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Article ; Online: Mucormycosis and Cryptococcosis with Gastrointestinal Involvement in a Patient with Poorly Managed Diabetes.

Aldahash, Bader A / Alnemer, Mohammed A / Alsaad, Khaled O / Alsohaibani, Fahad I

Saudi journal of medicine & medical sciences

2023 Volume 11, Issue 1, Page(s) 89–92

Abstract: Mucormycosis and cryptococcosis are invasive fungal infections that mostly infect immunocompromised patients and are associated with high mortality rates. Here, we report a case of a 54-year-old male with poorly controlled diabetes mellitus who was ... ...

Abstract	Mucormycosis and cryptococcosis are invasive fungal infections that mostly infect immunocompromised patients and are associated with high mortality rates. Here, we report a case of a 54-year-old male with poorly controlled diabetes mellitus who was initially admitted with a complaint of right frontal headache and vomiting for 5 days. The patient was found to have paranasal sinuses mucormycosis, and later developed gastrointestinal cryptococcosis. A multidisciplinary approach and early management are important to avoid any delay in managing these life-threatening infections. To the best of the authors' knowledge, this is the first case reporting concurrent invasive fungal infections in a patient.
Language	English
Publishing date	2023-01-04
Publishing country	India
Document type	Case Reports
ZDB-ID	2734896-9
ISSN	2321-4856 ; 2321-4856
ISSN (online)	2321-4856
ISSN	2321-4856
DOI	10.4103/sjmms.sjmms_201_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spectrum of histopathological findings in coronavirus disease-19, Middle East respiratory syndrome and severe acute respiratory syndrome.

Alsaad, Khaled O / Arabi, Yaseen M / Hajeer, Ali H

Annals of thoracic medicine

2020 Volume 15, Issue 2, Page(s) 52–53

Keywords	covid19
Language	English
Publishing date	2020-04-03
Publishing country	India
Document type	Journal Article
ZDB-ID	2241287-6
ISSN	1998-3557 ; 1817-1737
ISSN (online)	1998-3557
ISSN	1817-1737
DOI	10.4103/atm.ATM_105_20
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Article ; Online: The Pitfall of White Blood Cell Cystine Measurement to Diagnose Juvenile Cystinosis.

Bondue, Tjessa / Kouraich, Anas / Berlingerio, Sante Princiero / Veys, Koenraad / Marie, Sandrine / Alsaad, Khaled O / Al-Sabban, Essam / Levtchenko, Elena / van den Heuvel, Lambertus

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Cystinosis is an autosomal recessive lysosomal storage disease, caused by mutations in the CTNS gene, resulting in multi-organ cystine accumulation. Three forms of cystinosis are distinguished: infantile and juvenile nephropathic cystinosis affecting ... ...

Abstract	Cystinosis is an autosomal recessive lysosomal storage disease, caused by mutations in the CTNS gene, resulting in multi-organ cystine accumulation. Three forms of cystinosis are distinguished: infantile and juvenile nephropathic cystinosis affecting kidneys and other organs such as the eyes, endocrine system, muscles, and brain, and adult ocular cystinosis affecting only the eyes. Currently, elevated white blood cell (WBC) cystine content is the gold standard for the diagnosis of cystinosis. We present a patient with proteinuria at adolescent age and corneal cystine crystals, but only slightly elevated WBC cystine levels (1.31 ½ cystine/mg protein), precluding the diagnosis of nephropathic cystinosis. We demonstrate increased levels of cystine in skin fibroblasts and urine-derived kidney cells (proximal tubular epithelial cells and podocytes), that were higher than the values observed in the WBC and healthy control. CTNS gene analysis shows the presence of a homozygous missense mutation (c.590 A > G; p.Asn177Ser), previously described in the Arab population. Our observation underlines that low WBC cystine levels can be observed in patients with juvenile cystinosis, which may delay the diagnosis and timely administration of cysteamine. In such patients, the diagnosis can be confirmed by cystine measurement in slow-dividing cells and by molecular analysis of the CTNS gene.
MeSH term(s)	Adult ; Adolescent ; Humans ; Cystinosis/diagnosis ; Cystinosis/genetics ; Cystinosis/metabolism ; Cystine/metabolism ; Cysteamine ; Leukocytes/metabolism ; Amino Acid Transport Systems, Neutral/genetics
Chemical Substances	Cystine (48TCX9A1VT) ; Cysteamine (5UX2SD1KE2) ; Amino Acid Transport Systems, Neutral
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021253
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Article: Brunner's glands hamartoma with pylorus obstruction: a case report and review of literature.

Bakir, Mohammed A / AlYousef, Mohammed Y / Alsohaibani, Fahad I / Alsaad, Khaled O

Journal of surgical case reports

2020 Volume 2020, Issue 8, Page(s) rjaa191

Abstract: Proliferative lesions of the Brunner's glands are uncommonly encountered lesions of the small intestine, originating from the deeply seated mucosal and submucosal Brunner's glands, mainly in the duodenum. The vast majorities of these lesions are benign ... ...

Abstract	Proliferative lesions of the Brunner's glands are uncommonly encountered lesions of the small intestine, originating from the deeply seated mucosal and submucosal Brunner's glands, mainly in the duodenum. The vast majorities of these lesions are benign and include Brunner's glands hyperplasia (adenomas/nodules) and hamartomas. The etiology and pathogenesis of these lesions are not fully understood, and the diagnosis can sometimes be challenging. We report a case of Brunner's gland hamartoma in a 57-year-old man who presented with chronic dyspepsia, hematemesis and weight loss. Endoscopic and radiological investigations show a submucosal polypoid lesion at the first part of the duodenum. Routine endoscopic biopsies demonstrated normal duodenal mucosa. The lesion considered endoscopically unresectable and was surgically resected. Frozen section examination and intraoperative consultation showed unremarkable duodenal mucosa and histologically bland Brunner's glands.
Language	English
Publishing date	2020-08-26
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjaa191
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Article: Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft.

Alharbi, Abdullah / Al Turki, Maram S / Aloudah, Noura / Alsaad, Khaled O

Case reports in transplantation

2017 Volume 2017, Page(s) 4232474

Abstract: The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22-0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. ... ...

Abstract	The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22-0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routinely practiced and these tumours are commonly asymptomatic and incidentally discovered. We describe a case of incidental, eosinophilic chromophobe RCC in a 31-year-old, long-term renal transplant male recipient, who presented with acute gastroenteritis 11 years after transplantation. The graft was nonfunctional at the time of presentation. Abdominal ultrasound and computed tomography scan demonstrated 1.8 cm well-defined, round enhancing lesion, confined to the renal allograft and suspicious for malignancy. Pathological examination of graft nephrectomy specimen showed gross, histopathological, and immunohistochemical features of eosinophilic chromophobe RCC. Fifty-five months after surgery, the patient was alive and free of malignancy. To the best of our knowledge, only five chromophobe RCCs originating in a renal allograft were previously described in English literature. We suggest that chromophobe RCC should be considered in the differential diagnosis of renal allograft mass, including eosinophilic tumours, and emphasise the importance of periodic screening of renal allograft in all renal transplant recipients.
Language	English
Publishing date	2017-10-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627657-4
ISSN	2090-6951 ; 2090-6943
ISSN (online)	2090-6951
ISSN	2090-6943
DOI	10.1155/2017/4232474
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Article: Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male.

Adamu, Bappa / Al-Ghamdi, Mushabab / Ahmad, Mustafa / Alsaad, Khaled O

Case reports in nephrology

2016 Volume 2016, Page(s) 7485695

Abstract: Light chain deposition disease (LCDD) is a rare illness with, as yet, no clear evidence-based guidelines for its treatment. To the best of our knowledge, LCDD has not been previously reported from Saudi Arabia. We present in this report, a 38-year-old ... ...

Abstract	Light chain deposition disease (LCDD) is a rare illness with, as yet, no clear evidence-based guidelines for its treatment. To the best of our knowledge, LCDD has not been previously reported from Saudi Arabia. We present in this report, a 38-year-old Saudi male who presented with clinical features suggestive of hypertensive nephropathy but kidney biopsy later revealed the diagnosis of LCDD. His serum creatinine at presentation was 297
Language	English
Publishing date	2016-12-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627652-5
ISSN	2090-665X ; 2090-6641
ISSN (online)	2090-665X
ISSN	2090-6641
DOI	10.1155/2016/7485695
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Article: Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy.

Alsaad, Khaled O / Edrees, Burhan / Rahim, Khawla A / Alanazi, Abdulkareem / Ahmad, Muawia / Aloudah, Noura

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2017 Volume 28, Issue 4, Page(s) 898–905

Abstract: Collagenofìbrotic (collagen type III) glomerulopathy (CG) is a rare nonimmune-mediated glomerular disease. It is characterized by massive deposition of organized collagen type III fibers, which is localized in the mesangial and subendothelial glomerular ... ...

Abstract	Collagenofìbrotic (collagen type III) glomerulopathy (CG) is a rare nonimmune-mediated glomerular disease. It is characterized by massive deposition of organized collagen type III fibers, which is localized in the mesangial and subendothelial glomerular areas and associated with increased serum levels of procollagen type III peptide. Association with systemic diseases and malignancies is extremely rare. Herein, we present a case of a nine-year-old girl, known case of type I diabetes mellitus, who presented with fever, nephrotic range proteinuria, generalized edema, and hypertension. Clinical examination did not show nail abnormalities or bone abnormalities. Renal biopsy revealed mesangial expansion and remarkable narrowing and obliteration of the glomerular capillaries by pale, amorphous material. Immunohistochemical study demonstrated diffuse linear glomerular capillary and tubular basement membrane staining for immunoglobulin G (IgG) and albumin. Ultrastructural examination identified massive mesangial and sub-endothelial deposition of dense frayed, curvilinear banded fibers with characteristic features of type III collagen. The patient was diagnosed to have combined CG and diabetic nephropathy (DN). This is the first report of CG in association with diabetic changes in renal biopsy. In this report, we describe the clinicopathological characteristics of this disease, review CG in pediatric population, and explore its association with DN.
MeSH term(s)	Biopsy ; Child ; Collagen Type III/analysis ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Female ; Fibrosis ; Glomerulonephritis/etiology ; Glomerulonephritis/metabolism ; Glomerulonephritis/pathology ; Humans ; Immunohistochemistry ; Kidney Glomerulus/chemistry ; Kidney Glomerulus/ultrastructure ; Microscopy, Electron, Transmission
Chemical Substances	Collagen Type III
Language	English
Publishing date	2017-07-26
Publishing country	Saudi Arabia
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
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Zs.A 4735: Show issues

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Article ; Online: Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab.

Alfakeeh, Khalid / Azar, Mohammed / Alfadhel, Majid / Abdullah, Alsuayri Mansour / Aloudah, Nourah / Alsaad, Khaled O

Pediatric nephrology (Berlin, Germany)

2017 Volume 32, Issue 5, Page(s) 885–891

Abstract: Background: Complement factor B gene (CFB) is an important component of the alternate pathway of complement activation that provides an active subunit that associates with C3b to form the C3 convertase, which is an essential element in complement ... ...

Abstract	Background: Complement factor B gene (CFB) is an important component of the alternate pathway of complement activation that provides an active subunit that associates with C3b to form the C3 convertase, which is an essential element in complement activation. Among the complement-associated disorders, mutations and pathogenic variants in the CFB gene are relatively rare phenomena. Moreover, mutated CFB affiliation with immune-complex diffuse membranoproliferative glomerulonephritis (IC-MPGN) and atypical hemolytic uremic syndrome (aHUS) are considered a highly rare occurrence. Case presentation: We describe the clinical presentation, course, and pathological findings in a 7-year-old boy who has confirmed CFB heterozygous variants with pathological features compatible with IC-MPGN. Mutational analysis revealed a heterozygous variant p.Glu566Arg in exon 13 of the CFB gene. The patient did not respond to steroids and mycophenolate mofetil (MMF) therapy but responded clinically and biochemically to eculizumab treatment. This is the first case report of CFB alteration associated with IC-MPGN and aHUS that was successfully treated with eculizumab. Conclusions: Heterozygous variants in the CFB gene can be pathogenic and associated with IC-MPGN and aHUS. Early diagnosis and prompt management can be essential in preventing end-stage renal disease. Eculizumab may provide an effective modality of treatment.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Child ; Complement C3/analysis ; Complement Factor B/genetics ; Creatinine/blood ; DNA Mutational Analysis ; Exons/genetics ; Glomerulonephritis, Membranoproliferative/drug therapy ; Glomerulonephritis, Membranoproliferative/genetics ; Glomerulonephritis, Membranoproliferative/pathology ; Hemolytic-Uremic Syndrome/drug therapy ; Hemolytic-Uremic Syndrome/genetics ; Humans ; Kidney Failure, Chronic/prevention & control ; Kidney Function Tests ; Male ; Mutation
Chemical Substances	Antibodies, Monoclonal, Humanized ; Complement C3 ; eculizumab (A3ULP0F556) ; Creatinine (AYI8EX34EU) ; Complement Factor B (EC 3.4.21.47)
Language	English
Publishing date	2017-02-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-016-3577-0
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Article: Alport's syndrome with focal segmental glomerulosclerosis lesion - Pattern to recognize.

Alsahli, Afnan A / Alshahwan, Sara I / Alotaibi, Amal O / Alsaad, Khaled O / Aloudah, Nourah / Farooqui, Mahfooz / Al Sayyari, Abdullah A

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2018 Volume 29, Issue 1, Page(s) 167–172

Abstract: The association between Alport's syndrome (AS) and focal segmental glomerulosclerosis (FSGS) in the same patient is complex and rarely reported. We report a case of a 42-year-old male presenting with proteinuria, microscopic hematuria, elevated serum ... ...

Abstract	The association between Alport's syndrome (AS) and focal segmental glomerulosclerosis (FSGS) in the same patient is complex and rarely reported. We report a case of a 42-year-old male presenting with proteinuria, microscopic hematuria, elevated serum creatinine and hypertension with unremarkable physical examination apart from obesity. The renal biopsy showed well-established FSGS pattern of injury with mild interstitial fibrosis and tubular atrophy, while the electron microscopic examination demonstrated glomerular basement membranes (GBM) changes compatible with AS. AS can be complicated by segmental glomerular scarring, which can mimic primary FSGS, while familial FSGS can result from mutations in collagen IV network of the GBM. This overlap can complicate histopathological interpretation of renal biopsy, which should be accompanied by mutational analysis for accurate diagnosis and proper therapeutic intervention.
MeSH term(s)	Adult ; Biopsy ; Collagen Type IV/genetics ; Diagnosis, Differential ; Fluorescent Antibody Technique ; Genetic Predisposition to Disease ; Glomerular Basement Membrane/pathology ; Glomerular Basement Membrane/ultrastructure ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Male ; Microscopy, Electron ; Mutation ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/pathology ; Phenotype ; Predictive Value of Tests
Chemical Substances	Collagen Type IV
Language	English
Publishing date	2018-02-17
Publishing country	Saudi Arabia
Document type	Case Reports
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.225193
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Zs.A 4735: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy

Khaled O Alsaad / Burhan Edrees / Khawla A Rahim / Abdulkareem Alanazi / Muawia Ahmad / Noura Aloudah

Saudi Journal of Kidney Diseases and Transplantation, Vol 28, Iss 4, Pp 898-

2017 Volume 905

Abstract	Collagenofìbrotic (collagen type III) glomerulopathy (CG) is a rare nonimmune-mediated glomerular disease. It is characterized by massive deposition of organized collagen type III fibers, which is localized in the mesangial and subendothelial glomerular areas and associated with increased serum levels of procollagen type III peptide. Association with systemic diseases and malignancies is extremely rare. Herein, we present a case of a nine-year-old girl, known case of type I diabetes mellitus, who presented with fever, nephrotic range proteinuria, generalized edema, and hypertension. Clinical examination did not show nail abnormalities or bone abnormalities. Renal biopsy revealed mesangial expansion and remarkable narrowing and obliteration of the glomerular capillaries by pale, amorphous material. Immunohistochemical study demonstrated diffuse linear glomerular capillary and tubular basement membrane staining for immunoglobulin G (IgG) and albumin. Ultrastructural examination identified massive mesangial and sub-endothelial deposition of dense frayed, curvilinear banded fibers with characteristic features of type III collagen. The patient was diagnosed to have combined CG and diabetic nephropathy (DN). This is the first report of CG in association with diabetic changes in renal biopsy. In this report, we describe the clinicopathological characteristics of this disease, review CG in pediatric population, and explore its association with DN.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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