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  1. Article ; Online: Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology.

    Chi, Hongbo

    Cellular & molecular immunology

    2022  Volume 19, Issue 3, Page(s) 299–302

    MeSH term(s) Biochemical Phenomena ; Cell Differentiation ; Signal Transduction
    Language English
    Publishing date 2022-02-21
    Publishing country China
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-022-00840-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nutrients: Signal 4 in T cell immunity.

    Raynor, Jana L / Chi, Hongbo

    The Journal of experimental medicine

    2024  Volume 221, Issue 3

    Abstract: T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer. Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion and effector differentiation. These processes are shaped by three ... ...

    Abstract T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer. Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion and effector differentiation. These processes are shaped by three established immune signals, namely antigen stimulation (Signal 1), costimulation (Signal 2), and cytokines (Signal 3). Emerging findings reveal that nutrients, including glucose, amino acids, and lipids, are crucial regulators of T cell responses and interplay with Signals 1-3, highlighting nutrients as Signal 4 to license T cell immunity. Here, we first summarize the functional importance of Signal 4 and the underlying mechanisms of nutrient transport, sensing, and signaling in orchestrating T cell activation and quiescence exit. We also discuss the roles of nutrients in programming T cell differentiation and functional fitness and how nutrients can be targeted to improve disease therapy. Understanding how T cells respond to Signal 4 nutrients in microenvironments will provide insights into context-dependent functions of adaptive immunity and therapeutic interventions.
    MeSH term(s) T-Lymphocytes ; Adaptive Immunity ; Amino Acids ; Autoimmunity ; Nutrients
    Chemical Substances Amino Acids
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221839
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  3. Article ; Online: Metabolic rewiring and communication in cancer immunity.

    Chapman, Nicole M / Chi, Hongbo

    Cell chemical biology

    2024  

    Abstract: The immune system shapes tumor development and progression. Although immunotherapy has transformed cancer treatment, its overall efficacy remains limited, underscoring the need to uncover mechanisms to improve therapeutic effects. Metabolism-associated ... ...

    Abstract The immune system shapes tumor development and progression. Although immunotherapy has transformed cancer treatment, its overall efficacy remains limited, underscoring the need to uncover mechanisms to improve therapeutic effects. Metabolism-associated processes, including intracellular metabolic reprogramming and intercellular metabolic crosstalk, are emerging as instructive signals for anti-tumor immunity. Here, we first summarize the roles of intracellular metabolic pathways in controlling immune cell function in the tumor microenvironment. How intercellular metabolic communication regulates anti-tumor immunity, and the impact of metabolites or nutrients on signaling events, are also discussed. We then describe how targeting metabolic pathways in tumor cells or intratumoral immune cells or via nutrient-based interventions may boost cancer immunotherapies. Finally, we conclude with discussions on profiling and functional perturbation methods of metabolic activity in intratumoral immune cells, and perspectives on future directions. Uncovering the mechanisms for metabolic rewiring and communication in the tumor microenvironment may enable development of novel cancer immunotherapies.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2024.02.001
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  4. Article ; Online: mTORC2 forms iron-clad defense to guard memory.

    Saravia, Jordy / Chi, Hongbo

    Nature immunology

    2022  Volume 23, Issue 2, Page(s) 155–156

    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01100-2
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    Zs.A 5294: Show issues Location:
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  5. Article ; Online: Early immune pressure makes tumors metabolically stronger.

    Yuan, Sujing / Chi, Hongbo

    Cell metabolism

    2023  Volume 35, Issue 1, Page(s) 3–5

    Abstract: Metabolic communication in the tumor microenvironment underscores tumor-immune interactions and affects anti-tumor immunity, yet cell-extrinsic signals driving tumor metabolic remodeling are incompletely understood. In this issue, Tsai et al. show that ... ...

    Abstract Metabolic communication in the tumor microenvironment underscores tumor-immune interactions and affects anti-tumor immunity, yet cell-extrinsic signals driving tumor metabolic remodeling are incompletely understood. In this issue, Tsai et al. show that during initial tumorigenesis, T cell-derived IFNγ triggers STAT3 activation and c-Myc-dependent alterations of tumor cell metabolism, which potentiates immune evasion.
    MeSH term(s) Humans ; Neoplasms/metabolism ; Carcinogenesis ; Tumor Microenvironment
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.12.009
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  6. Article ; Online: Fructose sweetens the adipocyte-T cell alliance against tumors.

    Zhou, Peipei / Chi, Hongbo

    Cell metabolism

    2023  Volume 35, Issue 12, Page(s) 2093–2094

    Abstract: Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which ... ...

    Abstract Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Fructose/metabolism ; Neoplasms/metabolism ; Adipocytes
    Chemical Substances Fructose (30237-26-4)
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fasting as key tone for COVID immunity.

    Wang, Yan / Chi, Hongbo

    Nature metabolism

    2022  Volume 4, Issue 10, Page(s) 1229–1231

    MeSH term(s) Humans ; Fasting ; COVID-19
    Language English
    Publishing date 2022-09-30
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-022-00646-1
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  8. Article ; Online: Immunometabolism of dendritic cells in health and disease.

    Guo, Chuansheng / Chi, Hongbo

    Advances in immunology

    2023  Volume 160, Page(s) 83–116

    Abstract: Dendritic cells (DCs) are crucial mediators that bridge the innate and adaptive immune responses. Cellular rewiring of metabolism is an emerging regulator of the activation, migration, and functional specialization of DC subsets in specific ... ...

    Abstract Dendritic cells (DCs) are crucial mediators that bridge the innate and adaptive immune responses. Cellular rewiring of metabolism is an emerging regulator of the activation, migration, and functional specialization of DC subsets in specific microenvironments and immunological conditions. DCs undergo metabolic adaptation to exert immunogenic or tolerogenic effects in different contexts. Also, beyond their intracellular metabolic and signaling roles, metabolites and nutrients mediate the intercellular crosstalk between DCs and other cell types, and such crosstalk orchestrates DC function and immune responses. Here, we provide a comprehensive review of the metabolic regulation of DC biology in various contexts and summarize the current understanding of such regulation in directing immune homeostasis and inflammation, specifically with respect to infections, autoimmunity, tolerance, cancer, metabolic diseases, and crosstalk with gut microbes. Understanding context-specific metabolic alterations in DCs may identify mechanisms for physiological and pathological functions of DCs and yield potential opportunities for therapeutic targeting of DC metabolism in many diseases.
    MeSH term(s) Humans ; Autoimmunity ; Immune Tolerance ; Signal Transduction ; Inflammation/metabolism ; Dendritic Cells
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80226-8
    ISSN 1557-8445 ; 0065-2776
    ISSN (online) 1557-8445
    ISSN 0065-2776
    DOI 10.1016/bs.ai.2023.10.002
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  9. Article ; Online: Principles and therapeutic applications of adaptive immunity.

    Chi, Hongbo / Pepper, Marion / Thomas, Paul G

    Cell

    2024  Volume 187, Issue 9, Page(s) 2052–2078

    Abstract: Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we review key ... ...

    Abstract Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we review key principles underlying adaptive immunity orchestrated by distinct T cell and B cell populations and their extensions to disease therapies. We discuss the intracellular and intercellular processes shaping antigen specificity and recognition in immune activation and lymphocyte functions in mediating effector and memory responses. We also describe how lymphocytes balance protective immunity against autoimmunity and immunopathology, including during immune tolerance, response to chronic antigen stimulation, and adaptation to non-lymphoid tissues in coordinating tissue immunity and homeostasis. Finally, we discuss extracellular signals and cell-intrinsic programs underpinning adaptive immunity and conclude by summarizing key advances in vaccination and engineering adaptive immune responses for therapeutic interventions. A deeper understanding of these principles holds promise for uncovering new means to improve human health.
    MeSH term(s) Humans ; Adaptive Immunity ; Animals ; B-Lymphocytes/immunology ; T-Lymphocytes/immunology ; Autoimmunity/immunology
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.03.037
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  10. Article ; Online: Lipid metabolism in dendritic cell biology.

    You, Zhiyuan / Chi, Hongbo

    Immunological reviews

    2023  Volume 317, Issue 1, Page(s) 137–151

    Abstract: Dendritic cells (DCs) are innate immune cells that detect and process environmental signals and communicate them with T cells to bridge innate and adaptive immunity. Immune signals and microenvironmental cues shape the function of DC subsets in different ...

    Abstract Dendritic cells (DCs) are innate immune cells that detect and process environmental signals and communicate them with T cells to bridge innate and adaptive immunity. Immune signals and microenvironmental cues shape the function of DC subsets in different contexts, which is associated with reprogramming of cellular metabolic pathways. In addition to integrating these extracellular cues to meet bioenergetic and biosynthetic demands, cellular metabolism interplays with immune signaling to shape DC-dependent immune responses. Emerging evidence indicates that lipid metabolism serves as a key regulator of DC responses. Here, we summarize the roles of fatty acid and cholesterol metabolism, as well as selective metabolites, in orchestrating the functions of DCs. Specifically, we highlight how different lipid metabolic programs, including de novo fatty acid synthesis, fatty acid β oxidation, lipid storage, and cholesterol efflux, influence DC function in different contexts. Further, we discuss how dysregulation of lipid metabolism shapes DC intracellular signaling and contributes to the impaired DC function in the tumor microenvironment. Finally, we conclude with a discussion on key future directions for the regulation of DC biology by lipid metabolism. Insights into the connections between lipid metabolism and DC functional specialization may facilitate the development of new therapeutic strategies for human diseases.
    MeSH term(s) Humans ; Lipid Metabolism ; Dendritic Cells ; Fatty Acids/metabolism ; Cholesterol/metabolism ; Biology
    Chemical Substances Fatty Acids ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13215
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