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Article ; Online: Biomolecules for Removal of Heavy Metal.

Singh, Namita Ashish

Recent patents on biotechnology

2017 Volume 11, Issue 3, Page(s) 197–203

Abstract: Background: Patents reveal that heavy metals are natural constituents of the earth's crust, but some heavy metals like cadmium, lead, mercury, arsenic etc. are injurious to living organisms at higher concentration. Nowadays, anthropogenic activities ... ...

Abstract	Background: Patents reveal that heavy metals are natural constituents of the earth's crust, but some heavy metals like cadmium, lead, mercury, arsenic etc. are injurious to living organisms at higher concentration. Nowadays, anthropogenic activities have altered geochemical cycles and biochemical balance of heavy metals. Biomolecules are used nowadays for removal of heavy metals compared to other synthetic biosorbents due to their environmental friendly nature and cost effectiveness. Objective: The goal of this work is to identify the role of biomolecules like polysaccharides, polypeptides, natural compounds containing aromatic acid etc. for heavy metal removal by bio sorption. Discussion: It has been observed that efficiency of biomolecules can be increased by functionalization e.g. cellulose functionalization with EDTA, chitosan with sulphur groups, alginate with carboxyl/ hydroxyl group etc. It was found that the porous structure of aerogel beads improves both sorption and kinetic properties of the material. Out of polypeptides metallothionein has been widely used for removal of heavy metal up to 88% from seawater after a single centrifugation. Conclusion: These cost effective functionalized biomolecules are significantly used for remediation of heavy metals by immobilizing these biomolecules onto materials.
Language	English
Publishing date	2017
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2212-4012
ISSN (online)	2212-4012
DOI	10.2174/1872208311666170223155019
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Article ; Online: Spices and herbs: Potential antiviral preventives and immunity boosters during COVID-19.

Singh, Namita Ashish / Kumar, Pradeep / Jyoti / Kumar, Naresh

Phytotherapy research : PTR

2021 Volume 35, Issue 5, Page(s) 2745–2757

Abstract: A severe acute respiratory syndrome is an unusual type of contagious pneumonia that is caused by SARS coronavirus. At present, the whole world is trying to combat this coronavirus disease and scientific communities are putting rigorous efforts to develop ...

Abstract	A severe acute respiratory syndrome is an unusual type of contagious pneumonia that is caused by SARS coronavirus. At present, the whole world is trying to combat this coronavirus disease and scientific communities are putting rigorous efforts to develop vaccines. However, there are only a few specific medical treatments for SARS-CoV-2. Apart from other public health measures taken to prevent this virus, we can boost our immunity with natural products. In this article, we have highlighted the potential of common spices and herbs as antiviral agents and immunity boosters. A questionnaire-based online survey has been conducted on home remedies during COVID-19 among a wide range of peoples (n-531) of different age groups (13-68 years) from various countries. According to the survey, 71.8% of people are taking kadha for combating infection and boosting immunity. Most people (86.1%) think that there is no side effect of kadha while 13.9% think vice versa. A total of 93.6% of people think that spices are helpful in curing coronavirus or other viral infection as well as boosting immunity. Most people are using tulsi drops, vitamin C, and chyawanprash for boosting their immunity. Therefore, we conclude from the survey and available literature that spices and herbs play a significant role against viral infections.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antiviral Agents/therapeutic use ; Humans ; Middle Aged ; SARS-CoV-2 ; Spices ; Young Adult ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7019
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Article: Nanotechnology innovations, industrial applications and patents

Singh, Namita Ashish

Environmental chemistry letters. 2017 June, v. 15, no. 2

2017

Abstract: Nanotechnology can be defined as the use of nanomaterials for human benefit. Nanomaterials have unique properties due to their physical and chemical characteristics at the nanoscale (10â»â¹Â nm). Nowadays, nanotechnology is providing new products in ... ...

Abstract	Nanotechnology can be defined as the use of nanomaterials for human benefit. Nanomaterials have unique properties due to their physical and chemical characteristics at the nanoscale (10â»â¹Â nm). Nowadays, nanotechnology is providing new products in all industrial sectors. This article reviews innovations in fields such as biomedical, diagnosis of diseases, therapeutics, agriculture and food, nanofertilizers, oil, gas, textile and cosmeceuticals and packaging. Recent trends of patents and scholarly publications in nanotechnology are also discussed.
Keywords	cosmetics ; fabrics ; humans ; industrial applications ; nanomaterials ; new products ; oils ; packaging ; patents ; physicochemical properties ; therapeutics
Language	English
Dates of publication	2017-06
Size	p. 185-191.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	2107984-5
ISSN	1610-3661 ; 1610-3653
ISSN (online)	1610-3661
ISSN	1610-3653
DOI	10.1007/s10311-017-0612-8
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Article ; Online: Burden of Anxiety, Depression and Perceived Stress in Patients with Inflammatory Bowel Disease: A Cohort Study from North India.

Singh, Arshdeep / Bhardwaj, Arshia / Tripathi, Ashish / Ranjan, Mukesh Kumar / Singh, Dharmatma / Sachdeva, Ashi / Marwah, Mahima / Sadana, Kriti Sood / Bansal, Namita / Mahajan, Ramit / Kaur, Kirandeep / Midha, Vandana / Sood, Ajit

Digestive diseases and sciences

2024 Volume 69, Issue 3, Page(s) 775–790

Abstract: Background: Patients with Inflammatory bowel disease (IBD) are susceptible to psychiatric co-morbidities. We aimed to ascertain the burden of anxiety, depression, and perceived stress in patients with IBD from north India.: Methods: Consenting adult ... ...

Abstract	Background: Patients with Inflammatory bowel disease (IBD) are susceptible to psychiatric co-morbidities. We aimed to ascertain the burden of anxiety, depression, and perceived stress in patients with IBD from north India. Methods: Consenting adult patients with an established diagnosis of IBD were enrolled. The enrolled patients filled the Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS) questionnaires. The patient and disease characteristics were analyzed to determine the correlations and predictors of psychiatric comorbidities. Results: A total of 318 patients (255 UC, 63 CD; mean age 40.13 ± 12.06 years, 168 [52.8%] males; mean partial Mayo score 2.10 ± 2.35; and mean HBI 2.77 ± 2.13) were enrolled. The prevalence of anxiety, depression and moderate to high perceived stress was 14%, 12%, and 41%, respectively. Females had higher mean perceived stress, anxiety and depression scores compared to males. The partial Mayo score (PMS) correlated poorly with anxiety (ρ = 0.083, p = 0.187), depression (ρ = 0.123, p = 0.49) and perceived stress (ρ = 0.169; p = 0.007). The Harvey Bradshaw index (HBI) correlated fairly with anxiety (ρ = 0.336, p = 0.007) and poorly with depression (ρ = 0.287, p = 0.022) and perceived stress (ρ = 0.20; p = 0.117). Younger age (OR 0.93, 95% CI 0.90-0.97; p = 0.001) and hand-grip strength (OR 4.63, 95% CI 1.88-11.42; p = 0.001) predicted anxiety in patients with UC while rural area of residence (OR 4.75, 95% CI 1.03-21.98; p = 0.046) and HBI (OR 1.60, 95% CI 1.12-2.29; p = 0.009) were significant predictors of anxiety in patients with CD. Conclusion: Psychiatric comorbidities are common in patients with IBD, with higher prevalence in females. Young adults with UC and sarcopenia; and individuals with active CD living in rural areas are at an increased risk of anxiety.
MeSH term(s)	Male ; Young Adult ; Female ; Humans ; Adult ; Middle Aged ; Crohn Disease/diagnosis ; Colitis, Ulcerative/diagnosis ; Cohort Studies ; Depression/diagnosis ; Depression/epidemiology ; Inflammatory Bowel Diseases/diagnosis ; Anxiety/epidemiology ; Anxiety/etiology ; Stress, Psychological/diagnosis ; Stress, Psychological/epidemiology ; Severity of Illness Index ; Psychological Tests ; Self Report
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-023-08242-3
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Article ; Online: Low prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease in India

Arshdeep Singh / Vandana Midha / Vikram Narang / Saurabh Kedia / Ramit Mahajan / Pavan Dhoble / Bhavjeet Kaur Kahlon / Ashvin Singh Dhaliwal / Ashish Tripathi / Shivam Kalra / Narender Pal Jain / Namita Bansal / Rupa Banerjee / Devendra Desai / Usha Dutta / Vineet Ahuja / Ajit Sood

Intestinal Research, Vol 21, Iss 4, Pp 452-

2023 Volume 459

Abstract: Background/Aims Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Limited data exist on PSC in ... ...

Abstract	Background/Aims Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Limited data exist on PSC in patients with IBD from India. We aimed to assess the prevalence and disease spectrum of PSC in Indian patients with IBD. Methods Database of IBD patients at 5 tertiary care IBD centers in India were analyzed retrospectively. Data were extracted and the prevalence of PSC-IBD was calculated. Results Forty-eight patients out of 12,216 patients with IBD (9,231 UC, 2,939 CD, and 46 IBD unclassified) were identified to have PSC, resulting in a prevalence of 0.39%. The UC to CD ratio was 7:1. Male sex and pancolitis (UC) or colonic CD were more commonly associated with PSC-IBD. The diagnosis of IBD preceded the diagnosis of PSC in most of the patients. Majority of the patients were symptomatic for liver disease at diagnosis. Eight patients (16.66%) developed cirrhosis, 5 patients (10.41%), all UC, developed malignancies (3 colorectal cancer [6.25%] and 2 cholangiocarcinoma [4.16%]), and 3 patients died (2 decompensated liver disease [4.16%] and 1 cholangiocarcinoma [2.08%]) on follow-up. None of the patients mandated surgical therapy for IBD. Conclusions Concomitant PSC in patients with IBD is uncommon in India and is associated with lower rates of development of malignancies.
Keywords	colitis ; ulcerative ; cholangitis ; sclerosing ; prevalence ; inflammatory bowel diseases ; india ; Medicine ; R ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	610 ; 616
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Korean Association for the Study of Intestinal Diseases
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Patulin in food: A mycotoxin concern for human health and its management strategies

Mahato, Dipendra Kumar / Kamle, Madhu / Sharma, Bharti / Pandhi, Shikha / Devi, Sheetal / Dhawan, Kajal / Selvakumar, Raman / Mishra, Diwakar / Kumar, Arvind / Arora, Shalini / Singh, Namita Ashish / Kumar, Pradeep

Toxicon. 2021 July 30, v. 198

2021

Abstract: The mycotoxin patulin is primarily produced as a secondary metabolite by numerous fungal species and predominantly by Aspergillus, Byssochlamys, and Penicillium species. It is generally associated with fungal infected food materials. Penicillium expansum ...

Abstract	The mycotoxin patulin is primarily produced as a secondary metabolite by numerous fungal species and predominantly by Aspergillus, Byssochlamys, and Penicillium species. It is generally associated with fungal infected food materials. Penicillium expansum is considered the only fungal species liable for patulin contamination in pome fruits, especially in apples and apple-based products. This toxin in food poses serious health concerns and economic threat, which has aroused the need to adopt effective detection and mitigation strategies. Understanding its origin sources and biosynthetic mechanism stands essential for efficiently designing a management strategy against this fungal contamination. This review aims to present an updated outline of the sources of patulin occurrence in different foods and their biosynthetic mechanisms. It further provides information regarding the detrimental effects of patulin on human and agriculture as well as its effective detection, management, and control strategies.
Keywords	Aspergillus ; Byssochlamys ; Penicillium expansum ; biosynthesis ; fungal contamination ; fungi ; human health ; humans ; patulin ; secondary metabolites
Language	English
Dates of publication	2021-0730
Size	p. 12-23.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2021.04.027
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Article ; Online: Patulin in food: A mycotoxin concern for human health and its management strategies.

Toxicon : official journal of the International Society on Toxinology

2021 Volume 198, Page(s) 12–23

Abstract	The mycotoxin patulin is primarily produced as a secondary metabolite by numerous fungal species and predominantly by Aspergillus, Byssochlamys, and Penicillium species. It is generally associated with fungal infected food materials. Penicillium expansum is considered the only fungal species liable for patulin contamination in pome fruits, especially in apples and apple-based products. This toxin in food poses serious health concerns and economic threat, which has aroused the need to adopt effective detection and mitigation strategies. Understanding its origin sources and biosynthetic mechanism stands essential for efficiently designing a management strategy against this fungal contamination. This review aims to present an updated outline of the sources of patulin occurrence in different foods and their biosynthetic mechanisms. It further provides information regarding the detrimental effects of patulin on human and agriculture as well as its effective detection, management, and control strategies.
MeSH term(s)	Food Contamination/analysis ; Fruit/chemistry ; Humans ; Malus ; Patulin/toxicity ; Penicillium
Chemical Substances	Patulin (95X2BV4W8R)
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2021.04.027
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Article: Low prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease in India.

Singh, Arshdeep / Midha, Vandana / Narang, Vikram / Kedia, Saurabh / Mahajan, Ramit / Dhoble, Pavan / Kahlon, Bhavjeet Kaur / Dhaliwal, Ashvin Singh / Tripathi, Ashish / Kalra, Shivam / Jain, Narender Pal / Bansal, Namita / Banerjee, Rupa / Desai, Devendra / Dutta, Usha / Ahuja, Vineet / Sood, Ajit

Intestinal research

2022 Volume 21, Issue 4, Page(s) 452–459

Abstract: Background/aims: Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). Limited data exist on PSC in ... ...

Abstract	Background/aims: Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). Limited data exist on PSC in patients with IBD from India. We aimed to assess the prevalence and disease spectrum of PSC in Indian patients with IBD. Methods: Database of IBD patients at 5 tertiary care IBD centers in India were analyzed retrospectively. Data were extracted and the prevalence of PSC-IBD was calculated. Results: Forty-eight patients out of 12,216 patients with IBD (9,231 UC, 2,939 CD, and 46 IBD unclassified) were identified to have PSC, resulting in a prevalence of 0.39%. The UC to CD ratio was 7:1. Male sex and pancolitis (UC) or colonic CD were more commonly associated with PSC-IBD. The diagnosis of IBD preceded the diagnosis of PSC in most of the patients. Majority of the patients were symptomatic for liver disease at diagnosis. Eight patients (16.66%) developed cirrhosis, 5 patients (10.41%), all UC, developed malignancies (3 colorectal cancer [6.25%] and 2 cholangiocarcinoma [4.16%]), and 3 patients died (2 decompensated liver disease [4.16%] and 1 cholangiocarcinoma [2.08%]) on follow-up. None of the patients mandated surgical therapy for IBD. Conclusions: Concomitant PSC in patients with IBD is uncommon in India and is associated with lower rates of development of malignancies.
Language	English
Publishing date	2022-12-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018469-1
ISSN	2288-1956 ; 1598-9100
ISSN (online)	2288-1956
ISSN	1598-9100
DOI	10.5217/ir.2022.00087
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Article ; Online: Patient Controlled Epidural Analgesia during Labour: Effect of Addition of Background Infusion on Quality of Analgesia & Maternal Satisfaction.

Srivastava, Uma / Gupta, Amrita / Saxena, Surekha / Kumar, Aditya / Singh, Saroj / Saraswat, Namita / Mishra, Abhijeet R / Kannaujia, Ashish / Mishra, Sukhdev

Indian journal of anaesthesia

2010 Volume 53, Issue 6, Page(s) 649–653

Abstract: Patient controlled epidural analgesia (PCEA) is a well established technique for pain relief during labor. But the inclusion of continuous background infusion to PCEA is controversial. The aim of this study was to assess whether the use of continuous ... ...

Abstract	Patient controlled epidural analgesia (PCEA) is a well established technique for pain relief during labor. But the inclusion of continuous background infusion to PCEA is controversial. The aim of this study was to assess whether the use of continuous infusion along with PCEA was beneficial for laboring women with regards to quality of analgesia, maternal satisfaction and neonatal outcome in comparison to PCEA alone. Fifty five parturients received epidural bolus of 10ml solution containing 0.125% bupivacaine +2 microg.ml(-1) of fentanyl. For maintenance of analgesia the patients of Group PCEA self administered 8 ml bolus with lockout interval of 20 minutes of above solution on demand with no basal infusion. While the patients of Group PCEA + CI received continuous epidural infusion at the rate of 10 ml.hr-1 along with self administered boluses of 3 ml with lockout interval of 10 minutes of similar epidural solution. Patients of both groups were given rescue boluses by the anaesthetists for distressing pain. Verbal analogue pain scores, incidence of distressing pain, need of supplementary/rescue boluses, dose of bupivacaine consumed, maternal satisfaction and neonatal Apgar scores were recorded. No significant difference was observed between mean VAS pain scores during labor, maternal satisfaction, mode of delivery or neonatal Apgar scores. But more patients (n=8) required rescue boluses in PCEA group for distressing pain. The total volume consumed of bupivacaine and opioid was slightly more in PCEA + CI group. In both the techniques the highest sensory level, degree of motor block were comparable & prolongation of labor was not seen. It was concluded that both the techniques provided equivalent labor analgesia, maternal satisfaction and neonatal Apgar scores. PCEA along with continuous infusion at the rate of 10 ml/ hr resulted in lesser incidence of distressing pain and need for rescue analgesic. Although this group consumed higher dose of bupivacaine, it did not affect maternal or neonatal safety.
Language	English
Publishing date	2010-02-08
Publishing country	India
Document type	Journal Article
ZDB-ID	412570-8
ISSN	0976-2817 ; 0019-5049
ISSN (online)	0976-2817
ISSN	0019-5049
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Article ; Online: Patient Controlled Epidural Analgesia during Labour

Uma Srivastava / Amrita Gupta / Surekha Saxena / Aditya Kumar / Saroj Singh / Namita Saraswat / Abhijeet R Mishra / Ashish Kannaujia / Sukhdev Mishra

Indian Journal of Anaesthesia, Vol 53, Iss 6, Pp 649-

Effect of Addition of Background Infusion on Quality of Analgesia & Maternal Satisfaction

2009 Volume 653

Abstract	Patient controlled epidural analgesia (PCEA) is a well established technique for pain relief during labor. But the inclusion of continuous background infusion to PCEA is controversial. The aim of this study was to assess whether the use of continuous infusion along with PCEA was beneficial for laboring women with regards to quality of analgesia, maternal satisfaction and neonatal outcome in comparison to PCEA alone. Fifty five parturients received epidural bolus of 10ml solution containing 0.125% bupivacaine +2 ìg.ml-1 of fentanyl. For maintenance of analgesia the patients of Group PCEA self administered 8 ml bolus with lockout interval of 20 minutes of above solution on demand with no basal infusion. While the patients of Group PCEA + CI received continuous epidural infusion at the rate of 10 ml.hr-1 along with self administered boluses of 3 ml with lockout interval of 10 minutes of similar epidural solution. Patients of both groups were given rescue boluses by the anaesthetists for distressing pain. Verbal analogue pain scores, incidence of distressing pain, need of supplementary/rescue boluses, dose of bupivacaine consumed, maternal satisfaction and neonatal Apgar scores were recorded. No significant difference was observed between mean VAS pain scores during labor, maternal satisfaction, mode of delivery or neonatal Apgar scores. But more patients (n=8) required rescue boluses in PCEA group for distressing pain. The total volume consumed of bupivacaine and opioid was slightly more in PCEA + CI group. In both the techniques the highest sensory level, degree of motor block were comparable& prolongation of labor was not seen. It was concluded that both the techniques provided equivalent labor analgesia, maternal satisfaction and neonatal Apgar scores. PCEA along with continuous infusion at the rate of 10 ml/ hr resulted in lesser incidence of distressing pain and need for rescue analgesic. Although this group consumed higher dose of bupivacaine, it did not affect maternal or neonatal safety.
Keywords	PCEA ; Background infusion ; Labor analgesia ; Anesthesiology ; RD78.3-87.3 ; Surgery ; RD1-811 ; Medicine ; R
Subject code	616
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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