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  1. Article ; Online: Evaluation of the mechanism of Gong Ying San activity on dairy cows mastitis by network pharmacology and metabolomics analysis.

    Gao, Shuang / Tang, Liyun / Ma, Jiayi / Wang, Kaiming / Yao, Hua / Tong, Jinjin / Zhang, Hua

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0299234

    Abstract: ... the pharmacological mechanism of the traditional Chinese medicine formulation, Gong Ying San (GYS), by infrared ...

    Abstract Objectives: The goal of this investigation was to identify the main compounds and the pharmacological mechanism of the traditional Chinese medicine formulation, Gong Ying San (GYS), by infrared spectral absorption characteristics, metabolomics, network pharmacology, and molecular-docking analysis for mastitis. The antibacterial and antioxidant activities were determined in vitro.
    Methods: The chemical constituents of GYS were detected by ultra-high-performance liquid chromatography Q-extractive mass spectrometry (UHPLC-QE-MS). Related compounds were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP, http://tcmspw.com/tcmsp.php) and the Encyclopedia of Traditional Chinese Medicine (ETCM, http://www.tcmip.cn/ETCM/index.php/Home/) databases; genes associated with mastitis were identified in DisGENT. A protein-protein interaction (PPI) network was generated using STRING. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment screening was conducted using the R module. Molecular-docking analyses were performed with the AutoDockTools V1.5.6.
    Results: Fifty-four possible compounds in GYS with forty likely targets were found. The compound-target-network analysis showed that five of the ingredients, quercetin, luteolin, kaempferol, beta-sitosterol, and stigmasterol, had degree values >41.6, and the genes TNF, IL-6, IL-1β, ICAM1, CXCL8, CRP, IFNG, TP53, IL-2, and TGFB1 were core targets in the network. Enrichment analysis revealed that pathways associated with cancer, lipids, atherosclerosis, and PI3K-Akt signaling pathways may be critical in the pharmacology network. Molecular-docking data supported the hypothesis that quercetin and luteolin interacted well with TNF-α and IL-6.
    Conclusions: An integrative investigation based on a bioinformatics-network topology provided new insights into the synergistic, multicomponent mechanisms of GYS's anti-inflammatory, antibacterial, and antioxidant activities. It revealed novel possibilities for developing new combination medications for reducing mastitis and its complications.
    MeSH term(s) Animals ; Female ; Humans ; Cattle ; Network Pharmacology ; Antioxidants ; Interleukin-6 ; Luteolin ; Phosphatidylinositol 3-Kinases ; Quercetin ; Mastitis ; Anti-Bacterial Agents ; Molecular Docking Simulation ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional
    Chemical Substances Antioxidants ; Interleukin-6 ; Luteolin (KUX1ZNC9J2) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Quercetin (9IKM0I5T1E) ; Anti-Bacterial Agents ; Drugs, Chinese Herbal
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fungal Taxonomy, Phylogeny, and Ecology: A Themed Issue Dedicated to Academician Wen-Ying Zhuang.

    Gao, Cheng / Cai, Lei

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 12

    Abstract: ... A Themed Issue Dedicated to Academician Wen-Ying Zhuang" [...]. ...

    Abstract We are honored and privileged to edit this Special Issue, "Fungal Taxonomy, Phylogeny, and Ecology: A Themed Issue Dedicated to Academician Wen-Ying Zhuang" [...].
    Language English
    Publishing date 2022-12-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8121294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: On the construction of the relevance vector machine based on Bayesian Ying-Yang harmony learning.

    Cheng, Dansong / Nguyen, Minh Nhut / Gao, Junbin / Shi, Daming

    Neural networks : the official journal of the International Neural Network Society

    2013  Volume 48, Page(s) 173–179

    Abstract: ... pathway, using Xu's Bayesian Ying-Yang (BYY) harmony learning technique. The experimental results have ...

    Abstract Tipping's relevance vector machine (RVM) applies kernel methods to construct basis function networks using a least number of relevant basis functions. Compared to the well-known support vector machine (SVM), the RVM provides a better sparsity, and an automatic estimation of hyperparameters. However, the performance of the original RVM purely depends on the smoothness of the presumed prior of the connection weights and parameters. Consequently, the sparsity is actually still controlled by the choice of kernel functions and/or kernel parameters. This may lead to severe underfitting or overfitting in some cases. In this research, we explicitly involve the number of basis functions into the objective of the optimization procedure, and construct the RVM by maximizing the harmony function between "hypothetical" probability distribution in the forward training pathway and "true" probability distribution in the backward testing pathway, using Xu's Bayesian Ying-Yang (BYY) harmony learning technique. The experimental results have shown that our proposed methodology can achieve both the least complexity of structure and goodness of fit to data.
    MeSH term(s) Algorithms ; Artificial Intelligence ; Bayes Theorem ; Likelihood Functions ; Normal Distribution ; Support Vector Machine
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2013.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Yin yue zhi liao lin chuang ying yong yan jiu

    Gao, Tian

    2015  

    Author's details Gao Tian zhu bian
    MeSH term(s) Music Therapy
    Language Chinese
    Size iv, 407 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787030450753 ; 7030450752
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: WU Ying-kai, a pioneer in cardiothoracic surgery in China.

    Wang, Zhong-gao / Balas, Panagiotis

    Chinese medical journal

    2008  Volume 121, Issue 2, Page(s) 190–191

    MeSH term(s) China ; History, 20th Century ; History, 21st Century ; Thoracic Surgery
    Language English
    Publishing date 2008-01-20
    Publishing country China
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 127089-8
    ISSN 0366-6999 ; 1002-0187
    ISSN 0366-6999 ; 1002-0187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
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    Ua VI Zs.425: Show issues Location:
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  6. Book: Ying Han Han Ying shen nei ke ci hui shou ce

    Gao, Yanxia

    2008  

    Author's details zhu bian Gao Yanxia, Sun Jianping
    MeSH term(s) Nephrology ; Kidney ; Kidney Diseases
    Language Chinese
    Size 498 p. ;, 19 cm.
    Edition Di 1 ban.
    Publisher Jun shi yi xue ke xue chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787801219510 ; 7801219511
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: Traditional Chinese medicine, Qing Ying Tang, ameliorates the severity of acute lung injury induced by severe acute pancreatitis in rats via the upregulation of aquaporin-1.

    Gao, Zhenming / Xu, Junfeng / Sun, Deguang / Zhang, Rixin / Liang, Rui / Wang, Liming / Fan, Rong

    Experimental and therapeutic medicine

    2014  Volume 8, Issue 6, Page(s) 1819–1824

    Abstract: Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases. Qing Yin Tang (QYT), a traditional Chinese medicine, has been shown to ... ...

    Abstract Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases. Qing Yin Tang (QYT), a traditional Chinese medicine, has been shown to effectively reduce the mortality rate of acute lung injury (ALI) induced by severe acute pancreatitis (SAP). The current study aimed to investigate the detailed mechanisms underlying the effects of QYT on ALI induced by SAP, particularly the effects on the expression levels of AQP-1 in the lung tissue. ALI was established in Wister rats who were subsequently divided into four groups: SHAM, ALI, dexamethasone (DEX) and QYT groups (n=8 per group). In the QYT group, 20 ml/kg QYT was administered by gavage immediately following the induction of SAP. Blood and lung tissues were collected 8 h following the induction of pancreatitis. The lung wet/dry ratio, as well as the levels of blood gases, serum amylase and tumor necrosis factor-α (TNF-α), were measured at 4, 8 and 12 h following SAP-associated ALI induction surgery. The expression levels of AQP-1 in the lung tissue were detected by quantitative polymerase chain reaction, immunohistochemistry and western blot analysis. No statistically significant differences were observed with regard to the levels of serum amylase, wet/dry ratio, partial pressure of oxygen, serum TNF-α and pathological changes in the pulmonary tissue between the QYT and DEX groups; however, a statistically significant difference was observed when compared with the ALI group. The expression levels of AQP-1 significantly increased (P<0.05) and lung edema was alleviated in the QYT and DEX groups, when compared with ALI group. Therefore, the expression level of AQP-1 is associated with pulmonary edema. QYT protects the lungs from injury induced by SAP via the upregulation of AQP-1, which suppresses TNF-α expression.
    Language English
    Publishing date 2014-09-22
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2014.1987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Ying-Han-gaokeji-cidian

    Gao, Xuexian

    an English-Chinese dictionary of science and high technology

    2001  

    Title variant an English-Chinese dictionary of science and high technology
    Author's details Ed.: Xuexian Gao
    Language English ; Chinese
    Size 2, 1369 S.
    Publisher Jiangsu-Kexue-Jishu-Chubanshe
    Publishing place Beijing
    Document type Book
    ISBN 7534533260 ; 9787534533266
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book: Si wu tang xian dai yan jiu yu ying yong

    Gao, Yue

    (Zhong yao ming fang xian dai yan jiu yu ying yong cong shu)

    2011  

    Author's details zhu bian Gao Yue, Yang Minghui, Ma Baiping ; bian wei Ma Baiping ... [deng]
    Series title Zhong yao ming fang xian dai yan jiu yu ying yong cong shu
    MeSH term(s) Materia Medica ; Medicine, Chinese Traditional ; Rehmannia ; Angelica sinensis ; Paeonia ; Ligusticum
    Language Chinese
    Size 12, 371 p. :, ill. ;, 27 cm.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117139618 ; 7117139617
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extract.

    Liao, Qiongfeng / Yang, Wei / Jia, Ying / Chen, Xiaohui / Gao, Qiutao / Bi, Kaishun

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2005  Volume 125, Issue 6, Page(s) 509–515

    Abstract: ... In traditional Chinese medicine (TCM), this herb is known as Lu-Ying. Ursolic acid is the major effective constituent of Lu-Ying ... received Lu-Ying extract orally were acidified with acetic acid and then extracted with a mixture of hexane ... studies of ursolic acid after oral administration of Lu-Ying ethanolic extract (at a dose containing 80.32 ...

    Abstract Sambucus chinensis L. is a native perennial herb distributed throughout China. In traditional Chinese medicine (TCM), this herb is known as Lu-Ying. Ursolic acid is the major effective constituent of Lu-Ying. A rapid, sensitive, and accurate liquid chromatography-mass spectrometry (LC-MS) method for the determination of ursolic acid in rat plasma was developed and validated. Plasma samples taken from rats that had received Lu-Ying extract orally were acidified with acetic acid and then extracted with a mixture of hexane-dichloromethane-2-propanol (20:10:1, v/v/v). Separation of ursolic acid was accomplished on a C(18) column interfaced with a single quadrupole mass spectrometer. The mobile phase consisting of methanol and water (95:5, v/v) was delivered at a flow rate of 1.0 ml/min. Atmospheric pressure chemical ionization was operated in negative-ion mode. Using selected ion-monitoring mode, the deprotonated molecules [M-H](-) at m/z 455 and 469 were used to quantify ursolic acid and glycyrrhetic acid (internal standard), respectively. The assay was shown to be linear over the range of 10-1000 ng/ml (r> or =0.9960) with a lower limit of quantification of 10 ng/ml. The method was shown to be reproducible and reliable with intraday precision below 7.8%, interday precision below 8.1%, accuracy within +/-4.3%, and mean extraction recovery excess of 83.6%, which were all calculated from the blank plasma sample spiked with ursolic acid at three concentrations of 20, 200, and 800 ng/ml. The LC-MS method has been successfully applied to pharmacokinetic studies of ursolic acid after oral administration of Lu-Ying ethanolic extract (at a dose containing 80.32 mg/kg ursolic acid) to rats. The main pharmacokinetic parameters were: t(1/2), 4.3 h; K(e), 0.16 1/h; t(max), 1.0 h; C(max), 294.8 ng/ml; AUC(0-t) and AUC(0-infinity), 1007.1 ng.h/ml and 1175.3 ng.h/ml, respectively.
    MeSH term(s) Administration, Oral ; Animals ; Chromatography, Liquid/methods ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Male ; Mass Spectrometry/methods ; Rats ; Rats, Wistar ; Sensitivity and Specificity ; Triterpenes/blood ; Ursolic Acid
    Chemical Substances Drugs, Chinese Herbal ; Triterpenes
    Language English
    Publishing date 2005-06-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.125.509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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