LIVIVO - Search results -

Search results

Result 1 - 10 of total 511

Search options

Article ; Online: H/ACA snoRNA levels are regulated during stem cell differentiation.

McCann, Kathleen L / Kavari, Sanam L / Burkholder, Adam B / Phillips, Bart T / Hall, Traci M Tanaka

2020 Volume 48, Issue 15, Page(s) 8686–8703

Abstract: H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part of a small nucleolar ribonucleoprotein complex (snoRNP). Disruption of H/ACA snoRNA levels in stem cells impairs pluripotency, yet it remains unclear how H/ACA snoRNAs contribute to ... ...

Abstract	H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part of a small nucleolar ribonucleoprotein complex (snoRNP). Disruption of H/ACA snoRNA levels in stem cells impairs pluripotency, yet it remains unclear how H/ACA snoRNAs contribute to differentiation. To determine if H/ACA snoRNA levels are dynamic during differentiation, we comprehensively profiled H/ACA snoRNA abundance in multiple murine cell types and during differentiation in three cellular models, including mouse embryonic stem cells and mouse myoblasts. We determined that the profiles of H/ACA snoRNA abundance are cell-type specific, and we identified a subset of snoRNAs that are specifically regulated during differentiation. Additionally, we demonstrated that a decrease in Snora27 abundance upon differentiation corresponds to a decrease in pseudouridylation of its target site within the E-site transfer RNA (tRNA) binding region of the 28S ribosomal RNA (rRNA) in the large ribosomal subunit. Together, these data point toward a potential model in which H/ACA snoRNAs are specifically regulated during differentiation to alter pseudouridylation and fine tune ribosome function.
MeSH term(s)	Animals ; Base Sequence/genetics ; Cell Differentiation/genetics ; Mice ; Mouse Embryonic Stem Cells ; Myoblasts/metabolism ; Nucleic Acid Conformation ; Pseudouridine/genetics ; RNA, Ribosomal, 28S/genetics ; RNA, Small Nucleolar/genetics ; Ribonucleoproteins, Small Nucleolar/genetics ; Ribosomes/genetics
Chemical Substances	RNA, Ribosomal, 28S ; RNA, Small Nucleolar ; Ribonucleoproteins, Small Nucleolar ; Pseudouridine (1445-07-4)
Language	English
Publishing date	2020-07-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkaa612
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Pseudomonas syringae Pathogen Causes Foliar Disease of Upland Cotton in Texas

Phillips, A. Z / T. Wheeler / J. Woodward / R. S. Bart

Plant disease. 2018 June, v. 102, no. 6

2018

Abstract: ... has reemerged in the United States since 2011 (Phillips et al. 2017). In 2015, cotton fields near ...

Abstract	Cotton bacterial blight (CBB), caused by Xanthomonas citri pv. malvacearum (Xcm), can cause significant yield losses on susceptible varieties of upland cotton (Gossypium hirsutum L.) (Verma 1986). CBB has reemerged in the United States since 2011 (Phillips et al. 2017). In 2015, cotton fields near Plains, TX, exhibited symptoms of an unknown foliar disease on cotton cultivars that were reported to be resistant to CBB. In June 2016, bacteria were isolated from Fibermax 2007GLT (CBB Resistant) leaves exhibiting CBB-like symptoms. Culture on nutrient-rich NYGA medium with 50 μM cycloheximide revealed two predominant colony morphologies, yellow and white. The yellow colonies were confirmed to be Xcm. Koch’s postulates were used to determine that the white bacteria caused necrotic foliar lesions when infiltrated into cotton leaves alone or in combination with Xcm. Sequencing of the 16s rRNA gene identified this bacterium as Pseudomonas sp. with 99% sequence identity to the Pseudomonas syringae pv. syringae B728a (Gbk 230265-9). Further multilocus sequence analysis using concatenated regions of the gyrB, rpoD, gap1, and gltA on the PAMDB database grouped this pathogen with P. syringae pv. atrofaciens, P. syringae pv. apata, P. syringae pv. pisi, P. syringae pv. syringae, and P. syringae pv. aceris (http://genome.ppws.vt.edu/cgi-bin/MLST/home.pl). Thus, the isolated cotton pathogen is a member of P. syringae. Identification of a pseudomonad cotton pathogen has occurred at least once before in cotton seedlings near Lubbock, TX. This was recorded in the 1994 Cotton Beltwide Conferences Proceedings (ATCC 51506). No other reference to a pseudomonad pathogen of cotton has been found. However, evidence of a Pseudomonas-Xanthomonas disease complex has been found at least once in leafy crucifers (Zhao et al. 2000). Inoculations with a needleless syringe resulted in symptoms that initially appeared as a cell death phenotype but quickly progressed to a spreading necrotic lesion. Foliar disease symptoms were observed after inoculation with a bacterial suspension at OD₆₀₀ of 0.0001 to 0.01. Symptoms appeared as early as 1 day after inoculation. To date, this pathogen has been isolated from 11 different fields in six counties and always in association with Xcm. Additional isolates were identified from symptomatic leaf tissue of at least eight different cultivars at various locations. Four isolates from Donley County, TX, and four cotton cultivars (DP 1454NRB2RF, FM 1320GL, FM 1830GLT, and FM 2484B2F) were screened using the scratch method to identify whether variability existed in the disease response of cultivars. The cultivars were arranged in a split-plot design, with isolate as the main factor and cultivar as the subfactor. Both the main factor and the subfactors were randomized. There were four replications for each isolate/cultivar combination. The test was repeated once. Disease symptoms were less severe on FM 2484B2F (P < 0.05) than the other three cultivars, suggesting that variation exists among cotton germplasm for tolerance to this pathogen. Future phylogenetic analysis will focus on the origin of virulence of this pathogen and its distribution within the cotton production regions in the United States.
Keywords	Brassicaceae ; Gossypium hirsutum ; Pseudomonas syringae ; bacteria ; blight ; cell death ; cotton ; crop production ; cultivars ; cycloheximide ; databases ; experimental design ; foliar diseases ; genes ; germplasm ; leaves ; multilocus sequence typing ; pathogens ; phenotype ; phylogeny ; ribosomal RNA ; seedlings ; virulence ; Texas
Language	English
Dates of publication	2018-06
Size	p. 1171.
Publishing place	Plant Disease
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-11-17-1700-PDN
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2043: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mass spectrometric identification of candidate RNA-binding proteins associated with Transition Nuclear Protein mRNA in the mouse testis.

Phillips, Bart T / Williams, Jason G / Atchley, Dustin T / Xu, Xiaojiang / Li, Jian-Liang / Adams, Andrea L / Johnson, Katina L / Hall, Traci M Tanaka

Scientific reports

2019 Volume 9, Issue 1, Page(s) 13618

Abstract: Spermatogenesis is a differentiation process that requires dramatic changes to DNA architecture, a process governed in part by Transition Nuclear Proteins 1 and 2 (TNP1 and TNP2). Translation of Tnp1 and Tnp2 mRNAs is temporally disengaged from their ... ...

Abstract	Spermatogenesis is a differentiation process that requires dramatic changes to DNA architecture, a process governed in part by Transition Nuclear Proteins 1 and 2 (TNP1 and TNP2). Translation of Tnp1 and Tnp2 mRNAs is temporally disengaged from their transcription. We hypothesized that RNA regulatory proteins associate specifically with Tnp mRNAs to control the delayed timing of their translation. To identify potential regulatory proteins, we isolated endogenous mRNA/protein complexes from testis extract and identified by mass spectrometry proteins that associated with one or both Tnp transcripts. Five proteins showed strong association with Tnp transcripts but had low signal when Actin mRNA was isolated. We visualized the expression patterns in testis sections of the five proteins and found that each of the proteins was detected in germ cells at the appropriate stages to regulate Tnp RNA expression.
MeSH term(s)	Animals ; Cell Nucleus/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosomal Proteins, Non-Histone/physiology ; DNA-Binding Proteins/genetics ; Germ Cells/metabolism ; Male ; Mass Spectrometry/methods ; Mice ; Mice, Inbred DBA ; Nuclear Proteins/metabolism ; RNA/metabolism ; RNA, Messenger/genetics ; RNA-Binding Proteins/metabolism ; Spermatogenesis/genetics ; Testis/metabolism ; Testis/physiology ; Transcription Factors/metabolism
Chemical Substances	Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; Nuclear Proteins ; RNA, Messenger ; RNA-Binding Proteins ; Transcription Factors ; spermatid transition proteins ; RNA (63231-63-0)
Language	English
Publishing date	2019-09-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-50052-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The elusive spermatogonial stem cell marker?

Hermann, Brian P / Phillips, Bart T / Orwig, Kyle E

Biology of reproduction

2011 Volume 85, Issue 2, Page(s) 221–223

MeSH term(s)	Animals ; Gene Expression Regulation/physiology ; Inhibitor of Differentiation Proteins/metabolism ; Male ; Stem Cells/cytology ; Stem Cells/metabolism
Chemical Substances	Idb4 protein, mouse ; Inhibitor of Differentiation Proteins
Language	English
Publishing date	2011-05-12
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1095/biolreprod.111.093146
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 551: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Fruitful progress to fertility: male fertility in the test tube.

Clark, Amander T / Phillips, Bart T / Orwig, Kyle E

Nature medicine

2011 Volume 17, Issue 12, Page(s) 1564–1565

MeSH term(s)	Animals ; Antineoplastic Agents/adverse effects ; Cryopreservation/methods ; Fertility ; Fertilization ; Fertilization in Vitro/methods ; Humans ; Infertility, Male/etiology ; Infertility, Male/therapy ; Male ; Models, Animal
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2011-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/nm.2594
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 39: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nurse Care Management for Opioid Use Disorder Treatment: The PROUD Cluster Randomized Clinical Trial.

Wartko, Paige D / Bobb, Jennifer F / Boudreau, Denise M / Matthews, Abigail G / McCormack, Jennifer / Lee, Amy K / Qiu, Hongxiang / Yu, Onchee / Hyun, Noorie / Idu, Abisola E / Campbell, Cynthia I / Saxon, Andrew J / Liu, David S / Altschuler, Andrea / Samet, Jeffrey H / Labelle, Colleen T / Zare-Mehrjerdi, Mohammad / Stotts, Angela L / Braciszewski, Jordan M /

Murphy, Mark T / Dryden, Douglas / Arnsten, Julia H / Cunningham, Chinazo O / Horigian, Viviana E / Szapocznik, José / Glass, Joseph E / Caldeiro, Ryan M / Phillips, Rebecca C / Shea, Mary / Bart, Gavin / Schwartz, Robert P / McNeely, Jennifer / Liebschutz, Jane M / Tsui, Judith I / Merrill, Joseph O / Lapham, Gwen T / Addis, Megan / Bradley, Katharine A / Ghiroli, Megan M / Hamilton, Leah K / Hu, Yong / LaHue, Jennifer S / Loree, Amy M / Murphy, Sean M / Northrup, Thomas F / Shmueli-Blumberg, Dikla / Silva, Angela J / Weinstein, Zoe M / Wong, Mark TinFook / Burganowski, Rachael P

JAMA internal medicine

2023 Volume 183, Issue 12, Page(s) 1343–1354

Abstract: Importance: Few primary care (PC) practices treat patients with medications for opioid use disorder (OUD) despite availability of effective treatments.: Objective: To assess whether implementation of the Massachusetts model of nurse care management ... ...

Abstract	Importance: Few primary care (PC) practices treat patients with medications for opioid use disorder (OUD) despite availability of effective treatments. Objective: To assess whether implementation of the Massachusetts model of nurse care management for OUD in PC increases OUD treatment with buprenorphine or extended-release injectable naltrexone and secondarily decreases acute care utilization. Design, setting, and participants: The Primary Care Opioid Use Disorders Treatment (PROUD) trial was a mixed-methods, implementation-effectiveness cluster randomized clinical trial conducted in 6 diverse health systems across 5 US states (New York, Florida, Michigan, Texas, and Washington). Two PC clinics in each system were randomized to intervention or usual care (UC) stratified by system (5 systems were notified on February 28, 2018, and 1 system with delayed data use agreement on August 31, 2018). Data were obtained from electronic health records and insurance claims. An implementation monitoring team collected qualitative data. Primary care patients were included if they were 16 to 90 years old and visited a participating clinic from up to 3 years before a system's randomization date through 2 years after. Intervention: The PROUD intervention included 3 components: (1) salary for a full-time OUD nurse care manager; (2) training and technical assistance for nurse care managers; and (3) 3 or more PC clinicians agreeing to prescribe buprenorphine. Main outcomes and measures: The primary outcome was a clinic-level measure of patient-years of OUD treatment (buprenorphine or extended-release injectable naltrexone) per 10 000 PC patients during the 2 years postrandomization (follow-up). The secondary outcome, among patients with OUD prerandomization, was a patient-level measure of the number of days of acute care utilization during follow-up. Results: During the baseline period, a total of 130 623 patients were seen in intervention clinics (mean [SD] age, 48.6 [17.7] years; 59.7% female), and 159 459 patients were seen in UC clinics (mean [SD] age, 47.2 [17.5] years; 63.0% female). Intervention clinics provided 8.2 (95% CI, 5.4-∞) more patient-years of OUD treatment per 10 000 PC patients compared with UC clinics (P = .002). Most of the benefit accrued in 2 health systems and in patients new to clinics (5.8 [95% CI, 1.3-∞] more patient-years) or newly treated for OUD postrandomization (8.3 [95% CI, 4.3-∞] more patient-years). Qualitative data indicated that keys to successful implementation included broad commitment to treat OUD in PC from system leaders and PC teams, full financial coverage for OUD treatment, and straightforward pathways for patients to access nurse care managers. Acute care utilization did not differ between intervention and UC clinics (relative rate, 1.16; 95% CI, 0.47-2.92; P = .70). Conclusions and relevance: The PROUD cluster randomized clinical trial intervention meaningfully increased PC OUD treatment, albeit unevenly across health systems; however, it did not decrease acute care utilization among patients with OUD. Trial registration: ClinicalTrials.gov Identifier: NCT03407638.
MeSH term(s)	Humans ; Female ; Middle Aged ; Adolescent ; Young Adult ; Adult ; Aged ; Aged, 80 and over ; Male ; Naltrexone/therapeutic use ; Opiate Substitution Treatment/methods ; Leadership ; Opioid-Related Disorders/drug therapy ; Buprenorphine/therapeutic use
Chemical Substances	Naltrexone (5S6W795CQM) ; Buprenorphine (40D3SCR4GZ)
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2023.5701
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.119: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mass spectrometric identification of candidate RNA-binding proteins associated with Transition Nuclear Protein mRNA in the mouse testis

Bart T. Phillips / Jason G. Williams / Dustin T. Atchley / Xiaojiang Xu / Jian-Liang Li / Andrea L. Adams / Katina L. Johnson / Traci M. Tanaka Hall

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 11

Abstract: Abstract Spermatogenesis is a differentiation process that requires dramatic changes to DNA architecture, a process governed in part by Transition Nuclear Proteins 1 and 2 (TNP1 and TNP2). Translation of Tnp1 and Tnp2 mRNAs is temporally disengaged from ... ...

Abstract	Abstract Spermatogenesis is a differentiation process that requires dramatic changes to DNA architecture, a process governed in part by Transition Nuclear Proteins 1 and 2 (TNP1 and TNP2). Translation of Tnp1 and Tnp2 mRNAs is temporally disengaged from their transcription. We hypothesized that RNA regulatory proteins associate specifically with Tnp mRNAs to control the delayed timing of their translation. To identify potential regulatory proteins, we isolated endogenous mRNA/protein complexes from testis extract and identified by mass spectrometry proteins that associated with one or both Tnp transcripts. Five proteins showed strong association with Tnp transcripts but had low signal when Actin mRNA was isolated. We visualized the expression patterns in testis sections of the five proteins and found that each of the proteins was detected in germ cells at the appropriate stages to regulate Tnp RNA expression.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Gong, Grace Q / Bilanges, Benoit / Allsop, Ben / Masson, Glenn R / Roberton, Victoria / Askwith, Trevor / Oxenford, Sally / Madsen, Ralitsa R / Conduit, Sarah E / Bellini, Dom / Fitzek, Martina / Collier, Matt / Najam, Osman / He, Zhenhe / Wahab, Ben / McLaughlin, Stephen H / Chan, A W Edith / Feierberg, Isabella / Madin, Andrew /

Nature

2023 Volume 618, Issue 7963, Page(s) 159–168

Abstract: Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug ... ...

Abstract	Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Nerve Regeneration/drug effects ; Protein Isoforms/agonists ; Signal Transduction/drug effects ; Class I Phosphatidylinositol 3-Kinases/chemistry ; Class I Phosphatidylinositol 3-Kinases/drug effects ; Cardiotonic Agents/pharmacology ; Animals ; Biocatalysis/drug effects ; Protein Conformation/drug effects ; Neurites/drug effects ; Reperfusion Injury/prevention & control ; Nerve Crush ; Cell Proliferation/drug effects
Chemical Substances	Protein Isoforms ; PIK3CA protein, human (EC 2.7.1.137) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Cardiotonic Agents
Language	English
Publishing date	2023-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-05972-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Spermatogonial stem cell regulation and spermatogenesis.

Phillips, Bart T / Gassei, Kathrin / Orwig, Kyle E

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2010 Volume 365, Issue 1546, Page(s) 1663–1678

Abstract: This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with research using these tools ... ...

Abstract	This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with research using these tools to enhance our understanding of stem cell biology and spermatogenesis. Increased knowledge about the biology of SSCs improves our capacity to manipulate these cells for practical application. The chapter concludes with a discussion of future directions for fundamental investigation and practical applications of SSCs.
MeSH term(s)	Animals ; Cell Cycle/physiology ; Cell Growth Processes/physiology ; Cell Lineage/physiology ; Humans ; Male ; Spermatogenesis/physiology ; Spermatogonia/cytology ; Spermatogonia/physiology ; Stem Cells/cytology ; Stem Cells/physiology
Language	English
Publishing date	2010-04-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2010.0026
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Germline stem cells: toward the regeneration of spermatogenesis.

Valli, Hanna / Phillips, Bart T / Shetty, Gunapala / Byrne, James A / Clark, Amander T / Meistrich, Marvin L / Orwig, Kyle E

Fertility and sterility

2013 Volume 101, Issue 1, Page(s) 3–13

Abstract: Improved therapies for cancer and other conditions have resulted in a growing population of long-term survivors. Infertility is an unfortunate side effect of some cancer therapies that impacts the quality of life of survivors who are in their ... ...

Abstract	Improved therapies for cancer and other conditions have resulted in a growing population of long-term survivors. Infertility is an unfortunate side effect of some cancer therapies that impacts the quality of life of survivors who are in their reproductive or prereproductive years. Some of these patients have the opportunity to preserve their fertility using standard technologies that include sperm, egg, or embryo banking, followed by IVF and/or ET. However, these options are not available to all patients, especially the prepubertal patients who are not yet producing mature gametes. For these patients, there are several stem cell technologies in the research pipeline that may give rise to new fertility options and allow infertile patients to have their own biological children. We will review the role of stem cells in normal spermatogenesis as well as experimental stem cell-based techniques that may have potential to generate or regenerate spermatogenesis and sperm. We will present these technologies in the context of the fertility preservation paradigm, but we anticipate that they will have broad implications for the assisted reproduction field.
MeSH term(s)	Adult Stem Cells/physiology ; Adult Stem Cells/transplantation ; Animals ; Female ; Germ Cells/physiology ; Germ Cells/transplantation ; Humans ; Male ; Regeneration/physiology ; Reproductive Techniques, Assisted/trends ; Spermatogenesis/physiology ; Spermatozoa/physiology ; Spermatozoa/transplantation
Language	English
Publishing date	2013-12-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2013.10.052
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 73: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito