresearch and nonownership payments from industry to nephrologists to identify trends in ... ...

    Abstract Background Industry payments to physicians raise concerns about conflicts of interest that have the potential to impact patient care. In this study, we explored nonresearch and nonownership payments from industry to nephrologists to identify trends in compensation. Methodology Using data from the Centers for Medicare and Medicaid Services (CMS), we explored financial relationships between industry and US nephrologists from 2014 to 2018. We analyzed payment characteristics including payment categories, payment distribution among physicians, regional trends, and biomedical manufacturers. Results In this retrospective study, a total of $75,174,999 was paid to nephrologists in the United States during the study period (i.e., 2014-2018). The number of board-certified nephrologists receiving payment from the industry increased from 11,642 in 2014 to 13,297 in 2018. Among board-certified nephrologists, 56% to 63% received industry payments during the study period. The total payments to nephrologists increased from $13,113,512 in 2014 to $16,467,945 in 2017, with consulting fees (24%) and compensation for services other than consulting (35%) being the highest-paid categories. The top 10% of physician beneficiaries collected 90% of the total industry payments. Conclusions A small proportion of US nephrologists consistently received the majority of industry payments, the value of which grew over the study period.
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spectrum of COVID-19 in children.

    Ranabothu, Saritha / Onteddu, Sanjeeva / Nalleballe, Krishna / Dandu, Vasuki / Veerapaneni, Karthika / Veerapandiyan, Aravindhan

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 9, Page(s) 1899–1900

    MeSH term(s) Adolescent ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Female ; Humans ; Infant ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Prevalence ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Validation of automated Greulich-Pyle bone age determination in children with chronic renal failure?

    Ranabothu, Saritha / Kaskel, Frederick J

    Pediatric nephrology (Berlin, Germany)

    2015  Volume 30, Issue 7, Page(s) 1051–1052

    Abstract: Growth failure is a common problem in children with chronic kidney disease (CKD). The causes are multifactorial and are associated with increased mortality and morbidity. Standard deviations of bone age versus chronological age in children with CKD have ... ...

    Abstract Growth failure is a common problem in children with chronic kidney disease (CKD). The causes are multifactorial and are associated with increased mortality and morbidity. Standard deviations of bone age versus chronological age in children with CKD have not been developed to date. Accurate and early treatment of bone age is an important component of determining the utility of GH therapy. Improvements in bone age assessments are being evaluated to optimize the understanding of growth delay in CKD.
    MeSH term(s) Age Determination by Skeleton/methods ; Bone Diseases/diagnosis ; Bone Diseases/etiology ; Female ; Humans ; Male ; Renal Insufficiency, Chronic/complications
    Language English
    Publishing date 2015-07
    Publishing country Germany
    Document type Comment ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-015-3103-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Diagnosis and management of non-calcium-containing stones in the pediatric population.

    Ranabothu, Saritha / Bernstein, Ari P / Drzewiecki, Beth A

    International urology and nephrology

    2018  Volume 50, Issue 7, Page(s) 1191–1198

    Abstract: Compared to adults, urolithiasis is less common in children, with a definite rise in incidence, especially among young adults (Tasian et al. in Clin J Am Soc Nephrol 11:488, 2016). In the last 25 years, the incidence in children has increased by ... ...

    Abstract Compared to adults, urolithiasis is less common in children, with a definite rise in incidence, especially among young adults (Tasian et al. in Clin J Am Soc Nephrol 11:488, 2016). In the last 25 years, the incidence in children has increased by approximately 6-10% annually, for reasons still unknown, with an associated significant increase in related health care-related expenditures (Hyams and Matlaga in Transl Androl Urol 3(3):278-83, 2014). It has been shown that there is twice as high a risk of chronic kidney disease (CKD) or end stage renal disease (ESRD) in stone formers compared to non-stone formers (Tasian et al. 2016). While calcium-containing stones are by far the most common category of stone encountered in both children and adults, non-calcium stones are more common in children than adults and have been shown in several studies to be associated with greater morbidity and lower renal function than calcium stones (Issler et al. in BMC Nephrol 18(1):136, 2017; Gambaro et al. in J Urol 198:268-273, 2017). This could be related to the challenges in the management of non-calcium-containing stones due to associated infection or metabolic derangements, further leading to recurrence and loss of renal function. There is currently a gap in our understanding of how to appropriately and effectively encounter and manage patients with non-calcium-containing stones, as such cases are encountered less frequently. Identification of stone composition and appropriate management is very important to reduce serious complications and recurrence, especially in non-calcium stones. We present a review of diagnosis and management of non-calcium-containing stones in the pediatric population, in hopes of providing more clarity to providers and promoting a consideration of non-calcium stone composition with all children presenting with urolithiasis.
    MeSH term(s) Calcium Oxalate/chemistry ; Calculi/chemistry ; Disease Management ; Female ; Humans ; Kidney Calculi/diagnostic imaging ; Kidney Calculi/etiology ; Kidney Calculi/therapy ; Lithotripsy/methods ; Male ; Pediatrics/methods ; Prognosis ; Severity of Illness Index ; Struvite/analysis ; Struvite/chemistry ; Treatment Outcome ; Uric Acid/analysis ; Uric Acid/chemistry ; Urolithiasis/complications ; Urolithiasis/diagnostic imaging ; Urolithiasis/therapy
    Chemical Substances Calcium Oxalate (2612HC57YE) ; Uric Acid (268B43MJ25) ; Struvite (AW3EJL1462)
    Language English
    Publishing date 2018-05-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-018-1883-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Renal oximetry for early acute kidney injury detection in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.

    Rumpel, Jennifer A / Spray, Beverly J / Frymoyer, Adam / Rogers, Sydney / Cho, Seo-Ho / Ranabothu, Saritha / Blaszak, Richard / Courtney, Sherry E / Chock, Valerie Y

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 8, Page(s) 2839–2849

    Abstract: Background: Neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia are at high risk of acute kidney injury (AKI).: Methods: We performed a two-site prospective observational study from 2018 to 2019 to evaluate the ... ...

    Abstract Background: Neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia are at high risk of acute kidney injury (AKI).
    Methods: We performed a two-site prospective observational study from 2018 to 2019 to evaluate the utility of renal near-infrared spectroscopy (NIRS) in detecting AKI in 38 neonates with HIE receiving therapeutic hypothermia. AKI was defined by a delayed rate of serum creatinine decline (< 33% on day 3 of life, < 40% on day 5, and < 46% on day 7). Renal saturation (R
    Results: AKI occurred in 20 of 38 neonates (53%). During the first 96 HOL, R
    Conclusions: Lower RFTOE on renal NIRS and pH on infant first blood gas may be early predictors for AKI in neonates with HIE receiving therapeutic hypothermia. A higher resolution version of the Graphical abstract is available as Supplementary information.
    MeSH term(s) Infant, Newborn ; Infant ; Female ; Pregnancy ; Humans ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/diagnosis ; Hypoxia-Ischemia, Brain/therapy ; Kidney ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Hypothermia, Induced/adverse effects ; Hypothermia, Induced/methods ; Oximetry
    Language English
    Publishing date 2023-02-14
    Publishing country Germany
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05892-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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