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  1. Article ; Online: Selected aspects of cellular responses in heart failure.

    Karliner, Joel S

    Journal of cardiovascular pharmacology

    2014  Volume 63, Issue 2, Page(s) 83–84

    MeSH term(s) Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Stem Cells/metabolism
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000000066
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  2. Article ; Online: Arsonists and firefighters: the perpetual inflammatory civil war for survival.

    Karliner, Joel S

    Circulation

    2014  Volume 129, Issue 23, Page(s) 2368–2370

    MeSH term(s) Animals ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/metabolism ; Diet, High-Fat ; Glycosphingolipids/biosynthesis ; Male ; Morpholines/pharmacology ; Vascular Stiffness/drug effects
    Chemical Substances Glycosphingolipids ; Morpholines ; RV 538 (73257-80-4)
    Language English
    Publishing date 2014-04-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.114.010006
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  3. Article: Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress.

    Karliner, Joel S

    Biochimica et biophysica acta

    2012  Volume 1831, Issue 1, Page(s) 203–212

    Abstract: Activation of sphingosine kinase/sphingosine 1-phosphate (SK/S1P)-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. S1P is released in both ischemic pre- and post-conditioning. ... ...

    Abstract Activation of sphingosine kinase/sphingosine 1-phosphate (SK/S1P)-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. S1P is released in both ischemic pre- and post-conditioning. Application of exogenous S1P to cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset of reperfusion exerts prosurvival effects. Synthetic congeners of S1P such as FTY720 mimic these responses. Gene targeted mice null for the SK1 isoform whose hearts are subjected to ischemia/reperfusion injury exhibit increased infarct size and respond poorly either to ischemic pre- or postconditioning. Measurements of cardiac SK activity and S1P parallel these observations. Experiments in SK2 knockout mice have revealed that this isoform is necessary for survival in the heart. High density lipoprotein (HDL) is a major carrier of S1P, and studies of hearts in which selected S1P receptors have been inhibited implicate the S1P cargo of HDL in cardioprotection. Inhibition of S1P lyase, an endogenous enzyme that degrades S1P, also leads to cardioprotection. These observations have considerable relevance for future therapeutic approaches to acute and chronic myocardial injury. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
    MeSH term(s) Aldehyde-Lyases/metabolism ; Animals ; Cardiotonic Agents/metabolism ; Humans ; Lipoproteins, HDL/metabolism ; Lysophospholipids/metabolism ; Myocardium/enzymology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism
    Chemical Substances Cardiotonic Agents ; Lipoproteins, HDL ; Lysophospholipids ; sphingosine 1-phosphate (26993-30-6) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-) ; Aldehyde-Lyases (EC 4.1.2.-) ; sphingosine 1-phosphate lyase (aldolase) (EC 4.1.2.27) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2012-06-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2012.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Coronary care

    Karliner, Joel S.

    1981  

    Keywords CORONARY DISEASE / DIAGNOSIS ; CORONARY DISEASE / THERAPY ; CORONARY CARE UNITS
    Size XXV, 1108 S.
    Publisher Churchill Livingstone
    Publishing place New York
    Document type Book
    HBZ-ID HT002554028
    ISBN 0-443-08061-5 ; 978-0-443-08061-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1982 A 698 order for loan Magazin

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  5. Article ; Online: Lessons from the besotted heart.

    Karliner, Joel S

    Journal of the American College of Cardiology

    2009  Volume 54, Issue 23, Page(s) 2197–2198

    MeSH term(s) Acetaldehyde/antagonists & inhibitors ; Acetaldehyde/metabolism ; Aldehyde Dehydrogenase/biosynthesis ; Aldehyde Dehydrogenase, Mitochondrial ; Animals ; Disease Models, Animal ; Ethanol/toxicity ; Forkhead Transcription Factors/metabolism ; Heart/drug effects ; Humans ; Mitochondria, Heart/enzymology ; Mitochondria, Heart/pathology ; Myocardial Contraction/drug effects ; Myocardial Contraction/physiology ; Phosphoprotein Phosphatases/metabolism ; Ventricular Dysfunction, Left/chemically induced ; Ventricular Dysfunction, Left/metabolism ; Ventricular Dysfunction, Left/physiopathology
    Chemical Substances Forkhead Transcription Factors ; Ethanol (3K9958V90M) ; ALDH2 protein, mouse (EC 1.2.1.3) ; Aldehyde Dehydrogenase (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3) ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Acetaldehyde (GO1N1ZPR3B)
    Language English
    Publishing date 2009-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2009.06.052
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    Zs.MO 196: Show issues

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  6. Article ; Online: Sphingosine kinase and sphingosine 1-phosphate in cardioprotection.

    Karliner, Joel S

    Journal of cardiovascular pharmacology

    2009  Volume 53, Issue 3, Page(s) 189–197

    Abstract: Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac ... ...

    Abstract Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset of reperfusion (pharmacologic preconditioning or postconditioning) exerts prosurvival effects. Synthetic congeners of S1P mimic these responses. Gene-targeted mice null for the sphingosine kinase 1 isoform whose hearts are subjected to ischemia/reperfusion injury exhibit increased infarct size and respond poorly either to ischemic preconditioning or to ischemic postconditioning. Measurements of cardiac sphingosine kinase activity and S1P parallel these observations. High-density lipoprotein is a major carrier of S1P, and studies of hearts in which selected S1P receptors have been deleted implicate the S1P cargo of high-density lipoprotein in cardioprotection. These observations have considerable relevance for future therapeutic approaches to acute and chronic myocardial injury.
    MeSH term(s) Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Cell Survival/drug effects ; Cells, Cultured ; Fibroblasts/drug effects ; Fibroblasts/enzymology ; Fibroblasts/metabolism ; Humans ; Lysophospholipids/metabolism ; Lysophospholipids/physiology ; Myocardial Reperfusion Injury/enzymology ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/prevention & control ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/physiology ; Receptors, Lysosphingolipid/agonists ; Signal Transduction/drug effects ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Sphingosine/physiology
    Chemical Substances Cardiotonic Agents ; Lysophospholipids ; Receptors, Lysosphingolipid ; sphingosine 1-phosphate (26993-30-6) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2009-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0b013e3181926706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sphingosine kinase regulation and cardioprotection.

    Karliner, Joel S

    Cardiovascular research

    2008  Volume 82, Issue 2, Page(s) 184–192

    Abstract: Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury. Incubation of S1P with cultured cardiac myocytes subjected to ... ...

    Abstract Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury. Incubation of S1P with cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischaemia or at the onset of reperfusion (pharmacologic pre- or postconditioning) results in reduced myocyte injury. Synthetic agonists active at S1P receptors mimic these responses. Gene-targeted mice null for the SK1 isoform whose hearts are subjected to ischaemia/reperfusion injury exhibit increased infarct size and respond poorly either to ischaemic pre- or postconditioning. Measurements of cardiac SK activity and S1P parallel these observations. Ischaemic postconditioning combined with sphingosine and S1P rescues the heart from prolonged ischaemia. These observations may have considerable relevance for future therapeutic approaches to acute and chronic myocardial injury.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Lysophospholipids/physiology ; Mice ; Myocardial Reperfusion Injury/physiopathology ; Myocardial Reperfusion Injury/prevention & control ; Phosphotransferases (Alcohol Group Acceptor)/physiology ; Rats ; Sphingosine/analogs & derivatives ; Sphingosine/physiology
    Chemical Substances Lysophospholipids ; sphingosine 1-phosphate (26993-30-6) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2008-11-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvn309
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  8. Article ; Online: Toward solving the riddle: the enigma becomes less mysterious.

    Karliner, Joel S

    Circulation research

    2006  Volume 99, Issue 5, Page(s) 465–467

    MeSH term(s) Animals ; Cell Physiological Phenomena ; Humans ; Sphingolipids/physiology
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2006-09-01
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/01.RES.0000241060.26659.d3
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  9. Article: Symbols within words: have we neglected the AdeNOsine A2 receptor?

    Karliner, Joel S

    Cardiovascular research

    2005  Volume 65, Issue 4, Page(s) 763–765

    MeSH term(s) Adenosine/pharmacology ; Adenosine A2 Receptor Agonists ; Animals ; Cardiotonic Agents/pharmacology ; Humans ; Myocardial Infarction/drug therapy ; Receptors, Adenosine A2/physiology
    Chemical Substances Adenosine A2 Receptor Agonists ; Cardiotonic Agents ; Receptors, Adenosine A2 ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2005-03-01
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1016/j.cardiores.2005.01.002
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  10. Article: Off the shelf but not mass produced.

    Karliner, Joel S

    Chemistry & biology

    2005  Volume 12, Issue 6, Page(s) 614–615

    Abstract: Using high-throughput screening, Jo et al. in this issue of Chemistry & Biology [1] have identified SEW2871 as a structurally unique sphingosine 1-phosphate(1) (S1P(1)) receptor agonist. SEW2871 binds to and activates the S1P(1) receptor and initiates a ... ...

    Abstract Using high-throughput screening, Jo et al. in this issue of Chemistry & Biology [1] have identified SEW2871 as a structurally unique sphingosine 1-phosphate(1) (S1P(1)) receptor agonist. SEW2871 binds to and activates the S1P(1) receptor and initiates a survival signaling pathway similar to that of S1P.
    MeSH term(s) Drug Evaluation, Preclinical ; Lysophospholipids/pharmacology ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacology ; Receptors, Lysosphingolipid/agonists ; Receptors, Lysosphingolipid/metabolism ; Signal Transduction/drug effects ; Sphingosine/analogs & derivatives ; Sphingosine/pharmacology ; Thiophenes/chemistry ; Thiophenes/pharmacology
    Chemical Substances Lysophospholipids ; Oxadiazoles ; Receptors, Lysosphingolipid ; SEW2871 ; Thiophenes ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2005-06
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 917827-2
    ISSN 1879-1301 ; 1074-5521
    ISSN (online) 1879-1301
    ISSN 1074-5521
    DOI 10.1016/j.chembiol.2005.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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