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  1. Article: Tumor Stroma as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma.

    Lee, Dae Ui / Han, Beom Seok / Jung, Kyung Hee / Hong, Soon-Sun

    Biomolecules & therapeutics

    2024  Volume 32, Issue 3, Page(s) 281–290

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis owing to its desmoplastic stroma. Therefore, therapeutic strategies targeting this tumor stroma should be developed. In this study, we describe the heterogeneity of cancer-associated ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis owing to its desmoplastic stroma. Therefore, therapeutic strategies targeting this tumor stroma should be developed. In this study, we describe the heterogeneity of cancer-associated fibroblasts (CAFs) and their diverse roles in the progression, immune evasion, and resistance to treatment of PDAC. We subclassified the spatial distribution and functional activity of CAFs to highlight their effects on prognosis and drug delivery. Extracellular matrix components such as collagen and hyaluronan are described for their roles in tumor behavior and treatment outcomes, implying their potential as therapeutic targets. We also discussed the roles of extracellular matrix (ECM) including matrix metalloproteinases and tissue inhibitors in PDAC progression. Finally, we explored the role of the adaptive and innate immune systems in shaping the PDAC microenvironment and potential therapeutic strategies, with a focus on immune cell subsets, cytokines, and immunosuppressive mechanisms. These insights provide a comprehensive understanding of PDAC and pave the way for the development of prognostic markers and therapeutic interventions.
    Language English
    Publishing date 2024-04-10
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2734146-X
    ISSN 2005-4483 ; 1976-9148
    ISSN (online) 2005-4483
    ISSN 1976-9148
    DOI 10.4062/biomolther.2024.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Crack Monitoring in Rotating Shaft Using Rotational Speed Sensor-Based Torsional Stiffness Estimation with Adaptive Extended Kalman Filters.

    Park, Young-Hun / Lee, Hee-Beom / Kim, Gi-Woo

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 5

    Abstract: In this study, we present an alternative solution for detecting crack damages in rotating shafts under torque fluctuation by directly estimating the reduction in torsional shaft stiffness using the adaptive extended Kalman filter (AEKF) algorithm. A ... ...

    Abstract In this study, we present an alternative solution for detecting crack damages in rotating shafts under torque fluctuation by directly estimating the reduction in torsional shaft stiffness using the adaptive extended Kalman filter (AEKF) algorithm. A dynamic system model of a rotating shaft for designing AEKF was derived and implemented. An AEKF with a forgetting factor (
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23052437
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  3. Article ; Online: A 10-year follow-up of high-dose ambroxol treatment combined with enzyme replacement therapy for neuropathic Gaucher disease.

    Hwang, Soojin / Bae, Hyunwoo / Yoon, Ji-Hee / Kim, Dohyung / Do, Hyo-Sang / Heo, Sun Hee / Kim, Soyoung / Yoo, Han-Wook / Istaiti, Majdolen / Zimran, Ari / Lee, Beom Hee

    American journal of hematology

    2024  

    Abstract: High-dose ambroxol therapy combined with ERT in patients with neuropathic Gaucher disease. ...

    Abstract High-dose ambroxol therapy combined with ERT in patients with neuropathic Gaucher disease.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27302
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The impact of coping strategies and positive resources on post-traumatic stress symptoms among bereaved families of the Sewol ferry disaster.

    Lee, So Hee / Noh, Jin-Won / Kim, Kyoung-Beom / Chae, Jeong-Ho

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1367976

    Abstract: Introduction: This study investigated the long-term prevalence of, and factors associated with, post-traumatic stress disorder (PTSD) among the bereaved families of the Sewol ferry disaster, in which 250 students lost their lives during a school ... ...

    Abstract Introduction: This study investigated the long-term prevalence of, and factors associated with, post-traumatic stress disorder (PTSD) among the bereaved families of the Sewol ferry disaster, in which 250 students lost their lives during a school excursion.
    Methods: Eight years after the disaster, 181 family members were surveyed, and the prevalence of clinical PTSD symptoms was estimated. The Positive Resources Test (POREST), the Duke-UNC Functional Social Support Questionnaire, and the Brief COPE were evaluated using self-report measures. The multivariable binomial logistic regression was used to identify protective and risk factors for PTSD.
    Results: PTSD symptoms were present in 49.7% of the family members 8 years after the incident. A one-point increase in the score on the optimism subscale of the POREST was associated with a 20.1% decreased likelihood of having clinical PTSD symptoms (OR = 0.799; p = 0.027; 95% CI = 0.655-0.975). Conversely, a one-point increase in the score on the avoidant subscale of Brief COPE was associated with a 13.2% increased likelihood of having clinical PTSD symptoms (OR = 1.132; p = 0.041; 95% CI = 1.005-1.274).
    Discussion: Our results provide evidence of the need for long-term mental health monitoring of bereaved families of disaster victims, along with valuable insights for the development of mental health intervention programs.
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1367976
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  5. Article ; Online: Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint.

    Lee, Chul-Soo / Jeon, Ok-Hee / Han, Seung-Beom / Jang, Ki-Mo

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Knee Joint/surgery ; Wound Healing ; Collateral Ligaments ; Mesenchymal Stem Cells ; Anterior Cruciate Ligament Injuries
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59040725
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Eardrum-inspired soft viscoelastic diaphragms for CNN-based speech recognition with audio visualization images.

    Park, Seok-Jin / Lee, Hee-Beom / Kim, Gi-Woo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6414

    Abstract: In this study, we present initial efforts for a new speech recognition approach aimed at producing different input images for convolutional neural network (CNN)-based speech recognition. We explored the potential of the tympanic membrane (eardrum)- ... ...

    Abstract In this study, we present initial efforts for a new speech recognition approach aimed at producing different input images for convolutional neural network (CNN)-based speech recognition. We explored the potential of the tympanic membrane (eardrum)-inspired viscoelastic membrane-type diaphragms to deliver audio visualization images using a cross-recurrence plot (CRP). These images were formed by the two phase-shifted vibration responses of viscoelastic diaphragms. We expect this technique to replace the fast Fourier transform (FFT) spectrum currently used for speech recognition. Herein, we report that the new creation method of color images enabled by combining two phase-shifted vibration responses of viscoelastic diaphragms with CRP shows a lower computation burden and a promising potential alternative way to STFT (conventional spectrogram) when the image resolution (pixel size) is below critical resolution.
    MeSH term(s) Diaphragm ; Speech Perception ; Tympanic Membrane ; Neural Networks, Computer ; Speech
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33755-2
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  7. Article ; Online: Effects of Horse Meat Hydrolysate on Oxidative Stress, Proinflammatory Cytokines, and the Ubiquitin-Proteasomal System of C2C12 Cells.

    Lee, Hee-Jeong / Kim, Dongwook / Do, Kyoungtag / Yang, Chang-Beom / Jeon, Seong-Won / Jang, Aera

    Food science of animal resources

    2024  Volume 44, Issue 1, Page(s) 132–145

    Abstract: Sarcopenia, the age-related muscle atrophy, is a serious concern as it is associated with frailty, reduced physical functions, and increased mortality risk. Protein supplementation is essential for preserving muscle mass, and horse meat can be an ... ...

    Abstract Sarcopenia, the age-related muscle atrophy, is a serious concern as it is associated with frailty, reduced physical functions, and increased mortality risk. Protein supplementation is essential for preserving muscle mass, and horse meat can be an excellent source of proteins. Since sarcopenia occurs under conditions of oxidative stress, this study aimed to investigate the potential anti-muscle atrophy effect of horse meat hydrolysate using C2C12 cells. A horse meat hydrolysate less than 3 kDa (A4<3kDa) significantly increased the viability of C2C12 myoblasts against H
    Language English
    Publishing date 2024-01-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3016289-0
    ISSN 2636-0780 ; 2636-0772
    ISSN (online) 2636-0780
    ISSN 2636-0772
    DOI 10.5851/kosfa.2023.e65
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  8. Article ; Online: Fabrication and validation of flexible neural electrodes based on polyimide tape and gold sheet.

    Jeong, Hyunbeen / Lee, Taekyung / Kim, Jisung / Jeong, Hee Soo / Jun, Sang Beom / Seo, Jong-Mo

    Biomedical engineering letters

    2024  Volume 14, Issue 2, Page(s) 267–278

    Abstract: This research was conducted to apply polyimide tape, which has the advantages of low price ans strong adhesive strength, to the neural electrode process. In addition, to maximize the low-cost characteristics, a fabrication process based on UV laser ... ...

    Abstract This research was conducted to apply polyimide tape, which has the advantages of low price ans strong adhesive strength, to the neural electrode process. In addition, to maximize the low-cost characteristics, a fabrication process based on UV laser patterning rather than a photolithography process was introduced. The fabrication process started by attaching the gold sheet on the conductive double-sided tape without being torn or crushed. Then, the gold sheet and the double-sided tape were patterned together using UV laser. The patterned layer was transferred to the single-side polyimide tape. For insulation layer, electrode site opened single-sided polyimide tape was prepared. Polydimethylsiloxane was used as an adhesion layer, and alignment between electrode sites and opening sites was processed manually. The minimum line width achieved through the proposed fabrication process was approximately 100
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2602422-6
    ISSN 2093-985X ; 2093-9868
    ISSN (online) 2093-985X
    ISSN 2093-9868
    DOI 10.1007/s13534-023-00345-0
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  9. Article ; Online: Novel Organoid Culture System for Improved Safety Assessment of Nanomaterials.

    Baek, Ahruem / Kwon, Ik Hwan / Lee, Da-Hye / Choi, Woo Hee / Lee, Sang-Won / Yoo, Jongman / Heo, Min Beom / Lee, Tae Geol

    Nano letters

    2024  Volume 24, Issue 3, Page(s) 805–813

    Abstract: Over the past few decades, the increased application of nanomaterials has raised questions regarding their safety and possible toxic effects. Organoids have been suggested as promising tools, offering efficient assays for nanomaterial-induced toxicity ... ...

    Abstract Over the past few decades, the increased application of nanomaterials has raised questions regarding their safety and possible toxic effects. Organoids have been suggested as promising tools, offering efficient assays for nanomaterial-induced toxicity evaluation. However, organoid systems have some limitations, such as size heterogeneity and poor penetration of nanoparticles because of the extracellular matrix, which is necessary for organoid culture. Here, we developed a novel system for the improved safety assessment of nanomaterials by establishing a 3D floating organoid paradigm. In addition to overcoming the limitations of two-dimensional systems including the lack of
    MeSH term(s) Organoids ; Extracellular Matrix ; Nanostructures
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c02939
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  10. Article: Hormone Replacement Therapy and Risks of Various Cancers in Postmenopausal Women with De Novo or a History of Endometriosis.

    Lee, Hee Joong / Lee, Banghyun / Choi, Hangseok / Lee, Minkyung / Lee, Kyungjin / Lee, Tae Kyoung / Hwang, Sung Ook / Kim, Yong Beom

    Cancers

    2024  Volume 16, Issue 4

    Abstract: This study examined the impact of hormone replacement therapy (HRT) on the occurrence of various cancers in postmenopausal women with de novo or a history of endometriosis. In the datasets for ten cancers (cervical, uterine, ovarian, breast, colon, ... ...

    Abstract This study examined the impact of hormone replacement therapy (HRT) on the occurrence of various cancers in postmenopausal women with de novo or a history of endometriosis. In the datasets for ten cancers (cervical, uterine, ovarian, breast, colon, gastric, liver, lung, pancreatic, and thyroid), women who received HRT (the HRT group) and those who did not (the control group) were selected by a 1:1 matching with those who met the study criteria. In the dataset for each cancer, the incidence of each cancer was very low (0.2% to 1.5% in the HRT group and 0.2% to 1.3% in the control group). The duration of HRT was 1.3 ± 2.1 years. After adjusting for co-variables, HRT was a significant risk factor for uterine cancer (
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040809
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