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  1. Article ; Online: Th2 cells in rapid immune responses and protective avoidance reactions.

    Goetzl, Edward J

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2024  Volume 38, Issue 4, Page(s) e23485

    Abstract: Type 2 helper cells (Th2 cells) differentiate from CD4 helper T cells under the influence of IL-4 and conventional or monocyte-derived ... ...

    Abstract Type 2 helper cells (Th2 cells) differentiate from CD4 helper T cells under the influence of IL-4 and conventional or monocyte-derived CD11b
    MeSH term(s) Humans ; Th2 Cells ; Dermatitis, Atopic ; Interleukin-13 ; Interleukin-4 ; Interleukin-5 ; Asthma ; Cytokines ; Rhinitis, Allergic ; Antibodies, Monoclonal ; Immunoglobulin E
    Chemical Substances Interleukin-13 ; Interleukin-4 (207137-56-2) ; Interleukin-5 ; Cytokines ; Antibodies, Monoclonal ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202302584RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  2. Article ; Online: An emerging spectrum of therapeutic targets for Alzheimer's disease.

    Goetzl, Edward J

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Volume 37, Issue 11, Page(s) e23238

    Abstract: Development of effective preventative and therapeutic measures for Alzheimer's disease has been unsuccessful because of the long and subtly symptomatic preclinical period, difficulties obtaining tissue and biochemical data from living patients, and the ... ...

    Abstract Development of effective preventative and therapeutic measures for Alzheimer's disease has been unsuccessful because of the long and subtly symptomatic preclinical period, difficulties obtaining tissue and biochemical data from living patients, and the many complex underlying pathogenic processes. Recent applications of sensitive specific bioimaging techniques, analyses of RNAs and proteins of neural cell-derived extracellular vesicles in blood, and sophisticated genetic procedures in cellular and rodent models have yielded hopeful new therapeutic targets. These newer targets are described here in relation to their neural cellular location, potential genetic modifications and possible pharmacological approaches.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Extracellular Vesicles/metabolism ; Neurons/metabolism
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202301461R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CRISPR-Cas Gene Editing to the Genetic Rescue.

    Goetzl, Edward J / Alpert, Joseph S

    The American journal of medicine

    2024  

    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2024.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advancing medicine for Alzheimer's disease: A plasma neural exosome platform.

    Goetzl, Edward J

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 34, Issue 10, Page(s) 13079–13084

    Abstract: Enrichment of neurally derived extracellular vesicles of several cell-types from plasma for protein quantification longitudinally in living patients with Alzheimer's disease has permitted the development of a tentative temporal framework of initiating ... ...

    Abstract Enrichment of neurally derived extracellular vesicles of several cell-types from plasma for protein quantification longitudinally in living patients with Alzheimer's disease has permitted the development of a tentative temporal framework of initiating events, progression mechanisms, and amplification processes. Interactions of beta-amyloid peptides with an elevated level of their normal prion protein dendritic receptor and of phospho-tau species with their synaptogyrin-3 synaptic vesicle receptor replace excessive production and accumulation of neuropathic proteins as the major initiating events. Synaptic dysfunction and microvascular angiopathy are confirmed as early progression mechanisms of decreased neuronal network connectivity, hypoxia, altered blood-brain barrier, and neurocellular degeneration. Neurally derived extracellular vesicle protein abnormalities also reveal a range of later amplification processes that encompasses insulin resistance, lysosomal defects, decreased survival factors, increased reactive oxygen species, and excessive neuroinflammation. New potential therapeutic targets also are suggested as well as the likely timing of their pathogenic engagement.
    MeSH term(s) Alzheimer Disease/blood ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid/blood ; Animals ; Biomarkers/blood ; Exosomes/metabolism ; Humans ; Neurons/metabolism
    Chemical Substances Amyloid ; Biomarkers
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202001655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-COVID: Phase 2 of the COVID-19 Pandemic.

    Goetzl, Edward J / Kapogiannis, Dimitrios

    The American journal of medicine

    2022  Volume 135, Issue 11, Page(s) 1277–1279

    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/epidemiology ; Pandemics ; Post-Acute COVID-19 Syndrome/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.07.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings: Neural signaling

    Goetzl, Edward J.

    opportunities for novel diagnostic approaches and therapies ; [result of a symposium, entitled International Conference on Neural Signaling: Opportunities for Novel Diagnostic Approaches and Therapies, held at Asilomar Conference Grounds in Pacific Grove, California on February 16 - 20, 2008]

    (Annals of the New York Academy of Sciences ; 1144)

    2008  

    Event/congress International Conference on Neural Signaling: Opportunities for Novel Diagnostic Approaches and Therapies (2008, PacificGroveCalif.)
    Author's details ed. by Edward J. Goetzl
    Series title Annals of the New York Academy of Sciences ; 1144
    Collection
    Keywords Neurotransmitter Agents ; Receptors, Neurotransmitter ; Neuropeptides ; Receptors, Neuropeptide ; Signal Transduction / physiology ; Synaptic Transmission / physiology
    Language English
    Size XIII, 265 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015790246
    ISBN 978-1-57331-704-7 ; 1-57331-704-7
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Prediction of Post-Acute-Sequelae of COVID-19 by Cargo Protein Biomarkers of Blood Total Extracellular Vesicles in Acute COVID-19.

    Goetzl, Edward J / Yao, Pamela J / Kapogiannis, Dimitrios

    The American journal of medicine

    2023  Volume 136, Issue 8, Page(s) 824–829

    Abstract: Background: SARS-CoV-2 invades mitochondria of infected cells resulting in disordered metabolism, mitophagy, and abnormal levels of mitochondrial proteins in extracellular vesicles. Blood extracellular vesicle SARS-CoV-2 proteins and mitochondrial ... ...

    Abstract Background: SARS-CoV-2 invades mitochondria of infected cells resulting in disordered metabolism, mitophagy, and abnormal levels of mitochondrial proteins in extracellular vesicles. Blood extracellular vesicle SARS-CoV-2 proteins and mitochondrial proteins were quantified in COVID-19 to assess possible roles as biomarkers.
    Methods: Total extracellular vesicles were precipitated from blood of age- and gender-matched participants with no infection (n=10), acute COVID-19 (n=16), post-acute sequelae of COVID-19 (PASC or long COVID) (n=30), or post-acute COVID without PASC (n=8) and their extracted proteins quantified by enzyme-linked immunosorbent assays (ELISAs).
    Results: Total extracellular vesicle levels of S1 (receptor-binding domain [RBD]) protein were significantly higher in acute infections than in uninfected controls, post-acute infection without PASC, and PASC. Total extracellular vesicle levels of nucleocapsid (N) protein were significantly higher in PASC than in uninfected controls, acute infections, and post-acute infection without PASC. Neither acute levels of S1(RBD) or N proteins predicted progression to PASC. Levels of neither SARS-CoV-2 protein in established PASC correlated with neuropsychiatric manifestations. Significant decreases in total extracellular vesicle levels of the mitochondrial proteins MOTS-c, VDAC-1, and humanin, and elevations of levels of SARM-1 were observed in acutely infected patients who would develop PASC. Significant decreases in total extracellular vesicle levels of MOTS-c and humanin, but not VDAC-1, and elevations of total extracellular vesicle levels of SARM-1 were characteristic of PASC patients with neuropsychiatric manifestations.
    Conclusions: Total extracellular vesicle levels of SARS-CoV-2 proteins in COVID-19 indicate intracellular presence of SARS-CoV-2. Abnormal total extracellular vesicles levels of mitochondrial proteins in acute infections predict a high risk of PASC and later in established PASC are indicative of neuropsychiatric manifestations.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Mitochondrial Proteins ; Extracellular Vesicles ; Biomarkers ; Disease Progression
    Chemical Substances Mitochondrial Proteins ; Biomarkers
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.03.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Conference proceedings: Lysophospholipids and eicosanoids in biology and pathophysiology

    Goetzl, Edward J.

    [result of a Conference Entitled Lysophospholipids and Eicosanoids in Cancer and in Cardiovascular and Neurodegenerative Diseases held on June 25 - 28, 1999 in New York, New York

    (Annals of the New York Academy of Sciences ; 905)

    2000  

    Event/congress Conference Entitled Lysophospholipids and Eicosanoids in Cancer and in Cardiovascular and Neurodegenerative Diseases (1999, NewYorkNY)
    Author's details ed. by Edward J. Goetzl
    Series title Annals of the New York Academy of Sciences ; 905
    Collection
    Keywords Lysophospholipide ; Eicosanoide ; Physiologe ; Pathophysiologie ; New York <NY, 1999>
    Subject Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Eikosanoide ; Icosanoide
    Language English
    Size XIV, 357 S. : Ill., graph. Darst.
    Publishing place New York, N.Y
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT012777377
    ISBN 1-57331-213-4 ; 1-57331-214-2 ; 978-1-57331-213-4 ; 978-1-57331-214-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 110 -905- verfügbar in Königswinter Königswinter

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  9. Article ; Online: Correction: Neuron‑derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.

    Delgado-Peraza, Francheska / Nogueras-Ortiz, Carlos / Simonsen, Anja Hviid / Knight, De'Larrian DeAnté / Yao, Pamela J / Goetzl, Edward J / Jensen, Camilla Steen / Høgh, Peter / Gottrup, Hanne / Vestergaard, Karsten / Hasselbalch, Steen Gregers / Kapogiannis, Dimitrios

    Alzheimer's research & therapy

    2024  Volume 16, Issue 1, Page(s) 18

    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2506521-X
    ISSN 1758-9193 ; 1758-9193
    ISSN (online) 1758-9193
    ISSN 1758-9193
    DOI 10.1186/s13195-023-01371-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer's Disease.

    Yao, Pamela J / Eren, Erden / Goetzl, Edward J / Kapogiannis, Dimitrios

    Biomedicines

    2021  Volume 9, Issue 11

    Abstract: Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1). Dysfunctional mitochondria, manifesting decreased activity of electron transport chain (ETC) ... ...

    Abstract Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1). Dysfunctional mitochondria, manifesting decreased activity of electron transport chain (ETC) complexes and high ROS levels, are involved in Alzheimer's disease (AD) pathogenesis. We hypothesized that neuronal mitochondrial dysfunction in AD is reflected in ETC and SOD1 levels and activity in plasma neuron-derived extracellular vesicles (NDEVs). We immunoprecipitated NDEVs targeting neuronal marker L1CAM from two cohorts: one including 22 individuals with early AD and 29 control subjects; and another including 14 individuals with early AD and 14 control subjects. In the first cohort, we measured levels of complexes I, III, IV, ATP synthase, and SOD1; in the second cohort, we measured levels and catalytic activity of complexes IV and ATP synthase. AD individuals had lower levels of complexes I (
    Language English
    Publishing date 2021-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9111587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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