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  1. Book ; Conference proceedings: Mutation and the environment / D

    Mendelsohn, Mortimer L.

    proceedings of the Fifth International Conference on Environmental Mutagens, held in Cleveland, Ohio, July 10 - 15, 1989

    1990  

    Event/congress International Conference on Environmental Mutagens (5, 1989, ClevelandOhio)
    Author's details ed. Mortimer L. Mendelsohn
    Collection Mutation and the environment
    Size XVIII, 403 S. : Ill., graph. Darst.
    Publisher Wiley-Liss
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003617155
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5859 -D- order for loan Magazin

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  2. Article ; Online: The Depression: Online Therapy Study (D:OTS)-A Pilot Study of an Internet-Based Psychodynamic Treatment for Adolescents with Low Mood in the UK, in the Context of the COVID-19 Pandemic.

    Midgley, Nick / Guerrero-Tates, Brenda / Mortimer, Rose / Edbrooke-Childs, Julian / Mechler, Jakob / Lindqvist, Karin / Hajkowski, Susan / Leibovich, Liat / Martin, Peter / Andersson, Gerhard / Vlaescu, George / Lilliengren, Peter / Kitson, Annabel / Butler-Wheelhouse, Pamela / Philips, Björn

    International journal of environmental research and public health

    2021  Volume 18, Issue 24

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Adolescent ; COVID-19/psychology ; Depression/epidemiology ; Depression/therapy ; Humans ; Internet ; Pandemics ; Pilot Projects ; United Kingdom
    Language English
    Publishing date 2021-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182412993
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  3. Article ; Online: A 'D.I.Y.' nasal plug with airway: an alternative approach.

    Hussain, W / Mortimer, N J / Gleeson, C / Salmon, P J

    The British journal of dermatology

    2010  Volume 162, Issue 5, Page(s) 1141–1142

    MeSH term(s) Humans ; Nasal Cavity ; Rhinoplasty/instrumentation ; Skin Transplantation/instrumentation ; Tampons, Surgical
    Language English
    Publishing date 2010-05
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/j.1365-2133.2010.09654.x
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  4. Article ; Online: Effects of vitamin D deficiency in critically ill surgical patients.

    Flynn, Lisa / Zimmerman, Lisa Hall / McNorton, Kelly / Dolman, Mortimer / Tyburski, James / Baylor, Alfred / Wilson, Robert / Dolman, Heather

    American journal of surgery

    2012  Volume 203, Issue 3, Page(s) 379–82; discussion 382

    Abstract: Background: The incidence of vitamin D deficiency in critically ill patients is reported to be up ... to 50%, with a 3-fold increase in predicted mortality, but limited data exist concerning vitamin D ... patients who had 25-hydroxyvitamin D serum levels evaluated from January 2010 to February 2011 were ...

    Abstract Background: The incidence of vitamin D deficiency in critically ill patients is reported to be up to 50%, with a 3-fold increase in predicted mortality, but limited data exist concerning vitamin D deficiency in critically ill surgical patients.
    Methods: Sixty-six adult surgical intensive care unit patients who had 25-hydroxyvitamin D serum levels evaluated from January 2010 to February 2011 were prospectively identified. Patients were divided into groups according to vitamin D level (<20 vs ≥20 ng/mL).
    Results: Of the 66 patients evaluated, 49 (74%) had vitamin D levels < 20 ng/mL, and 17 (26%) had vitamin D levels ≥ 20 ng/mL. Patients with vitamin D levels < 20 versus ≥ 20 ng/mL had longer lengths of hospital stay. Lengths of intensive care unit stay were clinically longer, although not significant. Infection rates tended to be higher (P = .09), and a higher incidence of sepsis was seen in the patients with vitamin D levels < 20 ng/mL.
    Conclusions: Vitamin D levels < 20 ng/mL have a significant impact on length of stay, organ dysfunction, and infection rates. More data are needed on the value of supplementation to improve these outcomes.
    MeSH term(s) Adult ; Aged ; Critical Illness/mortality ; Critical Illness/therapy ; Female ; Hospital Mortality ; Humans ; Infection/etiology ; Intensive Care Units/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Multiple Organ Failure/etiology ; Prospective Studies ; Risk ; Sepsis/etiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2012-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2011.09.012
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  5. Article ; Online: Interactions between Loci Contributing to Antimicrobial Resistance and Virulence in Neisseria gonorrhoeae.

    Mortimer, Tatum D

    mBio

    2022  Volume 13, Issue 3, Page(s) e0041222

    Abstract: In a recent mBio article, Ayala et al. (mBio 13:e00276-22, 2022, https://doi.org/10.1128/mbio.00276-22) identified a single nucleotide variant in the ... ...

    Abstract In a recent mBio article, Ayala et al. (mBio 13:e00276-22, 2022, https://doi.org/10.1128/mbio.00276-22) identified a single nucleotide variant in the repressor
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Drug Resistance, Bacterial/genetics ; Gene Expression Regulation, Bacterial ; Microbial Sensitivity Tests ; Neisseria gonorrhoeae/drug effects ; Neisseria gonorrhoeae/pathogenicity ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Virulence/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Repressor Proteins
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00412-22
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  6. Article ; Online: Acute rehabilitation experience in a distinctive central nervous system inflammatory disorder: A Clinical Vignette.

    Joshi, Ameya Deepak / Mortimer, Diane

    American journal of physical medicine & rehabilitation

    2024  

    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002470
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  7. Article: Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization.

    Muntean, Andrew G / Pang, Liyan / Poncz, Mortimer / Dowdy, Steven F / Blobel, Gerd A / Crispino, John D

    Blood

    2007  Volume 109, Issue 12, Page(s) 5199–5207

    Abstract: ... of cyclin D-Cdk4 complexes with a TAT-p16 fusion peptide significantly blocked polyploidization of wild-type ... megakaryocytes. Together, these data show that GATA-1 controls growth and polyploidization by regulating cyclin D ...

    Abstract Endomitosis is a unique form of cell cycle used by megakaryocytes, in which the latter stages of mitosis are bypassed so that the cell can increase its DNA content and size. Although several transcription factors, including GATA-1 and RUNX-1, have been implicated in this process, the link between transcription factors and polyploidization remains undefined. Here we show that GATA-1-deficient megakaryocytes, which display reduced size and polyploidization, express nearly 10-fold less cyclin D1 and 10-fold increased levels of p16 compared with their wild-type counterparts. We further demonstrate that cyclin D1 is a direct GATA-1 target in megakaryocytes, but not erythroid cells. Restoration of cyclin D1 expression, when accompanied by ectopic overexpression of its partner Cdk4, resulted in a dramatic increase in megakaryocyte size and DNA content. However, terminal differentiation was not rescued. Of note, polyploidization was only modestly reduced in cyclin D1-deficient mice, likely due to compensation by elevated cyclin D3 expression. Finally, consistent with an additional defect conferred by increased levels of p16, inhibition of cyclin D-Cdk4 complexes with a TAT-p16 fusion peptide significantly blocked polyploidization of wild-type megakaryocytes. Together, these data show that GATA-1 controls growth and polyploidization by regulating cyclin D-Cdk4 kinase activity.
    MeSH term(s) Animals ; Cell Proliferation ; Cyclin D ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 4/metabolism ; Cyclins/genetics ; Cyclins/metabolism ; GATA1 Transcription Factor/deficiency ; GATA1 Transcription Factor/physiology ; Gene Expression Regulation ; Megakaryocytes/cytology ; Mice ; Mice, Inbred Strains ; Multiprotein Complexes ; Polyploidy
    Chemical Substances Cyclin D ; Cyclins ; GATA1 Transcription Factor ; Gata1 protein, mouse ; Multiprotein Complexes ; Cdk4 protein, mouse (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22)
    Language English
    Publishing date 2007-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2006-11-059378
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    Zs.MO 364: Show issues

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  8. Article: Total asymmetric synthesis of sperabillins B and D.

    Davies, Stephen G / Kelly, Richard J / Mortimer, Anne J Price

    Chemical communications (Cambridge, England)

    2003  , Issue 17, Page(s) 2132–2133

    Abstract: A concise route to the core fragment of sperabillins B and D, methyl (3R,5R,6R)-3,6-diamino-5 ... synthesis of sperabillins B and D. ...

    Abstract A concise route to the core fragment of sperabillins B and D, methyl (3R,5R,6R)-3,6-diamino-5-hydroxyheptanoate, has been developed with a subsequent novel protection strategy allowing the total asymmetric synthesis of sperabillins B and D.
    Language English
    Publishing date 2003-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
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  9. Article: A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on

    Mortimer, Tatum D / Grad, Yonatan H

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Post-exposure prophylaxis with doxycycline (doxyPEP) is being introduced to prevent bacterial sexually transmitted infections (STIs). Pre-existing tetracycline resistance ... ...

    Abstract Post-exposure prophylaxis with doxycycline (doxyPEP) is being introduced to prevent bacterial sexually transmitted infections (STIs). Pre-existing tetracycline resistance in
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.14.23287223
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  10. Article ; Online: A Genomic Perspective on the Near-term Impact of Doxycycline Post-exposure Prophylaxis on Neisseria gonorrhoeae Antimicrobial Resistance.

    Mortimer, Tatum D / Grad, Yonatan H

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 5, Page(s) 788–791

    Abstract: Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant ... ...

    Abstract Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from N. gonorrhoeae, we assessed the near-term impact of doxycycline PEP on N. gonorrhoeae resistance.
    MeSH term(s) Humans ; Neisseria gonorrhoeae/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Doxycycline/pharmacology ; Doxycycline/therapeutic use ; Post-Exposure Prophylaxis ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial/genetics ; Gonorrhea/epidemiology ; Gonorrhea/prevention & control ; Gonorrhea/drug therapy ; Genomics ; Tetracycline/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Doxycycline (N12000U13O) ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad279
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