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Article ; Online: Concurrent Antiglomerular Basement Membrane Nephritis and Antineutrophil Cytoplasmic Autoantibody-Mediated Glomerulonephritis After Second Dose of SARS-CoV-2 mRNA Vaccination.

Gupta, Rajib K / Ellis, Brigid K

Kidney international reports

2021 Volume 7, Issue 1, Page(s) 127–128

Language	English
Publishing date	2021-10-30
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2021.10.020
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Article ; Online: Autocombustion Route Derived Zinc Ferrite Nanoparticles as Chemiresistive Sensor for Detection of Alcohol Vapors.

Bhagat, Bhooma / Gupta, Santosh K / Mandal, Dipankar / Badyopadhyay, Rajib / Mukherjee, Kalisadhan

Chemphyschem : a European journal of chemical physics and physical chemistry

2024 , Page(s) e202300730

Abstract: Prolonged exposure to alcohol vapors can have detrimental effects on human health, potentially leading to eye irritation, dizziness, and in some cases, damage to the nervous system. The present article aims to provide a comprehensive understanding on the ...

Abstract	Prolonged exposure to alcohol vapors can have detrimental effects on human health, potentially leading to eye irritation, dizziness, and in some cases, damage to the nervous system. The present article aims to provide a comprehensive understanding on the synthesis and characterization of zinc ferrite (ZnFe2O4) nanoparticles, as well as their interactions with a range of alcohol vapors, including methanol, ethanol, n-propanol, and isopropanol. These alcohols differ in their molecular weight, boiling points, diffusivity, and other properties. The study reveals the semiconducting ZnFe2O4 nanoparticulate sensor's capability for reversible, repeatable, and sensitive detection of alcohol vapors. The sensor exhibits the highest response to ethanol within operating temperature range (225-300°C). An attempt is made to establish a correlation between the properties of the target analytes and the observed sensing signals. Additionally, the response conductance transients of ZnFe2O4 under the exposure to the studied alcohol vapors are modeled based on the Langmuir-Hinshelwood adsorption mechanism. The characteristic time constants obtained from this modeling are justified with respect to the properties of the analytes.
Language	English
Publishing date	2024-02-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2025223-7
ISSN	1439-7641 ; 1439-4235
ISSN (online)	1439-7641
ISSN	1439-4235
DOI	10.1002/cphc.202300730
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Article ; Online: Design and Synthesis of BODIPY-Hetero[5]helicenes as Heavy-Atom-Free Triplet Photosensitizers for Photodynamic Therapy of Cancer.

Koli, Mrunesh / Gupta, Sonali / Chakraborty, Saikat / Ghosh, Ayan / Ghosh, Rajib / Wadawale, A P / Ghanty, Tapan K / Patro, Birija S / Mula, Soumyaditya

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 57, Page(s) e202301605

Abstract: Designing heavy-atom-free triplet photosensitizers (PSs) is a challenge for the efficient photodynamic therapy (PDT) of cancer. Helicenes are twisted polycyclic aromatic hydrocarbons (PAHs) with an efficient intersystem crossing (ISC) that is ... ...

Abstract	Designing heavy-atom-free triplet photosensitizers (PSs) is a challenge for the efficient photodynamic therapy (PDT) of cancer. Helicenes are twisted polycyclic aromatic hydrocarbons (PAHs) with an efficient intersystem crossing (ISC) that is proportional to their twisting angle. But their difficult syntheses and weak absorption profile in the visible spectral region restrict their use as heavy-atom-free triplet PSs for PDT. On the other hand, boron-containing PAHs, BODIPYs are highly recognized for their outstanding optical properties. However, planar BODIPY dyes has low ISC and thus they are not very effective as PDT agents. We have designed and synthesized fused compounds containing both BODIPY and hetero[5]helicene structures to develop red-shifted chromophores with efficient ISC. One of the pyrrole units of the BODIPY core was also replaced by a thiazole unit to further enhance the triplet conversion. All the fused compounds have helical structure, and their twisting angles are also increased by substitutions at the boron centre. The helical structures of the BODIPY-hetero[5]helicenes were confirmed by X-ray crystallography and DFT structure optimization. The designed BODIPY-hetero[5]helicenes showed superior optical properties and high ISC with respect to [5]helicene. Interestingly their ISC efficiencies increase proportionally with their twisting angles. This is the first report on the relationship between the twisting angle and the ISC efficiency in twisted BODIPY-based compounds. Theoretical calculations showed that energy gap of the S1 and T1 states decreases in BODIPY-hetero[5]helicene as compared to planar BODIPY. This enhances the ISC rate in BODIPY-hetero[5]helicene, which is responsible for their high generation of singlet oxygen. Finally, their potential applications as PDT agents were investigated, and one BODIPY-hetero[5]helicene showed efficient cancer cell killing upon photo-exposure. This new design strategy will be very useful for the future development of heavy-atom-free PDT agents.
Language	English
Publishing date	2023-07-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301605
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Article ; Online: Catastrophic Antiphospholipid Syndrome-Associated Nephropathy in a Systemic Lupus Erythematosus Patient Without Lupus Nephritis.

Gupta, Rajib K / Liu, Eric / Bonilla, Eduardo / Elsaid, Hind

Arthritis & rheumatology (Hoboken, N.J.)

2019 Volume 72, Issue 1, Page(s) 149

MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Adult ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Humans ; Kidney/pathology ; Kidney/ultrastructure ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Male ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/pathology
Language	English
Publishing date	2019-12-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.41136
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Zs.A 24: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Hyalinizing cholecystitis with features of immunoglobulin G4-related disease-coincidence or an unrecognized association? A case report.

Gupta, Rajib K / Patton, Kurt T

Human pathology

2015 Volume 46, Issue 4, Page(s) 625–628

Abstract: Hyalinizing cholecystitis (HC) is a recently described rare subtype of chronic cholecystitis characterized by dense, paucicellular collagenous transmural fibrosis, which usually replaces the mucosa and muscularis propria. Immunoglobulin (Ig)G4-associated ...

Abstract	Hyalinizing cholecystitis (HC) is a recently described rare subtype of chronic cholecystitis characterized by dense, paucicellular collagenous transmural fibrosis, which usually replaces the mucosa and muscularis propria. Immunoglobulin (Ig)G4-associated cholecystitis is also a newly described cholecystitis variant characterized by transmural or extramural lymphoplasmacytic inflammation, lymphoid follicles, storiform fibrosis, phlebitis, and increased tissue IgG4-positive plasma cells. We describe a case of cholecystitis in an elderly white man who harbored features of both HC and IgG4-associated cholecystitis. In retrospect, the patient also had a significantly elevated serum IgG4 level. To the best of our knowledge, an association between HC and IgG4-related disease has not been previously described in the literature. Although not entirely conclusive, our observations raise the possibility that some cases of HC represent the end stage of IgG4-related disease.
MeSH term(s)	Aged ; Cholecystitis/diagnosis ; Cholecystitis/immunology ; Cholecystitis/pathology ; Dental Porcelain/metabolism ; Fibrosis/pathology ; Humans ; Immunoglobulin G/blood ; Male ; Plasma Cells/immunology ; Plasma Cells/pathology
Chemical Substances	Immunoglobulin G ; Dental Porcelain (12001-21-7)
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2014.12.015
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Zs.A 722: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Renal crystal-storing histiocytosis involving glomeruli - A comprehensive clinicopathologic analysis.

Gupta, Rajib K / Rosenberg, Avi Z / Bagnasco, Serena M / Arend, Lois J

Annals of diagnostic pathology

2019 Volume 43, Page(s) 151403

Abstract: Crystal-storing histiocytosis (CSH) is a rare manifestation of monoclonal gammopathy in which histiocytes containing monoclonal proteins in their cytoplasm are found in various organs of the body including the kidney. Within the kidney, these monoclonal ... ...

Abstract	Crystal-storing histiocytosis (CSH) is a rare manifestation of monoclonal gammopathy in which histiocytes containing monoclonal proteins in their cytoplasm are found in various organs of the body including the kidney. Within the kidney, these monoclonal crystal-laden histiocytes have been described to occur in the interstitium (most commonly) or in the glomerular mesangium. CSH within glomerular capillary loops has rarely been reported. We describe three cases of CSH primarily affecting the glomerular capillaries and review the literature of CSH in general. Twenty cases of CSH involving the kidney are present in the literature; three describe CSH in glomeruli, only one of which showed histiocytes predominantly in glomerular capillary loops, while 15 had predominantly or solely interstitial CSH. Most cases involve IgG kappa crystals with only one case involving lambda light chain. Patients with CSH predominantly involving the glomerular capillaries showed a trend toward lower serum creatinine and proteinuria at presentation, and several patients with CSH lacked a definitive diagnosis of a monoclonal gammopathy at the time of diagnosis, emphasizing the role that kidney biopsy and particularly electron microscopy play in diagnosis of this entity.
MeSH term(s)	Adult ; Aged ; Biopsy ; Creatinine/blood ; Female ; Glomerular Mesangium/blood supply ; Glomerular Mesangium/metabolism ; Glomerular Mesangium/pathology ; Glomerular Mesangium/ultrastructure ; Glomerulonephritis, Membranous/metabolism ; Glomerulonephritis, Membranous/pathology ; Histiocytes/metabolism ; Histiocytes/pathology ; Histiocytosis/complications ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney/ultrastructure ; Lymphoproliferative Disorders/complications ; Lymphoproliferative Disorders/metabolism ; Lymphoproliferative Disorders/pathology ; Male ; Microscopy, Electron/methods ; Middle Aged ; Multiple Myeloma/complications ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Myeloma Proteins/metabolism ; Paraproteinemias/pathology ; Proteinuria/diagnosis
Chemical Substances	Myeloma Proteins ; multiple myeloma M-proteins ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2019-08-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2019.151403
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Zs.A 5463: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease

Rajib K. Gupta / Ramya Bhargava / Al-Aman Shaukat / Emily Albert / John Leggat

BMC Nephrology, Vol 21, Iss 1, Pp 1-

a report of 2 cases

2020 Volume 7

Abstract: Abstract Background Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized ... ...

Abstract	Abstract Background Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. The findings include diffuse acute tubular injury (ATI) along with the glomerular lesion of collapsing glomerulopathy (CG). However, nephrotic syndrome as the presenting complaint of COVID-19 has not been reported widely, neither has any other glomerular lesion other than CG. Case presentation We describe the kidney biopsy findings of two patients who had recent diagnoses of COVID-19 and presented with new-onset nephrotic syndrome. Renal biopsy in both patients showed ATI (as in previous reports) and distinct glomerular findings on light microscopy – that of minimal change disease (MCD) initially in one patient followed by CG in a subsequent biopsy and CG at the outset in the other patient. The electron microscopic findings in both patients were that of severe podocytopathy (diffuse and severe podocyte foot process effacement). Conclusion Our cases highlight a novel clinical presentation of COVID-19 renal disease, not described before, that of new-onset nephrotic syndrome. While all published case reports describe CG as the glomerular pathology, we describe a non-CG pathology (MCD) in one of our cases, thereby adding to the repertoire of renal pathology described in association with COVID-19 patients. However, the exact mechanism by which podocyte injury or podocytopathy occurs in all such cases is still unknown. Optimal treatment options for these patients also remains unknown at this time.
Keywords	COVID-19 ; Nephrotic syndrome ; Podocytopathy ; Collapsing glomerulopathy ; Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
Subject code	610
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Crystalglobulin-associated nephropathy presenting as MGRS in a case of monoclonal B-cell lymphocytosis: a case report.

Gupta, Rajib K / Arend, Lois J / Bk, Anupama / Narsipur, Sriram / Bhargava, Ramya

BMC nephrology

2020 Volume 21, Issue 1, Page(s) 184

Abstract: Background: Crystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and occasionally monoclonal gammopathy of uncertain significance (MGUS), is characterized by occluding monoclonal ...

Abstract	Background: Crystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and occasionally monoclonal gammopathy of uncertain significance (MGUS), is characterized by occluding monoclonal pseudothrombi within renal glomerular capillaries and/or interstitial arterioles. Ultrastructurally, these pseudothrombi are unique for having a crystalline substructure. We describe a case of an adult patient with monoclonal B-cell lymphocytosis (MBL) and acute renal failure whose kidney biopsy revealed a rare diagnosis of CAN. Case presentation: A 63-year old male presented with a 2-month history of edema, arthralgia and malaise. He had acute kidney injury with hematoproteinuria on urine analysis. Serum and urine protein electrophoresis were both negative. A renal biopsy however revealed features of CAN. Organomegaly, bone pain and lymphadenopathy were absent. A repeat serum electrophoresis was positive for IgA kappa and a free light chain assay showed elevated free kappa light chains. Flow cytometry done subsequently revealed a diagnosis of MBL, chronic lymphocytic leukemia (CLL) type. Conclusion: CAN in association with MBL/CLL has not been previously described in literature, and our case highlights yet another instance of monoclonal gammopathy of renal significance (MGRS) where a small B-cell clone resulted in extensive renal pathology without systemic manifestations.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; B-Lymphocytes ; Crystallization ; Humans ; Immunoglobulin Light Chains/blood ; Immunoglobulin kappa-Chains/blood ; Kidney/pathology ; Kidney Diseases/blood ; Kidney Diseases/diagnosis ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Leukemia, Lymphocytic, Chronic, B-Cell ; Lymphocytosis/blood ; Lymphocytosis/complications ; Lymphocytosis/diagnosis ; Male ; Middle Aged ; Paraproteinemias/blood ; Paraproteinemias/complications ; Paraproteinemias/diagnosis
Chemical Substances	Immunoglobulin Light Chains ; Immunoglobulin kappa-Chains
Language	English
Publishing date	2020-05-18
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-020-01818-5
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Article ; Online: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease

Gupta, Rajib K. / Bhargava, Ramya / Shaukat, Al-Aman / Albert, Emily / Leggat, John

BMC Nephrology

a report of 2 cases

2020 Volume 21, Issue 1

Keywords	Nephrology ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2041348-8
ISSN	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-020-01970-y
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Article ; Online: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases.

Gupta, Rajib K / Bhargava, Ramya / Shaukat, Al-Aman / Albert, Emily / Leggat, John

BMC nephrology

2020 Volume 21, Issue 1, Page(s) 326

Abstract: Background: Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized COVID-19 ... ...

Abstract	Background: Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. The findings include diffuse acute tubular injury (ATI) along with the glomerular lesion of collapsing glomerulopathy (CG). However, nephrotic syndrome as the presenting complaint of COVID-19 has not been reported widely, neither has any other glomerular lesion other than CG. Case presentation: We describe the kidney biopsy findings of two patients who had recent diagnoses of COVID-19 and presented with new-onset nephrotic syndrome. Renal biopsy in both patients showed ATI (as in previous reports) and distinct glomerular findings on light microscopy - that of minimal change disease (MCD) initially in one patient followed by CG in a subsequent biopsy and CG at the outset in the other patient. The electron microscopic findings in both patients were that of severe podocytopathy (diffuse and severe podocyte foot process effacement). Conclusion: Our cases highlight a novel clinical presentation of COVID-19 renal disease, not described before, that of new-onset nephrotic syndrome. While all published case reports describe CG as the glomerular pathology, we describe a non-CG pathology (MCD) in one of our cases, thereby adding to the repertoire of renal pathology described in association with COVID-19 patients. However, the exact mechanism by which podocyte injury or podocytopathy occurs in all such cases is still unknown. Optimal treatment options for these patients also remains unknown at this time.
MeSH term(s)	Aged ; Betacoronavirus ; Biopsy ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Kidney/pathology ; Kidney Glomerulus/pathology ; Kidney Tubules/pathology ; Male ; Middle Aged ; Nephrosis, Lipoid/etiology ; Nephrosis, Lipoid/pathology ; Nephrotic Syndrome/etiology ; Nephrotic Syndrome/pathology ; Pandemics ; Pneumonia, Viral/complications ; Podocytes/pathology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-020-01970-y
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