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Article ; Online: N

von Hagen, Felix / Gundert, Larissa / Strick, Alexander / Klümper, Niklas / Schmidt, Doris / Kristiansen, Glen / Tolkach, Yuri / Toma, Marieta / Ritter, Manuel / Ellinger, Jörg

Molecular carcinogenesis

2021 Volume 60, Issue 5, Page(s) 354–362

Abstract: N ...

Abstract	N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Case-Control Studies ; Down-Regulation ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein Group C/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group C/metabolism ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Neoplasm Grading ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Prognosis ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Survival Analysis
Chemical Substances	HNRNPC protein, human ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B ; Heterogeneous-Nuclear Ribonucleoprotein Group C ; Nerve Tissue Proteins ; RNA Splicing Factors ; RNA-Binding Proteins ; YTHDC1 protein, human ; YTHDF1 protein, human ; YTHDF2 protein, human ; YTHDF3 protein, human ; hnRNP A2 ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1004029-8
ISSN	1098-2744 ; 0899-1987
ISSN (online)	1098-2744
ISSN	0899-1987
DOI	10.1002/mc.23297
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Article ; Online: The N

Strick, Alexander / von Hagen, Felix / Gundert, Larissa / Klümper, Niklas / Tolkach, Yuri / Schmidt, Doris / Kristiansen, Glen / Toma, Marieta / Ritter, Manuel / Ellinger, Jörg

BJU international

2020 Volume 125, Issue 4, Page(s) 617–624

Abstract: Objectives: To comprehensively investigate the role of the N: Patients and methods ...

Abstract	Objectives: To comprehensively investigate the role of the N Patients and methods: The collection of tissue samples was performed within the framework of the Biobank at the Centre for Integrated Oncology Cologne-Bonn. The gene expressions of alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) were determined using quantitative real-time polymerase chain reaction. ALKBH5 and FTO expressions were further investigated in ccRCC, papillary RCC, chromophobe RCC, sarcomatoid RCC, oncocytoma, and benign renal tissue using tissue microarrays. Results: ALKBH5 mRNA, as well as ALKBH5 and FTO protein expressions, was significantly downregulated in ccRCC compared to normal tissue and most of the other studied tumour entities. Decreased mRNA levels of ALKBH5 and FTO correlated with a shortened overall and cancer-specific survival following nephrectomy. Conclusions: Taken together, our present data indicate that the m
MeSH term(s)	Adenoma, Oxyphilic/chemistry ; Adenoma, Oxyphilic/mortality ; Adult ; Aged ; Aged, 80 and over ; AlkB Homolog 5, RNA Demethylase/analysis ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/analysis ; Biomarkers/analysis ; Carcinoma, Renal Cell/chemistry ; Carcinoma, Renal Cell/mortality ; Cohort Studies ; Female ; Humans ; Kidney Neoplasms/chemistry ; Kidney Neoplasms/mortality ; Male ; Middle Aged ; Prognosis ; Survival Rate
Chemical Substances	Biomarkers ; ALKBH5 protein, human (EC 1.14.11.-) ; AlkB Homolog 5, RNA Demethylase (EC 1.14.11.-) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
Language	English
Publishing date	2020-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.15019
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Article ; Online: Surprising Charge-Radius Kink in the Sc Isotopes at N=20.

König, Kristian / Fritzsche, Stephan / Hagen, Gaute / Holt, Jason D / Klose, Andrew / Lantis, Jeremy / Liu, Yuan / Minamisono, Kei / Miyagi, Takayuki / Nazarewicz, Witold / Papenbrock, Thomas / Pineda, Skyy V / Powel, Robert / Reinhard, Paul-Gerhard

Physical review letters

2023 Volume 131, Issue 10, Page(s) 102501

Abstract: ... laser spectroscopy. With the new data, the chain of Sc charge radii extends below the neutron magic number N=20 and ... in the neighboring Ca, K, and Ar isotopic chains. Theoretical models that explain the trend at N=20 for the Ca ...

Abstract	Charge radii of neutron deficient ^{40}Sc and ^{41}Sc nuclei were determined using collinear laser spectroscopy. With the new data, the chain of Sc charge radii extends below the neutron magic number N=20 and shows a pronounced kink, generally taken as a signature of a shell closure, but one notably absent in the neighboring Ca, K, and Ar isotopic chains. Theoretical models that explain the trend at N=20 for the Ca isotopes cannot reproduce this puzzling behavior.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.102501
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Article: Use of modified Custodiol-N as perfusion solution in ex vivo lung perfusion.

Olbertz, Carolin / Pizanis, Nikolaus / Bäumker, Hagen / Kalka, Katharina / Aigner, Clemens / Rauen, Ursula / Nolte, Ingo / Kamler, Markus / Koch, Achim

American journal of translational research

2020 Volume 12, Issue 1, Page(s) 153–161

Abstract: ... for lung transplantation. Custodiol-N solution was originally designed for organ preservation during cold static ... to compare the lung functional outcomes after 4 hours of EVLP using modified Custodiol-N or STEEN Solution ... that underwent EVLP with modified Custodiol-N showed significantly higher oxygen capacity (ΔpO: Conclusion ...

Abstract	Objectives: Ex vivo Lung Perfusion (EVLP) is a promising tool to increase the donor pool for lung transplantation. Custodiol-N solution was originally designed for organ preservation during cold static preservation (CSP) and was successfully used for machine perfusion in kidneys. It was the aim of this study to compare the lung functional outcomes after 4 hours of EVLP using modified Custodiol-N or STEEN Solution Methods: In a porcine DCD model, lungs were perfused either with STEEN Solution Results: Lungs that underwent EVLP with modified Custodiol-N showed significantly higher oxygen capacity (ΔpO Conclusion: In a porcine DCD model of 9 hours CSP followed by four hours of EVLP the use of modified Custodiol-N as perfusion solution was feasible and associated with higher oxygen capacity than STEEN Solution
Language	English
Publishing date	2020-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: N-Cadherin Distinguishes Intrahepatic Cholangiocarcinoma from Liver Metastases of Ductal Adenocarcinoma of the Pancreas.

Gerber, Tiemo S / Goeppert, Benjamin / Hausen, Anne / Witzel, Hagen R / Bartsch, Fabian / Schindeldecker, Mario / Gröger, Lisa-Katharina / Ridder, Dirk A / Cahyadi, Oscar / Esposito, Irene / Gaida, Matthias M / Schirmacher, Peter / Galle, Peter R / Lang, Hauke / Roth, Wilfried / Straub, Beate K

Cancers

2022 Volume 14, Issue 13

Abstract: ... We could previously show that E-cadherin and N-cadherin, transmembrane glycoproteins of adherens junctions, are ... characteristic features of hepatocytes and cholangiocytes. We therefore analyzed E-cadherin and N-cadherin ... with image analysis, fluorescence microscopy, and immunoblots. In the physiological liver, N-cadherin colocalizes ...

Abstract	Carcinomas of the pancreatobiliary system confer an especially unfavorable prognosis. The differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and its subtypes versus liver metastasis of ductal adenocarcinoma of the pancreas (PDAC) is clinically important to allow the best possible therapy. We could previously show that E-cadherin and N-cadherin, transmembrane glycoproteins of adherens junctions, are characteristic features of hepatocytes and cholangiocytes. We therefore analyzed E-cadherin and N-cadherin in the embryonally related epithelia of the bile duct and pancreas, as well as in 312 iCCAs, 513 carcinomas of the extrahepatic bile ducts, 228 gallbladder carcinomas, 131 PDACs, and precursor lesions, with immunohistochemistry combined with image analysis, fluorescence microscopy, and immunoblots. In the physiological liver, N-cadherin colocalizes with E-cadherin in small intrahepatic bile ducts, whereas larger bile ducts and pancreatic ducts are positive for E-cadherin but contain decreasing amounts of N-cadherin. N-cadherin was highly expressed in most iCCAs, whereas in PDACs, N-cadherin was negative or only faintly expressed. E- and N-cadherin expression in tumors of the pancreaticobiliary tract recapitulate their expression in their normal tissue counterparts. N-cadherin is a helpful marker for the differential diagnosis between iCCA and PDAC, with a specificity of 96% and a sensitivity of 67% for small duct iCCAs and 50% for large duct iCCAs.
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14133091
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Article ; Conference proceedings: Kritische Betrachtung der n-Klassifikation HPV-assoziierter Oropharynxkarzinomen – eine Analyse von 313 Patienten

Gehrke, Thomas / Dentler, Mai / Scheich, Matthias / Hagen, Rudolf / Scherzad, Agmal

Laryngo-Rhino-Otologie

2023 Volume 102, Issue S 02

Event/congress	94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
Language	German
Publishing date	2023-05-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0043-1766600
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Article ; Online: Ausgeprägte rechtsseitige Zephalgien mit Parese des rechten N. abducens.

Ickrath, P / Moratin, H / März, A / Pham, M / Neugebauer, H / Wilhelm, C / Hagen, R / Hackenberg, S

HNO

2020 Volume 69, Issue 11, Page(s) 920–924

Title translation	Severe right-sided cephalalgia with right sixth nerve palsy.
MeSH term(s)	Abducens Nerve Diseases/diagnosis ; Headache ; Humans
Language	German
Publishing date	2020-12-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-020-00982-2
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Article: Gold(I) N-heterocyclic carbene precursors for focused electron beam-induced deposition.

Glessi, Cristiano / Mahgoub, Aya / Hagen, Cornelis W / Tilset, Mats

Beilstein journal of nanotechnology

2021 Volume 12, Page(s) 257–269

Abstract: Seven gold(I) N-heterocyclic carbene (NHC) complexes were synthesized, characterized, and ... of the alkyl N-substituents (Me, Et, or iPr), and of the ancillary ligand X (Cl, Br, I, or CF ...

Abstract	Seven gold(I) N-heterocyclic carbene (NHC) complexes were synthesized, characterized, and identified as suitable precursors for focused electron beam-induced deposition (FEBID). Several variations on the core Au(NHC)X moiety were introduced, that is, variations of the NHC ring (imidazole or triazole), of the alkyl N-substituents (Me, Et, or iPr), and of the ancillary ligand X (Cl, Br, I, or CF
Language	English
Publishing date	2021-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.12.21
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Article ; Online: Impact of a conserved N-terminal proline-rich region of the α-subunit of CAAX-prenyltransferases on their enzyme properties.

Hagemann, Anna / Tasillo, Sandro / Aydin, Aykut / Kehrenberg, Miriam Caroline Alice / Bachmann, Hagen Sjard

Cell communication and signaling : CCS

2022 Volume 20, Issue 1, Page(s) 118

Abstract: ... e.g., human) that harbour an N-terminal proline-rich region (PRR) showed different dimerization ... FTase and GGTase I with truncated FTα were active. The K: Conclusions: Our data demonstrate that an N ... not influenced by the truncation of the N-terminal region. Nevertheless, this region shows common ...

Abstract	Background: The CAAX-prenyltransferases farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) are heterodimers with a common α- (FTα) and unique β-subunits. Recently, α-subunits of species (e.g., human) that harbour an N-terminal proline-rich region (PRR) showed different dimerization behaviours than α-subunits without PRR (e.g., yeast). However, the specific function of the PRR has not been elucidated so far. Methods: To determine whether the PRR is a conserved motif throughout eukaryotes, we performed phylogenetics. Elucidating the impact of the PRR on enzyme properties, we cloned human as well as rat PRR deficient FTα, expressed them heterologously and compared protein-protein interaction by pull-down as well as crosslinking experiments. Substrate binding, enzyme activity and sensitivity towards common FTase inhibitors of full length and PRR-deletion α-subunits and their physiological partners was determined by continuous fluorescence assays. Results: The PRR is highly conserved in mammals, with an exception for marsupials harbouring a poly-alanine region instead. The PRR shows similarities to canonical SH3-binding domains and to profilin-binding domains. Independent of the PRR, the α-subunits were able to dimerize with the different physiological β-subunits in in vitro as well as in yeast two-hybrid experiments. FTase and GGTase I with truncated FTα were active. The K Conclusions: Our data demonstrate that an N-terminal PRR of FTα is highly conserved in mammals. We could show that the activity and inhibitability is not influenced by the truncation of the N-terminal region. Nevertheless, this region shows common binding motifs for other proteins involved in cell-signalling, trafficking and phosphorylation, suggesting that this PRR might have other or additional functions in mammals. Our results provide new starting points due to the relevant but only partly understood role of FTα in eukaryotic FTase and GGTase I. Video Abstract.
MeSH term(s)	Animals ; Dimethylallyltranstransferase ; Humans ; Mammals ; Proline ; Protein Prenylation ; Rats ; Saccharomyces cerevisiae ; Substrate Specificity
Chemical Substances	Proline (9DLQ4CIU6V) ; Dimethylallyltranstransferase (EC 2.5.1.1)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-022-00929-w
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Article ; Online: N-Cadherin Distinguishes Intrahepatic Cholangiocarcinoma from Liver Metastases of Ductal Adenocarcinoma of the Pancreas

Tiemo S. Gerber / Benjamin Goeppert / Anne Hausen / Hagen R. Witzel / Fabian Bartsch / Mario Schindeldecker / Lisa-Katharina Gröger / Dirk A. Ridder / Oscar Cahyadi / Irene Esposito / Matthias M. Gaida / Peter Schirmacher / Peter R. Galle / Hauke Lang / Wilfried Roth / Beate K. Straub

Cancers, Vol 14, Iss 3091, p

2022 Volume 3091

Abstract	Carcinomas of the pancreatobiliary system confer an especially unfavorable prognosis. The differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and its subtypes versus liver metastasis of ductal adenocarcinoma of the pancreas (PDAC) is clinically important to allow the best possible therapy. We could previously show that E-cadherin and N-cadherin, transmembrane glycoproteins of adherens junctions, are characteristic features of hepatocytes and cholangiocytes. We therefore analyzed E-cadherin and N-cadherin in the embryonally related epithelia of the bile duct and pancreas, as well as in 312 iCCAs, 513 carcinomas of the extrahepatic bile ducts, 228 gallbladder carcinomas, 131 PDACs, and precursor lesions, with immunohistochemistry combined with image analysis, fluorescence microscopy, and immunoblots. In the physiological liver, N-cadherin colocalizes with E-cadherin in small intrahepatic bile ducts, whereas larger bile ducts and pancreatic ducts are positive for E-cadherin but contain decreasing amounts of N-cadherin. N-cadherin was highly expressed in most iCCAs, whereas in PDACs, N-cadherin was negative or only faintly expressed. E- and N-cadherin expression in tumors of the pancreaticobiliary tract recapitulate their expression in their normal tissue counterparts. N-cadherin is a helpful marker for the differential diagnosis between iCCA and PDAC, with a specificity of 96% and a sensitivity of 67% for small duct iCCAs and 50% for large duct iCCAs.
Keywords	liver cancer ; cell–cell contacts ; adherens junctions ; biliary tract cancer ; differential diagnosis ; tumor biology ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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